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Items: 1 to 50 of 90

1.

IL-22 Binding Protein Constrains IL-22 Activity, Host Defense and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia.

Trevejo-Nunez G, Elsegeiny W, Aggor FEY, Tweedle JL, Kaplan Z, Gandhi P, Castillo P, Ferguson A, Alcorn JF, Chen K, Kolls JK, Gaffen SL.

Infect Immun. 2019 Aug 26. pii: IAI.00550-19. doi: 10.1128/IAI.00550-19. [Epub ahead of print]

PMID:
31451621
2.

IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1.

Hebert KD, Mclaughlin N, Zhang Z, Cipriani A, Alcorn JF, Pociask DA.

Respir Res. 2019 Aug 15;20(1):184. doi: 10.1186/s12931-019-1153-4.

3.

Survival during influenza-associated bacterial superinfection improves following viral- and bacterial-specific monoclonal antibody treatment.

Robinson KM, Ramanan K, Tobin JM, Nickolich KL, Pilewski MJ, Kallewaard NL, Sellman BR, Cohen TS, Alcorn JF.

JCI Insight. 2019 Jul 25;4(14). pii: 125554. doi: 10.1172/jci.insight.125554. eCollection 2019 Jul 25.

4.

IL-22-binding protein exacerbates influenza, bacterial super-infection.

Abood RN, McHugh KJ, Rich HE, Ortiz MA, Tobin JM, Ramanan K, Robinson KM, Bomberger JM, Kolls JK, Manni ML, Pociask DA, Alcorn JF.

Mucosal Immunol. 2019 Sep;12(5):1231-1243. doi: 10.1038/s41385-019-0188-7. Epub 2019 Jul 11.

PMID:
31296910
5.

A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery.

Ackerman EE, Alcorn JF, Hase T, Shoemaker JE.

BMC Bioinformatics. 2019 Jun 3;20(1):297. doi: 10.1186/s12859-019-2917-z.

6.

Peroxisome Proliferator-Activated Receptor Gamma (PPAR) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection.

Gopal R, Mendy A, Marinelli MA, Richwalls LJ, Seger PJ, Patel S, McHugh KJ, Rich HE, Grousd JA, Forno E, Alcorn JF.

Viruses. 2019 Jun 1;11(6). pii: E505. doi: 10.3390/v11060505.

7.

Host-Pathogen Interactions in Gram-Positive Bacterial Pneumonia.

Grousd JA, Rich HE, Alcorn JF.

Clin Microbiol Rev. 2019 May 29;32(3). pii: e00107-18. doi: 10.1128/CMR.00107-18. Print 2019 Jun 19. Review.

PMID:
31142498
8.

Calprotectin-g the Lung during Type 2 Allergic Airway Inflammation.

Manni ML, Alcorn JF.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):405-407. doi: 10.1165/rcmb.2019-0125ED. No abstract available.

PMID:
31046403
9.

Host and Bacterial Markers that Differ in Children with Cystitis and Pyelonephritis.

Shaikh N, Martin JM, Hoberman A, Skae M, Milkovich L, Nowalk A, McElheny C, Hickey RW, Kearney D, Majd M, Shalaby-Rana E, Tseng G, Alcorn JF, Kolls J, Kurs-Lasky M, Huo Z, Horne W, Lockhart G, Pohl H, Shope TR.

J Pediatr. 2019 Jun;209:146-153.e1. doi: 10.1016/j.jpeds.2019.01.012. Epub 2019 Mar 21.

PMID:
30905425
10.

Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection.

Rich HE, McCourt CC, Zheng WQ, McHugh KJ, Robinson KM, Wang J, Alcorn JF.

Infect Immun. 2019 Apr 23;87(5). pii: e00114-19. doi: 10.1128/IAI.00114-19. Print 2019 Mar.

PMID:
30804099
11.

IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury.

Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR.

JCI Insight. 2019 Mar 21;4(6). pii: 123919. doi: 10.1172/jci.insight.123919. eCollection 2019 Mar 21.

12.

Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin.

Mendy A, Gopal R, Alcorn JF, Forno E.

Respirology. 2019 Jul;24(7):646-651. doi: 10.1111/resp.13486. Epub 2019 Feb 13.

PMID:
30761687
13.

Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics.

Chamberlain N, Korwin-Mihavics BR, Nakada EM, Bruno SR, Heppner DE, Chapman DG, Hoffman SM, van der Vliet A, Suratt BT, Dienz O, Alcorn JF, Anathy V.

