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Items: 1 to 50 of 251

1.

Druggable Transcriptional Networks in the Human Neurogenic Epigenome.

Higgins GA, Williams AM, Ade AS, Alam HB, Athey BD.

Pharmacol Rev. 2019 Oct;71(4):520-538. doi: 10.1124/pr.119.017681. Review.

PMID:
31530573
2.

The 'Omics' of Epigenetic Modulation by Valproic Acid Treatment in Traumatic Brain Injury-What We Know and What the Future Holds.

Bhatti UF, Williams AM, Georgoff PE, Alam HB.

Proteomics Clin Appl. 2019 Aug 23:e1900068. doi: 10.1002/prca.201900068. [Epub ahead of print] Review.

PMID:
31441601
3.

Defining the Burden of Emergency General Surgery in Transplant Patients: A Nationwide Examination.

Bhatti UF, Shah AA, Williams AM, Zuberi MK, Butt Z, Biesterveld B, Alam HB, Idrees K.

J Surg Res. 2019 Aug 14;245:315-320. doi: 10.1016/j.jss.2019.07.054. [Epub ahead of print]

PMID:
31421379
4.

Dose Optimization of Valproic Acid in a Lethal Model of Traumatic Brain Injury, Hemorrhage and Polytrauma in Swine.

Biesterveld BE, Williams AM, Pai MP, Dennahy IS, Graham NJ, Chtraklin K, Siddiqui AZ, O'Connell RL, Bhatti UF, Liu B, Russo RM, Li Y, Alam HB.

J Trauma Acute Care Surg. 2019 Aug 5. doi: 10.1097/TA.0000000000002460. [Epub ahead of print]

PMID:
31389922
5.

Choosing the right surgeon.

Wakam G, Alam HB.

Int J Surg. 2019 Aug;68:181. doi: 10.1016/j.ijsu.2019.07.021. Epub 2019 Jul 23. No abstract available.

PMID:
31349051
6.

Inhibition of Histone Deacetylase 6 Protects Hippocampal Cells Against Mitochondria-mediated Apoptosis in a Model of Severe Oxygen-glucose Deprivation.

Chang P, Tian Y, Williams AM, Bhatti UF, Liu B, Li Y, Alam HB.

Curr Mol Med. 2019 Jul 23. doi: 10.2174/1566524019666190724102755. [Epub ahead of print]

PMID:
31339071
7.

Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation.

Williams AM, Bhatti UF, Biesterveld BE, Graham NJ, Chtraklin K, Zhou J, Dennahy IS, Kathawate RG, Vercruysse CA, Russo RM, Li Y, Alam HB.

J Trauma Acute Care Surg. 2019 Aug;87(2):393-401. doi: 10.1097/TA.0000000000002281.

PMID:
31206419
8.

Western Trauma Association Critical Decisions in Trauma: Management of the Open Abdomen after Damage Control Surgery.

Sava J, Alam HB, Vercruysse G, Martin M, Brown CVR, Brasel K, Moore EE Jr, Ciesla D, Inaba K.

J Trauma Acute Care Surg. 2019 Jun 12. doi: 10.1097/TA.0000000000002389. [Epub ahead of print] No abstract available.

PMID:
31205219
9.

Western Trauma Association Critical Decisions in Trauma: Preferred Triage and Initial Management of the Burned Patient.

Vercruysse GA, Alam HB, Martin MJ, Brasel K, Moore EE, Brown CV, Bettencourt A, Schulz J, Palmieri T, Haith L, Inaba K.

J Trauma Acute Care Surg. 2019 Apr 25. doi: 10.1097/TA.0000000000002348. [Epub ahead of print]

PMID:
31045735
10.

What's New in Shock, May 2019?

Russo RM, Alam HB.

Shock. 2019 May;51(5):535-537. doi: 10.1097/SHK.0000000000001322. No abstract available.

PMID:
30985603
11.

Histone Deacetylase Inhibition Attenuates Cardiomyocyte Hypoxia-Reoxygenation Injury.

