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Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres.

Pettee KM, Becker KN, Alberts AS, Reinard KA, Schroeder JL, Eisenmann KM.

Cancers (Basel). 2019 Mar 20;11(3). pii: E392. doi: 10.3390/cancers11030392.


Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish.

LeCorgne H, Tudosie AM, Lavik K, Su R, Becker KN, Moore S, Walia Y, Wisner A, Koehler D, Alberts AS, Williams FE, Eisenmann KM.

Front Pharmacol. 2018 Apr 10;9:340. doi: 10.3389/fphar.2018.00340. eCollection 2018.


The Formin, DIAPH1, is a Key Modulator of Myocardial Ischemia/Reperfusion Injury.

O'Shea KM, Ananthakrishnan R, Li Q, Quadri N, Thiagarajan D, Sreejit G, Wang L, Zirpoli H, Aranda JF, Alberts AS, Schmidt AM, Ramasamy R.

EBioMedicine. 2017 Dec;26:165-174. doi: 10.1016/j.ebiom.2017.11.012. Epub 2017 Nov 21.


Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.

Thiam HR, Vargas P, Carpi N, Crespo CL, Raab M, Terriac E, King MC, Jacobelli J, Alberts AS, Stradal T, Lennon-Dumenil AM, Piel M.

Nat Commun. 2016 Mar 15;7:10997. doi: 10.1038/ncomms10997.


Corrigendum: Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells.

Vargas P, Maiuri P, Bretou M, Sáez PJ, Pierobon P, Maurin M, Chabaud M, Lankar D, Obino D, Terriac E, Raab M, Thiam HR, Brocker T, Kitchen-Goosen SM, Alberts AS, Sunareni P, Xia S, Li R, Voituriez R, Piel M, Lennon-Duménil AM.

Nat Cell Biol. 2016 Feb;18(2):234. doi: 10.1038/ncb3301. No abstract available.


Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells.

Vargas P, Maiuri P, Bretou M, Sáez PJ, Pierobon P, Maurin M, Chabaud M, Lankar D, Obino D, Terriac E, Raab M, Thiam HR, Brocker T, Kitchen-Goosen SM, Alberts AS, Sunareni P, Xia S, Li R, Voituriez R, Piel M, Lennon-Duménil AM.

Nat Cell Biol. 2016 Jan;18(1):43-53. doi: 10.1038/ncb3284. Epub 2015 Dec 7. Erratum in: Nat Cell Biol. 2016 Feb;18(2):234.


Small-molecule agonists of mammalian Diaphanous-related (mDia) formins reveal an effective glioblastoma anti-invasion strategy.

Arden JD, Lavik KI, Rubinic KA, Chiaia N, Khuder SA, Howard MJ, Nestor-Kalinoski AL, Alberts AS, Eisenmann KM.

Mol Biol Cell. 2015 Nov 1;26(21):3704-18. doi: 10.1091/mbc.E14-11-1502. Epub 2015 Sep 9.


The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons.

Pan J, Lordier L, Meyran D, Rameau P, Lecluse Y, Kitchen-Goosen S, Badirou I, Mokrani H, Narumiya S, Alberts AS, Vainchenker W, Chang Y.

Blood. 2014 Dec 18;124(26):3967-77. doi: 10.1182/blood-2013-12-544924. Epub 2014 Oct 8.


Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.

Ercan-Sencicek AG, Jambi S, Franjic D, Nishimura S, Li M, El-Fishawy P, Morgan TM, Sanders SJ, Bilguvar K, Suri M, Johnson MH, Gupta AR, Yuksel Z, Mane S, Grigorenko E, Picciotto M, Alberts AS, Gunel M, Šestan N, State MW.

Eur J Hum Genet. 2015 Feb;23(2):165-72. doi: 10.1038/ejhg.2014.82. Epub 2014 Apr 30.


A novel role for p115RhoGEF in regulation of epithelial plasticity.

Kher SS, Struckhoff AP, Alberts AS, Worthylake RA.

PLoS One. 2014 Jan 23;9(1):e85409. doi: 10.1371/journal.pone.0085409. eCollection 2014.


Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization.

Dong B, Zhang SS, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts AS, Zhang J, Siminovitch KA.

PLoS One. 2013 Nov 18;8(11):e80500. doi: 10.1371/journal.pone.0080500. eCollection 2013.


Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells.

Lash LL, Wallar BJ, Turner JD, Vroegop SM, Kilkuskie RE, Kitchen-Goosen SM, Xu HE, Alberts AS.

Cancer Res. 2013 Nov 15;73(22):6793-803. doi: 10.1158/0008-5472.CAN-13-1593.


Formin mDia1 mediates vascular remodeling via integration of oxidative and signal transduction pathways.

