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Items: 1 to 50 of 121

1.

Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies.

McBride KM, Kil H, Mu Y, Plummer JB, Lee J, Zelazowski MJ, Sebastian M, Abba MC, Aldaz CM.

Front Oncol. 2019 Jun 19;9:517. doi: 10.3389/fonc.2019.00517. eCollection 2019.

2.

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

Hussain T, Lee J, Abba MC, Chen J, Aldaz CM.

Front Oncol. 2018 Dec 13;8:591. doi: 10.3389/fonc.2018.00591. eCollection 2018.

3.

WWOX, the FRA16D gene: A target of and a contributor to genomic instability.

Hussain T, Liu B, Shrock MS, Williams T, Aldaz CM.

Genes Chromosomes Cancer. 2019 May;58(5):324-338. doi: 10.1002/gcc.22693. Epub 2018 Dec 26. Review.

PMID:
30350478
4.

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus.

Hussain T, Kil H, Hattiangady B, Lee J, Kodali M, Shuai B, Attaluri S, Takata Y, Shen J, Abba MC, Shetty AK, Aldaz CM.

Neurobiol Dis. 2019 Jan;121:163-176. doi: 10.1016/j.nbd.2018.09.026. Epub 2018 Oct 2.

5.

Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease.

Visschedijk MC, Spekhorst LM, Cheng SC, van Loo ES, Jansen BHD, Blokzijl T, Kil H, de Jong DJ, Pierik M, Maljaars JPWJ, van der Woude CJ, van Bodegraven AA, Oldenburg B, Löwenberg M, Nieuwenhuijs VB, Imhann F, van Sommeren S, Alberts R, Xavier RJ, Dijkstra G, Nico Faber K, Aldaz CM, Weersma RK, Festen EAM.

J Crohns Colitis. 2018 Apr 27;12(5):582-588. doi: 10.1093/ecco-jcc/jjy001.

PMID:
29361163
6.

Wwox-Brca1 interaction: role in DNA repair pathway choice.

Schrock MS, Batar B, Lee J, Druck T, Ferguson B, Cho JH, Akakpo K, Hagrass H, Heerema NA, Xia F, Parvin JD, Aldaz CM, Huebner K.

Oncogene. 2017 Apr 20;36(16):2215-2227. doi: 10.1038/onc.2016.389. Epub 2016 Nov 21.

7.

DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations.

Abba MC, Zhong Y, Lee J, Kil H, Lu Y, Takata Y, Simper MS, Gaddis S, Shen J, Aldaz CM.

Oncotarget. 2016 Sep 27;7(39):64289-64299. doi: 10.18632/oncotarget.11733.

8.

A Molecular Portrait of High-Grade Ductal Carcinoma In Situ.

Abba MC, Gong T, Lu Y, Lee J, Zhong Y, Lacunza E, Butti M, Takata Y, Gaddis S, Shen J, Estecio MR, Sahin AA, Aldaz CM.

Cancer Res. 2015 Sep 15;75(18):3980-90. doi: 10.1158/0008-5472.CAN-15-0506. Epub 2015 Aug 6.

9.

Karyotypic evolutions of cancer species in rats during the long latent periods after injection of nitrosourea.

Bloomfield M, McCormack A, Mandrioli D, Fiala C, Aldaz CM, Duesberg P.

Mol Cytogenet. 2014 Dec 16;7(1):71. doi: 10.1186/s13039-014-0071-x. eCollection 2014.

10.

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.

Aldaz CM, Ferguson BW, Abba MC.

Biochim Biophys Acta. 2014 Aug;1846(1):188-200. doi: 10.1016/j.bbcan.2014.06.001. Epub 2014 Jun 14. Review.

11.

The WWOX gene modulates high-density lipoprotein and lipid metabolism.

Iatan I, Choi HY, Ruel I, Reddy MV, Kil H, Lee J, Odeh MA, Salah Z, Abu-Remaileh M, Weissglas-Volkov D, Nikkola E, Civelek M, Awan Z, Croce CM, Aqeilan RI, Pajukanta P, Aldaz CM, Genest J.

Circ Cardiovasc Genet. 2014 Aug;7(4):491-504. doi: 10.1161/CIRCGENETICS.113.000248. Epub 2014 May 28.

12.

The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.

Mallaret M, Synofzik M, Lee J, Sagum CA, Mahajnah M, Sharkia R, Drouot N, Renaud M, Klein FA, Anheim M, Tranchant C, Mignot C, Mandel JL, Bedford M, Bauer P, Salih MA, Schüle R, Schöls L, Aldaz CM, Koenig M.

Brain. 2014 Feb;137(Pt 2):411-9. doi: 10.1093/brain/awt338. Epub 2013 Dec 24.

13.

The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding.

Ferguson BW, Gao X, Zelazowski MJ, Lee J, Jeter CR, Abba MC, Aldaz CM.

