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Items: 35


Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth.

Chen R, Park HA, Mnatsakanyan N, Niu Y, Licznerski P, Wu J, Miranda P, Graham M, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJS, Alavian KN, Jonas EA.

Cell Death Dis. 2019 Jun 13;10(6):469. doi: 10.1038/s41419-019-1679-x.


The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β.

Weinert M, Millet A, Jonas EA, Alavian KN.

FASEB J. 2019 Aug;33(8):8925-8934. doi: 10.1096/fj.201802754R. Epub 2019 Apr 29.


Post mortem examination of Parkinson's disease brains suggests decline in mitochondrial biomass, reversed by deep brain stimulation of subthalamic nucleus.

Mallach A, Weinert M, Arthur J, Gveric D, Tierney TS, Alavian KN.

FASEB J. 2019 Jun;33(6):6957-6961. doi: 10.1096/fj.201802628R. Epub 2019 Mar 12.


Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules.

Niu Y, Moghimyfiroozabad S, Safaie S, Yang Y, Jonas EA, Alavian KN.

J Mol Evol. 2017 Dec;85(5-6):219-233. doi: 10.1007/s00239-017-9819-3. Epub 2017 Nov 24.


PrePhyloPro: phylogenetic profile-based prediction of whole proteome linkages.

Niu Y, Liu C, Moghimyfiroozabad S, Yang Y, Alavian KN.

PeerJ. 2017 Aug 28;5:e3712. doi: 10.7717/peerj.3712. eCollection 2017.


Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity.

Park HA, Licznerski P, Mnatsakanyan N, Niu Y, Sacchetti S, Wu J, Polster BM, Alavian KN, Jonas EA.

Cell Death Differ. 2017 Nov;24(11):1963-1974. doi: 10.1038/cdd.2017.123. Epub 2017 Aug 4.


Erratum to: The Mitochondrial Permeability Transition Pore and ATP Synthase.

Beutner G, Alavian KN, Jonas EA, Porter GA Jr.

Handb Exp Pharmacol. 2017;240:489. doi: 10.1007/164_2016_87. No abstract available.


The Mitochondrial Permeability Transition Pore and ATP Synthase.

Beutner G, Alavian KN, Jonas EA, Porter GA Jr.

Handb Exp Pharmacol. 2017;240:21-46. doi: 10.1007/164_2016_5. Erratum in: Handb Exp Pharmacol. 2017;240:489.


Physiological roles of the mitochondrial permeability transition pore.

Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA.

J Bioenerg Biomembr. 2017 Feb;49(1):13-25. doi: 10.1007/s10863-016-9652-1. Epub 2016 Feb 11. Review.


Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress.

Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS; Traumatic Stress Brain Study Group.

PLoS Biol. 2015 Oct 27;13(10):e1002282. doi: 10.1371/journal.pbio.1002282. eCollection 2015 Oct.


Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase.

Jonas EA, Porter GA Jr, Beutner G, Mnatsakanyan N, Alavian KN.

Pharmacol Res. 2015 Sep;99:382-92. doi: 10.1016/j.phrs.2015.04.013. Epub 2015 May 5. Review.


Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.

Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, Busbridge M, Alavian KN, Wilkins MR, Zhao L.

Circ Res. 2015 May 8;116(10):1680-90. doi: 10.1161/CIRCRESAHA.116.305265. Epub 2015 Mar 12.


Isolation, culture and long-term maintenance of primary mesencephalic dopaminergic neurons from embryonic rodent brains.

Weinert M, Selvakumar T, Tierney TS, Alavian KN.

J Vis Exp. 2015 Feb 19;(96). doi: 10.3791/52475.


The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole.

Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Li H, Signore AP, Smith PJ, Gribkoff VK, Jonas EA.

Mol Pharmacol. 2015 Jan;87(1):1-8. doi: 10.1124/mol.114.095661. Epub 2014 Oct 20.


Bcl-xL in neuroprotection and plasticity.

Jonas EA, Porter GA, Alavian KN.