Touré F, Fritz G, Li Q, Rai V, Daffu G, Zou YS, Rosario R, Ramasamy R, Alberts AS, Yan SF, Schmidt AM.

Circ Res. 2012 May 11;110(10):1279-93. doi: 10.1161/CIRCRESAHA.111.262519. Epub 2012 Apr 17.


Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response.

He Y, Xu Y, Zhang C, Gao X, Dykema KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, Xu HE.

Sci Signal. 2011 Jul 5;4(180):ra44. doi: 10.1126/scisignal.2001450.


G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.

Thomas SG, Calaminus SD, Machesky LM, Alberts AS, Watson SP.

J Thromb Haemost. 2011 Aug;9(8):1648-51. doi: 10.1111/j.1538-7836.2011.04357.x. No abstract available.


Formins: dangling plot threads in a multi-act performance.

Alberts AS.

Biochim Biophys Acta. 2010 Feb;1803(2):151. doi: 10.1016/j.bbamcr.2010.02.002. No abstract available.


The role of formins in human disease.

DeWard AD, Eisenmann KM, Matheson SF, Alberts AS.

Biochim Biophys Acta. 2010 Feb;1803(2):226-33. doi: 10.1016/j.bbamcr.2009.11.006. Epub 2009 Nov 24. Review.


Phase II study of pegylated liposomal doxorubicin and carboplatin in patients with platinum-sensitive and partially platinum-sensitive metastatic ovarian cancer.

Rapoport BL, Vorobiof DA, Slabber C, Alberts AS, Hlophe HS, Mohammed C.

Int J Gynecol Cancer. 2009 Aug;19(6):1137-41. doi: 10.1111/IGC.0b013e3181a8b938.


Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice.

DeWard AD, Leali K, West RA, Prendergast GC, Alberts AS.

PLoS One. 2009 Sep 21;4(9):e7102. doi: 10.1371/journal.pone.0007102.


5q- myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics.

Eisenmann KM, Dykema KJ, Matheson SF, Kent NF, DeWard AD, West RA, Tibes R, Furge KA, Alberts AS.

Oncogene. 2009 Oct 1;28(39):3429-41. doi: 10.1038/onc.2009.207. Epub 2009 Jul 13. Review.


Phase 2 study of single-agent IV vinflunine as third-line treatment of metastatic breast cancer after failure of anthracycline-/taxane-based chemotherapy.

Fumoleau P, Cortés-Funes H, Taleb AB, Chan S, Campone M, Pouget JC, Tubiana-Hulin M, Slabber CF, Caroff-Paraïso I, Alberts AS, Ben Ayed F.

Am J Clin Oncol. 2009 Aug;32(4):375-80. doi: 10.1097/COC.0b013e31818f2d2f.


Ubiquitin-mediated degradation of the formin mDia2 upon completion of cell division.

DeWard AD, Alberts AS.

J Biol Chem. 2009 Jul 24;284(30):20061-9. doi: 10.1074/jbc.M109.000885. Epub 2009 May 19.


The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis.

Shi Y, Zhang J, Mullin M, Dong B, Alberts AS, Siminovitch KA.

J Immunol. 2009 Mar 15;182(6):3837-45. doi: 10.4049/jimmunol.0803838.


Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils.

Shi Y, Dong B, Miliotis H, Liu J, Alberts AS, Zhang J, Siminovitch KA.

Biochem Cell Biol. 2009 Feb;87(1):207-16. doi: 10.1139/O08-130.


Microtubule stabilization: formins assert their independence.

DeWard AD, Alberts AS.

Curr Biol. 2008 Jul 22;18(14):R605-8. doi: 10.1016/j.cub.2008.06.001.


Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice.

Wang P, Bowl MR, Bender S, Peng J, Farber L, Chen J, Ali A, Zhang Z, Alberts AS, Thakker RV, Shilatifard A, Williams BO, Teh BT.

Mol Cell Biol. 2008 May;28(9):2930-40. doi: 10.1128/MCB.00654-07. Epub 2008 Jan 22.


Filopodia are required for cortical neurite initiation.

Dent EW, Kwiatkowski AV, Mebane LM, Philippar U, Barzik M, Rubinson DA, Gupton S, Van Veen JE, Furman C, Zhang J, Alberts AS, Mori S, Gertler FB.

Nat Cell Biol. 2007 Dec;9(12):1347-59. Epub 2007 Nov 18.


mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration.

Gupton SL, Eisenmann K, Alberts AS, Waterman-Storer CM.

J Cell Sci. 2007 Oct 1;120(Pt 19):3475-87. Epub 2007 Sep 12.


mDia function is critical for the cell suicide program triggered by farnesyl transferase inhibition.

