Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 71

1.

Rehabilitation of dynamic visual acuity in patients with unilateral vestibular hypofunction: earlier is better.

Michel L, Laurent T, Alain T.

Eur Arch Otorhinolaryngol. 2019 Oct 21. doi: 10.1007/s00405-019-05690-4. [Epub ahead of print]

PMID:
31637477
2.

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R.

Neuron. 2019 Aug 26. pii: S0896-6273(19)30691-9. doi: 10.1016/j.neuron.2019.08.007. [Epub ahead of print]

PMID:
31522764
3.

Co-targeting Bulk Tumor and CSCs in Clinically Translatable TNBC Patient-Derived Xenografts via Combination Nanotherapy.

Sulaiman A, McGarry S, El-Sahli S, Li L, Chambers J, Phan A, Côté M, Cron GO, Alain T, Le Y, Lee SH, Liu S, Figeys D, Gadde S, Wang L.

Mol Cancer Ther. 2019 Oct;18(10):1755-1764. doi: 10.1158/1535-7163.MCT-18-0873. Epub 2019 Jul 15.

PMID:
31308079
4.

Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T cells.

William M, Leroux LP, Chaparro V, Graber TE, Alain T, Jaramillo M.

Eur J Immunol. 2019 Aug;49(8):1200-1212. doi: 10.1002/eji.201847857. Epub 2019 May 6.

PMID:
31032899
5.

Characterizing Cellular Responses During Oncolytic Maraba Virus Infection.

Hassanzadeh G, Naing T, Graber T, Jafarnejad SM, Stojdl DF, Alain T, Holcik M.

Int J Mol Sci. 2019 Jan 29;20(3). pii: E580. doi: 10.3390/ijms20030580.

6.

Oncolytic Viruses on Drugs: Achieving Higher Therapeutic Efficacy.

Phan M, Watson MF, Alain T, Diallo JS.

ACS Infect Dis. 2018 Oct 12;4(10):1448-1467. doi: 10.1021/acsinfecdis.8b00144. Epub 2018 Sep 12.

PMID:
30152676
7.

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.

Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T.

PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug.

8.

Publisher Correction: Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.

Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG.

Nat Commun. 2018 Jul 18;9:16231. doi: 10.1038/ncomms16231.

9.

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.

Leroux LP, Lorent J, Graber TE, Chaparro V, Masvidal L, Aguirre M, Fonseca BD, van Kempen LC, Alain T, Larsson O, Jaramillo M.

Infect Immun. 2018 Aug 22;86(9). pii: e00244-18. doi: 10.1128/IAI.00244-18. Print 2018 Sep.

10.

Battling for Ribosomes: Translational Control at the Forefront of the Antiviral Response.

Hoang HD, Graber TE, Alain T.

J Mol Biol. 2018 Jul 6;430(14):1965-1992. doi: 10.1016/j.jmb.2018.04.040. Epub 2018 May 7. Review.

PMID:
29746850
11.

LARP1 on TOP of ribosome production.

Fonseca BD, Lahr RM, Damgaard CK, Alain T, Berman AJ.

Wiley Interdiscip Rev RNA. 2018 May 2:e1480. doi: 10.1002/wrna.1480. [Epub ahead of print] Review.

12.

eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2.

William M, Leroux LP, Chaparro V, Lorent J, Graber TE, M'Boutchou MN, Charpentier T, Fabié A, Dozois CM, Stäger S, van Kempen LC, Alain T, Larsson O, Jaramillo M.

J Immunol. 2018 Jun 15;200(12):4102-4116. doi: 10.4049/jimmunol.1701670. Epub 2018 Apr 30.

13.

Translational control of ERK signaling through miRNA/4EHP-directed silencing.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N.

Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554/eLife.35034.

14.

Social and leisure activity profiles and well-being among the older adults: a longitudinal study.

Michèle J, Guillaume M, Alain T, Nathalie B, Claude F, Kamel G.

Aging Ment Health. 2019 Jan;23(1):77-83. doi: 10.1080/13607863.2017.1394442. Epub 2017 Nov 21.

PMID:
29160718
15.

UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule.

Graber TE, Freemantle E, Anadolu MN, Hébert-Seropian S, MacAdam RL, Shin U, Hoang HD, Alain T, Lacaille JC, Sossin WS.

J Neurosci. 2017 Sep 20;37(38):9116-9131. doi: 10.1523/JNEUROSCI.0088-17.2017. Epub 2017 Aug 18. Erratum in: J Neurosci. 2017 Oct 18;37(42):10253.

16.

Cap-binding protein 4EHP effects translation silencing by microRNAs.

Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. doi: 10.1073/pnas.1701488114. Epub 2017 May 9.

17.

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.

Lahr RM, Fonseca BD, Ciotti GE, Al-Ashtal HA, Jia JJ, Niklaus MR, Blagden SP, Alain T, Berman AJ.

Elife. 2017 Apr 7;6. pii: e24146. doi: 10.7554/eLife.24146.

18.

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma.

Beug ST, Beauregard CE, Healy C, Sanda T, St-Jean M, Chabot J, Walker DE, Mohan A, Earl N, Lun X, Senger DL, Robbins SM, Staeheli P, Forsyth PA, Alain T, LaCasse EC, Korneluk RG.

