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Murine models of Pneumocystis infection recapitulate human primary immune disorders.

Elsegeiny W, Zheng M, Eddens T, Gallo RL, Dai G, Trevejo-Nunez G, Castillo P, Kracinovsky K, Cleveland H, Horne W, Franks J, Pociask D, Pilarski M, Alcorn JF, Chen K, Kolls JK.

JCI Insight. 2018 Jun 21;3(12). pii: 91894. doi: 10.1172/jci.insight.91894. [Epub ahead of print]


IL-17 Strikes a Chord in Chronic Obstructive Pulmonary Disease Exacerbation.

Rich HE, Alcorn JF.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):669-670. doi: 10.1165/rcmb.2018-0078ED. No abstract available.


The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice.

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, Muzumdar R, Alcorn JF.

JCI Insight. 2018 Apr 5;3(7). pii: 97470. doi: 10.1172/jci.insight.97470. [Epub ahead of print]


STAT1 Is Required for Suppression of Type 17 Immunity during Influenza and Bacterial Superinfection.

Lee B, Gopal R, Manni ML, McHugh KJ, Mandalapu S, Robinson KM, Alcorn JF.

Immunohorizons. 2017 Aug 1;1(6):81-91. doi: 10.4049/immunohorizons.1700030.


Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice.

Shinde A, Luo J, Bharathi SS, Shi H, Beck ME, McHugh KJ, Alcorn JF, Wang J, Goetzman ES.

Biochem Biophys Res Commun. 2018 Mar 4;497(2):700-704. doi: 10.1016/j.bbrc.2018.02.135. Epub 2018 Feb 16.


Differential gene expression elicited by children in response to the 2015-16 live attenuated versus inactivated influenza vaccine.

Cole KS, Martin JM, Horne WT, Lin CJ, Nowalk MP, Alcorn JF, Zimmerman RK.

Vaccine. 2017 Dec 14;35(49 Pt B):6893-6897. doi: 10.1016/j.vaccine.2017.09.019. Epub 2017 Nov 11.


Vitamin D insufficiency, plasma cytokines, and severe asthma exacerbations in school-aged children.

Szentpetery SE, Han YY, Brehm JM, Acosta-Pérez E, Forno E, Boutaoui N, Canino G, Alcorn JF, Celedón JC.

J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):289-291.e2. doi: 10.1016/j.jaip.2017.07.019. Epub 2017 Aug 26. No abstract available.


Cockroach allergen exposure and plasma cytokines among children in a tropical environment.

Medsker BH, Forno E, Han YY, Acosta-Pérez E, Colón-Semidey A, Alvarez M, Alcorn JF, Canino GJ, Celedón JC.

Ann Allergy Asthma Immunol. 2017 Jul;119(1):65-70.e3. doi: 10.1016/j.anai.2017.05.008.


A Multiomics Approach to Identify Genes Associated with Childhood Asthma Risk and Morbidity.

Forno E, Wang T, Yan Q, Brehm J, Acosta-Perez E, Colon-Semidey A, Alvarez M, Boutaoui N, Cloutier MM, Alcorn JF, Canino G, Chen W, Celedón JC.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):439-447. doi: 10.1165/rcmb.2017-0002OC.


AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality.

Zhang H, Luo J, Alcorn JF, Chen K, Fan S, Pilewski J, Liu A, Chen W, Kolls JK, Wang J.

J Immunol. 2017 Jun 1;198(11):4383-4393. doi: 10.4049/jimmunol.1600714. Epub 2017 Apr 19.


Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection.

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Rich HE, Alcorn JF.

Mucosal Immunol. 2018 Jan;11(1):199-208. doi: 10.1038/mi.2017.32. Epub 2017 Apr 12.


Proximity to a Major Road and Plasma Cytokines in School-Aged Children.

Rosser F, Forno E, Brehm J, Han YY, Boutaoui N, Colón-Semidey A, Alvarez M, Acosta-Pérez E, Kurland KS, Alcorn JF, Canino G, Celedón JC.

Pediatr Allergy Immunol Pulmonol. 2016 Sep 1;29(3):111-117. doi: 10.1089/ped.2016.0649.


Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.

