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Items: 1 to 50 of 84

1.

Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.

Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG.

Eur J Hum Genet. 2018 Sep 25. doi: 10.1038/s41431-018-0270-8. [Epub ahead of print]

PMID:
30254217
2.

Author Correction: 137 ancient human genomes from across the Eurasian steppes.

de Barros Damgaard P, Marchi N, Rasmussen S, Peyrot M, Renaud G, Korneliussen T, Moreno-Mayar JV, Pedersen MW, Goldberg A, Usmanova E, Baimukhanov N, Loman V, Hedeager L, Pedersen AG, Nielsen K, Afanasiev G, Akmatov K, Aldashev A, Alpaslan A, Baimbetov G, Bazaliiskii VI, Beisenov A, Boldbaatar B, Boldgiv B, Dorzhu C, Ellingvag S, Erdenebaatar D, Dajani R, Dmitriev E, Evdokimov V, Frei KM, Gromov A, Goryachev A, Hakonarson H, Hegay T, Khachatryan Z, Khaskhanov R, Kitov E, Kolbina A, Kubatbek T, Kukushkin A, Kukushkin I, Lau N, Margaryan A, Merkyte I, Mertz IV, Mertz VK, Mijiddorj E, Moiyesev V, Mukhtarova G, Nurmukhanbetov B, Orozbekova Z, Panyushkina I, Pieta K, Smrčka V, Shevnina I, Logvin A, Sjogren KG, Štolcova T, Taravella AM, Tashbaeva K, Tkachev A, Tulegenov T, Voyakin D, Yepiskoposyan L, Undrakhbold S, Varfolomeev V, Weber A, Wilson Sayres MA, Kradin N, Allentoft ME, Orlando L, Nielsen R, Sikora M, Heyer E, Kristiansen K, Willerslev E.

Nature. 2018 Aug 30. doi: 10.1038/s41586-018-0488-1. [Epub ahead of print]

PMID:
30166629
3.

137 ancient human genomes from across the Eurasian steppes.

Damgaard PB, Marchi N, Rasmussen S, Peyrot M, Renaud G, Korneliussen T, Moreno-Mayar JV, Pedersen MW, Goldberg A, Usmanova E, Baimukhanov N, Loman V, Hedeager L, Pedersen AG, Nielsen K, Afanasiev G, Akmatov K, Aldashev A, Alpaslan A, Baimbetov G, Bazaliiskii VI, Beisenov A, Boldbaatar B, Boldgiv B, Dorzhu C, Ellingvag S, Erdenebaatar D, Dajani R, Dmitriev E, Evdokimov V, Frei KM, Gromov A, Goryachev A, Hakonarson H, Hegay T, Khachatryan Z, Khaskhanov R, Kitov E, Kolbina A, Kubatbek T, Kukushkin A, Kukushkin I, Lau N, Margaryan A, Merkyte I, Mertz IV, Mertz VK, Mijiddorj E, Moiyesev V, Mukhtarova G, Nurmukhanbetov B, Orozbekova Z, Panyushkina I, Pieta K, Smrčka V, Shevnina I, Logvin A, Sjögren KG, Štolcová T, Taravella AM, Tashbaeva K, Tkachev A, Tulegenov T, Voyakin D, Yepiskoposyan L, Undrakhbold S, Varfolomeev V, Weber A, Wilson Sayres MA, Kradin N, Allentoft ME, Orlando L, Nielsen R, Sikora M, Heyer E, Kristiansen K, Willerslev E.

Nature. 2018 May;557(7705):369-374. doi: 10.1038/s41586-018-0094-2. Epub 2018 May 9. Erratum in: Nature. 2018 Aug 30;:.

PMID:
29743675
4.

Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.

Isakova J, Sovkhozova N, Vinnikov D, Goncharova Z, Talaibekova E, Aldasheva N, Aldashev A.

BMC Microbiol. 2018 Mar 22;18(1):22. doi: 10.1186/s12866-018-1168-x.

5.

The association of Val109Asp polymorphic marker of intelectin 1 gene with abdominal obesity in Kyrgyz population.

Isakova J, Talaibekova E, Vinnikov D, Aldasheva N, Mirrakhimov E, Aldashev A.

BMC Endocr Disord. 2018 Feb 27;18(1):15. doi: 10.1186/s12902-018-0242-6.

6.