Redox Biol. 2019 Apr;22:101129. doi: 10.1016/j.redox.2019.101129. Epub 2019 Jan 29.

14.

Inflammatory Mediator Expression Associated With Antibody Response Induced by Live Attenuated vs Inactivated Influenza Virus Vaccine in Children.

Martin JM, Avula R, Nowalk MP, Lin CJ, Horne WT, Chandran UR, Nagg JP, Zimmerman RK, Cole KS, Alcorn JF.

Open Forum Infect Dis. 2018 Oct 24;5(11):ofy277. doi: 10.1093/ofid/ofy277. eCollection 2018 Nov.

15.

STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection.

Gopal R, Lee B, McHugh KJ, Rich HE, Ramanan K, Mandalapu S, Clay ME, Seger PJ, Enelow RI, Manni ML, Robinson KM, Rangel-Moreno J, Alcorn JF.

Front Immunol. 2018 Sep 25;9:2151. doi: 10.3389/fimmu.2018.02151. eCollection 2018.

16.

Murine models of Pneumocystis infection recapitulate human primary immune disorders.

Elsegeiny W, Zheng M, Eddens T, Gallo RL, Dai G, Trevejo-Nunez G, Castillo P, Kracinovsky K, Cleveland H, Horne W, Franks J, Pociask D, Pilarski M, Alcorn JF, Chen K, Kolls JK.

JCI Insight. 2018 Jun 21;3(12). pii: 91894. doi: 10.1172/jci.insight.91894. eCollection 2018 Jun 21.

17.

IL-17 Strikes a Chord in Chronic Obstructive Pulmonary Disease Exacerbation.

Rich HE, Alcorn JF.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):669-670. doi: 10.1165/rcmb.2018-0078ED. No abstract available.

PMID:
29708399
18.

The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice.

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Pilewski MJ, Nickolich KL, Corey C, Shiva S, Wang J, Muzumdar R, Alcorn JF.

JCI Insight. 2018 Apr 5;3(7). pii: 97470. doi: 10.1172/jci.insight.97470. eCollection 2018 Apr 5.

19.

STAT1 Is Required for Suppression of Type 17 Immunity during Influenza and Bacterial Superinfection.

Lee B, Gopal R, Manni ML, McHugh KJ, Mandalapu S, Robinson KM, Alcorn JF.

Immunohorizons. 2017 Aug 1;1(6):81-91. doi: 10.4049/immunohorizons.1700030.

20.

Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice.

Shinde A, Luo J, Bharathi SS, Shi H, Beck ME, McHugh KJ, Alcorn JF, Wang J, Goetzman ES.

Biochem Biophys Res Commun. 2018 Mar 4;497(2):700-704. doi: 10.1016/j.bbrc.2018.02.135. Epub 2018 Feb 16.

21.

Differential gene expression elicited by children in response to the 2015-16 live attenuated versus inactivated influenza vaccine.

Cole KS, Martin JM, Horne WT, Lin CJ, Nowalk MP, Alcorn JF, Zimmerman RK.

Vaccine. 2017 Dec 14;35(49 Pt B):6893-6897. doi: 10.1016/j.vaccine.2017.09.019. Epub 2017 Nov 11.

22.

Vitamin D insufficiency, plasma cytokines, and severe asthma exacerbations in school-aged children.

Szentpetery SE, Han YY, Brehm JM, Acosta-Pérez E, Forno E, Boutaoui N, Canino G, Alcorn JF, Celedón JC.

J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):289-291.e2. doi: 10.1016/j.jaip.2017.07.019. Epub 2017 Aug 26. No abstract available.

23.

Cockroach allergen exposure and plasma cytokines among children in a tropical environment.

Medsker BH, Forno E, Han YY, Acosta-Pérez E, Colón-Semidey A, Alvarez M, Alcorn JF, Canino GJ, Celedón JC.

Ann Allergy Asthma Immunol. 2017 Jul;119(1):65-70.e3. doi: 10.1016/j.anai.2017.05.008.

24.

A Multiomics Approach to Identify Genes Associated with Childhood Asthma Risk and Morbidity.

Forno E, Wang T, Yan Q, Brehm J, Acosta-Perez E, Colon-Semidey A, Alvarez M, Boutaoui N, Cloutier MM, Alcorn JF, Canino G, Chen W, Celedón JC.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):439-447. doi: 10.1165/rcmb.2017-0002OC.

