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Items: 43

1.

Crystal structure of the TreS:Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria.

Kermani AA, Roy R, Gopalasingam C, Kocurek KI, Patel TR, Alderwick LJ, Besra GS, Fütterer K.

J Biol Chem. 2019 May 3;294(18):7348-7359. doi: 10.1074/jbc.RA118.004297. Epub 2019 Mar 15.

2.

Utilisation of the Prestwick Chemical Library to identify drugs that inhibit the growth of mycobacteria.

Kanvatirth P, Jeeves RE, Bacon J, Besra GS, Alderwick LJ.

PLoS One. 2019 Mar 12;14(3):e0213713. doi: 10.1371/journal.pone.0213713. eCollection 2019.

3.

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach.

Soto R, Perez-Herran E, Rodriguez B, Duma BM, Cacho-Izquierdo M, Mendoza-Losana A, Lelievre J, Aguirre DB, Ballell L, Cox LR, Alderwick LJ, Besra GS.

Sci Rep. 2018 Aug 23;8(1):12664. doi: 10.1038/s41598-018-31157-3.

4.

The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis.

Jankute M, Alderwick LJ, Moorey AR, Joe M, Gurcha SS, Eggeling L, Lowary TL, Dell A, Pang PC, Yang T, Haslam S, Besra GS.

Cell Surf. 2018 Jun;2:38-53. doi: 10.1016/j.tcsw.2018.06.003.

5.

The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases.

AlAmri MA, Kadri H, Alderwick LJ, Jeeves M, Mehellou Y.

Chembiochem. 2018 Oct 4;19(19):2072-2080. doi: 10.1002/cbic.201800272. Epub 2018 Aug 22.

PMID:
29999233
6.

AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core.

Alderwick LJ, Birch HL, Krumbach K, Bott M, Eggeling L, Besra GS.

Cell Surf. 2018 Mar;1:2-14. doi: 10.1016/j.tcsw.2017.10.001.

7.

Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.

AlAmri MA, Kadri H, Alderwick LJ, Simpkins NS, Mehellou Y.

ChemMedChem. 2017 May 9;12(9):639-645. doi: 10.1002/cmdc.201700077. Epub 2017 Apr 12.

PMID:
28371477
8.

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan.

Jankute M, Alderwick LJ, Noack S, Veerapen N, Nigou J, Besra GS.

ACS Chem Biol. 2017 Jan 20;12(1):183-190. doi: 10.1021/acschembio.6b00898. Epub 2016 Dec 5.

9.

Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.

Kadri H, Alamri MA, Navratilova IH, Alderwick LJ, Simpkins NS, Mehellou Y.

Chembiochem. 2017 Mar 2;18(5):460-465. doi: 10.1002/cbic.201600620. Epub 2017 Jan 30.

PMID:
28004876
10.

Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis.

Harrison J, Lloyd G, Joe M, Lowary TL, Reynolds E, Walters-Morgan H, Bhatt A, Lovering A, Besra GS, Alderwick LJ.

MBio. 2016 Aug 2;7(4). pii: e00972-16. doi: 10.1128/mBio.00972-16.

11.

Erratum: Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus.

Lambert C, Cadby IT, Till R, Bui NK, Lerner TR, Hughes WS, Lee DJ, Alderwick LJ, Vollmer W, Sockett RE, Lovering AL.

Nat Commun. 2016 Jan 21;7:10483. doi: 10.1038/ncomms10483. No abstract available.

12.

Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus.

Lambert C, Cadby IT, Till R, Bui NK, Lerner TR, Hughes WS, Lee DJ, Alderwick LJ, Vollmer W, Sockett RE, Lovering AL.

Nat Commun. 2015 Dec 2;6:8884. doi: 10.1038/ncomms9884. Erratum in: Nat Commun. 2016;7:10483. Sockett, Elizabeth R [Corrected to Sockett, R Elizabeth].

13.

The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan.

Alderwick LJ, Harrison J, Lloyd GS, Birch HL.

Cold Spring Harb Perspect Med. 2015 Mar 27;5(8):a021113. doi: 10.1101/cshperspect.a021113. Review.