[Risk of type 2 diabetes mellitus in the Kyrgyz population in the presence of ADIPOQ (G276T), KCNJ11 (Glu23Lys), TCF7L2 (IVS3C>T) gene polymorphisms].

Isakova ZT, Talaibekova ET, Asambaeva DA, Kerimkulova AS, Lunegova OS, Aldasheva NM, Aldashev AA.

Ter Arkh. 2017;89(10):40-47. doi: 10.17116/terarkh2017891040-47. Russian.

PMID:
29171469
7.

The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females.

Isakova J, Talaibekova E, Aldasheva N, Vinnikov D, Aldashev A.

BMC Cancer. 2017 Nov 13;17(1):758. doi: 10.1186/s12885-017-3762-y.

8.

[Association of the polymorphic marker Glu23Lys in the KCNJ11 gene with hypertension in Kyrgyz patients].

Isakova ZT, Talaibekova ET, Asambaeva DA, Kerimkulova AS, Lunegova OS, Aldashev AA.

Ter Arkh. 2017;89(1):14-17. doi: 10.17116/terarkh201789114-17. Russian.

PMID:
28252621
9.

Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations.

Marchi N, Hegay T, Mennecier P, Georges M, Laurent R, Whitten M, Endicott P, Aldashev A, Dorzhu C, Nasyrova F, Chichlo B, Ségurel L, Heyer E.

Am J Phys Anthropol. 2017 Apr;162(4):627-640. doi: 10.1002/ajpa.23151. Epub 2017 Feb 3.

PMID:
28158897
10.

Association between sleep apnoea and pulmonary hypertension in Kyrgyz highlanders.

Latshang TD, Furian M, Aeschbacher SS, Ulrich S, Osmonov B, Mirrakhimov EM, Isakova J, Aldashev AA, Sooronbaev TM, Bloch KE.

Eur Respir J. 2017 Feb 2;49(2). pii: 1601530. doi: 10.1183/13993003.01530-2016. Print 2017 Feb.

11.

[Concentration of Lipoprotein-Associated Phospholipase A2 in Patients With Ischemic Heart Disease].

Noruzbaeva AM, Osmankulova GE, Aldashev AA, Mainazarova ES.

Kardiologiia. 2016 Jan;56(1):49-50. Russian. No abstract available.

PMID:
28294732
12.

[An Association Between T455C Polymorphism of Apolipoprotein C-III Gene, Insulin Resistance and Metabolic Syndrome Components].

Lunegova OS, Kerimkulova AS, Mjrrakhimov AE, Zalesskaya YV, Nabiev MP, Abilova SS, Neronova KV, Isakova ZhT, Aldashev AA, Mirrakhimov EM.

Kardiologiia. 2015;55(6):47-53. Russian.

PMID:
26625519
13.

Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks.

Mizuno S, Ishizaki T, Toga H, Sakai A, Isakova J, Taalaibekova E, Baiserkeev Z, Kojonazarov B, Aldashev A.

Biomed Res Int. 2015;2015:196904. doi: 10.1155/2015/196904. Epub 2015 Aug 26.

14.

The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.

Zhao L, Oliver E, Maratou K, Atanur SS, Dubois OD, Cotroneo E, Chen CN, Wang L, Arce C, Chabosseau PL, Ponsa-Cobas J, Frid MG, Moyon B, Webster Z, Aldashev A, Ferrer J, Rutter GA, Stenmark KR, Aitman TJ, Wilkins MR.

Nature. 2015 Aug 20;524(7565):356-60. doi: 10.1038/nature14620. Epub 2015 Aug 10.

15.

[Association Between T455C Polymorphism of Apolipoprotein C-III Gene, Insulin Resistance and Metabolic Syndrome Components].

Lunegova OS, Kerimkulova AS, Mirrakhimov AE, Zalesskaya YV, Nabiev MP, Abilova SS, Neronova KV, Isakova ZT, Aldashev AA, Mirrakhimov EM.

Kardiologiia. 2015 Jun;55(6):47-53. Russian.

PMID:
28294782
16.

Cerebral oxygenation in highlanders with and without high-altitude pulmonary hypertension.

Furian M, Latshang TD, Aeschbacher SS, Ulrich S, Sooronbaev T, Mirrakhimov EM, Aldashev A, Bloch KE.