Treerat P, Prince O, Cruz-Lagunas A, Muñoz-Torrico M, Salazar-Lezama MA, Selman M, Fallert-Junecko B, Reinhardt TA, Alcorn JF, Kaushal D, Zuñiga J, Rangel-Moreno J, Kolls JK, Khader SA.

Mucosal Immunol. 2017 Jul;10(4):1069-1081. doi: 10.1038/mi.2017.15. Epub 2017 Mar 1.


Bromodomain and Extra-Terminal Protein Inhibition Attenuates Neutrophil-dominant Allergic Airway Disease.

Manni ML, Mandalapu S, Salmeron A, Lora JM, Kolls JK, Alcorn JF.

Sci Rep. 2017 Feb 24;7:43139. doi: 10.1038/srep43139.


Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

Pociask DA, Robinson KM, Chen K, McHugh KJ, Clay ME, Huang GT, Benos PV, Janssen-Heininger YMW, Kolls JK, Anathy V, Alcorn JF.

Am J Pathol. 2017 Apr;187(4):851-863. doi: 10.1016/j.ajpath.2016.12.012. Epub 2017 Feb 10.


The enigmatic role of IL-22 in asthma.

Manni ML, Alcorn JF.

Expert Rev Respir Med. 2016 Jun;10(6):619-23. doi: 10.1080/17476348.2016.1174580. Epub 2016 Apr 18. Review.


Vitamin D supplementation decreases Aspergillus fumigatus specific Th2 responses in CF patients with aspergillus sensitization: a phase one open-label study.

Nguyen NL, Pilewski JM, Celedón JC, Mandalapu S, Blanchard ML, DeRicco A, Hartigan E, Alcorn JF, Kolls JK.

Asthma Res Pract. 2015;1. pii: 3. Epub 2015 Jun 4.


A Novel CD4+ T Cell-Dependent Murine Model of Pneumocystis-driven Asthma-like Pathology.

Eddens T, Campfield BT, Serody K, Manni ML, Horne W, Elsegeiny W, McHugh KJ, Pociask D, Chen K, Zheng M, Alcorn JF, Wenzel S, Kolls JK.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):807-820.


Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation.

Manni ML, Mandalapu S, McHugh KJ, Elloso MM, Dudas PL, Alcorn JF.

J Immunol. 2016 Feb 1;196(3):963-77. doi: 10.4049/jimmunol.1501531. Epub 2016 Jan 4.


Looking Beyond Respiratory Cultures: Microbiome-Cytokine Signatures of Bacterial Pneumonia and Tracheobronchitis in Lung Transplant Recipients.

Shankar J, Nguyen MH, Crespo MM, Kwak EJ, Lucas SK, McHugh KJ, Mounaud S, Alcorn JF, Pilewski JM, Shigemura N, Kolls JK, Nierman WC, Clancy CJ.

Am J Transplant. 2016 Jun;16(6):1766-78. doi: 10.1111/ajt.13676. Epub 2016 Feb 10.


Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.

Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH.

J Biol Chem. 2015 Dec 11;290(50):29742-57. doi: 10.1074/jbc.M115.691253. Epub 2015 Oct 22.


Differential Susceptibilities of Human Lung Primary Cells to H1N1 Influenza Viruses.

Travanty E, Zhou B, Zhang H, Di YP, Alcorn JF, Wentworth DE, Mason R, Wang J.

J Virol. 2015 Dec;89(23):11935-44. doi: 10.1128/JVI.01792-15. Epub 2015 Sep 16.


Diet, interleukin-17, and childhood asthma in Puerto Ricans.

Han YY, Forno E, Brehm JM, Acosta-Pérez E, Alvarez M, Colón-Semidey A, Rivera-Soto W, Campos H, Litonjua AA, Alcorn JF, Canino G, Celedón JC.

Ann Allergy Asthma Immunol. 2015 Oct;115(4):288-293.e1. doi: 10.1016/j.anai.2015.07.020. Epub 2015 Aug 28.


Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.

Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES.

J Biol Chem. 2015 Sep 25;290(39):23897-904. doi: 10.1074/jbc.M115.655837. Epub 2015 Aug 3.


Influenza and Bacterial Superinfection: Illuminating the Immunologic Mechanisms of Disease.

Rynda-Apple A, Robinson KM, Alcorn JF.

Infect Immun. 2015 Oct;83(10):3764-70. doi: 10.1128/IAI.00298-15. Epub 2015 Jul 27. Review.


Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice.

Lee B, Robinson KM, McHugh KJ, Scheller EV, Mandalapu S, Chen C, Di YP, Clay ME, Enelow RI, Dubin PJ, Alcorn JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L158-67. doi: 10.1152/ajplung.00338.2014. Epub 2015 May 22.


Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells.

Oczypok EA, Milutinovic PS, Alcorn JF, Khare A, Crum LT, Manni ML, Epperly MW, Pawluk AM, Ray A, Oury TD.

J Allergy Clin Immunol. 2015 Sep;136(3):747-756.e4. doi: 10.1016/j.jaci.2015.03.011. Epub 2015 Apr 28.


The immunology of influenza virus-associated bacterial pneumonia.

Robinson KM, Kolls JK, Alcorn JF.

Curr Opin Immunol. 2015 Jun;34:59-67. doi: 10.1016/j.coi.2015.02.002. Epub 2015 Feb 24. Review.


The role of IL-27 in susceptibility to post-influenza Staphylococcus aureus pneumonia.

Robinson KM, Lee B, Scheller EV, Mandalapu S, Enelow RI, Kolls JK, Alcorn JF.

Respir Res. 2015 Feb 5;16:10. doi: 10.1186/s12931-015-0168-8.


Physiology. Killer fat.

Alcorn JF, Kolls JK.

Science. 2015 Jan 2;347(6217):26-7. doi: 10.1126/science.aaa4567. No abstract available.


What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?

Alcorn JF, Sarkar SN.

Expert Rev Respir Med. 2015 Feb;9(1):1-3. doi: 10.1586/17476348.2015.994608. Epub 2014 Dec 29.


Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation.

van der Velden JL, Hoffman SM, Alcorn JF, Tully JE, Chapman DG, Lahue KG, Guala AS, Lundblad LK, Aliyeva M, Daphtary N, Irvin CG, Janssen-Heininger YM.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L866-75. doi: 10.1152/ajplung.00153.2013. Epub 2014 Mar 7.


Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.

Goetzman ES, Alcorn JF, Bharathi SS, Uppala R, McHugh KJ, Kosmider B, Chen R, Zuo YY, Beck ME, McKinney RW, Skilling H, Suhrie KR, Karunanidhi A, Yeasted R, Otsubo C, Ellis B, Tyurina YY, Kagan VE, Mallampalli RK, Vockley J.

J Biol Chem. 2014 Apr 11;289(15):10668-79. doi: 10.1074/jbc.M113.540260. Epub 2014 Mar 3.


The complex relationship between inflammation and lung function in severe asthma.

Manni ML, Trudeau JB, Scheller EV, Mandalapu S, Elloso MM, Kolls JK, Wenzel SE, Alcorn JF.

Mucosal Immunol. 2014 Sep;7(5):1186-98. doi: 10.1038/mi.2014.8. Epub 2014 Feb 19.


A tale of two cytokines: IL-17 and IL-22 in asthma and infection.

Manni ML, Robinson KM, Alcorn JF.

Expert Rev Respir Med. 2014 Feb;8(1):25-42. doi: 10.1586/17476348.2014.854167. Epub 2013 Dec 10. Review.


A novel outbred mouse model of 2009 pandemic influenza and bacterial co-infection severity.

McHugh KJ, Mandalapu S, Kolls JK, Ross TM, Alcorn JF.

PLoS One. 2013 Dec 6;8(12):e82865. doi: 10.1371/journal.pone.0082865. eCollection 2013.


Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection.

Gopal R, Rangel-Moreno J, Fallert Junecko BA, Mallon DJ, Chen K, Pociask DA, Connell TD, Reinhart TA, Alcorn JF, Ross TM, Kolls JK, Khader SA.

Am J Pathol. 2014 Jan;184(1):55-63. doi: 10.1016/j.ajpath.2013.09.012. Epub 2013 Nov 1.


Influenza A exacerbates Staphylococcus aureus pneumonia by attenuating IL-1β production in mice.

Robinson KM, Choi SM, McHugh KJ, Mandalapu S, Enelow RI, Kolls JK, Alcorn JF.

J Immunol. 2013 Nov 15;191(10):5153-9. doi: 10.4049/jimmunol.1301237. Epub 2013 Oct 2.


Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production.

