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Items: 45

1.

High-Resolution Melting Assay for Genotyping Variants of the CYP2C19 Enzyme and Predicting Voriconazole Effectiveness.

Bernal-Martínez L, Alcazar Fuoli L, Miguel-Revilla B, Carvalho A, Cuétara Garcia MS, Garcia-Rodriguez J, Cunha C, Gómez-García de la Pedrosa E, Gomez-Lopez A.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e02399-18. doi: 10.1128/AAC.02399-18. Print 2019 Jun.

PMID:
30910893
2.

Two KTR Mannosyltransferases Are Responsible for the Biosynthesis of Cell Wall Mannans and Control Polarized Growth in Aspergillus fumigatus.

Henry C, Li J, Danion F, Alcazar-Fuoli L, Mellado E, Beau R, Jouvion G, Latgé JP, Fontaine T.

MBio. 2019 Feb 12;10(1). pii: e02647-18. doi: 10.1128/mBio.02647-18.

3.

Genome-Wide Comparative Analysis of Aspergillus fumigatus Strains: The Reference Genome as a Matter of Concern.

Garcia-Rubio R, Monzon S, Alcazar-Fuoli L, Cuesta I, Mellado E.

Genes (Basel). 2018 Jul 19;9(7). pii: E363. doi: 10.3390/genes9070363.

4.

Molecular Identification and Susceptibility Testing of Molds Isolated in a Prospective Surveillance of Triazole Resistance in Spain (FILPOP2 Study).

Alastruey-Izquierdo A, Alcazar-Fuoli L, Rivero-Menéndez O, Ayats J, Castro C, García-Rodríguez J, Goterris-Bonet L, Ibáñez-Martínez E, Linares-Sicilia MJ, Martin-Gomez MT, Martín-Mazuelos E, Pelaez T, Peman J, Rezusta A, Rojo S, Tejero R, Anza DV, Viñuelas J, Zapico MS, Cuenca-Estrella M; the FILPOP2 Project from GEMICOMED (SEIMC) and REIPI.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00358-18. doi: 10.1128/AAC.00358-18. Print 2018 Sep.

5.

Simultaneous quantification of systemic azoles and their major metabolites in human serum by HPLC/PDA: role of azole metabolic rate.

Gomez-Lopez A, Alcazar-Fuoli L, Bernal-Martínez L.

Diagn Microbiol Infect Dis. 2018 Sep;92(1):78-83. doi: 10.1016/j.diagmicrobio.2018.04.003. Epub 2018 Apr 14.

PMID:
29778564
6.

Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms.

Garcia-Rubio R, Alcazar-Fuoli L, Monteiro MC, Monzon S, Cuesta I, Pelaez T, Mellado E.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00241-18. doi: 10.1128/AAC.00241-18. Print 2018 Jun.

7.

Evaluation of Bronchoalveolar Lavage Fluid Cytokines as Biomarkers for Invasive Pulmonary Aspergillosis in At-Risk Patients.

Gonçalves SM, Lagrou K, Rodrigues CS, Campos CF, Bernal-Martínez L, Rodrigues F, Silvestre R, Alcazar-Fuoli L, Maertens JA, Cunha C, Carvalho A.

Front Microbiol. 2017 Nov 29;8:2362. doi: 10.3389/fmicb.2017.02362. eCollection 2017.

8.

Could the determination of Aspergillus fumigatus mating type have prognostic value in invasive aspergillosis?

Monteiro MC, Garcia-Rubio R, Alcazar-Fuoli L, Peláez T, Mellado E.

Mycoses. 2018 Mar;61(3):172-178. doi: 10.1111/myc.12720. Epub 2017 Nov 22.

PMID:
29082564
9.

Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis.

Lupiañez CB, Villaescusa MT, Carvalho A, Springer J, Lackner M, Sánchez-Maldonado JM, Canet LM, Cunha C, Segura-Catena J, Alcazar-Fuoli L, Solano C, Fianchi L, Pagano L, Potenza L, Aguado JM, Luppi M, Cuenca-Estrella M, Lass-Flörl C, Einsele H, Vázquez L; PCRAGA Study Group, Ríos-Tamayo R, Loeffler J, Jurado M, Sainz J.