Exp Physiol. 2015 Aug;100(8):905-14. doi: 10.1113/EP085200. Epub 2015 Jul 5.

17.

Patrilineal populations show more male transmission of reproductive success than cognatic populations in Central Asia, which reduces their genetic diversity.

Heyer E, Brandenburg JT, Leonardi M, Toupance B, Balaresque P, Hegay T, Aldashev A, Austerlitz F.

Am J Phys Anthropol. 2015 Aug;157(4):537-43. doi: 10.1002/ajpa.22739. Epub 2015 Mar 27.

PMID:
25821184
18.

Pathophysiology and treatment of high-altitude pulmonary vascular disease.

Wilkins MR, Ghofrani HA, Weissmann N, Aldashev A, Zhao L.

Circulation. 2015 Feb 10;131(6):582-90. doi: 10.1161/CIRCULATIONAHA.114.006977. Review. No abstract available.

PMID:
25666980
19.

Blunted activation of Rho-kinase in yak pulmonary circulation.

Ishizaki T, Mizuno S, Sakai A, Matsukawa S, Kojonazarov B, Zamirbek B, Umeda Y, Morikawa M, Anzai M, Ishizuka T, Aldashev A.

Biomed Res Int. 2015;2015:720250. doi: 10.1155/2015/720250. Epub 2015 Jan 14.

20.

[Association of the Arg399Gln polymorphisms of the XRCC1 gene with breast cancer risk in Kyrgiz women].

Isakova ZhT, Makieva KB, E T Talaibekova, Asambaeva DA, Sultangazieva BB, Aldashev AA.

Vopr Onkol. 2015;61(6):941-4. Russian.

PMID:
26995983
21.

[Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients].

Isakova JT, Lunegova OS, Talaibekova ET, Asambaeva DA, Kerimkulova AS, Aldashev AA.

Ter Arkh. 2015;87(10):85-90. doi: 10.17116/terarkh2015871085-90. Russian.

PMID:
26978180
22.

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

Wilkins MR, Aldashev AA, Wharton J, Rhodes CJ, Vandrovcova J, Kasperaviciute D, Bhosle SG, Mueller M, Geschka S, Rison S, Kojonazarov B, Morrell NW, Neidhardt I, Surmeli NB, Aitman TJ, Stasch JP, Behrends S, Marletta MA.

Circ Cardiovasc Genet. 2014 Dec;7(6):920-9. doi: 10.1161/CIRCGENETICS.114.000763. Epub 2014 Nov 4. Erratum in: Circ Cardiovasc Genet. 2015 Feb;8(1):244. Surmeli, Nur Basek [corrected to Surmeli, Nur Basak].

23.

[An association of the 825 polymorphism of the g protein 3 subunit with obesity in Kyrgyz population].

Lunegova OS, Kerimkulova AS, Mirrakhimov AE, Abilova SS, Zalesskaia IuV, Alibaeva NT, Sovkhozova MB, Isakova ZhT, Aldashev AA, Mirrakhimov EM.

Kardiologiia. 2013;53(4):55-61. Russian.

PMID:
23952954
24.

Molecular snapshot of Mycobacterium tuberculosis population structure and drug-resistance in Kyrgyzstan.

Mokrousov I, Isakova J, Valcheva V, Aldashev A, Rastogi N.

Tuberculosis (Edinb). 2013 Sep;93(5):501-7. doi: 10.1016/j.tube.2013.05.008. Epub 2013 Jul 24.

PMID:
23890973
25.

Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.

Ségurel L, Austerlitz F, Toupance B, Gautier M, Kelley JL, Pasquet P, Lonjou C, Georges M, Voisin S, Cruaud C, Couloux A, Hegay T, Aldashev A, Vitalis R, Heyer E.

Eur J Hum Genet. 2013 Oct;21(10):1146-51. doi: 10.1038/ejhg.2012.295. Epub 2013 Jan 23.

26.

[Role of methyltetrahydrofolate reductase (MTHFR) gene polymorphism in the development of ischemic stroke in the dwellers of the Kyrgyz Republic].

Kudaĭbergenova NT, Moldotashev IK, Aldashev AA, Mukhanova AK.

Ter Arkh. 2012;84(10):37-41. Russian.

PMID:
23227498
27.

Bosentan reduces pulmonary artery pressure in high altitude residents.

Kojonazarov B, Isakova J, Imanov B, Sovkhozova N, Sooronbaev T, Ishizaki T, Aldashev AA.

