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Items: 49


Trypanosoma cruzi Neurotrophic Factor Facilitates Cardiac Repair in a Mouse Model of Chronic Chagas Disease.

Ledoux T, Aridgides D, Salvador R, Ngwenyama N, Panagiotidou S, Alcaide P, Blanton RM, Perrin MA.

J Pharmacol Exp Ther. 2019 Jan;368(1):11-20. doi: 10.1124/jpet.118.251900. Epub 2018 Oct 22.


Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure.

Valiente-Alandi I, Potter SJ, Salvador AM, Schafer AE, Schips T, Carrillo-Salinas F, Gibson AM, Nieman ML, Perkins C, Sargent MA, Huo J, Lorenz JN, DeFalco T, Molkentin JD, Alcaide P, Blaxall BC.

Circulation. 2018 Sep 18;138(12):1236-1252. doi: 10.1161/CIRCULATIONAHA.118.034609.


Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure.

Nevers T, Salvador AM, Velazquez F, Ngwenyama N, Carrillo-Salinas FJ, Aronovitz M, Blanton RM, Alcaide P.

J Exp Med. 2017 Nov 6;214(11):3311-3329. doi: 10.1084/jem.20161791. Epub 2017 Oct 2.


Four Years' Experience in the Diagnosis of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency in Infants Detected in Three Spanish Newborn Screening Centers.

Merinero B, Alcaide P, Martín-Hernández E, Morais A, García-Silva MT, Quijada-Fraile P, Pedrón-Giner C, Dulin E, Yahyaoui R, Egea JM, Belanger-Quintana A, Blasco-Alonso J, Fernandez Ruano ML, Besga B, Ferrer-López I, Leal F, Ugarte M, Ruiz-Sala P, Pérez B, Pérez-Cerdá C.

JIMD Rep. 2018;39:63-74. doi: 10.1007/8904_2017_40. Epub 2017 Jul 29.


Endothelial mineralocorticoid receptor contributes to systolic dysfunction induced by pressure overload without modulating cardiac hypertrophy or inflammation.

Salvador AM, Moss ME, Aronovitz M, Mueller KB, Blanton RM, Jaffe IZ, Alcaide P.

Physiol Rep. 2017 Jun;5(12). pii: e13313. doi: 10.14814/phy2.13313.


Cardiac Myosin Protein C: New Roles, New Questions, Potential Opportunities.

Blanton RM, Alcaide P.

JACC Basic Transl Sci. 2017 Apr 24;2(2):132-134. doi: 10.1016/j.jacbts.2017.03.007. eCollection 2017 Apr. No abstract available.


Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure.

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P.

J Am Heart Assoc. 2016 Mar 15;5(3):e003126. doi: 10.1161/JAHA.115.003126.


Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality.

Schnoor M, Alcaide P, Voisin MB, van Buul JD.

Mediators Inflamm. 2016;2016:1561368. doi: 10.1155/2016/1561368. Epub 2016 Feb 17. No abstract available.


Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.

Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P.

Nat Commun. 2016 Feb 2;7:10363. doi: 10.1038/ncomms10363.


CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.

Velázquez F, Grodecki-Pena A, Knapp A, Salvador AM, Nevers T, Croce K, Alcaide P.

J Immunol. 2016 Feb 1;196(3):1305-1316. doi: 10.4049/jimmunol.1501171. Epub 2015 Dec 23.


Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation.

Schnoor M, Alcaide P, Voisin MB, van Buul JD.

Mediators Inflamm. 2015;2015:946509. doi: 10.1155/2015/946509. Epub 2015 Oct 19. Review.


Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment.

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM.

PLoS Pathog. 2015 Aug 27;11(8):e1005126. doi: 10.1371/journal.ppat.1005126. eCollection 2015 Aug.


Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure.

Nevers T, Salvador AM, Grodecki-Pena A, Knapp A, Velázquez F, Aronovitz M, Kapur NK, Karas RH, Blanton RM, Alcaide P.

Circ Heart Fail. 2015 Jul;8(4):776-87. doi: 10.1161/CIRCHEARTFAILURE.115.002225. Epub 2015 May 28.


Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.

Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS.