Front Microbiol. 2016 Aug 12;7:1243. doi: 10.3389/fmicb.2016.01243. eCollection 2016.

10.

Amino acid biosynthetic pathways as antifungal targets for fungal infections.

Alcazar-Fuoli L.

Virulence. 2016 May 18;7(4):376-8. doi: 10.1080/21505594.2016.1169360. No abstract available.

11.

Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium.

Lupiañez CB, Canet LM, Carvalho A, Alcazar-Fuoli L, Springer J, Lackner M, Segura-Catena J, Comino A, Olmedo C, Ríos R, Fernández-Montoya A, Cuenca-Estrella M, Solano C, López-Nevot MÁ, Cunha C, Oliveira-Coelho A, Villaescusa T, Fianchi L, Aguado JM, Pagano L, López-Fernández E, Potenza L, Luppi M, Lass-Flörl C, Loeffler J, Einsele H, Vazquez L; PCRAGA Study Group, Jurado M, Sainz J.

Infect Immun. 2015 Dec 14;84(3):643-57. doi: 10.1128/IAI.01359-15.

12.

Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2015 Jun 18;11(6):e1004943. doi: 10.1371/journal.ppat.1004943. eCollection 2015 Jun. No abstract available.

13.

An alternative host model of a mixed fungal infection by azole susceptible and resistant Aspergillus spp strains.

Alcazar-Fuoli L, Buitrago M, Gomez-Lopez A, Mellado E.

Virulence. 2015;6(4):376-84. doi: 10.1080/21505594.2015.1025192.

14.

Erratum to: Antifungal susceptibility profile of cryptic species of Aspergillus.

Alastruey-Izquierdo A, Alcazar-Fuoli L, Cuenca-Estrella M.

Mycopathologia. 2015 Apr;179(3-4):333-4. doi: 10.1007/s11046-014-9842-5. No abstract available.

PMID:
25487976
15.

A modified recombineering protocol for the genetic manipulation of gene clusters in Aspergillus fumigatus.

Alcazar-Fuoli L, Cairns T, Lopez JF, Zonja B, Pérez S, Barceló D, Igarashi Y, Bowyer P, Bignell E.

PLoS One. 2014 Nov 5;9(11):e111875. doi: 10.1371/journal.pone.0111875. eCollection 2014.

16.

The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2014 Oct 16;10(10):e1004413. doi: 10.1371/journal.ppat.1004413. eCollection 2014 Oct. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004802. PLoS Pathog. 2015 Jun 18;11(6):e1004943.

17.

Antifungal susceptibility profile of cryptic species of Aspergillus.

Alastruey-Izquierdo A, Alcazar-Fuoli L, Cuenca-Estrella M.

Mycopathologia. 2014 Dec;178(5-6):427-33. doi: 10.1007/s11046-014-9775-z. Epub 2014 Jun 28. Review. Erratum in: Mycopathologia. 2015 Apr;179(3-4):333-4.

PMID:
24972670
18.

Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion.

Muszkieta L, Aimanianda V, Mellado E, Gribaldo S, Alcàzar-Fuoli L, Szewczyk E, Prevost MC, Latgé JP.

Cell Microbiol. 2014 Dec;16(12):1784-805. doi: 10.1111/cmi.12326. Epub 2014 Aug 15.

PMID:
24946720
19.

Current status of antifungal resistance and its impact on clinical practice.

Alcazar-Fuoli L, Mellado E.

Br J Haematol. 2014 Aug;166(4):471-84. doi: 10.1111/bjh.12896. Epub 2014 Apr 18. Review.

PMID:
24749533
20.

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA Jr, Brown R, Fuchter MJ.

J Med Chem. 2013 Nov 14;56(21):8616-25. doi: 10.1021/jm401063r. Epub 2013 Oct 25.

PMID:
24099080
21.

Candida tropicalis antifungal cross-resistance is related to different azole target (Erg11p) modifications.