14.

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.

Gurcha SS, Usha V, Cox JA, Fütterer K, Abrahams KA, Bhatt A, Alderwick LJ, Reynolds RC, Loman NJ, Nataraj V, Alemparte C, Barros D, Lloyd AJ, Ballell L, Hobrath JV, Besra GS.

PLoS One. 2014 Nov 19;9(11):e113568. doi: 10.1371/journal.pone.0113568. eCollection 2014.

15.
16.

Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix.

Bacon J, Alderwick LJ, Allnutt JA, Gabasova E, Watson R, Hatch KA, Clark SO, Jeeves RE, Marriott A, Rayner E, Tolley H, Pearson G, Hall G, Besra GS, Wernisch L, Williams A, Marsh PD.

PLoS One. 2014 Feb 6;9(2):e87329. doi: 10.1371/journal.pone.0087329. eCollection 2014.

17.

Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis.

Grover S, Alderwick LJ, Mishra AK, Krumbach K, Marienhagen J, Eggeling L, Bhatt A, Besra GS.

J Biol Chem. 2014 Feb 28;289(9):6177-87. doi: 10.1074/jbc.M113.522623. Epub 2014 Jan 20.

18.

Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling.

Capeness MJ, Lambert C, Lovering AL, Till R, Uchida K, Chaudhuri R, Alderwick LJ, Lee DJ, Swarbreck D, Liddell S, Aizawa S, Sockett RE.

PLoS One. 2013 Nov 5;8(11):e79759. doi: 10.1371/journal.pone.0079759. eCollection 2013.

19.

Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2.

Roy R, Usha V, Kermani A, Scott DJ, Hyde EI, Besra GS, Alderwick LJ, Fütterer K.

ACS Chem Biol. 2013 Oct 18;8(10):2245-55. doi: 10.1021/cb400508k. Epub 2013 Aug 13.

20.

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.

Batt SM, Jabeen T, Bhowruth V, Quill L, Lund PA, Eggeling L, Alderwick LJ, Fütterer K, Besra GS.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11354-9. doi: 10.1073/pnas.1205735109. Epub 2012 Jun 25.

21.

The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module.

Alderwick LJ, Lloyd GS, Ghadbane H, May JW, Bhatt A, Eggeling L, Fütterer K, Besra GS.

PLoS Pathog. 2011 Feb;7(2):e1001299. doi: 10.1371/journal.ppat.1001299. Epub 2011 Feb 24.

22.

Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase.

Alderwick LJ, Lloyd GS, Lloyd AJ, Lovering AL, Eggeling L, Besra GS.

Glycobiology. 2011 Apr;21(4):410-25. doi: 10.1093/glycob/cwq173. Epub 2010 Nov 2.

23.

A truncated lipoglycan from mycobacteria with altered immunological properties.

Birch HL, Alderwick LJ, Appelmelk BJ, Maaskant J, Bhatt A, Singh A, Nigou J, Eggeling L, Geurtsen J, Besra GS.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2634-9. doi: 10.1073/pnas.0915082107. Epub 2010 Jan 25.

24.

Identification of a terminal rhamnopyranosyltransferase (RptA) involved in Corynebacterium glutamicum cell wall biosynthesis.

Birch HL, Alderwick LJ, Rittmann D, Krumbach K, Etterich H, Grzegorzewicz A, McNeil MR, Eggeling L, Besra GS.

J Bacteriol. 2009 Aug;191(15):4879-87. doi: 10.1128/JB.00296-09. Epub 2009 May 29.

25.

Tuberculosis: a balanced diet of lipids and carbohydrates.

Bhowruth V, Alderwick LJ, Brown AK, Bhatt A, Besra GS.

Biochem Soc Trans. 2008 Aug;36(Pt 4):555-65. doi: 10.1042/BST0360555. Review.

PMID:
18631118
26.

Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase.

Birch HL, Alderwick LJ, Bhatt A, Rittmann D, Krumbach K, Singh A, Bai Y, Lowary TL, Eggeling L, Besra GS.