Williams AM, He W, Li Y, Bhatti UF, Nikolian VC, Chang P, Chang Z, Halaweish I, Liu B, Cheng X, Alam HB.

Curr Mol Med. 2018;18(10):711-718. doi: 10.2174/1566524019666190208102729.

PMID:
30734677
12.

Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model.

Chang P, Williams AM, Bhatti UF, Biesterveld BE, Liu B, Nikolian VC, Dennahy IS, Lee J, Li Y, Alam HB.

J Am Coll Surg. 2019 Mar;228(3):265-275. doi: 10.1016/j.jamcollsurg.2018.12.026. Epub 2019 Jan 9.

PMID:
30639301
13.

Traumatic brain injury may worsen clinical outcomes after prolonged partial resuscitative endovascular balloon occlusion of the aorta in severe hemorrhagic shock model.

Williams AM, Bhatti UF, Dennahy IS, Graham NJ, Nikolian VC, Chtraklin K, Chang P, Zhou J, Biesterveld BE, Eliason J, Alam HB.

J Trauma Acute Care Surg. 2019 Mar;86(3):415-423. doi: 10.1097/TA.0000000000002149.

PMID:
30605139
14.

Histone Deacetylase Inhibitors: A Novel Strategy in Trauma and Sepsis.

Williams AM, Dennahy IS, Bhatti UF, Biesterveld BE, Graham NJ, Li Y, Alam HB.

Shock. 2019 Sep;52(3):300-306. doi: 10.1097/SHK.0000000000001308.

PMID:
30601405
15.

Inhibition of histone deacetylase 6 attenuates intestinal inflammation and apoptosis in a rodent model of hemorrhagic shock.

Chang P, Bhatti UF, Williams AM, Dennahy IS, Liu B, Li Y, Alam HB.

J Trauma Acute Care Surg. 2019 May;86(5):874-880. doi: 10.1097/TA.0000000000002169.

PMID:
30562325
16.

HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.

Tian S, Lei I, Gao W, Liu L, Guo Y, Creech J, Herron TJ, Xian S, Ma PX, Eugene Chen Y, Li Y, Alam HB, Wang Z.

EBioMedicine. 2019 Jan;39:83-94. doi: 10.1016/j.ebiom.2018.12.003. Epub 2018 Dec 11.

17.

Isoform 6-selective histone deacetylase inhibition reduces lesion size and brain swelling following traumatic brain injury and hemorrhagic shock.

Nikolian VC, Dennahy IS, Weykamp M, Williams AM, Bhatti UF, Eidy H, Ghandour MH, Chtraklin K, Li Y, Alam HB.

J Trauma Acute Care Surg. 2019 Feb;86(2):232-239. doi: 10.1097/TA.0000000000002119.

PMID:
30399139
18.

Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine.

Williams AM, Bhatti UF, Dennahy IS, Chtraklin K, Chang P, Graham NJ, Baccouche BM, Roy S, Harajli M, Zhou J, Nikolian VC, Deng Q, Tian Y, Liu B, Li Y, Hays GL, Hays JL, Alam HB.

J Vis Exp. 2018 Aug 24;(138). doi: 10.3791/58284.

PMID:
30199035
19.

Pilot Study to Evaluate the Safety, Feasibility, and Financial Implications of a Postoperative Telemedicine Program.

Nikolian VC, Williams AM, Jacobs BN, Kemp MT, Wilson JK, Mulholland MW, Alam HB.

Ann Surg. 2018 Oct;268(4):700-707. doi: 10.1097/SLA.0000000000002931.

PMID:
30095477
20.

Protective Effect of Tubastatin A in CLP-Induced Lethal Sepsis.

Deng Q, Zhao T, Pan B, Dennahy IS, Duan X, Williams AM, Liu B, Lin N, Bhatti UF, Chen E, Alam HB, Li Y.

Inflammation. 2018 Dec;41(6):2101-2109. doi: 10.1007/s10753-018-0853-0.

PMID:
30047002
21.

Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.

Liang Y, Pan B, Alam HB, Deng Q, Wang Y, Chen E, Liu B, Tian Y, Williams AM, Duan X, Wang Y, Zhang J, Li Y.

Eur J Pharmacol. 2018 Aug 15;833:432-440. doi: 10.1016/j.ejphar.2018.07.005. Epub 2018 Jul 5.

22.

The role of telemedicine in postoperative care.

Williams AM, Bhatti UF, Alam HB, Nikolian VC.

Mhealth. 2018 May 2;4:11. doi: 10.21037/mhealth.2018.04.03. eCollection 2018. Review.

23.

Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock.

Weykamp M, Nikolian VC, Dennahy IS, Higgins GA, Georgoff PE, Remmer H, Ghandour MH, Alam HB.

J Surg Res. 2018 Aug;228:84-92. doi: 10.1016/j.jss.2018.02.046. Epub 2018 Apr 25.

PMID:
29907235
24.

Time to stroke: A Western Trauma Association multicenter study of blunt cerebrovascular injuries.

Burlew CC, Sumislawski JJ, Behnfield CD, McNutt MK, McCarthy J, Sharpe JP, Croce MA, Bala M, Kashuk J, Spalding MC, Beery PR, John S, Hunt DJ, Harmon L, Stein DM, Callcut R, Wybourn C, Sperry J, Anto V, Dunn J, Veith JP, Brown CVR, Celii A, Zander TL, Coimbra R, Berndtson AE, Moss TZ, Malhotra AK, Hazelton JP, Linden K, West M, Alam HB, Williams AM, Kim J, Inaba K, Moulton S, Choi YM, Warren HL, Collier B, Ball CG, Savage S, Hartwell JL, Cullinane DC, Zielinski MD, Ray-Zack MD, Morse BC, Rhee P, Rutherford EJ, Udekwu P, Reynolds C, Toschlog E, Gondek S, Ju T, Haan JM, Lightwine KL, Kulvatunyou N, Coates B, Khouqeer AF, Todd SR, Zarzaur B, Waller CJ, Kallies KJ, Neideen T, Eddine SBZ, Peck KA, Dunne CE, Kramer K, Bokhari F, Dhillon TS, Galante JM, Cohen MJ.

J Trauma Acute Care Surg. 2018 Nov;85(5):858-866. doi: 10.1097/TA.0000000000001989.

PMID:
29847537
25.

Western Trauma Association Critical Decisions in Trauma: Management of renal trauma.

Brown CVR, Alam HB, Brasel K, Hauser CJ, de Moya M, Martin M, Moore EE, Rowell S, Vercruysse G, Inaba K.

J Trauma Acute Care Surg. 2018 Nov;85(5):1021-1025. doi: 10.1097/TA.0000000000001960. No abstract available.

PMID:
29787554
26.

Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection and Improve Long-Term Neurologic Outcomes in a Swine Model of Traumatic Brain Injury and Hemorrhagic Shock.

Williams AM, Dennahy IS, Bhatti UF, Halaweish I, Xiong Y, Chang P, Nikolian VC, Chtraklin K, Brown J, Zhang Y, Zhang ZG, Chopp M, Buller B, Alam HB.

J Neurotrauma. 2019 Jan 1;36(1):54-60. doi: 10.1089/neu.2018.5711. Epub 2018 Jul 30.

PMID:
29690826
27.

Evaluation and management of abdominal stab wounds: A Western Trauma Association critical decisions algorithm.

Martin MJ, Brown CVR, Shatz DV, Alam HB, Brasel KJ, Hauser CJ, de Moya M, Moore EE, Rowell SE, Vercruysse GA, Baron BJ, Inaba K.

J Trauma Acute Care Surg. 2018 Nov;85(5):1007-1015. doi: 10.1097/TA.0000000000001930.

PMID:
29659472
28.

What's New in Shock, May 2018?

Williams AM, Alam HB.

Shock. 2018 May;49(5):483-485. doi: 10.1097/SHK.0000000000001121. No abstract available.