Forastiero A, Mesa-Arango AC, Alastruey-Izquierdo A, Alcazar-Fuoli L, Bernal-Martinez L, Pelaez T, Lopez JF, Grimalt JO, Gomez-Lopez A, Cuesta I, Zaragoza O, Mellado E.

Antimicrob Agents Chemother. 2013 Oct;57(10):4769-81. doi: 10.1128/AAC.00477-13. Epub 2013 Jul 22.

22.

Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance.

Alcazar-Fuoli L, Mellado E.

Front Microbiol. 2013 Jan 10;3:439. doi: 10.3389/fmicb.2012.00439. eCollection 2012.

23.

Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.

Yasmin S, Alcazar-Fuoli L, Gründlinger M, Puempel T, Cairns T, Blatzer M, Lopez JF, Grimalt JO, Bignell E, Haas H.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E497-504. doi: 10.1073/pnas.1106399108. Epub 2011 Nov 21.

24.

Role of Aspergillus lentulus 14-α sterol demethylase (Cyp51A) in azole drug susceptibility.

Mellado E, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2011 Dec;55(12):5459-68. doi: 10.1128/AAC.05178-11. Epub 2011 Sep 26.

25.

On the determination of the stereochemistry of semisynthetic natural product analogues using chiroptical spectroscopy: desulfurization of epidithiodioxopiperazine fungal metabolites.

Cherblanc F, Lo YP, De Gussem E, Alcazar-Fuoli L, Bignell E, He Y, Chapman-Rothe N, Bultinck P, Herrebout WA, Brown R, Rzepa HS, Fuchter MJ.

Chemistry. 2011 Oct 10;17(42):11868-75. doi: 10.1002/chem.201101129. Epub 2011 Sep 5.

PMID:
21898613
26.

Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction.

Alcazar-Fuoli L, Cuesta I, Rodriguez-Tudela JL, Cuenca-Estrella M, Sanglard D, Mellado E.

Int J Antimicrob Agents. 2011 Nov;38(5):426-34. doi: 10.1016/j.ijantimicag.2011.06.005. Epub 2011 Aug 25.

PMID:
21871783
27.

Functional analysis of the fungal/plant class chitinase family in Aspergillus fumigatus.

Alcazar-Fuoli L, Clavaud C, Lamarre C, Aimanianda V, Seidl-Seiboth V, Mellado E, Latgé JP.

Fungal Genet Biol. 2011 Apr;48(4):418-29. doi: 10.1016/j.fgb.2010.12.007. Epub 2010 Dec 22.

PMID:
21184840
28.

Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae.

Alcazar-Fuoli L, Mellado E, Cuenca-Estrella M, Sanglard D.

Med Mycol. 2011 Apr;49(3):276-84. doi: 10.3109/13693786.2010.512926. Epub 2010 Sep 10.

PMID:
20831364
29.

Incidence of zygomycosis in transplant recipients.

Cuenca-Estrella M, Bernal-Martinez L, Isla G, Gomez-Lopez A, Alcazar-Fuoli L, Buitrago MJ.

Clin Microbiol Infect. 2009 Oct;15 Suppl 5:37-40. doi: 10.1111/j.1469-0691.2009.02978.x. Review.

30.

Species identification and antifungal susceptibility patterns of species belonging to Aspergillus section Nigri.

Alcazar-Fuoli L, Mellado E, Alastruey-Izquierdo A, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2009 Oct;53(10):4514-7. doi: 10.1128/AAC.00585-09. Epub 2009 Jul 27.

31.

Interlaboratory reproducibility of a microsatellite-based typing assay for Aspergillus fumigatus through the use of allelic ladders: proof of concept.

de Valk HA, Meis JF, Bretagne S, Costa JM, Lasker BA, Balajee SA, Pasqualotto AC, Anderson MJ, Alcázar-Fuoli L, Mellado E, Klaassen CH.

Clin Microbiol Infect. 2009 Feb;15(2):180-7. doi: 10.1111/j.1469-0691.2008.02656.x. Epub 2009 Jan 10.

32.

Clinical relevance of resistance to antifungals.

Rodriguez-Tudela JL, Alcazar-Fuoli L, Cuesta I, Alastruey-Izquierdo A, Monzon A, Mellado E, Cuenca-Estrella M.