Kamasani U, Duhadaway JB, Alberts AS, Prendergast GC.

Cancer Biol Ther. 2007 Sep;6(9):1422-7. Epub 2007 Jun 5.


Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1.

Peng J, Kitchen SM, West RA, Sigler R, Eisenmann KM, Alberts AS.

Cancer Res. 2007 Aug 15;67(16):7565-71.


T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice.

Eisenmann KM, West RA, Hildebrand D, Kitchen SM, Peng J, Sigler R, Zhang J, Siminovitch KA, Alberts AS.

J Biol Chem. 2007 Aug 24;282(34):25152-8. Epub 2007 Jun 26.


Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.

Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS.

Curr Biol. 2007 Apr 3;17(7):579-91.


RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking.

Wallar BJ, Deward AD, Resau JH, Alberts AS.

Exp Cell Res. 2007 Feb 1;313(3):560-71. Epub 2006 Nov 11.


The basic region of the diaphanous-autoregulatory domain (DAD) is required for autoregulatory interactions with the diaphanous-related formin inhibitory domain.

Wallar BJ, Stropich BN, Schoenherr JA, Holman HA, Kitchen SM, Alberts AS.

J Biol Chem. 2006 Feb 17;281(7):4300-7. Epub 2005 Dec 18.


Rho GTPase-formin pairs in cytoskeletal remodelling.

Eisenmann KM, Peng J, Wallar BJ, Alberts AS.

Novartis Found Symp. 2005;269:206-218; discussion 219-30.


A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages.

Colucci-Guyon E, Niedergang F, Wallar BJ, Peng J, Alberts AS, Chavrier P.

Curr Biol. 2005 Nov 22;15(22):2007-12.


PAK1 negatively regulates the activity of the Rho exchange factor NET1.

Alberts AS, Qin H, Carr HS, Frost JA.

J Biol Chem. 2005 Apr 1;280(13):12152-61. Epub 2005 Jan 31.


EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration.

Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M, Wallar BJ, Alberts AS, Gundersen GG.

Nat Cell Biol. 2004 Sep;6(9):820-30. Epub 2004 Aug 15.


Direct percutaneous intratumoral bleomycin injection for palliative treatment of impending quadriplegia.

Duncan IC, Fourie PA, Alberts AS.

AJNR Am J Neuroradiol. 2004 Jun-Jul;25(6):1121-3.


The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas.

Chen J, Lui WO, Vos MD, Clark GJ, Takahashi M, Schoumans J, Khoo SK, Petillo D, Lavery T, Sugimura J, Astuti D, Zhang C, Kagawa S, Maher ER, Larsson C, Alberts AS, Kanayama HO, Teh BT.

Cancer Cell. 2003 Nov;4(5):405-13.


The formins: active scaffolds that remodel the cytoskeleton.

Wallar BJ, Alberts AS.

Trends Cell Biol. 2003 Aug;13(8):435-46. Review.


Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42.

Peng J, Wallar BJ, Flanders A, Swiatek PJ, Alberts AS.

Curr Biol. 2003 Apr 1;13(7):534-45.


Diaphanous-related Formin homology proteins.

Alberts AS.

Curr Biol. 2002 Dec 10;12(23):R796. No abstract available.


The Rho GTPase effector protein, mDia, inhibits the DNA binding ability of the transcription factor Pax6 and changes the pattern of neurite extension in cerebellar granule cells through its binding to Pax6.

Tominaga T, Meng W, Togashi K, Urano H, Alberts AS, Tominaga M.

J Biol Chem. 2002 Dec 6;277(49):47686-91. Epub 2002 Sep 24. Erratum in: J Biol Chem. 2003 May 9;278(19):17580.


Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization.

Palazzo AF, Joseph HL, Chen YJ, Dujardin DL, Alberts AS, Pfister KK, Vallee RB, Gundersen GG.

Curr Biol. 2001 Oct 2;11(19):1536-41.


mDia mediates Rho-regulated formation and orientation of stable microtubules.

Palazzo AF, Cook TA, Alberts AS, Gundersen GG.

Nat Cell Biol. 2001 Aug;3(8):723-9.


p21-activated kinase 1 plays a critical role in cellular activation by Nef.

Fackler OT, Lu X, Frost JA, Geyer M, Jiang B, Luo W, Abo A, Alberts AS, Peterlin BM.

Mol Cell Biol. 2000 Apr;20(7):2619-27.


Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.

Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS.

Mol Cell. 2000 Jan;5(1):13-25.


Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions.

Fackler OT, Luo W, Geyer M, Alberts AS, Peterlin BM.

Mol Cell. 1999 Jun;3(6):729-39.

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