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Items: 1 to 50 of 155

1.

The TCR is an allosterically regulated macromolecular machinery changing its conformation while working.

Schamel WW, Alarcon B, Minguet S.

Immunol Rev. 2019 Sep;291(1):8-25. doi: 10.1111/imr.12788. Review.

PMID:
31402501
2.

RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.

Martínez-Riaño A, Bovolenta ER, Boccasavia VL, Ponomarenko J, Abia D, Oeste CL, Fresno M, van Santen HM, Alarcon B.

J Exp Med. 2019 Jul 19. pii: jem.20181959. doi: 10.1084/jem.20181959. [Epub ahead of print]

PMID:
31324740
3.

Live-cell assays reveal selectivity and sensitivity of the multidrug response in budding yeast.

Vanacloig-Pedros E, Lozano-Pérez C, Alarcón B, Pascual-Ahuir A, Proft M.

J Biol Chem. 2019 Aug 30;294(35):12933-12946. doi: 10.1074/jbc.RA119.009291. Epub 2019 Jul 11.

PMID:
31296662
4.

Etomidate improves seizure adequacy during electroconvulsive therapy.

Alcoverro-Fortuny Ò, Alarcón BG, Usan FV, Ruíz DS, Oscoz-Irurozqui M, Señé GM.

Psychiatry Res. 2019 Mar;273:350-354. doi: 10.1016/j.psychres.2019.01.065. Epub 2019 Jan 17.

PMID:
30682556
5.

Dynamic reorganisation of intermediate filaments coordinates early B-cell activation.

Tsui C, Maldonado P, Montaner B, Borroto A, Alarcon B, Bruckbauer A, Martinez-Martin N, Batista FD.

Life Sci Alliance. 2018 Aug 20;1(5):e201800060. doi: 10.26508/lsa.201800060. eCollection 2018 Oct.

6.

Antigen phagocytosis by B cells is required for a potent humoral response.

Martínez-Riaño A, Bovolenta ER, Mendoza P, Oeste CL, Martín-Bermejo MJ, Bovolenta P, Turner M, Martínez-Martín N, Alarcón B.

EMBO Rep. 2018 Sep;19(9). pii: e46016. doi: 10.15252/embr.201846016. Epub 2018 Jul 9.

7.

A window of opportunity for cooperativity in the T Cell Receptor.

Martin-Blanco N, Blanco R, Alda-Catalinas C, Bovolenta ER, Oeste CL, Palmer E, Schamel WW, Lythe G, Molina-París C, Castro M, Alarcon B.

Nat Commun. 2018 Jul 5;9(1):2618. doi: 10.1038/s41467-018-05050-6.

8.

R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.

Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B.

Sci Signal. 2018 May 29;11(532). pii: eaal1506. doi: 10.1126/scisignal.aal1506.

PMID:
29844052
9.

Differential expression of SofDIR16 and SofCAD genes in smut resistant and susceptible sugarcane cultivars in response to Sporisorium scitamineum.

Sánchez-Elordi E, Contreras R, de Armas R, Benito MC, Alarcón B, de Oliveira E, Del Mazo C, Díaz-Peña EM, Santiago R, Vicente C, Legaz ME.

J Plant Physiol. 2018 Jul;226:103-113. doi: 10.1016/j.jplph.2018.04.016. Epub 2018 May 4.

PMID:
29753910
10.

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.

Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L.

Nat Commun. 2018 Mar 14;9(1):1080. doi: 10.1038/s41467-018-03385-8.

11.

Author Correction: Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.

Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, Veiga E.

Nat Commun. 2018 Jan 31;9(1):495. doi: 10.1038/s41467-018-03074-6.

12.

Cell Biology of T Cell Receptor Expression and Regulation.

Alcover A, Alarcón B, Di Bartolo V.

Annu Rev Immunol. 2018 Apr 26;36:103-125. doi: 10.1146/annurev-immunol-042617-053429. Epub 2017 Dec 20. Review.

PMID:
29261409
13.

Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.

Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, Veiga E.

Nat Commun. 2017 Nov 17;8(1):1591. doi: 10.1038/s41467-017-01661-7. Erratum in: Nat Commun. 2018 Jan 31;9(1):495.

14.

Multilayered control of peroxisomal activity upon salt stress in Saccharomyces cerevisiae.

Manzanares-Estreder S, Espí-Bardisa J, Alarcón B, Pascual-Ahuir A, Proft M.

Mol Microbiol. 2017 Jun;104(5):851-868. doi: 10.1111/mmi.13669. Epub 2017 Apr 10.

15.

Studying the Dynamics of TCR Internalization at the Immune Synapse.

Calleja E, Alarcón B, Oeste CL.

Methods Mol Biol. 2017;1584:89-99. doi: 10.1007/978-1-4939-6881-7_7.

PMID:
28255698
16.

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.

Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J, Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C, Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P, Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B.

Sci Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.

PMID:
28003549
17.

The Allostery Model of TCR Regulation.

Schamel WW, Alarcon B, Höfer T, Minguet S.