Mol Cell Biol. 2014 Dec 1;34(23):4343-54. doi: 10.1128/MCB.00533-14. Epub 2014 Sep 22.


Enzymatic diagnosis of homocystinuria by determination of cystathionine-ß-synthase activity in plasma using LC-MS/MS.

Alcaide P, Krijt J, Ruiz-Sala P, Ješina P, Ugarte M, Kožich V, Merinero B.

Clin Chim Acta. 2015 Jan 1;438:261-5. doi: 10.1016/j.cca.2014.09.009. Epub 2014 Sep 16.


Mineralocorticoid receptors in immune cells: emerging role in cardiovascular disease.

Bene NC, Alcaide P, Wortis HH, Jaffe IZ.

Steroids. 2014 Dec;91:38-45. doi: 10.1016/j.steroids.2014.04.005. Epub 2014 Apr 21. Review.


Two novel mutations in the BCKDK (branched-chain keto-acid dehydrogenase kinase) gene are responsible for a neurobehavioral deficit in two pediatric unrelated patients.

García-Cazorla A, Oyarzabal A, Fort J, Robles C, Castejón E, Ruiz-Sala P, Bodoy S, Merinero B, Lopez-Sala A, Dopazo J, Nunes V, Ugarte M, Artuch R, Palacín M, Rodríguez-Pombo P, Alcaide P, Navarrete R, Sanz P, Font-Llitjós M, Vilaseca MA, Ormaizabal A, Pristoupilova A, Agulló SB.

Hum Mutat. 2014 Apr;35(4):470-7. doi: 10.1002/humu.22513. Epub 2014 Mar 5.


p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.

Alcaide P, Martinelli R, Newton G, Williams MR, Adam A, Vincent PA, Luscinskas FW.

Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C385-95. doi: 10.1152/ajpcell.00126.2012. Epub 2012 May 30.


IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.

Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH.

J Immunol. 2012 Jun 15;188(12):6287-99. doi: 10.4049/jimmunol.1200385. Epub 2012 May 7.


Difference in Th1 and Th17 lymphocyte adhesion to endothelium.

Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH.

J Immunol. 2012 Feb 1;188(3):1421-30. doi: 10.4049/jimmunol.1101647. Epub 2012 Jan 4.


Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment.

Maganto-García E, Bu DX, Tarrio ML, Alcaide P, Newton G, Griffin GK, Croce KJ, Luscinskas FW, Lichtman AH, Grabie N.

J Immunol. 2011 Oct 1;187(7):3521-9. doi: 10.4049/jimmunol.1003947. Epub 2011 Aug 26.


Emerging mechanisms of neutrophil recruitment across endothelium.

Williams MR, Azcutia V, Newton G, Alcaide P, Luscinskas FW.

Trends Immunol. 2011 Oct;32(10):461-9. doi: 10.1016/ Epub 2011 Aug 11. Review.


Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.

Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi GP.

PLoS One. 2011 Jan 14;6(1):e14525. doi: 10.1371/journal.pone.0014525.


Defining the pathogenicity of creatine deficiency syndrome.

Alcaide P, Merinero B, Ruiz-Sala P, Richard E, Navarrete R, Arias A, Ribes A, Artuch R, Campistol J, Ugarte M, Rodríguez-Pombo P.

Hum Mutat. 2011 Mar;32(3):282-91. doi: 10.1002/humu.21421. Epub 2011 Feb 8.


Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.

Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16252-6. doi: 10.1073/pnas.1002747107. Epub 2010 Aug 30.


Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.

Alcaide P, Lim YC, Luscinskas FW, Fresno M.

Infect Immun. 2010 Mar;78(3):1260-8. doi: 10.1128/IAI.00794-09. Epub 2010 Jan 11.


A new case of creatine transporter deficiency associated with mild clinical phenotype and a novel mutation in the SLC6A8 gene.

Alcaide P, Rodriguez-Pombo P, Ruiz-Sala P, Ferrer I, Castro P, Ruiz Martin Y, Merinero B, Ugarte M.

Dev Med Child Neurol. 2010 Feb;52(2):215-7. doi: 10.1111/j.1469-8749.2009.03480.x. Epub 2009 Nov 30. No abstract available.


