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Central Nervous System-Related Pathogens.

Aldrich CC.

ACS Infect Dis. 2019 Dec 13;5(12):1975. doi: 10.1021/acsinfecdis.9b00445. Epub 2019 Nov 22. No abstract available.


Macozinone: revised synthesis and crystal structure of a promising new drug for treating drug-sensitive and drug-resistant tuberculosis.

Zhang G, Aldrich CC.

Acta Crystallogr C Struct Chem. 2019 Aug 1;75(Pt 8):1031-1035. doi: 10.1107/S2053229619009185. Epub 2019 Jul 5.


Noncompetitive inhibitors of TNFR1 probe conformational activation states.

Lo CH, Schaaf TM, Grant BD, Lim CK, Bawaskar P, Aldrich CC, Thomas DD, Sachs JN.

Sci Signal. 2019 Jul 30;12(592). pii: eaav5637. doi: 10.1126/scisignal.aav5637.


Development of an imidazole salt catalytic system for the preparation of bis(indolyl)methanes and bis(naphthyl)methane.

Wang X, Aldrich CC.

PLoS One. 2019 Apr 25;14(4):e0216008. doi: 10.1371/journal.pone.0216008. eCollection 2019.


Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties.

Zhang G, Howe M, Aldrich CC.

ACS Med Chem Lett. 2019 Feb 23;10(3):348-351. doi: 10.1021/acsmedchemlett.8b00634. eCollection 2019 Mar 14.


Mechanism of a Standalone β-Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme.

Robinson SL, Christenson JK, Richman JE, Jenkins DJ, Neres J, Fonseca DR, Aldrich CC, Wackett LP.

Chembiochem. 2019 Jul 1;20(13):1701-1711. doi: 10.1002/cbic.201800821. Epub 2019 May 16.


A Cinchona Alkaloid Antibiotic That Appears To Target ATP Synthase in Streptococcus pneumoniae.

Wang X, Zeng Y, Sheng L, Larson P, Liu X, Zou X, Wang S, Guo K, Ma C, Zhang G, Cui H, Ferguson DM, Li Y, Zhang J, Aldrich CC.

J Med Chem. 2019 Mar 14;62(5):2305-2332. doi: 10.1021/acs.jmedchem.8b01353. Epub 2019 Mar 1.


Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.

Bockman MR, Engelhart CA, Cramer JD, Howe MD, Mishra NK, Zimmerman M, Larson P, Alvarez-Cabrera N, Park SW, Boshoff HIM, Bean JM, Young VG Jr, Ferguson DM, Dartois V, Jarrett JT, Schnappinger D, Aldrich CC.

ACS Infect Dis. 2019 Apr 12;5(4):598-617. doi: 10.1021/acsinfecdis.8b00345. Epub 2019 Feb 4.


Structural Basis of Polyketide Synthase O-Methylation.

Skiba MA, Bivins MM, Schultz JR, Bernard SM, Fiers WD, Dan Q, Kulkarni S, Wipf P, Gerwick WH, Sherman DH, Aldrich CC, Smith JL.

ACS Chem Biol. 2018 Dec 21;13(12):3221-3228. doi: 10.1021/acschembio.8b00687. Epub 2018 Dec 3.


Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis.

Howe MD, Kordus SL, Cole MS, Bauman AA, Aldrich CC, Baughn AD, Minato Y.

Front Cell Infect Microbiol. 2018 Nov 12;8:399. doi: 10.3389/fcimb.2018.00399. eCollection 2018.


Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.

Gulick AM, Aldrich CC.

Nat Prod Rep. 2018 Nov 14;35(11):1156-1184. doi: 10.1039/c8np00044a. Review.


PKS-NRPS Enzymology and Structural Biology: Considerations in Protein Production.

Skiba MA, Maloney FP, Dan Q, Fraley AE, Aldrich CC, Smith JL, Brown WC.

Methods Enzymol. 2018;604:45-88. doi: 10.1016/bs.mie.2018.01.035. Epub 2018 Mar 16.


Targeting protein biotinylation enhances tuberculosis chemotherapy.

Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, Dartois V, Schnappinger D.

Sci Transl Med. 2018 Apr 25;10(438). pii: eaal1803. doi: 10.1126/scitranslmed.aal1803.


Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.

Dawadi S, Boshoff HIM, Park SW, Schnappinger D, Aldrich CC.

ACS Med Chem Lett. 2018 Mar 16;9(4):386-391. doi: 10.1021/acsmedchemlett.8b00090. eCollection 2018 Apr 12.


Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification.

Bockman MR, Engelhart CA, Dawadi S, Larson P, Tiwari D, Ferguson DM, Schnappinger D, Aldrich CC.