BMC Cancer. 2013 Dec 11;13:593. doi: 10.1186/1471-2407-13-593.

14.

Identification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response.

Lacunza E, Rabassa ME, Canzoneri R, Pellon-Maison M, Croce MV, Aldaz CM, Abba MC.

Cell Stress Chaperones. 2014 May;19(3):379-88.

15.

Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.

Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, Seshadri A, Sun L, Aldaz CM, Tang DG, Chandra D.

J Biol Chem. 2013 Jan 4;288(1):368-81. doi: 10.1074/jbc.M112.386102. Epub 2012 Nov 14.

16.

Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches.

Ferguson BW, Gao X, Kil H, Lee J, Benavides F, Abba MC, Aldaz CM.

PLoS One. 2012;7(5):e36618. doi: 10.1371/journal.pone.0036618. Epub 2012 May 4.

17.

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.

Thangavel C, Dean JL, Ertel A, Knudsen KE, Aldaz CM, Witkiewicz AK, Clarke R, Knudsen ES.

Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.

18.

Activation of the canonical Wnt/β-catenin pathway in ATF3-induced mammary tumors.

Yan L, Della Coletta L, Powell KL, Shen J, Thames H, Aldaz CM, MacLeod MC.

PLoS One. 2011 Jan 31;6(1):e16515. doi: 10.1371/journal.pone.0016515.

19.

Breast cancer biomarker discovery in the functional genomic age: a systematic review of 42 gene expression signatures.

Abba MC, Lacunza E, Butti M, Aldaz CM.

Biomark Insights. 2010 Oct 27;5:103-18. doi: 10.4137/BMI.S5740.

20.

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.

Ludes-Meyers JH, Kil H, Parker-Thornburg J, Kusewitt DF, Bedford MT, Aldaz CM.

PLoS One. 2009 Nov 10;4(11):e7775. doi: 10.1371/journal.pone.0007775.

21.

Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats.

Krishnan P, Yan KJ, Windler D, Tubbs J, Grand R, Li BD, Aldaz CM, McLarty J, Kleiner-Hancock HE.

BMC Cancer. 2009 Jul 29;9:259. doi: 10.1186/1471-2407-9-259.

22.

Rhomboid domain containing 2 (RHBDD2): a novel cancer-related gene over-expressed in breast cancer.

Abba MC, Lacunza E, Nunez MI, Colussi A, Isla-Larrain M, Segal-Eiras A, Croce MV, Aldaz CM.

Biochim Biophys Acta. 2009 Oct;1792(10):988-97. doi: 10.1016/j.bbadis.2009.07.006. Epub 2009 Jul 17.

23.

Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model.

Abba MC, Hu Y, Levy CC, Gaddis S, Kittrell FS, Hill J, Bissonnette RP, Brown PH, Medina D, Aldaz CM.

Cancer Prev Res (Phila). 2009 Feb;2(2):175-84. doi: 10.1158/1940-6207.CAPR-08-0104. Epub 2009 Jan 27.

24.

The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis.

Wang A, Arantes S, Yan L, Kiguchi K, McArthur MJ, Sahin A, Thames HD, Aldaz CM, Macleod MC.

BMC Cancer. 2008 Sep 22;8:268. doi: 10.1186/1471-2407-8-268.

25.

Transcriptomic signature of bexarotene (rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models.

Abba MC, Hu Y, Levy CC, Gaddis S, Kittrell FS, Zhang Y, Hill J, Bissonnette RP, Medina D, Brown PH, Aldaz CM.

BMC Med Genomics. 2008 Sep 11;1:40. doi: 10.1186/1755-8794-1-40.

26.

Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours.

Ramos D, Abba M, López-Guerrero JA, Rubio J, Solsona E, Almenar S, Llombart-Bosch A, Aldaz CM.

Histopathology. 2008 Jun;52(7):831-9. doi: 10.1111/j.1365-2559.2008.03033.x. Epub 2008 Apr 29.

27.

CARM1 promotes adipocyte differentiation by coactivating PPARgamma.

Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT.

EMBO Rep. 2008 Feb;9(2):193-8. doi: 10.1038/sj.embor.7401151. Epub 2008 Jan 11.

28.

CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer.

Wu M, Soler DR, Abba MC, Nunez MI, Baer R, Hatzis C, Llombart-Cussac A, Llombart-Bosch A, Aldaz CM.

Mol Cancer Res. 2007 Dec;5(12):1285-95. doi: 10.1158/1541-7786.MCR-07-0126.

29.

Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias.

Pimenta FJ, Cordeiro GT, Pimenta LG, Viana MB, Lopes J, Gomez MV, Aldaz CM, De Marco L, Gomez RS.

Oral Oncol. 2008 Aug;44(8):753-8. Epub 2007 Dec 3.

30.

Association between decreased WWOX protein expression and thyroid cancer development.

Dias EP, Pimenta FJ, Sarquis MS, Dias Filho MA, Aldaz CM, Fujii JB, Gomez RS, De Marco L.