Front Physiol. 2014 Sep 17;5:355. doi: 10.3389/fphys.2014.00355. eCollection 2014. Review.


An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore.

Alavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA Jr, Jonas EA.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10580-5. doi: 10.1073/pnas.1401591111. Epub 2014 Jun 16.


Bcl-xL is necessary for neurite outgrowth in hippocampal neurons.

Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA.

Antioxid Redox Signal. 2015 Jan 10;22(2):93-108. doi: 10.1089/ars.2013.5570.


The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed.

Alavian KN, Jeddi S, Naghipour SI, Nabili P, Licznerski P, Tierney TS.

J Biomed Sci. 2014 Apr 1;21:27. doi: 10.1186/1423-0127-21-27. Review.


A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

Li H, Alavian KN, Lazrove E, Mehta N, Jones A, Zhang P, Licznerski P, Graham M, Uo T, Guo J, Rahner C, Duman RS, Morrison RS, Jonas EA.

Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.


F1FO ATPase vesicle preparation and technique for performing patch clamp recordings of submitochondrial vesicle membranes.

Sacchetti S, Alavian KN, Lazrove E, Jonas EA.

J Vis Exp. 2013 May 4;(75):e4394. doi: 10.3791/4394.


NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells.

Gray JP, Alavian KN, Jonas EA, Heart EA.

Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E191-9. doi: 10.1152/ajpendo.00465.2011. Epub 2012 May 1.


N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death.

Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA.

Nat Neurosci. 2012 Feb 26;15(4):574-80. doi: 10.1038/nn.3054.


Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.

Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Mariggio MA, Onofrj M, Thomas A, Li H, Mangold JE, Signore AP, Demarco U, Demady DR, Nabili P, Lazrove E, Smith PJ, Gribkoff VK, Jonas EA.

Brain Res. 2012 Mar 29;1446:1-11. doi: 10.1016/j.brainres.2012.01.046. Epub 2012 Jan 28.


Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM.

J Cell Biol. 2011 Oct 17;195(2):263-76. doi: 10.1083/jcb.201108059. Epub 2011 Oct 10.


Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA.

Nat Cell Biol. 2011 Sep 18;13(10):1224-33. doi: 10.1038/ncb2330. Erratum in: Nat Cell Biol. 2011 Nov;13(11):1383.


Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation.

Sanchez CE, Tierney TS, Gale JT, Alavian KN, Sahin A, Lee JS, Mulligan RC, Carter BS.

J Neurosurg. 2011 Mar;114(3):672-80. doi: 10.3171/2010.8.JNS091583. Epub 2010 Oct 15.


Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons.

Vahedi S, Rajabian M, Misaghian A, Grbec D, Simon HH, Alavian KN.

J Biomed Sci. 2010 Aug 17;17:66. doi: 10.1186/1423-0127-17-66.


The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.

Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O.

Brain. 2010 Jul;133(Pt 7):2022-31. doi: 10.1093/brain/awq142. Epub 2010 Jun 23.


Transcriptional regulation of their survival: the Engrailed homeobox genes.

Simon HH, Alavian KN.

Adv Exp Med Biol. 2009;651:66-72. Review. No abstract available.


Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.

Alavian KN, Sgadò P, Alberi L, Subramaniam S, Simon HH.

Neural Dev. 2009 Mar 16;4:11. doi: 10.1186/1749-8104-4-11.


Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death.

Alavian KN, Scholz C, Simon HH.

Mov Disord. 2008 Feb 15;23(3):319-28. Review.


Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice.

Sgadò P, Albéri L, Gherbassi D, Galasso SL, Ramakers GM, Alavian KN, Smidt MP, Dyck RH, Simon HH.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15242-7. Epub 2006 Oct 2.


The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta.

Thuret S, Alavian KN, Gassmann M, Lloyd CK, Smits SM, Smidt MP, Klein R, Dyck RH, Simon HH.

J Neurochem. 2004 Dec;91(6):1302-11.

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