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Items: 1 to 50 of 153

1.

Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase.

Blázquez G, Castañé A, Saavedra A, Masana M, Alberch J, Pérez-Navarro E.

Front Behav Neurosci. 2019 Jan 25;12:317. doi: 10.3389/fnbeh.2018.00317. eCollection 2018.

2.

Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease.

de Pins B, Cifuentes-Díaz C, Thamila Farah A, López-Molina L, Montalban E, Sancho-Balsells A, López A, Ginés S, Delgado-García JM, Alberch J, Gruart A, Girault JA, Giralt A.

J Neurosci. 2019 Jan 30. pii: 2121-18. doi: 10.1523/JNEUROSCI.2121-18.2019. [Epub ahead of print]

PMID:
30700530
3.

Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes.

Montalban E, Al-Massadi O, Sancho-Balsells A, Brito V, de Pins B, Alberch J, Ginés S, Girault JA, Giralt A.

Transl Psychiatry. 2019 Jan 15;9(1):3. doi: 10.1038/s41398-018-0352-y.

4.

A FBN1 3'UTR mutation variant is associated with endoplasmic reticulum stress in aortic aneurysm in Marfan syndrome.

Siegert AM, García Díaz-Barriga G, Esteve-Codina A, Navas-Madroñal M, Gorbenko Del Blanco D, Alberch J, Heath S, Galán M, Egea G.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):107-114. doi: 10.1016/j.bbadis.2018.10.029. Epub 2018 Oct 30.

PMID:
30385411
5.

Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease.

García-Forn M, Martínez-Torres S, García-Díaz Barriga G, Alberch J, Milà M, Azkona G, Pérez-Navarro E.

Neurobiol Dis. 2018 Dec;120:88-97. doi: 10.1016/j.nbd.2018.08.024. Epub 2018 Aug 31.

PMID:
30176350
6.

Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning.

Saavedra A, Ballesteros JJ, Tyebji S, Martínez-Torres S, Blázquez G, López-Hidalgo R, Azkona G, Alberch J, Martín ED, Pérez-Navarro E.

Mol Neurobiol. 2018 Jun 12. doi: 10.1007/s12035-018-1170-1. [Epub ahead of print]

PMID:
29948948
7.

Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression.

Cabezas-Llobet N, Camprubí S, García B, Alberch J, Xifró X.

Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1852-1861. doi: 10.1016/j.bbagen.2018.05.017. Epub 2018 May 30.

PMID:
29857082
8.

Early Downregulation of p75NTR by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington's Disease Mice.

Suelves N, Miguez A, López-Benito S, Barriga GG, Giralt A, Alvarez-Periel E, Arévalo JC, Alberch J, Ginés S, Brito V.

Mol Neurobiol. 2018 May 27. doi: 10.1007/s12035-018-1126-5. [Epub ahead of print]

PMID:
29804232
9.

Huntington's disease: novel therapeutic perspectives hanging in the balance.

Saavedra A, García-Díaz Barriga G, Pérez-Navarro E, Alberch J.

Expert Opin Ther Targets. 2018 May;22(5):385-399. doi: 10.1080/14728222.2018.1465930. Epub 2018 Apr 26. Review.

PMID:
29671352
10.

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease.

Cabezas-Llobet N, Vidal-Sancho L, Masana M, Fournier A, Alberch J, Vaudry D, Xifró X.

Mol Neurobiol. 2018 Nov;55(11):8263-8277. doi: 10.1007/s12035-018-0972-5. Epub 2018 Mar 10.

PMID:
29526016
11.

Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration.

Creus-Muncunill J, Rué L, Alcalá-Vida R, Badillos-Rodríguez R, Romaní-Aumedes J, Marco S, Alberch J, Perez-Otaño I, Malagelada C, Pérez-Navarro E.

Mol Neurobiol. 2018 Oct;55(10):7728-7742. doi: 10.1007/s12035-018-0956-5. Epub 2018 Feb 19.

PMID:
29460266
12.

Cdk5 Contributes to Huntington's Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates.

Alvarez-Periel E, Puigdellívol M, Brito V, Plattner F, Bibb JA, Alberch J, Ginés S.

Mol Neurobiol. 2018 Aug;55(8):6250-6268. doi: 10.1007/s12035-017-0828-4. Epub 2017 Dec 29.