25.

AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality.

Zhang H, Luo J, Alcorn JF, Chen K, Fan S, Pilewski J, Liu A, Chen W, Kolls JK, Wang J.

J Immunol. 2017 Jun 1;198(11):4383-4393. doi: 10.4049/jimmunol.1600714. Epub 2017 Apr 19.

26.

Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection.

Robinson KM, Ramanan K, Clay ME, McHugh KJ, Rich HE, Alcorn JF.

Mucosal Immunol. 2018 Jan;11(1):199-208. doi: 10.1038/mi.2017.32. Epub 2017 Apr 12.

27.

Proximity to a Major Road and Plasma Cytokines in School-Aged Children.

Rosser F, Forno E, Brehm J, Han YY, Boutaoui N, Colón-Semidey A, Alvarez M, Acosta-Pérez E, Kurland KS, Alcorn JF, Canino G, Celedón JC.

Pediatr Allergy Immunol Pulmonol. 2016 Sep 1;29(3):111-117. doi: 10.1089/ped.2016.0649.

28.

Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.

Treerat P, Prince O, Cruz-Lagunas A, Muñoz-Torrico M, Salazar-Lezama MA, Selman M, Fallert-Junecko B, Reinhardt TA, Alcorn JF, Kaushal D, Zuñiga J, Rangel-Moreno J, Kolls JK, Khader SA.

Mucosal Immunol. 2017 Jul;10(4):1069-1081. doi: 10.1038/mi.2017.15. Epub 2017 Mar 1.

29.

Bromodomain and Extra-Terminal Protein Inhibition Attenuates Neutrophil-dominant Allergic Airway Disease.

Manni ML, Mandalapu S, Salmeron A, Lora JM, Kolls JK, Alcorn JF.

Sci Rep. 2017 Feb 24;7:43139. doi: 10.1038/srep43139.

30.

Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

Pociask DA, Robinson KM, Chen K, McHugh KJ, Clay ME, Huang GT, Benos PV, Janssen-Heininger YMW, Kolls JK, Anathy V, Alcorn JF.

Am J Pathol. 2017 Apr;187(4):851-863. doi: 10.1016/j.ajpath.2016.12.012. Epub 2017 Feb 10.

31.

The enigmatic role of IL-22 in asthma.

Manni ML, Alcorn JF.

Expert Rev Respir Med. 2016 Jun;10(6):619-23. doi: 10.1080/17476348.2016.1174580. Epub 2016 Apr 18. Review.

PMID:
27043459
32.

Vitamin D supplementation decreases Aspergillus fumigatus specific Th2 responses in CF patients with aspergillus sensitization: a phase one open-label study.

Nguyen NL, Pilewski JM, Celedón JC, Mandalapu S, Blanchard ML, DeRicco A, Hartigan E, Alcorn JF, Kolls JK.

Asthma Res Pract. 2015;1. pii: 3. Epub 2015 Jun 4.

33.

A Novel CD4+ T Cell-Dependent Murine Model of Pneumocystis-driven Asthma-like Pathology.

Eddens T, Campfield BT, Serody K, Manni ML, Horne W, Elsegeiny W, McHugh KJ, Pociask D, Chen K, Zheng M, Alcorn JF, Wenzel S, Kolls JK.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):807-820.

34.

Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation.

Manni ML, Mandalapu S, McHugh KJ, Elloso MM, Dudas PL, Alcorn JF.

J Immunol. 2016 Feb 1;196(3):963-77. doi: 10.4049/jimmunol.1501531. Epub 2016 Jan 4.

35.

Looking Beyond Respiratory Cultures: Microbiome-Cytokine Signatures of Bacterial Pneumonia and Tracheobronchitis in Lung Transplant Recipients.

Shankar J, Nguyen MH, Crespo MM, Kwak EJ, Lucas SK, McHugh KJ, Mounaud S, Alcorn JF, Pilewski JM, Shigemura N, Kolls JK, Nierman WC, Clancy CJ.

Am J Transplant. 2016 Jun;16(6):1766-78. doi: 10.1111/ajt.13676. Epub 2016 Feb 10.

36.

Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.

Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH.

J Biol Chem. 2015 Dec 11;290(50):29742-57. doi: 10.1074/jbc.M115.691253. Epub 2015 Oct 22.

37.

Differential Susceptibilities of Human Lung Primary Cells to H1N1 Influenza Viruses.

