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Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B.

Morley SA, Peralta-Castro A, Brieba LG, Miller J, Ong KL, Ridge PG, Oliphant A, Aldous S, Nielsen BL.

BMC Plant Biol. 2019 Jun 6;19(1):241. doi: 10.1186/s12870-019-1854-3.


Validity of a Novel Point-of-Care Troponin Assay for Single-Test Rule-Out of Acute Myocardial Infarction.

Pickering JW, Young JM, George PM, Watson AS, Aldous SJ, Troughton RW, Pemberton CJ, Richards AM, Cullen LA, Than MP.

JAMA Cardiol. 2018 Nov 1;3(11):1108-1112. doi: 10.1001/jamacardio.2018.3368.


Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department.

Kavsak PA, Neumann JT, Cullen L, Than M, Shortt C, Greenslade JH, Pickering JW, Ojeda F, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Westermann D, Sörensen NA, Parsonage WA, Griffith L, Mehta SR, Devereaux PJ, Richards M, Troughton R, Pemberton C, Aldous S, Blankenberg S, Worster A.

CMAJ. 2018 Aug 20;190(33):E974-E984. doi: 10.1503/cmaj.180144.


Proteomic analysis of S-nitrosylated nuclear proteins in rat cortical neurons.

Smith JG, Aldous SG, Andreassi C, Cuda G, Gaspari M, Riccio A.

Sci Signal. 2018 Jul 3;11(537). pii: eaar3396. doi: 10.1126/scisignal.aar3396.


Detectable High-Sensitivity Cardiac Troponin within the Population Reference Interval Conveys High 5-Year Cardiovascular Risk: An Observational Study.

Than MP, Aldous SJ, Troughton RW, Pemberton CJ, Richards AM, Frampton CMA, Florkowski CM, George PM, Bailey S, Young JM, Cullen L, Greenslade JH, Parsonage WA, Everett BM, Peacock WF, Jaffe AS, Pickering JW.

Clin Chem. 2018 Jul;64(7):1044-1053. doi: 10.1373/clinchem.2017.285700. Epub 2018 May 14.


Systematic review of high-level mobility training in people with a neurological impairment.

Spencer T, Aldous S, Williams G, Fahey M.

Brain Inj. 2018;32(4):403-415. doi: 10.1080/02699052.2018.1429656. Epub 2018 Feb 2.


ICare-ACS (Improving Care Processes for Patients With Suspected Acute Coronary Syndrome): A Study of Cross-System Implementation of a National Clinical Pathway.

Than MP, Pickering JW, Dryden JM, Lord SJ, Aitken SA, Aldous SJ, Allan KE, Ardagh MW, Bonning JWN, Callender R, Chapman LRE, Christiansen JP, Cromhout APJ, Cullen L, Deely JM, Devlin GP, Ferrier KA, Florkowski CM, Frampton CMA, George PM, Hamilton GJ, Jaffe AS, Kerr AJ, Larkin GL, Makower RM, Matthews TJE, Parsonage WA, Peacock WF, Peckler BF, van Pelt NC, Poynton L, Richards AM, Scott AG, Simmonds MB, Smyth D, Thomas OP, To ACY, Du Toit SA, Troughton RW, Yates KM; ICare-ACS Implementation Group.

Circulation. 2018 Jan 23;137(4):354-363. doi: 10.1161/CIRCULATIONAHA.117.031984. Epub 2017 Nov 14.


Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis.

Pickering JW, Than MP, Cullen L, Aldous S, Ter Avest E, Body R, Carlton EW, Collinson P, Dupuy AM, Ekelund U, Eggers KM, Florkowski CM, Freund Y, George P, Goodacre S, Greenslade JH, Jaffe AS, Lord SJ, Mokhtari A, Mueller C, Munro A, Mustapha S, Parsonage W, Peacock WF, Pemberton C, Richards AM, Sanchis J, Staub LP, Troughton R, Twerenbold R, Wildi K, Young J.

Ann Intern Med. 2017 May 16;166(10):715-724. doi: 10.7326/M16-2562. Epub 2017 Apr 18. Erratum in: Ann Intern Med. 2017 Oct 3;167(7):528.


Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction.

Pickering JW, Greenslade JH, Cullen L, Flaws D, Parsonage W, Aldous S, George P, Worster A, Kavsak PA, Than MP.

Circulation. 2016 Nov 15;134(20):1532-1541. Epub 2016 Oct 17.


Heart Fatty Acid Binding Protein and cardiac troponin: development of an optimal rule-out strategy for acute myocardial infarction.

Young JM, Pickering JW, George PM, Aldous SJ, Wallace J, Frampton CM, Troughton RW, Richards MA, Greenslade JH, Cullen L, Than MP.

BMC Emerg Med. 2016 Aug 31;16(1):34. doi: 10.1186/s12873-016-0089-y.


Evaluation of High-Sensitivity Cardiac Troponin I Levels in Patients With Suspected Acute Coronary Syndrome.

Carlton E, Greenslade J, Cullen L, Body R, Than M, Pickering JW, Aldous S, Carley S, Hammett C, Kendall J, Keevil B, Lord S, Parsonage W, Greaves K.

JAMA Cardiol. 2016 Jul 1;1(4):405-12. doi: 10.1001/jamacardio.2016.1309.


External validation of the emergency department assessment of chest pain score accelerated diagnostic pathway (EDACS-ADP).

Flaws D, Than M, Scheuermeyer FX, Christenson J, Boychuk B, Greenslade JH, Aldous S, Hammett CJ, Parsonage WA, Deely JM, Pickering JW, Cullen L.

Emerg Med J. 2016 Sep;33(9):618-25. doi: 10.1136/emermed-2015-205028. Epub 2016 Jul 12.


Validation of NICE diagnostic guidance for rule out of myocardial infarction using high-sensitivity troponin tests.

Parsonage WA, Mueller C, Greenslade JH, Wildi K, Pickering J, Than M, Aldous S, Boeddinghaus J, Hammett CJ, Hawkins T, Nestelberger T, Reichlin T, Reidt S, Rubin Gimenez M, Tate JR, Twerenbold R, Ungerer JP, Cullen L.

Heart. 2016 Aug 15;102(16):1279-86. doi: 10.1136/heartjnl-2016-309270. Epub 2016 Jun 10.


Autophagy gene expression profiling identifies a defective microtubule-associated protein light chain 3A mutant in cancer.

Costa JR, Prak K, Aldous S, Gewinner CA, Ketteler R.

Oncotarget. 2016 Jul 5;7(27):41203-41216. doi: 10.18632/oncotarget.9754.


B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain.

Pemberton CJ, Frampton CM, Aldous S, Bailey M, Young J, Troughton R, Than M, Richards M.

Clin Biochem. 2016 Jun;49(9):645-650. doi: 10.1016/j.clinbiochem.2016.02.015. Epub 2016 Mar 9.


Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice.

Than MP, Pickering JW, Aldous SJ, Cullen L, Frampton CM, Peacock WF, Jaffe AS, Goodacre SW, Richards AM, Ardagh MW, Deely JM, Florkowski CM, George P, Hamilton GJ, Jardine DL, Troughton RW, van Wyk P, Young JM, Bannister L, Lord SJ.

Ann Emerg Med. 2016 Jul;68(1):93-102.e1. doi: 10.1016/j.annemergmed.2016.01.001.


Two-Hour Algorithm for Triage toward Rule-Out and Rule-In of Acute Myocardial Infarction by Use of High-Sensitivity Cardiac Troponin I.

Boeddinghaus J, Reichlin T, Cullen L, Greenslade JH, Parsonage WA, Hammett C, Pickering JW, Hawkins T, Aldous S, Twerenbold R, Wildi K, Nestelberger T, Grimm K, Rubini-Gimenez M, Puelacher C, Kern V, Rentsch K, Than M, Mueller C.

Clin Chem. 2016 Mar;62(3):494-504. doi: 10.1373/clinchem.2015.249508. Epub 2016 Jan 21.


Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome.

Cullen L, Greenslade JH, Menzies L, Leong A, Than M, Pemberton C, Aldous S, Pickering J, Dalton E, Crosling B, Foreman R, Parsonage WA.