PMID:
29652787
29.

Valproic Acid Treatment Decreases Serum Glial Fibrillary Acidic Protein and Neurofilament Light Chain Levels in Swine Subjected to Traumatic Brain Injury.

Korley FK, Nikolian VC, Williams AM, Dennahy IS, Weykamp M, Alam HB.

J Neurotrauma. 2018 May 15;35(10):1185-1191. doi: 10.1089/neu.2017.5581. Epub 2018 Mar 13.

PMID:
29415612
30.

Histone deacetylase inhibitors: Isoform selectivity improves survival in a hemorrhagic shock model.

Chang P, Weykamp M, Dennahy IS, Williams AM, Bhatti UF, Liu B, Nikolian VC, Li Y, Alam HB.

J Trauma Acute Care Surg. 2018 May;84(5):795-801. doi: 10.1097/TA.0000000000001824.

31.

Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.

Nikolian VC, Dennahy IS, Higgins GA, Williams AM, Weykamp M, Georgoff PE, Eidy H, Ghandour MH, Chang P, Alam HB.

J Trauma Acute Care Surg. 2018 Mar;84(3):459-465. doi: 10.1097/TA.0000000000001765.

32.

Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock.

Georgoff PE, Nikolian VC, Higgins G, Chtraklin K, Eidy H, Ghandour MH, Williams A, Athey B, Alam HB.

J Trauma Acute Care Surg. 2018 Apr;84(4):642-649. doi: 10.1097/TA.0000000000001763.

PMID:
29251706
33.

Tubastatin A prevents hemorrhage-induced endothelial barrier dysfunction.

Bruhn PJ, Nikolian VC, Halaweish I, Chang Z, Sillesen M, Liu B, Li Y, Alam HB.

J Trauma Acute Care Surg. 2018 Feb;84(2):386-392. doi: 10.1097/TA.0000000000001753.

34.

Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma.

Nikolian VC, Dekker SE, Bambakidis T, Higgins GA, Dennahy IS, Georgoff PE, Williams AM, Andjelkovic AV, Alam HB.

Crit Care Med. 2018 Jan;46(1):e59-e66. doi: 10.1097/CCM.0000000000002800.

PMID:
29095204
35.

Transfusion Strategies are Associated with Epigenetic Changes Following Blunt Trauma.

Sillesen M, Li Y, Alam HB.

Shock. 2018 Jul;50(1):24-30. doi: 10.1097/SHK.0000000000001035.

PMID:
29059104
36.

Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex.

Conner TM, Nikolian VC, Georgoff PE, Pai MP, Alam HB, Sun D, Reed RC, Zhang T.

Eur J Pharm Sci. 2018 Jan 1;111:465-481. doi: 10.1016/j.ejps.2017.10.009. Epub 2017 Oct 10.

PMID:
29030176
37.

CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock.

Pan B, Alam HB, Chong W, Mobley J, Liu B, Deng Q, Liang Y, Wang Y, Chen E, Wang T, Tewari M, Li Y.

Sci Rep. 2017 Aug 21;7(1):8972. doi: 10.1038/s41598-017-09337-4.

38.

Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury.

Dekker SE, Nikolian VC, Sillesen M, Bambakidis T, Schober P, Alam HB.

J Neurosci Res. 2018 Apr;96(4):711-719. doi: 10.1002/jnr.24125. Epub 2017 Jul 25. Review.

39.

Trauma care: Finding a better way.

Alam HB.

PLoS Med. 2017 Jul 18;14(7):e1002350. doi: 10.1371/journal.pmed.1002350. eCollection 2017 Jul.

40.

Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.

Nikolian VC, Georgoff PE, Pai MP, Dennahy IS, Chtraklin K, Eidy H, Ghandour MH, Han Y, Srinivasan A, Li Y, Alam HB.

J Trauma Acute Care Surg. 2017 Dec;83(6):1066-1073. doi: 10.1097/TA.0000000000001612.

PMID:
28697014
41.