PMID:
29288339
13.

Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF.

Cases S, Saavedra A, Tyebji S, Giralt A, Alberch J, Pérez-Navarro E.

Mol Cell Neurosci. 2018 Jan;86:41-49. doi: 10.1016/j.mcn.2017.11.003. Epub 2017 Nov 6.

PMID:
29122705
14.

The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice.

Giralt A, Gómez-Climent MÁ, Alcalá R, Bretin S, Bertrand D, María Delgado-García J, Pérez-Navarro E, Alberch J, Gruart A.

Neuropharmacology. 2017 Sep 1;123:395-409. doi: 10.1016/j.neuropharm.2017.06.009. Epub 2017 Jun 8.

15.

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA.

Nat Commun. 2017 May 30;8:15592. doi: 10.1038/ncomms15592.

16.

7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway.

García-Díaz Barriga G, Giralt A, Anglada-Huguet M, Gaja-Capdevila N, Orlandi JG, Soriano J, Canals JM, Alberch J.

Hum Mol Genet. 2017 Aug 15;26(16):3144-3160. doi: 10.1093/hmg/ddx198.

PMID:
28541476
17.

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.

Martín-Ibáñez R, Pardo M, Giralt A, Miguez A, Guardia I, Marion-Poll L, Herranz C, Esgleas M, Garcia-Díaz Barriga G, Edel MJ, Vicario-Abejón C, Alberch J, Girault JA, Chan S, Kastner P, Canals JM.

Development. 2017 Apr 15;144(8):1566-1577. doi: 10.1242/dev.138248. Epub 2017 Mar 13.

18.

Chelerythrine promotes Ca2+-dependent calpain activation in neuronal cells in a PKC-independent manner.

Saavedra A, Fernández-García S, Cases S, Puigdellívol M, Alcalá-Vida R, Martín-Flores N, Alberch J, Ginés S, Malagelada C, Pérez-Navarro E.

Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):922-935. doi: 10.1016/j.bbagen.2017.01.021. Epub 2017 Jan 24.

PMID:
28130160
19.

Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease.

Canal M, Martín-Flores N, Pérez-Sisqués L, Romaní-Aumedes J, Altas B, Man HY, Kawabe H, Alberch J, Malagelada C.

Oncotarget. 2016 Sep 13;7(37):58813-58831. doi: 10.18632/oncotarget.11020.

20.

Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.

Anglada-Huguet M, Giralt A, Rué L, Alberch J, Xifró X.

Biochim Biophys Acta. 2016 Jul;1862(7):1255-66. doi: 10.1016/j.bbadis.2016.04.002. Epub 2016 Apr 6.

21.

Metabolic profiling for the identification of Huntington biomarkers by on-line solid-phase extraction capillary electrophoresis mass spectrometry combined with advanced data analysis tools.

Pont L, Benavente F, Jaumot J, Tauler R, Alberch J, Ginés S, Barbosa J, Sanz-Nebot V.

Electrophoresis. 2016 Mar;37(5-6):795-808. doi: 10.1002/elps.201500378. Epub 2016 Feb 8.

PMID:
26685060
22.

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients.

Fernández-Santiago R, Carballo-Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez-Danés A, Vilarrasa-Blasi R, Sánchez-Pla A, Mosquera JL, Soriano J, López-Barneo J, Canals JM, Alberch J, Raya Á, Vila M, Consiglio A, Martín-Subero JI, Ezquerra M, Tolosa E.

EMBO Mol Med. 2015 Dec;7(12):1529-46. doi: 10.15252/emmm.201505439.

23.

A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.

Puigdellívol M, Cherubini M, Brito V, Giralt A, Suelves N, Ballesteros J, Zamora-Moratalla A, Martín ED, Eipper BA, Alberch J, Ginés S.

Hum Mol Genet. 2015 Dec 20;24(25):7265-85. doi: 10.1093/hmg/ddv426. Epub 2015 Oct 12.

24.

Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons.

Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, Kemp PJ, Arjomand J, Schoenfeld RC, Alberch J, Allen ND, Rosser AE, Canals JM.

Mol Ther Methods Clin Dev. 2015 Sep 16;2:15030. doi: 10.1038/mtm.2015.30. eCollection 2015.

25.

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity.