Emerg Med J. 2016 Jun;33(6):390-5. doi: 10.1136/emermed-2015-204978. Epub 2016 Jan 18.


Frequency and characteristics of goal attainment following BoNT-A injection for management of spasticity.

Mullins D, Winter A, Fini N, Dixon C, Aldous S, Palit M, Holland AE.

Disabil Rehabil. 2016 Sep;38(19):1927-33. doi: 10.3109/09638288.2015.1107781. Epub 2015 Dec 30.


CNP Signal Peptide in Patients with Cardiovascular Disease.

Lee J, Than M, Aldous S, Troughton R, Richards M, Pemberton CJ.

Front Cardiovasc Med. 2015 Jun 15;2:28. doi: 10.3389/fcvm.2015.00028. eCollection 2015.


The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing.

Aldous S, Richards AM, Cullen L, Pickering JW, Than M.

Emerg Med J. 2016 May;33(5):319-24. doi: 10.1136/emermed-2015-204823. Epub 2015 Oct 28.


A Clinical Decision Rule to Identify Emergency Department Patients at Low Risk for Acute Coronary Syndrome Who Do Not Need Objective Coronary Artery Disease Testing: The No Objective Testing Rule.

Greenslade JH, Parsonage W, Than M, Scott A, Aldous S, Pickering JW, Hammett CJ, Cullen L.

Ann Emerg Med. 2016 Apr;67(4):478-489.e2. doi: 10.1016/j.annemergmed.2015.08.006. Epub 2015 Sep 10.


The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department.

Pickering JW, Young JM, George P, Aldous S, Cullen L, Greenslade JH, Richards AM, Troughton R, Ardagh M, Frampton CM, Than MP.

Clin Biochem. 2015 Dec;48(18):1219-24. doi: 10.1016/j.clinbiochem.2015.07.033. Epub 2015 Jul 29.


A novel troponin T peptide in humans: Assay, biochemistry and preliminary findings in acute coronary syndromes.

Lee J, Young J, Frampton CM, Aldous S, Troughton RW, Than M, Richards AM, Pemberton CJ.

Int J Cardiol. 2015;190:68-74. doi: 10.1016/j.ijcard.2015.04.145. Epub 2015 Apr 17.


Outcomes in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome with Elevated Cardiac Troponin but Non-obstructive Coronary Disease on Angiography.

Aldous S, Elliott J, McClean D, Puri A, Richards AM.

Heart Lung Circ. 2015 Sep;24(9):869-78. doi: 10.1016/j.hlc.2015.02.019. Epub 2015 Mar 14.


Two-hour diagnostic algorithms for early assessment of patients with acute chest pain--Implications of lowering the cardiac troponin I cut-off to the 97.5th percentile.

Eggers KM, Aldous S, Greenslade JH, Johnston N, Lindahl B, Parsonage WA, Pickering JW, Than M, Cullen L.

Clin Chim Acta. 2015 May 20;445:19-24. doi: 10.1016/j.cca.2015.03.002. Epub 2015 Mar 11.


Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients.

Meller B, Cullen L, Parsonage WA, Greenslade JH, Aldous S, Reichlin T, Wildi K, Twerenbold R, Jaeger C, Hillinger P, Haaf P, Puelacher C, Kern V, Rentsch K, Stallone F, Rubini Gimenez M, Ballarino P, Bassetti S, Walukiewicz A, Troughton R, Pemberton CJ, Richards AM, Chu K, Reid CM, Than M, Mueller C.

Int J Cardiol. 2015 Apr 1;184:208-15. doi: 10.1016/j.ijcard.2015.02.006. Epub 2015 Feb 11.


Quasi-experimental evaluation of a telephone-based peer support intervention for maternal depression.

Letourneau N, Secco L, Colpitts J, Aldous S, Stewart M, Dennis CL.

J Adv Nurs. 2015 Jul;71(7):1587-99. doi: 10.1111/jan.12622. Epub 2015 Feb 23.


Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction.

Aldous S, Mark Richards A, George PM, Cullen L, Parsonage WA, Flaws D, Florkowski CM, Troughton RW, O'Sullivan JW, Reid CM, Bannister L, Than M.