Mol Microbiol. 2008 Sep;69(5):1191-206. doi: 10.1111/j.1365-2958.2008.06354.x. Epub 2008 Jul 4.

27.

Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.

Mishra AK, Alderwick LJ, Rittmann D, Wang C, Bhatt A, Jacobs WR Jr, Takayama K, Eggeling L, Besra GS.

Mol Microbiol. 2008 Jun;68(6):1595-613. doi: 10.1111/j.1365-2958.2008.06265.x. Epub 2008 Apr 28.

28.

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant.

Mishra AK, Klein C, Gurcha SS, Alderwick LJ, Babu P, Hitchen PG, Morris HR, Dell A, Besra GS, Eggeling L.

Antonie Van Leeuwenhoek. 2008 Aug;94(2):277-87. doi: 10.1007/s10482-008-9243-1. Epub 2008 Apr 18.

29.

Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.

Alderwick LJ, Dover LG, Veerapen N, Gurcha SS, Kremer L, Roper DL, Pathak AK, Reynolds RC, Besra GS.

Protein Expr Purif. 2008 Apr;58(2):332-41. doi: 10.1016/j.pep.2007.11.012. Epub 2007 Dec 8.

PMID:
18248822
30.

EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.

Molle V, Reynolds RC, Alderwick LJ, Besra GS, Cozzone AJ, Fütterer K, Kremer L.

Biochem J. 2008 Mar 1;410(2):309-17.

PMID:
17999640
31.
32.

Identification of an alpha(1-->6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis.

Mishra AK, Alderwick LJ, Rittmann D, Tatituri RV, Nigou J, Gilleron M, Eggeling L, Besra GS.

Mol Microbiol. 2007 Sep;65(6):1503-17. Epub 2007 Aug 21.

33.

Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent.

Vafiadi C, Topakas E, Alderwick LJ, Besra GS, Christakopoulos P.

Biotechnol Lett. 2007 Nov;29(11):1771-4. Epub 2007 Aug 4.

PMID:
17676274
34.

Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant.

Tatituri RV, Alderwick LJ, Mishra AK, Nigou J, Gilleron M, Krumbach K, Hitchen P, Giordano A, Morris HR, Dell A, Eggeling L, Besra GS.

Microbiology. 2007 Aug;153(Pt 8):2621-9.

35.

Regulation of cell wall synthesis and growth.

Dover LG, Alderwick LJ, Brown AK, Futterer K, Besra GS.

Curr Mol Med. 2007 May;7(3):247-76. Review.

PMID:
17504111
36.
37.
38.

Arabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-D-arabinose metabolism.

Alderwick LJ, Dover LG, Seidel M, Gande R, Sahm H, Eggeling L, Besra GS.

Glycobiology. 2006 Nov;16(11):1073-81. Epub 2006 Aug 4.

PMID:
16891347
39.

Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis.

Alderwick LJ, Seidel M, Sahm H, Besra GS, Eggeling L.

J Biol Chem. 2006 Jun 9;281(23):15653-61. Epub 2006 Apr 4.

40.

Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.

Alderwick LJ, Molle V, Kremer L, Cozzone AJ, Dafforn TR, Besra GS, Fütterer K.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2558-63. Epub 2006 Feb 13.

41.

Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core.

Alderwick LJ, Radmacher E, Seidel M, Gande R, Hitchen PG, Morris HR, Dell A, Sahm H, Eggeling L, Besra GS.

J Biol Chem. 2005 Sep 16;280(37):32362-71. Epub 2005 Jul 21.

42.

Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum.

Radmacher E, Alderwick LJ, Besra GS, Brown AK, Gibson KJ, Sahm H, Eggeling L.

Microbiology. 2005 Jul;151(Pt 7):2421-7.

PMID:
16000732
43.

Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum.

Radmacher E, Stansen KC, Besra GS, Alderwick LJ, Maughan WN, Hollweg G, Sahm H, Wendisch VF, Eggeling L.

Microbiology. 2005 May;151(Pt 5):1359-68.

PMID:
15870446

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