Anglada-Huguet M, Vidal-Sancho L, Giralt A, García-Díaz Barriga G, Xifró X, Alberch J.

Neurobiol Dis. 2016 Nov;95:22-34. doi: 10.1016/j.nbd.2015.09.001. Epub 2015 Sep 11.

PMID:
26369879
26.

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.

Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E.

Pain. 2016 Feb;157(2):377-86. doi: 10.1097/j.pain.0000000000000329.

27.

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.

Saavedra A, Puigdellívol M, Tyebji S, Kurup P, Xu J, Ginés S, Alberch J, Lombroso PJ, Pérez-Navarro E.

Mol Neurobiol. 2016 Aug;53(6):4261-4273. doi: 10.1007/s12035-015-9335-7. Epub 2015 Jul 30.

28.

Cryostat Slice Irregularities May Introduce Bias in Tissue Thickness Estimation: Relevance for Cell Counting Methods.

Puigdellívol-Sánchez A, Giralt A, Casanovas A, Alberch J, Prats-Galino A.

Microsc Microanal. 2015 Aug;21(4):893-901. doi: 10.1017/S143192761501380X. Epub 2015 Jul 15.

29.

Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease.

Cherubini M, Puigdellívol M, Alberch J, Ginés S.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2145-60. doi: 10.1016/j.bbadis.2015.06.025. Epub 2015 Jul 2.

30.

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

Fernández-Nogales M, Hernández F, Miguez A, Alberch J, Ginés S, Pérez-Navarro E, Lucas JJ.

Hum Mol Genet. 2015 Sep 1;24(17):5040-52. doi: 10.1093/hmg/ddv224. Epub 2015 Jun 16.

31.

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.

Miguez A, García-Díaz Barriga G, Brito V, Straccia M, Giralt A, Ginés S, Canals JM, Alberch J.

Hum Mol Genet. 2015 Sep 1;24(17):4958-70. doi: 10.1093/hmg/ddv218. Epub 2015 Jun 10.

PMID:
26063761
32.

RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.

Martín-Flores N, Romaní-Aumedes J, Rué L, Canal M, Sanders P, Straccia M, Allen ND, Alberch J, Canals JM, Pérez-Navarro E, Malagelada C.

Mol Neurobiol. 2016 Jul;53(5):2857-2868. doi: 10.1007/s12035-015-9166-6. Epub 2015 Apr 16.

PMID:
25876513
33.

Novel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in mice.

Xifró X, Vidal-Sancho L, Boadas-Vaello P, Turrado C, Alberch J, Puig T, Verdú E.

PLoS One. 2015 Apr 9;10(4):e0123122. doi: 10.1371/journal.pone.0123122. eCollection 2015.

34.

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Tyebji S, Saavedra A, Canas PM, Pliassova A, Delgado-García JM, Alberch J, Cunha RA, Gruart A, Pérez-Navarro E.

Neurobiol Dis. 2015 Feb;74:41-57. doi: 10.1016/j.nbd.2014.11.004. Epub 2014 Nov 11.

PMID:
25449908
35.

Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.

Brito V, Giralt A, Enriquez-Barreto L, Puigdellívol M, Suelves N, Zamora-Moratalla A, Ballesteros JJ, Martín ED, Dominguez-Iturza N, Morales M, Alberch J, Ginés S.

J Clin Invest. 2014 Oct;124(10):4411-28. doi: 10.1172/JCI74809. Epub 2014 Sep 2.

36.

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.

Romaní-Aumedes J, Canal M, Martín-Flores N, Sun X, Pérez-Fernández V, Wewering S, Fernández-Santiago R, Ezquerra M, Pont-Sunyer C, Lafuente A, Alberch J, Luebbert H, Tolosa E, Levy OA, Greene LA, Malagelada C.

Cell Death Dis. 2014 Aug 7;5:e1364. doi: 10.1038/cddis.2014.333.

37.

Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.

Moreno B, Lopez I, Fernández-Díez B, Gottlieb M, Matute C, Sánchez-Gómez MV, Domercq M, Giralt A, Alberch J, Collon KW, Zhang H, Parent JM, Teixido M, Giralt E, Ceña V, Posadas I, Martínez-Pinilla E, Villoslada P, Franco R.

PLoS One. 2014 Mar 5;9(3):e90671. doi: 10.1371/journal.pone.0090671. eCollection 2014.

