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Items: 18


Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors.

Conforti F, Zhang X, Rao G, De Pas T, Yonemori Y, Rodriguez JA, McCutcheon JN, Rahhal R, Alberobello AT, Wang Y, Zhang YW, Guha U, Giaccone G.

Cancer Res. 2017 Oct 15;77(20):5614-5627. doi: 10.1158/0008-5472.CAN-17-1323. Epub 2017 Aug 17.


PI3K as a Potential Therapeutic Target in Thymic Epithelial Tumors.

Alberobello AT, Wang Y, Beerkens FJ, Conforti F, McCutcheon JN, Rao G, Raffeld M, Liu J, Rahhal R, Zhang YW, Giaccone G.

J Thorac Oncol. 2016 Aug;11(8):1345-1356. doi: 10.1016/j.jtho.2016.04.013. Epub 2016 Apr 24.


Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.

Ma X, Xu L, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E.

Cell Metab. 2015 Oct 6;22(4):695-708. doi: 10.1016/j.cmet.2015.08.005. Epub 2015 Sep 3.


Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling.

Conforti F, Wang Y, Rodriguez JA, Alberobello AT, Zhang YW, Giaccone G.

Clin Cancer Res. 2015 Oct 15;21(20):4508-13. doi: 10.1158/1078-0432.CCR-15-0408. Epub 2015 Aug 31. Review.


Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.

Adler-Wailes DC, Alberobello AT, Ma X, Hugendubler L, Stern EA, Mou Z, Han JC, Kim PW, Sumner AE, Yanovski JA, Mueller E.

Int J Obes (Lond). 2015 Jun;39(6):888-92. doi: 10.1038/ijo.2015.17. Epub 2015 Feb 12.


HSP-90 inhibitor ganetespib is synergistic with doxorubicin in small cell lung cancer.

Lai CH, Park KS, Lee DH, Alberobello AT, Raffeld M, Pierobon M, Pin E, Petricoin Iii EF, Wang Y, Giaccone G.

Oncogene. 2014 Oct 2;33(40):4867-76. doi: 10.1038/onc.2013.439. Epub 2013 Oct 28.


The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.

Lee JH, Park KS, Alberobello AT, Kallakury B, Weng MT, Wang Y, Giaccone G.

Clin Cancer Res. 2013 Dec 15;19(24):6777-86. doi: 10.1158/1078-0432.CCR-13-1110. Epub 2013 Oct 24.


The -258A/G (SNP rs12885300) polymorphism of the human type 2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSH.

Peltsverger MY, Butler PW, Alberobello AT, Smith S, Guevara Y, Dubaz OM, Luzon JA, Linderman J, Celi FS.

Eur J Endocrinol. 2012 May;166(5):839-45. doi: 10.1530/EJE-11-1073. Epub 2012 Feb 3.


PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.

Formisano P, Ragno P, Pesapane A, Alfano D, Alberobello AT, Rea VE, Giusto R, Rossi FW, Beguinot F, Rossi G, Montuori N.

J Cell Mol Med. 2012 Jul;16(7):1435-46. doi: 10.1111/j.1582-4934.2011.01411.x.


The Thr92Ala 5' type 2 deiodinase gene polymorphism is associated with a delayed triiodothyronine secretion in response to the thyrotropin-releasing hormone-stimulation test: a pharmacogenomic study.

Butler PW, Smith SM, Linderman JD, Brychta RJ, Alberobello AT, Dubaz OM, Luzon JA, Skarulis MC, Cochran CS, Wesley RA, Pucino F, Celi FS.

Thyroid. 2010 Dec;20(12):1407-12. doi: 10.1089/thy.2010.0244. Epub 2010 Nov 7.


Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults.

Celi FS, Brychta RJ, Linderman JD, Butler PW, Alberobello AT, Smith S, Courville AB, Lai EW, Costello R, Skarulis MC, Csako G, Remaley A, Pacak K, Chen KY.

Eur J Endocrinol. 2010 Dec;163(6):863-72. doi: 10.1530/EJE-10-0627. Epub 2010 Sep 8.


Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.

Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P.

J Biol Chem. 2010 Feb 26;285(9):6563-72. doi: 10.1074/jbc.M109.097410. Epub 2009 Dec 31.


Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.

Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6. doi: 10.1073/pnas.0904506106. Epub 2009 Jul 10.


The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase.

Esposito I, Proto MC, Gazzerro P, Laezza C, Miele C, Alberobello AT, D'Esposito V, Beguinot F, Formisano P, Bifulco M.

Mol Pharmacol. 2008 Dec;74(6):1678-86. doi: 10.1124/mol.108.049205. Epub 2008 Sep 18.


Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

Perfetti A, Oriente F, Iovino S, Alberobello AT, Barbagallo AP, Esposito I, Fiory F, Teperino R, Ungaro P, Miele C, Formisano P, Beguinot F.

J Biol Chem. 2007 Mar 23;282(12):8648-57. Epub 2007 Jan 16.


Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.

Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F.

Mol Cell Biol. 2005 Dec;25(24):10803-14.


Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting.

Fiory F, Oriente F, Miele C, Romano C, Trencia A, Alberobello AT, Esposito I, Valentino R, Beguinot F, Formisano P.

J Biol Chem. 2004 Mar 19;279(12):11137-45. Epub 2004 Jan 6.

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