ACS Infect Dis. 2018 Jul 13;4(7):1102-1113. doi: 10.1021/acsinfecdis.8b00038. Epub 2018 Apr 17.


Scalable Synthesis of Hydrido-Disiloxanes from Silanes: A One-Pot Preparation of 1,3-Diphenyldisiloxane from Phenylsilane.

Buonomo JA, Eiden CG, Aldrich CC.

Synthesis (Stuttg). 2018 Jan;50(2):278-281. doi: 10.1055/s-0036-1588580. Epub 2017 Sep 26.


2nd SCI/RSC Symposium on Medicinal Chemistry for Global Health: A Unique Opportunity for the Field.

Aldrich CC, Calderón F.

ACS Infect Dis. 2018 Apr 13;4(4):424-428. doi: 10.1021/acsinfecdis.8b00022. No abstract available.


Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae.

Bailey DC, Alexander E, Rice MR, Drake EJ, Mydy LS, Aldrich CC, Gulick AM.

J Biol Chem. 2018 May 18;293(20):7841-7852. doi: 10.1074/jbc.RA118.002798. Epub 2018 Apr 4.


Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole.

Minato Y, Dawadi S, Kordus SL, Sivanandam A, Aldrich CC, Baughn AD.

Nat Commun. 2018 Mar 8;9(1):1003. doi: 10.1038/s41467-018-03447-x.


Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular.

Negatu DA, Liu JJJ, Zimmerman M, Kaya F, Dartois V, Aldrich CC, Gengenbacher M, Dick T.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01571-17. doi: 10.1128/AAC.01571-17. Print 2018 Mar.


Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates.

Dawadi S, Kordus SL, Baughn AD, Aldrich CC.

Org Lett. 2017 Oct 6;19(19):5220-5223. doi: 10.1021/acs.orglett.7b02487. Epub 2017 Sep 19.


Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma.

Okon A, Han J, Dawadi S, Demosthenous C, Aldrich CC, Gupta M, Wagner CR.

J Med Chem. 2017 Oct 12;60(19):8131-8144. doi: 10.1021/acs.jmedchem.7b00916. Epub 2017 Sep 20.


Chemoselective Reduction of Phosphine Oxides by 1,3-Diphenyl-Disiloxane.

Buonomo JA, Eiden CG, Aldrich CC.

Chemistry. 2017 Oct 17;23(58):14434-14438. doi: 10.1002/chem.201703875. Epub 2017 Sep 18.


Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.

Liu F, Dawadi S, Maize KM, Dai R, Park SW, Schnappinger D, Finzel BC, Aldrich CC.

J Med Chem. 2017 Jul 13;60(13):5507-5520. doi: 10.1021/acs.jmedchem.7b00189. Epub 2017 Jun 22.


Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.

Eiden CG, Maize KM, Finzel BC, Lipscomb JD, Aldrich CC.

J Am Chem Soc. 2017 May 31;139(21):7132-7135. doi: 10.1021/jacs.7b00962. Epub 2017 May 18.


ACS Infectious Diseases Special Issue Focused on Drug Discovery for Global Health.

Aldrich CC, Calderón F.

ACS Infect Dis. 2017 May 12;3(5):329. doi: 10.1021/acsinfecdis.7b00050. No abstract available.


Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol.

Zhang XK, Liu F, Fiers WD, Sun WM, Guo J, Liu Z, Aldrich CC.

J Org Chem. 2017 Apr 7;82(7):3432-3440. doi: 10.1021/acs.joc.6b02801. Epub 2017 Mar 17.


Introducing a New Associate Editor for ACS Infectious Diseases.

Aldrich CC.

ACS Infect Dis. 2017 Feb 10;3(2):110. doi: 10.1021/acsinfecdis.7b00018. No abstract available.


Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.

Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC.

J Am Chem Soc. 2016 Dec 14;138(49):16024-16036. Epub 2016 Nov 30.


Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.

Štular T, Lešnik S, Rožman K, Schink J, Zdouc M, Ghysels A, Liu F, Aldrich CC, Haupt VJ, Salentin S, Daminelli S, Schroeder M, Langer T, Gobec S, Janežič D, Konc J.

J Med Chem. 2016 Dec 22;59(24):11069-11078. doi: 10.1021/acs.jmedchem.6b01277. Epub 2016 Dec 12.


Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates.

Thiede JM, Kordus SL, Turman BJ, Buonomo JA, Aldrich CC, Minato Y, Baughn AD.

Sci Rep. 2016 Dec 1;6:38083. doi: 10.1038/srep38083.


Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL.

ACS Chem Biol. 2016 Dec 16;11(12):3319-3327. Epub 2016 Oct 18.


The Known Unknowns of Emerging Viruses.

Aldrich CC.

ACS Infect Dis. 2016 May 13;2(5):310-1. doi: 10.1021/acsinfecdis.6b00072. No abstract available.


A Role for Chemists in Microbiome Research.

Aldrich CC.

ACS Infect Dis. 2016 Jul 8;2(7):451. doi: 10.1021/acsinfecdis.6b00118. No abstract available.


Antibiotic Discovery for Mycobacteria.

Aldrich CC.

ACS Infect Dis. 2015 Dec 11;1(12):576-7. doi: 10.1021/acsinfecdis.5b00138. No abstract available.


Going Viral.

Kindrachuk KN, Aldrich CC.

ACS Infect Dis. 2015 Sep 11;1(9):399. doi: 10.1021/acsinfecdis.5b00098. No abstract available.


Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture.

Miller BR, Drake EJ, Shi C, Aldrich CC, Gulick AM.

J Biol Chem. 2016 Oct 21;291(43):22559-22571. Epub 2016 Sep 5.


Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.

Kuhn ML, Alexander E, Minasov G, Page HJ, Warwrzak Z, Shuvalova L, Flores KJ, Wilson DJ, Shi C, Aldrich CC, Anderson WF.

ACS Infect Dis. 2016 Aug 12;2(8):579-591. Epub 2016 Jul 1.


2-Aryl-8-aza-3-deazaadenosine analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis.

Krajczyk A, Zeidler J, Januszczyk P, Dawadi S, Boshoff HI, Barry CE 3rd, Ostrowski T, Aldrich CC.

Bioorg Med Chem. 2016 Jul 15;24(14):3133-43. doi: 10.1016/j.bmc.2016.05.037. Epub 2016 May 20.


Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.

Dawadi S, Kawamura S, Rubenstein A, Remmel R, Aldrich CC.

Bioorg Med Chem. 2016 Mar 15;24(6):1314-21. doi: 10.1016/j.bmc.2016.02.002. Epub 2016 Feb 3.


Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay.

Duckworth BP, Wilson DJ, Aldrich CC.

Methods Mol Biol. 2016;1401:53-61. doi: 10.1007/978-1-4939-3375-4_3.


Structures of two distinct conformations of holo-non-ribosomal peptide synthetases.

Drake EJ, Miller BR, Shi C, Tarrasch JT, Sundlov JA, Allen CL, Skiniotis G, Aldrich CC, Gulick AM.

Nature. 2016 Jan 14;529(7585):235-8. doi: 10.1038/nature16163.


Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.

Srivastava S, Chaudhary S, Thukral L, Shi C, Gupta RD, Gupta R, Priyadarshan K, Vats A, Haque AS, Sankaranarayanan R, Natarajan VT, Sharma R, Aldrich CC, Gokhale RS.

Chem Biol. 2015 Dec 17;22(12):1577-87. doi: 10.1016/j.chembiol.2015.10.009. Epub 2015 Nov 25.


Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches.

Anand A, Verma P, Singh AK, Kaushik S, Pandey R, Shi C, Kaur H, Chawla M, Elechalawar CK, Kumar D, Yang Y, Bhavesh NS, Banerjee R, Dash D, Singh A, Natarajan VT, Ojha AK, Aldrich CC, Gokhale RS.

Mol Cell. 2015 Nov 19;60(4):637-50. doi: 10.1016/j.molcel.2015.10.016. Epub 2015 Nov 12.


Mitsunobu Reactions Catalytic in Phosphine and a Fully Catalytic System.

Buonomo JA, Aldrich CC.

Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13041-4. doi: 10.1002/anie.201506263. Epub 2015 Sep 8.


Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.

Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D, Finzel BC, Aldrich CC.

J Med Chem. 2015 Sep 24;58(18):7349-7369. doi: 10.1021/acs.jmedchem.5b00719. Epub 2015 Sep 3.


Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis.

Nelson KM, Viswanathan K, Dawadi S, Duckworth BP, Boshoff HI, Barry CE 3rd, Aldrich CC.

J Med Chem. 2015 Jul 23;58(14):5459-75. doi: 10.1021/acs.jmedchem.5b00391. Epub 2015 Jul 9.


Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.

Dai R, Geders TW, Liu F, Park SW, Schnappinger D, Aldrich CC, Finzel BC.

J Med Chem. 2015 Jul 9;58(13):5208-17. doi: 10.1021/acs.jmedchem.5b00092. Epub 2015 Jun 24.

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