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Items: 1 to 50 of 346

1.

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD.

Pharmacol Rev. 2018 Jul;70(3):621-660. doi: 10.1124/pr.117.015198. Review. Erratum in: Pharmacol Rev. 2018 Oct;70(4):879.

2.

Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms.

Burke RD, Todd SW, Lumsden E, Mullins RJ, Mamczarz J, Fawcett WP, Gullapalli RP, Randall WR, Pereira EFR, Albuquerque EX.

J Neurochem. 2017 Aug;142 Suppl 2:162-177. doi: 10.1111/jnc.14077. Review.

3.

Zanos et al. reply.

Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KSS, Fang Y, Huang XP, Mayo CL, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA, Gould TD.

Nature. 2017 Jun 21;546(7659):E4-E5. doi: 10.1038/nature22085. No abstract available.

4.

Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.

Zanos P, Moaddel R, Morris PJ, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD.

Biol Psychiatry. 2017 Apr 15;81(8):e69-e71. doi: 10.1016/j.biopsych.2016.08.039. Epub 2016 Sep 30. No abstract available.

5.

Spatial learning impairment in prepubertal guinea pigs prenatally exposed to the organophosphorus pesticide chlorpyrifos: Toxicological implications.

Mamczarz J, Pescrille JD, Gavrushenko L, Burke RD, Fawcett WP, DeTolla LJ Jr, Chen H, Pereira EFR, Albuquerque EX.

Neurotoxicology. 2016 Sep;56:17-28. doi: 10.1016/j.neuro.2016.06.008. Epub 2016 Jun 11.

6.

NMDAR inhibition-independent antidepressant actions of ketamine metabolites.

Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD.

Nature. 2016 May 26;533(7604):481-6. doi: 10.1038/nature17998. Epub 2016 May 4.

7.

Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brain.

Mullins RJ, Xu S, Pereira EF, Pescrille JD, Todd SW, Mamczarz J, Albuquerque EX, Gullapalli RP.

Neurotoxicology. 2015 May;48:9-20. doi: 10.1016/j.neuro.2015.02.002. Epub 2015 Feb 19.

8.

Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus.

Alkondon M, Pereira EF, Todd SW, Randall WR, Lane MV, Albuquerque EX.

Biochem Pharmacol. 2015 Feb 15;93(4):506-18. doi: 10.1016/j.bcp.2014.12.009. Epub 2014 Dec 24.

PMID:
25542997
9.

Galantamine prevents long-lasting suppression of excitatory synaptic transmission in CA1 pyramidal neurons of soman-challenged guinea pigs.

Alexandrova EA, Alkondon M, Aracava Y, Pereira EF, Albuquerque EX.

Neurotoxicology. 2014 Sep;44:270-8. doi: 10.1016/j.neuro.2014.07.005. Epub 2014 Jul 23.

10.

Animal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compounds.

Pereira EF, Aracava Y, DeTolla LJ Jr, Beecham EJ, Basinger GW Jr, Wakayama EJ, Albuquerque EX.

J Pharmacol Exp Ther. 2014 Aug;350(2):313-21. doi: 10.1124/jpet.114.214932. Epub 2014 Jun 6.

11.

Contribution of CA3 and CA1 pyramidal neurons to the tonic α7 nAChR-dependent glutamatergic input to CA1 pyramidal neurons.

Banerjee J, Alkondon M, Albuquerque EX, Pereira EF.

Neurosci Lett. 2013 Oct 25;554:167-71. doi: 10.1016/j.neulet.2013.08.025. Epub 2013 Aug 21.

12.

Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices.

Alkondon M, Albuquerque EX, Pereira EF.

Neurotoxicology. 2013 May;36:72-81. doi: 10.1016/j.neuro.2013.02.005. Epub 2013 Mar 16.

13.

Delayed hippocampal effects from a single exposure of prepubertal guinea pigs to sub-lethal dose of chlorpyrifos: a magnetic resonance imaging and spectroscopy study.

Mullins RJ, Xu S, Pereira EF, Mamczarz J, Albuquerque EX, Gullapalli RP.

Neurotoxicology. 2013 May;36:42-8. doi: 10.1016/j.neuro.2013.02.002. Epub 2013 Feb 11.

14.

Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges.

Albuquerque EX, Schwarcz R.

Biochem Pharmacol. 2013 Apr 15;85(8):1027-32. doi: 10.1016/j.bcp.2012.12.014. Epub 2012 Dec 25. Review.

15.

Kynurenic acid inhibits glutamatergic transmission to CA1 pyramidal neurons via α7 nAChR-dependent and -independent mechanisms.

Banerjee J, Alkondon M, Albuquerque EX.

