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Items: 20


Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2.

Bilousova T, Elias C, Miyoshi E, Alam MP, Zhu C, Campagna J, Vadivel K, Jagodzinska B, Gylys KH, John V.

Biochem Biophys Res Commun. 2018 May 23;499(4):751-757. doi: 10.1016/j.bbrc.2018.03.209. Epub 2018 Apr 9.


Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair.

Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D.

Ann Rheum Dis. 2018 May;77(5):760-769. doi: 10.1136/annrheumdis-2017-212037. Epub 2018 Feb 7.


A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity.

Alam MP, Bilousova T, Spilman P, Vadivel K, Bai D, Elias CJ, Evseenko D, John V.

ACS Chem Neurosci. 2018 Mar 21;9(3):462-468. doi: 10.1021/acschemneuro.7b00350. Epub 2017 Dec 6.


Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery.

Subbiah N, Campagna J, Spilman P, Alam MP, Sharma S, Hokugo A, Nishimura I, John V.

J Drug Deliv. 2017;2017:4759839. doi: 10.1155/2017/4759839. Epub 2017 Apr 5.


Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability.

Chevalier A, Alam MP, Khdour OM, Schmierer M, Arce PM, Cripe CD, Hecht SM.

Bioorg Med Chem. 2016 Nov 1;24(21):5206-5220. doi: 10.1016/j.bmc.2016.08.039. Epub 2016 Aug 23.


Correction to "The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure".

Kendrick S, Kang HJ, Alam MP, Madathil MM, Agrawal P, Gokhale V, Yang D, Hecht SM, Hurley LH.

J Am Chem Soc. 2016 Sep 7;138(35):11408. doi: 10.1021/jacs.6b07292. Epub 2016 Aug 29. No abstract available.


Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA.

Roy B, Talukder P, Kang HJ, Tsuen SS, Alam MP, Hurley LH, Hecht SM.

J Am Chem Soc. 2016 Aug 31;138(34):10950-62. doi: 10.1021/jacs.6b05036. Epub 2016 Aug 17.


C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides.

Alam MP, Jagodzinska B, Campagna J, Spilman P, John V.

Tetrahedron Lett. 2016 May 11;57(19):2059-2062.


Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction.

Talukder P, Chen S, Roy B, Yakovchuk P, Spiering MM, Alam MP, Madathil MM, Bhattacharya C, Benkovic SJ, Hecht SM.

Biochemistry. 2015 Dec 29;54(51):7457-69. doi: 10.1021/acs.biochem.5b01085. Epub 2015 Dec 16.


Differential nuclease sensitivity profiling of chromatin reveals biochemical footprints coupled to gene expression and functional DNA elements in maize.

Vera DL, Madzima TF, Labonne JD, Alam MP, Hoffman GG, Girimurugan SB, Zhang J, McGinnis KM, Dennis JH, Bass HW.

Plant Cell. 2014 Oct;26(10):3883-93. doi: 10.1105/tpc.114.130609. Epub 2014 Oct 31.


A short DNA sequence confers strong bleomycin binding to hairpin DNAs.

Tang C, Paul A, Alam MP, Roy B, Wilson WD, Hecht SM.

J Am Chem Soc. 2014 Oct 1;136(39):13715-26. doi: 10.1021/ja505733u. Epub 2014 Sep 22.


DNA methylation reduces binding and cleavage by bleomycin.

Roy B, Tang C, Alam MP, Hecht SM.

Biochemistry. 2014 Sep 30;53(38):6103-12. doi: 10.1021/bi5010848. Epub 2014 Sep 17.


Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases.

Alam MP, Khdour OM, Arce PM, Chen Y, Roy B, Johnson WG, Dey S, Hecht SM.

Bioorg Med Chem. 2014 Sep 1;22(17):4935-47. doi: 10.1016/j.bmc.2014.06.040. Epub 2014 Jun 28.


Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity.

Yadav VK, Thakur RK, Eckloff B, Baral A, Singh A, Halder R, Kumar A, Alam MP, Kundu TK, Pandita R, Pandita TK, Wieben ED, Chowdhury S.

Nucleic Acids Res. 2014 Sep;42(15):9602-11. doi: 10.1093/nar/gku596. Epub 2014 Jul 31.


The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.

Kendrick S, Kang HJ, Alam MP, Madathil MM, Agrawal P, Gokhale V, Yang D, Hecht SM, Hurley LH.

J Am Chem Soc. 2014 Mar 19;136(11):4161-71. doi: 10.1021/ja410934b. Epub 2014 Mar 7. Erratum in: J Am Chem Soc. 2016 Sep 7;138(35):11408.


Proximity of H2A.Z containing nucleosome to the transcription start site influences gene expression levels in the mammalian liver and brain.

Bargaje R, Alam MP, Patowary A, Sarkar M, Ali T, Gupta S, Garg M, Singh M, Purkanti R, Scaria V, Sivasubbu S, Brahmachari V, Pillai B.

Nucleic Acids Res. 2012 Oct;40(18):8965-78. doi: 10.1093/nar/gks665. Epub 2012 Jul 19.


Thermodynamic, diffusional, and structural anomalies in rigid-body water models.

Agarwal M, Alam MP, Chakravarty C.

J Phys Chem B. 2011 Jun 2;115(21):6935-45. doi: 10.1021/jp110695t. Epub 2011 May 10.


Nucleosomal occupancy and CGG repeat expansion: a comparative analysis of triplet repeat region from mouse and human fragile X mental retardation gene 1.

Datta S, Alam MP, Majumdar SS, Mehta AK, Maiti S, Wadhwa N, Brahmachari V.

Chromosome Res. 2011 May;19(4):445-55. doi: 10.1007/s10577-011-9206-7. Epub 2011 Apr 16.


Relationship between structure, entropy, and diffusivity in water and water-like liquids.

Agarwal M, Singh M, Sharma R, Alam MP, Chakravarty C.

J Phys Chem B. 2010 May 27;114(20):6995-7001. doi: 10.1021/jp101956u.


Comparative analysis of DNA methylation in transgenic mice with unstable CGG repeats from FMR1 gene.

Alam MP, Datta S, Majumdar S, Mehta AK, Baskaran S, Gulati N, Brahmachari V.

Epigenetics. 2010 Apr;5(3):241-8. Epub 2010 Apr 1.


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