38.

Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease.

Anglada-Huguet M, Xifró X, Giralt A, Zamora-Moratalla A, Martín ED, Alberch J.

Mol Neurobiol. 2014 Apr;49(2):784-95. doi: 10.1007/s12035-013-8556-x. Epub 2013 Nov 7.

PMID:
24198227
39.

Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease.

Saavedra A, Giralt A, Arumí H, Alberch J, Pérez-Navarro E.

PLoS One. 2013 Sep 5;8(9):e73664. doi: 10.1371/journal.pone.0073664. eCollection 2013.

40.

Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease.

Rué L, Alcalá-Vida R, López-Soop G, Creus-Muncunill J, Alberch J, Pérez-Navarro E.

Neuromolecular Med. 2014 Mar;16(1):25-37. doi: 10.1007/s12017-013-8248-8. Epub 2013 Jul 30.

PMID:
23896721
41.

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.

Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I.

Nat Med. 2013 Aug;19(8):1030-8. doi: 10.1038/nm.3246. Epub 2013 Jul 14.

42.

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.

Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Déglon N, Beal MF, Brouillet E.

Hum Mol Genet. 2013 Oct 1;22(19):3869-82. doi: 10.1093/hmg/ddt242. Epub 2013 May 29.

43.

Neurobehavioral characterization of Endonuclease G knockout mice reveals a new putative molecular player in the regulation of anxiety.

Giralt A, Sanchis D, Cherubini M, Ginés S, Cañas X, Comella JX, Alberch J.

Exp Neurol. 2013 Sep;247:122-9. doi: 10.1016/j.expneurol.2013.03.028. Epub 2013 Apr 18.

PMID:
23603365
44.

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.

Brito V, Puigdellívol M, Giralt A, del Toro D, Alberch J, Ginés S.

Cell Death Dis. 2013 Apr 18;4:e595. doi: 10.1038/cddis.2013.116.

45.

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.

Giralt A, Saavedra A, Carretón O, Arumí H, Tyebji S, Alberch J, Pérez-Navarro E.

Hippocampus. 2013 Aug;23(8):684-95. doi: 10.1002/hipo.22128. Epub 2013 Apr 29.

PMID:
23576401
46.

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.

Barroso E, del Valle J, Porquet D, Vieira Santos AM, Salvadó L, Rodríguez-Rodríguez R, Gutiérrez P, Anglada-Huguet M, Alberch J, Camins A, Palomer X, Pallàs M, Michalik L, Wahli W, Vázquez-Carrera M.

Biochim Biophys Acta. 2013 Aug;1832(8):1241-8. doi: 10.1016/j.bbadis.2013.03.006. Epub 2013 Mar 16.

47.

Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease.

Rué L, López-Soop G, Gelpi E, Martínez-Vicente M, Alberch J, Pérez-Navarro E.

Neurobiol Dis. 2013 Apr;52:219-28. doi: 10.1016/j.nbd.2012.12.008. Epub 2013 Jan 4.

PMID:
23295856
48.

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression.

Canela L, Selga E, García-Martínez JM, Amaral OB, Fernández-Dueñas V, Alberch J, Canela EI, Franco R, Noé V, Lluís C, Ciudad CJ, Ciruela F.

Gene. 2012 Oct 25;508(2):199-205. doi: 10.1016/j.gene.2012.07.074. Epub 2012 Aug 7.

PMID:
22892378
49.

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

Carretón O, Giralt A, Torres-Peraza JF, Brito V, Lucas JJ, Ginés S, Canals JM, Alberch J.

Exp Neurol. 2012 Oct;237(2):335-45. doi: 10.1016/j.expneurol.2012.06.033. Epub 2012 Jul 6.

PMID:
22776425
50.

The dopaminergic stabilizer, (-)-OSU6162, rescues striatal neurons with normal and expanded polyglutamine chains in huntingtin protein from exposure to free radicals and mitochondrial toxins.

Ruiz C, Casarejos MJ, Rubio I, Gines S, Puigdellivol M, Alberch J, Mena MA, de Yebenes JG.

Brain Res. 2012 Jun 12;1459:100-12. doi: 10.1016/j.brainres.2012.04.021. Epub 2012 Apr 21.

PMID:
22560595

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