Thyroid. 2007 Nov;17(11):1055-9.

31.

Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status.

Abba MC, Sun H, Hawkins KA, Drake JA, Hu Y, Nunez MI, Gaddis S, Shi T, Horvath S, Sahin A, Aldaz CM.

Mol Cancer Res. 2007 Sep;5(9):881-90.

32.

WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.

Ludes-Meyers JH, Kil H, Nuñez MI, Conti CJ, Parker-Thornburg J, Bedford MT, Aldaz CM.

Genes Chromosomes Cancer. 2007 Dec;46(12):1129-36.

33.

Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34.

Abba MC, Fabris VT, Hu Y, Kittrell FS, Cai WW, Donehower LA, Sahin A, Medina D, Aldaz CM.

Cancer Res. 2007 May 1;67(9):4104-12.

34.

Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells.

Wang A, Arantes S, Conti C, McArthur M, Aldaz CM, MacLeod MC.

Mol Carcinog. 2007 Jun;46(6):476-87.

PMID:
17295236
35.

WWOX, a chromosomal fragile site gene and its role in cancer.

Ramos D, Aldaz CM.

Adv Exp Med Biol. 2006;587:149-59. Review.

PMID:
17163164
36.

GATA3 protein as a MUC1 transcriptional regulator in breast cancer cells.

Abba MC, Nunez MI, Colussi AG, Croce MV, Segal-Eiras A, Aldaz CM.

Breast Cancer Res. 2006;8(6):R64.

37.

WWOX protein expression in normal human tissues.

Nunez MI, Ludes-Meyers J, Aldaz CM.

J Mol Histol. 2006 May;37(3-4):115-25. Epub 2006 Aug 29.

38.

P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation.

Rayala SK, Talukder AH, Balasenthil S, Tharakan R, Barnes CJ, Wang RA, Aldaz CM, Khan S, Kumar R.

Cancer Res. 2006 Feb 1;66(3):1694-701.

40.

Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas.

Pimenta FJ, Gomes DA, Perdigão PF, Barbosa AA, Romano-Silva MA, Gomez MV, Aldaz CM, De Marco L, Gomez RS.

Int J Cancer. 2006 Mar 1;118(5):1154-8.

41.

Quantitative high-throughput measurement of gene expression with sub-zeptomole sensitivity by capillary electrophoresis.

Spyres L, Gaddis S, Bedford E, Arantes S, Liburd N, Powell KL, Thames H, Mitchell D, Walborg E, Rouabhia M, Aldaz CM, MacLeod MC.

Anal Biochem. 2005 Oct 15;345(2):284-95.

PMID:
16125665
42.

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome.

Nunez MI, Rosen DG, Ludes-Meyers JH, Abba MC, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB, Aldaz CM.

BMC Cancer. 2005 Jun 27;5:64.

43.

WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear.

Gourley C, Paige AJW, Taylor KJ, Scott D, Francis NJ, Rush R, Aldaz CM, Smyth JF, Gabra H.

Int J Oncol. 2005 Jun;26(6):1681-1689.

44.

Gene expression signature of estrogen receptor alpha status in breast cancer.

Abba MC, Hu Y, Sun H, Drake JA, Gaddis S, Baggerly K, Sahin A, Aldaz CM.

BMC Genomics. 2005 Mar 11;6:37.

45.

Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status.

Nunez MI, Ludes-Meyers J, Abba MC, Kil H, Abbey NW, Page RE, Sahin A, Klein-Szanto AJ, Aldaz CM.

Breast Cancer Res Treat. 2005 Jan;89(2):99-105.

46.

SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects.

Rundhaug JE, Hawkins KA, Pavone A, Gaddis S, Kil H, Klein RD, Berton TR, McCauley E, Johnson DG, Lubet RA, Fischer SM, Aldaz CM.

Mol Carcinog. 2005 Jan;42(1):40-52.

PMID:
15547921
47.

From mice to humans: identification of commonly deregulated genes in mammary cancer via comparative SAGE studies.

Hu Y, Sun H, Drake J, Kittrell F, Abba MC, Deng L, Gaddis S, Sahin A, Baggerly K, Medina D, Aldaz CM.

Cancer Res. 2004 Nov 1;64(21):7748-55.

48.

Overdispersed logistic regression for SAGE: modelling multiple groups and covariates.

Baggerly KA, Deng L, Morris JS, Aldaz CM.

BMC Bioinformatics. 2004 Oct 6;5:144.

49.

Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression.

Abba MC, Drake JA, Hawkins KA, Hu Y, Sun H, Notcovich C, Gaddis S, Sahin A, Baggerly K, Aldaz CM.

Breast Cancer Res. 2004;6(5):R499-513. Epub 2004 Jul 6. Erratum in: Breast Cancer Res. 2005;7(1):32.

50.

Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma.

Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM.

Br J Cancer. 2004 Aug 16;91(4):753-9.

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