Novel Noninvasive Method of Cerebrovascular Blood Volume Assessment Using Brain Bioimpedance.

Tiba MH, McCracken BM, Ansari S, Belle A, Cummings BC, Rajajee V, Patil PG, Alam HB, Ward KR.

J Neurotrauma. 2017 Nov 15;34(22):3089-3096. doi: 10.1089/neu.2017.5090. Epub 2017 Aug 4.

PMID:
28657491
42.

Mortality after emergent trauma laparotomy: A multicenter, retrospective study.

Harvin JA, Maxim T, Inaba K, Martinez-Aguilar MA, King DR, Choudhry AJ, Zielinski MD, Akinyeye S, Todd SR, Griffin RL, Kerby JD, Bailey JA, Livingston DH, Cunningham K, Stein DM, Cattin L, Bulger EM, Wilson A, Undurraga Perl VJ, Schreiber MA, Cherry-Bukowiec JR, Alam HB, Holcomb JB.

J Trauma Acute Care Surg. 2017 Sep;83(3):464-468. doi: 10.1097/TA.0000000000001619.

43.

Development of the emergency preservation and resuscitation for cardiac arrest from trauma clinical trial.

Tisherman SA, Alam HB, Rhee PM, Scalea TM, Drabek T, Forsythe RM, Kochanek PM.

J Trauma Acute Care Surg. 2017 Nov;83(5):803-809. doi: 10.1097/TA.0000000000001585.

PMID:
28538639
44.

Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial.

Georgoff PE, Nikolian VC, Bonham T, Pai MP, Tafatia C, Halaweish I, To K, Watcharotone K, Parameswaran A, Luo R, Sun D, Alam HB.

Clin Pharmacokinet. 2018 Feb;57(2):209-219. doi: 10.1007/s40262-017-0553-1.

45.

Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock.

Nikolian VC, Pan B, Mesar T, Dennahy IS, Georgoff PE, Duan X, Liu B, Wu X, Duggan MJ, Alam HB, Li Y.

Inflammation. 2017 Aug;40(4):1264-1274. doi: 10.1007/s10753-017-0569-6.

PMID:
28493077
46.

Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways.

Higgins GA, Allyn-Feuer A, Georgoff P, Nikolian V, Alam HB, Athey BD.

Methods. 2017 Jul 1;123:102-118. doi: 10.1016/j.ymeth.2017.03.012. Epub 2017 Apr 4. Review.

PMID:
28385536
47.

Valproic acid modulates platelet and coagulation function ex vivo.

Bambakidis T, Dekker SE, Halaweish I, Liu B, Nikolian VC, Georgoff PE, Piascik P, Li Y, Sillesen M, Alam HB.

Blood Coagul Fibrinolysis. 2017 Sep;28(6):479-484. doi: 10.1097/MBC.0000000000000626.

PMID:
28230635
48.

Resuscitation with Lyophilized Plasma Is Safe and Improves Neurological Recovery in a Long-Term Survival Model of Swine Subjected to Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma.

Georgoff PE, Nikolian VC, Halaweish I, Chtraklin K, Bruhn PJ, Eidy H, Rasmussen M, Li Y, Srinivasan A, Alam HB.

J Neurotrauma. 2017 Jul 1;34(13):2167-2175. doi: 10.1089/neu.2016.4859. Epub 2017 Apr 25.

PMID:
28228060
49.

Early resuscitation with lyophilized plasma provides equal neuroprotection compared with fresh frozen plasma in a large animal survival model of traumatic brain injury and hemorrhagic shock.

Halaweish I, Bambakidis T, Nikolian VC, Georgoff P, Bruhn P, Piascik P, Buckley L, Srinivasan A, Liu B, Li Y, Alam HB.

J Trauma Acute Care Surg. 2016 Dec;81(6):1080-1087.

PMID:
27893618
50.

What's New in Shock, December 2016?

Alam HB.

Shock. 2016 Dec;46(6):593-596. No abstract available.

PMID:
27846131

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