High Alt Med Biol. 2012 Sep;13(3):217-23.

PMID:
22994522
28.

Effects of fasudil in patients with high-altitude pulmonary hypertension.

Kojonazarov B, Myrzaakhmatova A, Sooronbaev T, Ishizaki T, Aldashev A.

Eur Respir J. 2012 Feb;39(2):496-8. doi: 10.1183/09031936.00095211. No abstract available.

29.

An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances.

Mirrakhimov AE, Kerimkulova AS, Lunegova OS, Moldokeeva CB, Zalesskaya YV, Abilova SS, Sovhozova NA, Aldashev AA, Mirrakhimov EM.

Cardiovasc Diabetol. 2011 Oct 12;10:89. doi: 10.1186/1475-2840-10-89.

30.

[Association of C677T gene polymorphism of methylenetetrahydrofolate reductase with insulin resistance among Kirghizes].

Lunegova OS, Kerimkulova AS, Turdakmatov NB, Sovkhozova NA, Nabiev MP, Isakova ZhT, Iusupova ÉU, Moldokeeva ChB, Gotfrid IIu, Mirrakhimov AÉ, Aldasheva NM, Kheĭer E, Aldashev AA, Mirrakhimov ÉM.

Kardiologiia. 2011;51(3):58-62. Russian.

PMID:
21627615
31.

[Investigation of peroxide modification of low- and very low-density lipoproteins in patients with coronary heart disease by the method of fluorescent spectroscopy].

Aĭdyraliev RK, Igemberdieva OA, Dadabaev MKh, Murataliev TM, Aĭtbaev KA, Aldashev AA.

Biomed Khim. 2011 Jan-Feb;57(1):127-32. Russian.

PMID:
21516784
32.

[Study of blood cholesterol and triglycerides in patients with acute myocardial infarction].

Aĭdyraliev RK, Rezepkina LB, Igemberdieva OA, Beĭshenkulov MT, Aldashev AA.

Klin Lab Diagn. 2010 Aug;(8):25-6. Russian.

PMID:
20886716
33.

In the heartland of Eurasia: the multilocus genetic landscape of Central Asian populations.

Martínez-Cruz B, Vitalis R, Ségurel L, Austerlitz F, Georges M, Théry S, Quintana-Murci L, Hegay T, Aldashev A, Nasyrova F, Heyer E.

Eur J Hum Genet. 2011 Feb;19(2):216-23. doi: 10.1038/ejhg.2010.153. Epub 2010 Sep 8.

34.

Changes in plasma bradykinin concentration and citric acid cough threshold at high altitude.

Mason NP, Petersen M, Mélot C, Kim EV, Aldashev A, Sarybaev A, Mirrakhimov MM, Naeije R.

Wilderness Environ Med. 2009 Winter;20(4):353-8. doi: 10.1580/1080-6032-020.004.0353.

PMID:
20030444
35.

Genetic diversity and the emergence of ethnic groups in Central Asia.

Heyer E, Balaresque P, Jobling MA, Quintana-Murci L, Chaix R, Segurel L, Aldashev A, Hegay T.

BMC Genet. 2009 Sep 1;10:49. doi: 10.1186/1471-2156-10-49.

36.

Penitentiary population of Mycobacterium tuberculosis in Kyrgyzstan: exceptionally high prevalence of the Beijing genotype and its Russia-specific subtype.

Mokrousov I, Valcheva V, Sovhozova N, Aldashev A, Rastogi N, Isakova J.

Infect Genet Evol. 2009 Dec;9(6):1400-5. doi: 10.1016/j.meegid.2009.07.007. Epub 2009 Aug 6.

PMID:
19647804
37.

[Characterization of the drug resistance spectrum of rifampicin-resistant M. tuberculosis to other first-line antituberculous drugs].

Isakova ZhT, Goncharova ZK, Aldashev AA.

Probl Tuberk Bolezn Legk. 2008;(11):39-42. Russian.

PMID:
19140379
38.

Sex-specific genetic structure and social organization in Central Asia: insights from a multi-locus study.

Ségurel L, Martínez-Cruz B, Quintana-Murci L, Balaresque P, Georges M, Hegay T, Aldashev A, Nasyrova F, Jobling MA, Heyer E, Vitalis R.