J Immunol. 2017 Jan 1;198(1):47-52. Review.

18.

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation.

Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnár E, Schulze AK, Blanco R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S, Schamel WW.

Immunity. 2016 May 17;44(5):1091-101. doi: 10.1016/j.immuni.2016.04.011.

19.

Aurora A drives early signalling and vesicle dynamics during T-cell activation.

Blas-Rus N, Bustos-Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F.

Nat Commun. 2016 Apr 19;7:11389. doi: 10.1038/ncomms11389.

20.

CD3ε recruits Numb to promote TCR degradation.

Martin-Blanco N, Jiménez Teja D, Bretones G, Borroto A, Caraballo M, Screpanti I, León J, Alarcón B, Canelles M.

Int Immunol. 2016 Mar;28(3):127-37. doi: 10.1093/intimm/dxv060. Epub 2015 Oct 27.

PMID:
26507128
21.

Editorial: Nck has a knack for T cell differentiation.

Oeste CL, Alarcón B.

J Leukoc Biol. 2015 Sep;98(3):297-8. doi: 10.1189/jlb.2CE0415-181R. No abstract available.

22.

Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.

Fabbiano S, Menacho-Márquez M, Robles-Valero J, Pericacho M, Matesanz-Marín A, García-Macías C, Sevilla MA, Montero MJ, Alarcón B, López-Novoa JM, Martín P, Bustelo XR.

Mol Cell Biol. 2015 Oct;35(20):3528-46. doi: 10.1128/MCB.00518-15. Epub 2015 Aug 3.

23.

Preface to special issue on nanoscale membrane organisations.

Alarcón B, Reth M, Schamel W.

Biochim Biophys Acta. 2015 Apr;1853(4):765-6. doi: 10.1016/j.bbamcr.2015.02.003. Epub 2015 Feb 10. No abstract available.

24.

Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains.

Beck-García K, Beck-García E, Bohler S, Zorzin C, Sezgin E, Levental I, Alarcón B, Schamel WW.

Biochim Biophys Acta. 2015 Apr;1853(4):802-9. doi: 10.1016/j.bbamcr.2014.12.017. Epub 2014 Dec 20.

25.

Conformational changes in the T cell receptor differentially determine T cell subset development in mice.

Blanco R, Borroto A, Schamel W, Pereira P, Alarcon B.

Sci Signal. 2014 Dec 2;7(354):ra115. doi: 10.1126/scisignal.2005650.

PMID:
25468995
26.

Crammed signaling motifs in the T-cell receptor.

Borroto A, Abia D, Alarcón B.

Immunol Lett. 2014 Sep;161(1):113-7. doi: 10.1016/j.imlet.2014.05.007. Epub 2014 May 27. Review.

PMID:
24877875
27.

The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.

Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WWA.

Cell Rep. 2014 Jun 12;7(5):1704-1715. doi: 10.1016/j.celrep.2014.04.049. Epub 2014 May 22.

28.

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.

Larive RM, Moriggi G, Menacho-Márquez M, Cañamero M, de Álava E, Alarcón B, Dosil M, Bustelo XR.

Nat Commun. 2014 May 14;5:3881. doi: 10.1038/ncomms4881.

29.

Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms.

Castro M, van Santen HM, Férez M, Alarcón B, Lythe G, Molina-París C.

Front Immunol. 2014 Apr 30;5:132. doi: 10.3389/fimmu.2014.00132. eCollection 2014. Review.

30.

β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism.

Fernández-Arenas E, Calleja E, Martínez-Martín N, Gharbi SI, Navajas R, García-Medel N, Penela P, Alcamí A, Mayor F Jr, Albar JP, Alarcón B.

EMBO J. 2014 Mar 18;33(6):559-77. doi: 10.1002/embj.201386022. Epub 2014 Feb 6.

31.

Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.

Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B.

J Immunol. 2014 Mar 1;192(5):2042-53. doi: 10.4049/jimmunol.1203414. Epub 2014 Jan 27.

32.

Cognate peptide-MHC complexes are expressed as tightly apposed nanoclusters in virus-infected cells to allow TCR crosslinking.

Ferez M, Castro M, Alarcon B, van Santen HM.

J Immunol. 2014 Jan 1;192(1):52-8. doi: 10.4049/jimmunol.1301224. Epub 2013 Dec 4.

33.

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

Menacho-Márquez M, García-Escudero R, Ojeda V, Abad A, Delgado P, Costa C, Ruiz S, Alarcón B, Paramio JM, Bustelo XR.

PLoS Biol. 2013 Jul;11(7):e1001615. doi: 10.1371/journal.pbio.1001615. Epub 2013 Jul 23.

34.

Organization of the resting TCR in nanoscale oligomers.

Schamel WW, Alarcón B.

Immunol Rev. 2013 Jan;251(1):13-20. doi: 10.1111/imr.12019. Review.

PMID:
23278737
35.

Nck recruitment to the TCR required for ZAP70 activation during thymic development.

Borroto A, Arellano I, Dopfer EP, Prouza M, Suchànek M, Fuentes M, Orfao A, Schamel WW, Alarcón B.