[Cerebral creatine deficiency: first Spanish patients harbouring mutations in GAMT gene].

Sempere A, Fons C, Arias A, Rodríguez-Pombo P, Merinero B, Alcaide P, Capdevila A, Ribes A, Duque R, Eirís J, Poo P, Fernández-Alvarez E, Campistol J, Artuch R.

Med Clin (Barc). 2009 Nov 21;133(19):745-9. doi: 10.1016/j.medcli.2009.06.065. Epub 2009 Nov 5. Spanish.


Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells.

Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF.

J Immunol. 2009 Oct 15;183(8):5251-60. doi: 10.4049/jimmunol.0901471. Epub 2009 Sep 25.


Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.

Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR.

J Immunol. 2009 Jul 15;183(2):1032-43. doi: 10.4049/jimmunol.0802984. Epub 2009 Jun 26.


Creatine transporter deficiency in two adult patients with static encephalopathy.

Sempere A, Fons C, Arias A, Rodríguez-Pombo P, Colomer R, Merinero B, Alcaide P, Capdevila A, Ribes A, Artuch R, Campistol J.

J Inherit Metab Dis. 2009 Dec;32 Suppl 1:S91-6. doi: 10.1007/s10545-009-1083-2. Epub 2009 Mar 25. Review.


Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps.

Alcaide P, Auerbach S, Luscinskas FW.

Microcirculation. 2009 Jan;16(1):43-57. doi: 10.1080/10739680802273892. Review. Erratum in: Microcirculation. 2009 Nov;16(8):782.


p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.

Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW.

Blood. 2008 Oct 1;112(7):2770-9. doi: 10.1182/blood-2008-03-147181. Epub 2008 Jul 18.


ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.

Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK.

J Clin Invest. 2008 May;118(5):1632-44. doi: 10.1172/JCI29226.


Mechanical forces induced by the transendothelial migration of human neutrophils.

Rabodzey A, Alcaide P, Luscinskas FW, Ladoux B.

Biophys J. 2008 Aug;95(3):1428-38. doi: 10.1529/biophysj.107.119156. Epub 2008 Apr 4.


Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent.

Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW.

J Immunol. 2007 May 1;178(9):5879-87.


The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.

Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW.

J Invest Dermatol. 2007 Aug;127(8):1964-72. Epub 2007 Mar 29.


Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.

Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Arinobu Y, Akashi K, Paterson AM, Gurish MA, Luscinskas FW.

J Exp Med. 2007 Feb 19;204(2):431-9. Epub 2007 Feb 12.


CD99 is a key mediator of the transendothelial migration of neutrophils.

Lou O, Alcaide P, Luscinskas FW, Muller WA.

J Immunol. 2007 Jan 15;178(2):1136-43.


Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.

Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ.

J Clin Invest. 2007 Jan;117(1):195-205.


Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells.

Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM.

Circulation. 2006 Aug 15;114(7):681-7. Epub 2006 Aug 7.


Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.

Cai YH, Alvarez A, Alcaide P, Duramad P, Lim YC, Jarolim P, Lowe JB, Luscinskas FW, Lichtman AH.

J Immunol. 2006 Jun 1;176(11):6568-75.


Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus.

Xie C, Alcaide P, Geisbrecht BV, Schneider D, Herrmann M, Preissner KT, Luscinskas FW, Chavakis T.

J Exp Med. 2006 Apr 17;203(4):985-94. Epub 2006 Apr 3.


Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.

Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK.

Circ Res. 2006 May 12;98(9):1134-40. Epub 2006 Mar 30.


Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells.

Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM.

Circulation. 2006 Feb 7;113(5):691-700.


The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin.

Alcaide P, Fresno M.

Int Immunol. 2004 Oct;16(10):1365-75. Epub 2004 Aug 16.


Acute rejection, cytomegalovirus infection and endothelial dysfunction early after heart transplantation.

Sabaté M, Manito N, Cequier A, Roca J, Mauri J, Jara F, Gomez-Hospital JA, Ruiz-Majoral A, Sala J, Alcaide P, et al.

Transplant Proc. 1995 Aug;27(4):2346-8. No abstract available.


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