Robinson KM, McHugh KJ, Mandalapu S, Clay ME, Lee B, Scheller EV, Enelow RI, Chan YR, Kolls JK, Alcorn JF.

J Infect Dis. 2014 Mar;209(6):865-75. doi: 10.1093/infdis/jit527. Epub 2013 Sep 26.


The endogenous Th17 response in NO2-promoted allergic airway disease is dispensable for airway hyperresponsiveness and distinct from Th17 adoptive transfer.

Martin RA, Ather JL, Daggett R, Hoyt L, Alcorn JF, Suratt BT, Weiss DJ, Lundblad LK, Poynter ME.

PLoS One. 2013 Sep 19;8(9):e74730. doi: 10.1371/journal.pone.0074730. eCollection 2013.


Clinical consequences of targeting IL-17 and TH17 in autoimmune and allergic disorders.

Robinson KM, Manni ML, Biswas PS, Alcorn JF.

Curr Allergy Asthma Rep. 2013 Dec;13(6):587-95. doi: 10.1007/s11882-013-0361-0. Review.


Preservation of micro-architecture and angiogenic potential in a pulmonary acellular matrix obtained using intermittent intra-tracheal flow of detergent enzymatic treatment.

Maghsoudlou P, Georgiades F, Tyraskis A, Totonelli G, Loukogeorgakis SP, Orlando G, Shangaris P, Lange P, Delalande JM, Burns AJ, Cenedese A, Sebire NJ, Turmaine M, Guest BN, Alcorn JF, Atala A, Birchall MA, Elliott MJ, Eaton S, Pierro A, Gilbert TW, De Coppi P.

Biomaterials. 2013 Sep;34(28):6638-48. doi: 10.1016/j.biomaterials.2013.05.015. Epub 2013 May 30.


T-cell immunotherapy in cystic fibrosis: weighing the risk/reward.

Robinson KM, Alcorn JF.

Am J Respir Crit Care Med. 2013 Mar 15;187(6):564-6. doi: 10.1164/rccm.201212-2201ED. No abstract available.


IL-22 is essential for lung epithelial repair following influenza infection.

Pociask DA, Scheller EV, Mandalapu S, McHugh KJ, Enelow RI, Fattman CL, Kolls JK, Alcorn JF.

Am J Pathol. 2013 Apr;182(4):1286-96. doi: 10.1016/j.ajpath.2012.12.007. Epub 2013 Mar 11.


Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease.

Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC, Poynter ME.

Am J Respir Cell Mol Biol. 2013 May;48(5):655-64. doi: 10.1165/rcmb.2012-0423OC.


Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury.

Lee SM, McLaughlin JN, Frederick DR, Zhu L, Thambiayya K, Wasserloos KJ, Kaminski I, Pearce LL, Peterson J, Li J, Latoche JD, Peck Palmer OM, Stolz DB, Fattman CL, Alcorn JF, Oury TD, Angus DC, Pitt BR, Kaynar AM.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L350-60. doi: 10.1152/ajplung.00243.2012. Epub 2012 Dec 28.


Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections.

Guglani L, Gopal R, Rangel-Moreno J, Junecko BF, Lin Y, Berger T, Mak TW, Alcorn JF, Randall TD, Reinhart TA, Chan YR, Khader SA.

PLoS One. 2012;7(11):e50052. doi: 10.1371/journal.pone.0050052. Epub 2012 Nov 20.


The receptor for advanced glycation end products is a central mediator of asthma pathogenesis.

Milutinovic PS, Alcorn JF, Englert JM, Crum LT, Oury TD.

Am J Pathol. 2012 Oct;181(4):1215-25. doi: 10.1016/j.ajpath.2012.06.031. Epub 2012 Aug 11.


Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense.

Van der Velden J, Janssen-Heininger YM, Mandalapu S, Scheller EV, Kolls JK, Alcorn JF.

PLoS One. 2012;7(4):e34638. doi: 10.1371/journal.pone.0034638. Epub 2012 Apr 13.


Airway Hyperresponsiveness and Inflammation: Causation, Correlation, or No Relation?

Janssen-Heininger YM, Irvin CG, Scheller EV, Brown AL, Kolls JK, Alcorn JF.

J Allergy Ther. 2012 Jan 26;2012(Suppl 1). pii: 008.

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