J Immunol. 2013 Feb 1;190(3):1103-12. doi: 10.4049/jimmunol.1202055. Epub 2012 Dec 24.

36.

End-binding protein 1 controls signal propagation from the T cell receptor.

Martín-Cófreces NB, Baixauli F, López MJ, Gil D, Monjas A, Alarcón B, Sánchez-Madrid F.

EMBO J. 2012 Nov 5;31(21):4140-52. doi: 10.1038/emboj.2012.242. Epub 2012 Aug 24.

37.

RRas2, RhoG and T-cell phagocytosis.

Alarcón B, Martínez-Martín N.

Small GTPases. 2012 Apr-Jun;3(2):97-101. doi: 10.4161/sgtp.19138.

38.

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.

Blanco R, Alarcón B.

Front Immunol. 2012 May 9;3:115. doi: 10.3389/fimmu.2012.00115. eCollection 2012.

39.

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.

Larive RM, Abad A, Cardaba CM, Hernández T, Cañamero M, de Álava E, Santos E, Alarcón B, Bustelo XR.

Mol Biol Cell. 2012 Jun;23(12):2373-87. doi: 10.1091/mbc.E12-01-0060. Epub 2012 Apr 25.

40.

Changes in cinnamyl alcohol dehydrogenase activities from sugarcane cultivars inoculated with Sporisorium scitamineum sporidia.

Santiago R, Alarcón B, de Armas R, Vicente C, Legaz ME.

Physiol Plant. 2012 Jun;145(2):245-59. doi: 10.1111/j.1399-3054.2012.01577.x. Epub 2012 Feb 21.

PMID:
22248248
41.

Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.

Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcon B, van Santen HM.

Immunity. 2011 Sep 23;35(3):375-87. doi: 10.1016/j.immuni.2011.08.010. Epub 2011 Sep 8.

42.

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.

Martínez-Martín N, Fernández-Arenas E, Cemerski S, Delgado P, Turner M, Heuser J, Irvine DJ, Huang B, Bustelo XR, Shaw A, Alarcón B.

Immunity. 2011 Aug 26;35(2):208-22. doi: 10.1016/j.immuni.2011.06.003. Epub 2011 Aug 4.

43.

The immunological synapse: a cause or consequence of T-cell receptor triggering?

Alarcón B, Mestre D, Martínez-Martín N.

Immunology. 2011 Aug;133(4):420-5. doi: 10.1111/j.1365-2567.2011.03458.x. Epub 2011 Jun 2. Review.

44.

High mortality in patients with influenza A pH1N1 2009 admitted to a pediatric intensive care unit: a predictive model of mortality.

Torres SF, Iolster T, Schnitzler EJ, Farias JA, Bordogna AC, Rufach D, Montes MJ, Siaba AJ, Rodríguez MG, Jabornisky R, Colman C, Fernández A, Caprotta G, Diaz S, Poterala R, De Meyer M, Penazzi ME, González G, Saenz S, Recupero O, Zapico L, Alarcon B, Ariel E, Minces P, Mari E, Carnie A, Garea M, Jaen R.

Pediatr Crit Care Med. 2012 Mar;13(2):e78-83. doi: 10.1097/PCC.0b013e318219266b.

PMID:
21552180
45.

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity.

Iborra S, Soto M, Stark-Aroeira L, Castellano E, Alarcón B, Alonso C, Santos E, Fernández-Malavé E.

Blood. 2011 May 12;117(19):5102-11. doi: 10.1182/blood-2010-10-315770. Epub 2011 Mar 28.

46.

Tubulin and actin interplay at the T cell and antigen-presenting cell interface.

Martín-Cófreces NB, Alarcón B, Sánchez-Madrid F.

Front Immunol. 2011 Jul 4;2:24. doi: 10.3389/fimmu.2011.00024. eCollection 2011.

47.

Structural characterization of the TCR complex by electron microscopy.

Arechaga I, Swamy M, Abia D, Schamel WA, Alarcón B, Valpuesta JM.

Int Immunol. 2010 Nov;22(11):897-903. doi: 10.1093/intimm/dxq443. Epub 2010 Nov 8.

PMID:
21059766
48.

Cytotoxic T cells. Handing over the baton.

Alarcón B, Martínez-Martin N.

Immunol Cell Biol. 2010 Jul;88(5):505-6. doi: 10.1038/icb.2010.50. Epub 2010 Apr 13. No abstract available.

PMID:
20386558
49.

Two receptors, two kinases, and T cell lineage determination.

Alarcón B, van Santen HM.

Sci Signal. 2010 Mar 23;3(114):pe11. doi: 10.1126/scisignal.3114pe11. Review.

PMID:
20332426
50.

Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon.

Martínez-Martín N, Risueño RM, Morreale A, Zaldívar I, Fernández-Arenas E, Herranz F, Ortiz AR, Alarcón B.

Sci Signal. 2009 Aug 11;2(83):ra43. doi: 10.1126/scisignal.2000402.

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