Int J Cardiol. 2014 Nov 15;177(1):182-6. doi: 10.1016/j.ijcard.2014.09.026. Epub 2014 Sep 28.


Comparison of conventional and high-sensitivity troponin in patients with chest pain: a collaborative meta-analysis.

Lipinski MJ, Baker NC, Escárcega RO, Torguson R, Chen F, Aldous SJ, Christ M, Collinson PO, Goodacre SW, Mair J, Inoue K, Lotze U, Sebbane M, Cristol JP, Freund Y, Chenevier-Gobeaux C, Meune C, Eggers KM, Pracoń R, Schreiber DH, Wu AH, Ordoñez-Llanos J, Jaffe AS, Twerenbold R, Mueller C, Waksman R.

Am Heart J. 2015 Jan;169(1):6-16.e6. doi: 10.1016/j.ahj.2014.10.007. Epub 2014 Oct 22.


Combining presentation high-sensitivity cardiac troponin I and glucose measurements to rule-out an acute myocardial infarction in patients presenting to emergency department with chest pain.

Greenslade JH, Kavsak P, Parsonage W, Shortt C, Than M, Pickering JW, Aldous S, Cullen L.

Clin Biochem. 2015 Mar;48(4-5):288-91. doi: 10.1016/j.clinbiochem.2014.11.019. Epub 2014 Dec 5.


Admission glycaemia and its association with acute coronary syndrome in Emergency Department patients with chest pain.

Gardner LS, Nguyen-Pham S, Greenslade JH, Parsonage W, D'Emden M, Than M, Aldous S, Brown A, Cullen L.

Emerg Med J. 2015 Aug;32(8):608-12. doi: 10.1136/emermed-2014-204046. Epub 2014 Oct 24.


Low-risk chest pain in the emergency department--reply.

Than M, Aldous S, Young J.

JAMA Intern Med. 2014 Jun;174(6):1010. doi: 10.1001/jamainternmed.2014.914. No abstract available.


Evolution of the Phosphoenolpyruvate Carboxylase Protein Kinase Family in C3 and C4 Flaveria spp.

Aldous SH, Weise SE, Sharkey TD, Waldera-Lupa DM, Stühler K, Mallmann J, Groth G, Gowik U, Westhoff P, Arsova B.

Plant Physiol. 2014 Jul;165(3):1076-1091. Epub 2014 May 21.


Development and validation of the Emergency Department Assessment of Chest pain Score and 2 h accelerated diagnostic protocol.

Than M, Flaws D, Sanders S, Doust J, Glasziou P, Kline J, Aldous S, Troughton R, Reid C, Parsonage WA, Frampton C, Greenslade JH, Deely JM, Hess E, Sadiq AB, Singleton R, Shopland R, Vercoe L, Woolhouse-Williams M, Ardagh M, Bossuyt P, Bannister L, Cullen L.

Emerg Med Australas. 2014 Feb;26(1):34-44. doi: 10.1111/1742-6723.12164. Epub 2014 Jan 15.


Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain.

Cullen L, Aldous S, Than M, Greenslade JH, Tate JR, George PM, Hammett CJ, Richards AM, Ungerer JP, Troughton RW, Brown AF, Flaws DF, Lamanna A, Pemberton CJ, Florkowski C, Pretorius CJ, Chu K, Parsonage WA.

Clin Biochem. 2014 Apr;47(6):321-6. doi: 10.1016/j.clinbiochem.2013.11.019. Epub 2013 Dec 5.


A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a randomized clinical trial.

Than M, Aldous S, Lord SJ, Goodacre S, Frampton CM, Troughton R, George P, Florkowski CM, Ardagh M, Smyth D, Jardine DL, Peacock WF, Young J, Hamilton G, Deely JM, Cullen L, Richards AM.

JAMA Intern Med. 2014 Jan;174(1):51-8. doi: 10.1001/jamainternmed.2013.11362.


Electroconvulsive therapy in a patient with pulmonary aneurysm.

Pascoe N, Gray H, Aldous S, Porter R.

J ECT. 2014 Sep;30(3):e22-3. doi: 10.1097/YCT.0000000000000079.