Int J Antimicrob Agents. 2008 Nov;32 Suppl 2:S111-3. doi: 10.1016/S0924-8579(08)70010-4. Review.

PMID:
19013333
33.

Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.

Rodriguez-Tudela JL, Alcazar-Fuoli L, Mellado E, Alastruey-Izquierdo A, Monzon A, Cuenca-Estrella M.

Antimicrob Agents Chemother. 2008 Jul;52(7):2468-72. doi: 10.1128/AAC.00156-08. Epub 2008 May 12.

34.

Rapid detection of triazole antifungal resistance in Aspergillus fumigatus.

Garcia-Effron G, Dilger A, Alcazar-Fuoli L, Park S, Mellado E, Perlin DS.

J Clin Microbiol. 2008 Apr;46(4):1200-6. doi: 10.1128/JCM.02330-07. Epub 2008 Jan 30.

35.

Aspergillus section Fumigati: antifungal susceptibility patterns and sequence-based identification.

Alcazar-Fuoli L, Mellado E, Alastruey-Izquierdo A, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2008 Apr;52(4):1244-51. doi: 10.1128/AAC.00942-07. Epub 2008 Jan 22.

36.

In vitro activities of 35 double combinations of antifungal agents against Scedosporium apiospermum and Scedosporium prolificans.

Cuenca-Estrella M, Alastruey-Izquierdo A, Alcazar-Fuoli L, Bernal-Martinez L, Gomez-Lopez A, Buitrago MJ, Mellado E, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2008 Mar;52(3):1136-9. doi: 10.1128/AAC.01160-07. Epub 2008 Jan 14.

37.

Ergosterol biosynthesis pathway in Aspergillus fumigatus.

Alcazar-Fuoli L, Mellado E, Garcia-Effron G, Lopez JF, Grimalt JO, Cuenca-Estrella JM, Rodriguez-Tudela JL.

Steroids. 2008 Mar;73(3):339-47. doi: 10.1016/j.steroids.2007.11.005. Epub 2007 Dec 3.

PMID:
18191972
38.

Time of incubation for antifungal susceptibility testing of Aspergillus fumigatus: can MIC values be obtained at 24 hours?

Rodriguez-Tudela JL, Alcazar-Fuoli L, Alastruey-Izquierdo A, Monzon A, Mellado E, Cuenca-Estrella M.

Antimicrob Agents Chemother. 2007 Dec;51(12):4502-4. Epub 2007 Oct 15.

39.

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

Mellado E, Garcia-Effron G, Alcázar-Fuoli L, Melchers WJ, Verweij PE, Cuenca-Estrella M, Rodríguez-Tudela JL.

Antimicrob Agents Chemother. 2007 Jun;51(6):1897-904. Epub 2007 Mar 19.

40.

New resistance mechanisms to azole drugs in Aspergillus fumigatus and emergence of antifungal drugs-resistant A. fumigatus atypical strains.

Mellado E, Alcazar-Fuoli L, García-Effrón G, Alastruey-Izquierdo A, Cuenca-Estrella M, Rodríguez-Tudela JL.

Med Mycol. 2006 Sep 1;44(Supplement_1):S367-S371. doi: 10.1080/13693780600902243.

PMID:
30408931
41.

Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.

Alcazar-Fuoli L, Mellado E, Garcia-Effron G, Buitrago MJ, Lopez JF, Grimalt JO, Cuenca-Estrella JM, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2006 Feb;50(2):453-60.

42.

Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.

Mellado E, Garcia-Effron G, Buitrago MJ, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2005 Jun;49(6):2536-8.

43.

Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus.

Garcia-Effron G, Mellado E, Gomez-Lopez A, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2005 May;49(5):2119-21.

44.

Combined activity in vitro of caspofungin, amphotericin B, and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatus.

Cuenca-Estrella M, Gomez-Lopez A, Garcia-Effron G, Alcazar-Fuoli L, Mellado E, Buitrago MJ, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2005 Mar;49(3):1232-5.

45.

Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs.

Mellado E, Garcia-Effron G, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2004 Jul;48(7):2747-50.

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