Biochem Pharmacol. 2012 Oct 15;84(8):1078-87. doi: 10.1016/j.bcp.2012.07.030. Epub 2012 Aug 2.

PMID:
22889930
16.

Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid.

Banerjee J, Alkondon M, Pereira EF, Albuquerque EX.

J Pharmacol Exp Ther. 2012 May;341(2):500-9. doi: 10.1124/jpet.111.189860. Epub 2012 Feb 17.

17.

Galantamine counteracts development of learning impairment in guinea pigs exposed to the organophosphorus poison soman: clinical significance.

Mamczarz J, Kulkarni GS, Pereira EF, Albuquerque EX.

Neurotoxicology. 2011 Dec;32(6):785-98. doi: 10.1016/j.neuro.2011.07.001. Epub 2011 Jul 19.

18.

Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: effects of kynurenic acid.

Alkondon M, Pereira EF, Albuquerque EX.

Biochem Pharmacol. 2011 Oct 15;82(8):842-51. doi: 10.1016/j.bcp.2011.06.004. Epub 2011 Jun 13.

19.

Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.

Alkondon M, Pereira EF, Eisenberg HM, Kajii Y, Schwarcz R, Albuquerque EX.

J Pharmacol Exp Ther. 2011 Jun;337(3):572-82. doi: 10.1124/jpet.110.177386. Epub 2011 Jan 26.

20.

Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain.

Ludwig J, Höffle-Maas A, Samochocki M, Luttmann E, Albuquerque EX, Fels G, Maelicke A.

J Recept Signal Transduct Res. 2010 Dec;30(6):469-83. doi: 10.3109/10799893.2010.505239. Epub 2010 Nov 9.

PMID:
21062106
21.

Pretreatment of Guinea pigs with galantamine prevents immediate and delayed effects of soman on inhibitory synaptic transmission in the hippocampus.

Alexandrova EA, Aracava Y, Pereira EF, Albuquerque EX.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):1051-8. doi: 10.1124/jpet.110.167700. Epub 2010 Jun 16.

22.

Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior.

Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu HQ, Schwarcz R.

Neuropsychopharmacology. 2010 Jul;35(8):1734-42. doi: 10.1038/npp.2010.39. Epub 2010 Mar 24.

23.

An acute exposure to a sub-lethal dose of soman triggers anxiety-related behavior in guinea pigs: interactions with acute restraint.

Mamczarz J, Pereira EF, Aracava Y, Adler M, Albuquerque EX.

Neurotoxicology. 2010 Jan;31(1):77-84. doi: 10.1016/j.neuro.2009.10.012. Epub 2009 Oct 31.

24.

Magnetic resonance imaging reveals that galantamine prevents structural brain damage induced by an acute exposure of guinea pigs to soman.

Gullapalli RP, Aracava Y, Zhuo J, Helal Neto E, Wang J, Makris G, Merchenthaler I, Pereira EF, Albuquerque EX.

Neurotoxicology. 2010 Jan;31(1):67-76. doi: 10.1016/j.neuro.2009.09.004. Epub 2009 Sep 24.

PMID:
19782102
25.

Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.

Aracava Y, Pereira EF, Akkerman M, Adler M, Albuquerque EX.

J Pharmacol Exp Ther. 2009 Dec;331(3):1014-24. doi: 10.1124/jpet.109.160028. Epub 2009 Sep 9.

26.

Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning.

Pereira EF, Aracava Y, Alkondon M, Akkerman M, Merchenthaler I, Albuquerque EX.

J Mol Neurosci. 2010 Jan;40(1-2):196-203. doi: 10.1007/s12031-009-9234-3. Epub 2009 Aug 19.

PMID:
19690988
27.

The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex.

Wu HQ, Pereira EF, Bruno JP, Pellicciari R, Albuquerque EX, Schwarcz R.

J Mol Neurosci. 2010 Jan;40(1-2):204-10. doi: 10.1007/s12031-009-9235-2. Epub 2009 Aug 19.

28.

Mammalian nicotinic acetylcholine receptors: from structure to function.

Albuquerque EX, Pereira EF, Alkondon M, Rogers SW.

Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008. Review.

29.

Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition.

Fawcett WP, Aracava Y, Adler M, Pereira EF, Albuquerque EX.

J Pharmacol Exp Ther. 2009 Feb;328(2):516-24. doi: 10.1124/jpet.108.146639. Epub 2008 Nov 4.

30.

A single in vivo application of cholinesterase inhibitors has neuron type-specific effects on nicotinic receptor activity in guinea pig hippocampus.

Alkondon M, Aracava Y, Pereira EF, Albuquerque EX.

J Pharmacol Exp Ther. 2009 Jan;328(1):69-82. doi: 10.1124/jpet.108.146068. Epub 2008 Oct 8.