The HEART score for the assessment of patients with chest pain in the emergency department: a multinational validation study.

Six AJ, Cullen L, Backus BE, Greenslade J, Parsonage W, Aldous S, Doevendans PA, Than M.

Crit Pathw Cardiol. 2013 Sep;12(3):121-6. doi: 10.1097/HPC.0b013e31828b327e.


Characterization of the phosphofructokinase gene family in rice and its expression under oxygen deficiency stress.

Mustroph A, Stock J, Hess N, Aldous S, Dreilich A, Grimm B.

Front Plant Sci. 2013 May 14;4:125. doi: 10.3389/fpls.2013.00125. eCollection 2013.


Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study.

Greenslade JH, Cullen L, Than M, Aldous S, Chu K, Brown AF, Richards AM, Pemberton CJ, George P, Parsonage WA.

Am J Emerg Med. 2013 Jul;31(7):1103-7. doi: 10.1016/j.ajem.2013.04.016. Epub 2013 May 20.


Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome.

Cullen L, Mueller C, Parsonage WA, Wildi K, Greenslade JH, Twerenbold R, Aldous S, Meller B, Tate JR, Reichlin T, Hammett CJ, Zellweger C, Ungerer JPJ, Rubini Gimenez M, Troughton R, Murray K, Brown AFT, Mueller M, George P, Mosimann T, Flaws DF, Reiter M, Lamanna A, Haaf P, Pemberton CJ, Richards AM, Chu K, Reid CM, Peacock WF, Jaffe AS, Florkowski C, Deely JM, Than M.

J Am Coll Cardiol. 2013 Oct 1;62(14):1242-1249. doi: 10.1016/j.jacc.2013.02.078. Epub 2013 Apr 10.


Examining renal impairment as a risk factor for acute coronary syndrome: a prospective observational study.

Greenslade JH, Cullen L, Kalinowski L, Parsonage W, Palmer S, Aldous S, Richards M, Chu K, Brown AF, Troughton R, Pemberton C, Than M.

Ann Emerg Med. 2013 Jul;62(1):38-46.e1. doi: 10.1016/j.annemergmed.2013.01.011. Epub 2013 Mar 28.


The use of troponin in general practice.

Aldous S, Gent P, McGeoch G, Nicholson D.

N Z Med J. 2012 Jun 29;125(1357):36-43.


A new improved accelerated diagnostic protocol safely identifies low-risk patients with chest pain in the emergency department.

Aldous SJ, Richards MA, Cullen L, Troughton R, Than M.

Acad Emerg Med. 2012 May;19(5):510-6. doi: 10.1111/j.1553-2712.2012.01352.x.


2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial.

Than M, Cullen L, Aldous S, Parsonage WA, Reid CM, Greenslade J, Flaws D, Hammett CJ, Beam DM, Ardagh MW, Troughton R, Brown AF, George P, Florkowski CM, Kline JA, Peacock WF, Maisel AS, Lim SH, Lamanna A, Richards AM.

J Am Coll Cardiol. 2012 Jun 5;59(23):2091-8. doi: 10.1016/j.jacc.2012.02.035. Epub 2012 May 9.


Rapid detection of rpoB gene mutations conferring rifampin resistance in Mycobacterium tuberculosis.

Ao W, Aldous S, Woodruff E, Hicke B, Rea L, Kreiswirth B, Jenison R.

J Clin Microbiol. 2012 Jul;50(7):2433-40. doi: 10.1128/JCM.00208-12. Epub 2012 Apr 18.


The performance of high sensitivity troponin for the diagnosis of acute myocardial infarction is underestimated.

Aldous SJ, Florkowski CM, Crozier IG, Than MP.

Clin Chem Lab Med. 2011 Dec 17;50(4):727-9. doi: 10.1515/cclm.2011.830.


ST2 has diagnostic and prognostic utility for all-cause mortality and heart failure in patients presenting to the emergency department with chest pain.

Aldous SJ, Richards AM, Troughton R, Than M.

J Card Fail. 2012 Apr;18(4):304-10. doi: 10.1016/j.cardfail.2012.01.008. Epub 2012 Feb 2.


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