Travanty E, Zhou B, Zhang H, Di YP, Alcorn JF, Wentworth DE, Mason R, Wang J.

J Virol. 2015 Dec;89(23):11935-44. doi: 10.1128/JVI.01792-15. Epub 2015 Sep 16.

38.

Diet, interleukin-17, and childhood asthma in Puerto Ricans.

Han YY, Forno E, Brehm JM, Acosta-Pérez E, Alvarez M, Colón-Semidey A, Rivera-Soto W, Campos H, Litonjua AA, Alcorn JF, Canino G, Celedón JC.

Ann Allergy Asthma Immunol. 2015 Oct;115(4):288-293.e1. doi: 10.1016/j.anai.2015.07.020. Epub 2015 Aug 28.

39.

Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.

Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES.

J Biol Chem. 2015 Sep 25;290(39):23897-904. doi: 10.1074/jbc.M115.655837. Epub 2015 Aug 3.

40.

Influenza and Bacterial Superinfection: Illuminating the Immunologic Mechanisms of Disease.

Rynda-Apple A, Robinson KM, Alcorn JF.

Infect Immun. 2015 Oct;83(10):3764-70. doi: 10.1128/IAI.00298-15. Epub 2015 Jul 27. Review.

41.

Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice.

Lee B, Robinson KM, McHugh KJ, Scheller EV, Mandalapu S, Chen C, Di YP, Clay ME, Enelow RI, Dubin PJ, Alcorn JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L158-67. doi: 10.1152/ajplung.00338.2014. Epub 2015 May 22.

42.

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells.

Oczypok EA, Milutinovic PS, Alcorn JF, Khare A, Crum LT, Manni ML, Epperly MW, Pawluk AM, Ray A, Oury TD.

J Allergy Clin Immunol. 2015 Sep;136(3):747-756.e4. doi: 10.1016/j.jaci.2015.03.011. Epub 2015 Apr 28.

43.

The immunology of influenza virus-associated bacterial pneumonia.

Robinson KM, Kolls JK, Alcorn JF.

Curr Opin Immunol. 2015 Jun;34:59-67. doi: 10.1016/j.coi.2015.02.002. Epub 2015 Feb 24. Review.

44.

The role of IL-27 in susceptibility to post-influenza Staphylococcus aureus pneumonia.

Robinson KM, Lee B, Scheller EV, Mandalapu S, Enelow RI, Kolls JK, Alcorn JF.

Respir Res. 2015 Feb 5;16:10. doi: 10.1186/s12931-015-0168-8.

45.

Physiology. Killer fat.

Alcorn JF, Kolls JK.

Science. 2015 Jan 2;347(6217):26-7. doi: 10.1126/science.aaa4567. No abstract available.

PMID:
25554774
46.

What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?

Alcorn JF, Sarkar SN.

Expert Rev Respir Med. 2015 Feb;9(1):1-3. doi: 10.1586/17476348.2015.994608. Epub 2014 Dec 29.

47.

Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation.

van der Velden JL, Hoffman SM, Alcorn JF, Tully JE, Chapman DG, Lahue KG, Guala AS, Lundblad LK, Aliyeva M, Daphtary N, Irvin CG, Janssen-Heininger YM.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L866-75. doi: 10.1152/ajplung.00153.2013. Epub 2014 Mar 7.

48.

Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.

Goetzman ES, Alcorn JF, Bharathi SS, Uppala R, McHugh KJ, Kosmider B, Chen R, Zuo YY, Beck ME, McKinney RW, Skilling H, Suhrie KR, Karunanidhi A, Yeasted R, Otsubo C, Ellis B, Tyurina YY, Kagan VE, Mallampalli RK, Vockley J.

J Biol Chem. 2014 Apr 11;289(15):10668-79. doi: 10.1074/jbc.M113.540260. Epub 2014 Mar 3.

49.

The complex relationship between inflammation and lung function in severe asthma.

Manni ML, Trudeau JB, Scheller EV, Mandalapu S, Elloso MM, Kolls JK, Wenzel SE, Alcorn JF.

Mucosal Immunol. 2014 Sep;7(5):1186-98. doi: 10.1038/mi.2014.8. Epub 2014 Feb 19.

50.

A tale of two cytokines: IL-17 and IL-22 in asthma and infection.

Manni ML, Robinson KM, Alcorn JF.

Expert Rev Respir Med. 2014 Feb;8(1):25-42. doi: 10.1586/17476348.2014.854167. Epub 2013 Dec 10. Review.

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