31.

Age-dependent changes in the functional expression of two nicotinic receptor subtypes in CA1 stratum radiatum interneurons in the rat hippocampus.

Alkondon M, Pereira EF, Albuquerque EX.

Biochem Pharmacol. 2007 Oct 15;74(8):1134-44. Epub 2007 Jun 21.

PMID:
17645875
32.

Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptors.

Lopes C, Pereira EF, Wu HQ, Purushottamachar P, Njar V, Schwarcz R, Albuquerque EX.

J Pharmacol Exp Ther. 2007 Jul;322(1):48-58. Epub 2007 Apr 19.

34.

Strain-specific nicotinic modulation of glutamatergic transmission in the CA1 field of the rat hippocampus: August Copenhagen Irish versus Sprague-Dawley.

Alkondon M, Pereira EF, Potter MC, Kauffman FC, Schwarcz R, Albuquerque EX.

J Neurophysiol. 2007 Feb;97(2):1163-70. Epub 2006 Dec 6.

35.

Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry.

Guidetti P, Hoffman GE, Melendez-Ferro M, Albuquerque EX, Schwarcz R.

Glia. 2007 Jan 1;55(1):78-92.

PMID:
17024659
36.

Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.

Albuquerque EX, Pereira EF, Aracava Y, Fawcett WP, Oliveira M, Randall WR, Hamilton TA, Kan RK, Romano JA Jr, Adler M.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13220-5. Epub 2006 Aug 16.

37.

The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarization.

Santos HR, Ribeiro HS, Setti-Perdigão P, Albuquerque EX, Castro NG.

J Pharmacol Exp Ther. 2006 Oct;319(1):376-85. Epub 2006 Jul 12.

38.

Subtype-specific inhibition of nicotinic acetylcholine receptors by choline: a regulatory pathway.

Alkondon M, Albuquerque EX.

J Pharmacol Exp Ther. 2006 Jul;318(1):268-75. Epub 2006 Mar 24.

40.

Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons.

Aracava Y, Pereira EF, Maelicke A, Albuquerque EX.

J Pharmacol Exp Ther. 2005 Mar;312(3):1195-205. Epub 2004 Nov 2.

41.

Prolonged nicotine administration results in biphasic, brain-specific changes in kynurenate levels in the rat.

Rassoulpour A, Wu HQ, Albuquerque EX, Schwarcz R.

Neuropsychopharmacology. 2005 Apr;30(4):697-704.

42.

Pb2+ via protein kinase C inhibits nicotinic cholinergic modulation of synaptic transmission in the hippocampus.

Braga MF, Pereira EF, Mike A, Albuquerque EX.

J Pharmacol Exp Ther. 2004 Nov;311(2):700-10. Epub 2004 Jun 28.

43.

Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus.

Alkondon M, Pereira EF, Yu P, Arruda EZ, Almeida LE, Guidetti P, Fawcett WP, Sapko MT, Randall WR, Schwarcz R, Tagle DA, Albuquerque EX.

J Neurosci. 2004 May 12;24(19):4635-48.

44.

Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation.

Almeida LE, Pereira EF, Camara AL, Maelicke A, Albuquerque EX.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1879-87.

PMID:
15050620
45.

Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon.

Santos HR, Cintra WM, Aracava Y, Maciel CM, Castro NG, Albuquerque EX.

Neurotoxicology. 2004 Mar;25(3):481-94.

PMID:
15019311
46.

The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex.

Alkondon M, Albuquerque EX.

Prog Brain Res. 2004;145:109-20. Review.

PMID:
14650910
47.

Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands.

Menegatti R, Cunha AC, Ferreira VF, Perreira EF, El-Nabawi A, Eldefrawi AT, Albuquerque EX, Neves G, Rates SM, Fraga CA, Barreiro EJ.

Bioorg Med Chem. 2003 Nov 3;11(22):4807-13.

PMID:
14556797
48.

NMDA and AMPA receptors contribute to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus.

Alkondon M, Pereira EF, Albuquerque EX.

J Neurophysiol. 2003 Sep;90(3):1613-25. Epub 2003 Apr 17.

49.

Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.

Samochocki M, Höffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, Radina M, Zerlin M, Ullmer C, Pereira EF, Lübbert H, Albuquerque EX, Maelicke A.

J Pharmacol Exp Ther. 2003 Jun;305(3):1024-36. Epub 2003 Mar 20.

50.

Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors.

Santos MD, Pereira EF, Aracava Y, Castro NG, Fawcett WP, Randall WR, Albuquerque EX.

J Pharmacol Exp Ther. 2003 Jan;304(1):254-65.

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