PLoS Genet. 2008 Sep 26;4(9):e1000200. doi: 10.1371/journal.pgen.1000200.

39.

Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia.

Magalon H, Patin E, Austerlitz F, Hegay T, Aldashev A, Quintana-Murci L, Heyer E.

Eur J Hum Genet. 2008 Feb;16(2):243-51. Epub 2007 Nov 28.

40.

[Statistically mapping modeling of the spread of rifampicin-resistant M. tuberculosis strains in different regions of the Kyrghyz Republic].

Isakova ZhT, Goncharova ZK, Iusupova EU, Pak OA, Tumashova AF, Kozhomkulov MD, Kozhomkulov DK, Chubakov TCh, Alisherov ASh, Aldashev AA.

Probl Tuberk Bolezn Legk. 2007;(7):33-6. Russian.

PMID:
17722290
41.

The effects of hypoxia on the cells of the pulmonary vasculature.

Pak O, Aldashev A, Welsh D, Peacock A.

Eur Respir J. 2007 Aug;30(2):364-72. Review.

42.

[Analysis of mutations of multidrug-resistant M. tuberculosis strains in patients with tuberculosis in the Kyrghyz Republic].

Isakova ZhT, Goncharova ZK, Iusupova EU, Tumashova AF, Kozhomkulov MD, Kozhomkulov DK, Chubakov TCh, Alisherov ASh, Aldashev AA.

Probl Tuberk Bolezn Legk. 2007;(4):17-21. Russian.

PMID:
17657962
43.

Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders.

Kojonazarov BK, Imanov BZ, Amatov TA, Mirrakhimov MM, Naeije R, Wilkins MR, Aldashev AA.

Eur Respir J. 2007 Feb;29(2):352-6. Epub 2006 Nov 1.

44.

Genome-wide scan for premature hypertension supports linkage to chromosome 2 in a large Kyrgyz family.

Kalmyrzaev B, Aldashev A, Khalmatov M, Polupanov A, Jumagulova A, Mamanova L, Wilkins MR, Town M.

Hypertension. 2006 Nov;48(5):908-13. Epub 2006 Sep 25.

PMID:
17000929
45.

[Use of biological microchips in the determination of drug-resistance of Mycobacterium tuberculosis to rifampicin].

Isakova ZhT, Pak OA, Iusupova EIu, Myrzaliev BB, Chubakov TCh, Goncharova ZA, Tumashova AF, Kozhomkulov MD, Kozhomkulov DK, Alisherov ASh, Friedland J, Aldashev AA.

Probl Tuberk Bolezn Legk. 2005;(8):50-3. Russian.

PMID:
16209022
46.

[I/D relationship between polymorphism of ACE gene and progression of chronic glomerulonephritis].

Kaliev RR, Budaĭchiev AB, Aldashev AA, Mirrakhimov MM.

Ter Arkh. 2005;77(6):12-5. Russian.

PMID:
16078593
47.

Phosphodiesterase type 5 and high altitude pulmonary hypertension.

Aldashev AA, Kojonazarov BK, Amatov TA, Sooronbaev TM, Mirrakhimov MM, Morrell NW, Wharton J, Wilkins MR.

Thorax. 2005 Aug;60(8):683-7.

48.

Consensus statement on chronic and subacute high altitude diseases.

León-Velarde F, Maggiorini M, Reeves JT, Aldashev A, Asmus I, Bernardi L, Ge RL, Hackett P, Kobayashi T, Moore LG, Penaloza D, Richalet JP, Roach R, Wu T, Vargas E, Zubieta-Castillo G, Zubieta-Calleja G.

High Alt Med Biol. 2005 Summer;6(2):147-57. Review.

PMID:
16060849
49.

Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities.

Frid MG, Aldashev AA, Crossno JT, Jorgensen JM, Kale VA, Stenmark KR.

Paediatr Respir Rev. 2004;5 Suppl A:S253-7. Review. No abstract available.

PMID:
14980281
50.

Serial changes in nasal potential difference and lung electrical impedance tomography at high altitude.

Mason NP, Petersen M, Melot C, Imanow B, Matveykine O, Gautier MT, Sarybaev A, Aldashev A, Mirrakhimov MM, Brown BH, Leathard AD, Naeije R.

J Appl Physiol (1985). 2003 May;94(5):2043-50. Epub 2002 Dec 6.

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