Nat Commun. 2017 Feb 15;8. doi: 10.1038/ncomms14278. Erratum in: Nat Commun. 2018 Jul 18;9:16231.

19.

Transcriptional induction of 4E-BP3 prolongs translation repression.

Tsukumo Y, Sonenberg N, Alain T.

Cell Cycle. 2016 Dec 16;15(24):3325-3326. doi: 10.1080/15384101.2016.1224786. Epub 2016 Aug 26. No abstract available.

20.

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells.

Bhat M, Yanagiya A, Graber T, Razumilava N, Bronk S, Zammit D, Zhao Y, Zakaria C, Metrakos P, Pollak M, Sonenberg N, Gores G, Jaramillo M, Morita M, Alain T.

Oncotarget. 2016 Jul 18;8(31):50542-50556. doi: 10.18632/oncotarget.10671. eCollection 2017 Aug 1.

21.

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.

Tsukumo Y, Alain T, Fonseca BD, Nadon R, Sonenberg N.

Nat Commun. 2016 Jun 20;7:11776. doi: 10.1038/ncomms11776.

22.

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.

Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4.

23.

Translational control of nociception via 4E-binding protein 1.

Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N.

Elife. 2015 Dec 18;4. pii: e12002. doi: 10.7554/eLife.12002.

24.

Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.

Beug ST, Conrad DP, Alain T, Korneluk RG, Lacasse EC.

Int J Dev Biol. 2015;59(1-3):141-7. doi: 10.1387/ijdb.150084el. Review.

25.

Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.

Beug ST, Conrad DP, Alain T, Korneluk RG, Lacasse EC.

Int J Dev Biol. 2015 May 21. [Epub ahead of print]

PMID:
26009240
26.

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).

Fonseca BD, Zakaria C, Jia JJ, Graber TE, Svitkin Y, Tahmasebi S, Healy D, Hoang HD, Jensen JM, Diao IT, Lussier A, Dajadian C, Padmanabhan N, Wang W, Matta-Camacho E, Hearnden J, Smith EM, Tsukumo Y, Yanagiya A, Morita M, Petroulakis E, González JL, Hernández G, Alain T, Damgaard CK.

J Biol Chem. 2015 Jun 26;290(26):15996-6020. doi: 10.1074/jbc.M114.621730. Epub 2015 May 4.

27.

Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.

Arulanandam R, Batenchuk C, Varette O, Zakaria C, Garcia V, Forbes NE, Davis C, Krishnan R, Karmacharya R, Cox J, Sinha A, Babawy A, Waite K, Weinstein E, Falls T, Chen A, Hamill J, De Silva N, Conrad DP, Atkins H, Garson K, Ilkow C, Kærn M, Vanderhyden B, Sonenberg N, Alain T, Le Boeuf F, Bell JC, Diallo JS.

Nat Commun. 2015 Mar 30;6:6410. doi: 10.1038/ncomms7410.

PMID:
25817275
28.

Video-laryngoscopy introduction in a Sub-Saharan national teaching hospital: luxury or necessity?

Alain TI, Drissa BS, Flavien K, Serge I, Idriss T.

Pan Afr Med J. 2015 Dec 21;22:381. doi: 10.11604/pamj.2015.22.381.8175. eCollection 2015.

29.

Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses.

Nehdi A, Sean P, Linares I, Colina R, Jaramillo M, Alain T.

PLoS One. 2014 Dec 22;9(12):e114854. doi: 10.1371/journal.pone.0114854. eCollection 2014.

30.

The ever-evolving role of mTOR in translation.

Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A.

Semin Cell Dev Biol. 2014 Dec;36:102-12. doi: 10.1016/j.semcdb.2014.09.014. Epub 2014 Sep 27. Review.

PMID:
25263010
31.

Transfer, transformation, and impacts of ceria nanomaterials in aquatic mesocosms simulating a pond ecosystem.

Marie T, Mélanie A, Lenka B, Julien I, Isabelle K, Christine P, Elise M, Catherine S, Bernard A, Ester A, Jérôme R, Alain T, Jean-Yves B.

Environ Sci Technol. 2014 Aug 19;48(16):9004-13. doi: 10.1021/es501641b. Epub 2014 Aug 4.

PMID:
25050645
32.

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.

Robichaud N, del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N.

Oncogene. 2015 Apr 16;34(16):2032-42. doi: 10.1038/onc.2014.146. Epub 2014 Jun 9.

33.

Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale.

Gandin V, Sikström K, Alain T, Morita M, McLaughlan S, Larsson O, Topisirovic I.

J Vis Exp. 2014 May 17;(87). doi: 10.3791/51455.

34.

Multifaceted regulation of somatic cell reprogramming by mRNA translational control.

Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, Kim K, Yang XJ, Sonenberg N.

Cell Stem Cell. 2014 May 1;14(5):606-16. doi: 10.1016/j.stem.2014.02.005. Epub 2014 Mar 13.

35.

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.

Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N.

Mol Cell Biol. 2014 Mar;34(6):1046-53. doi: 10.1128/MCB.01079-13. Epub 2014 Jan 6.

36.

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N.

Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001.

37.

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling.

Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N.

Neuron. 2013 Aug 21;79(4):712-24. doi: 10.1016/j.neuron.2013.06.026.

38.

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N.

PLoS Biol. 2013;11(5):e1001564. doi: 10.1371/journal.pbio.1001564. Epub 2013 May 21.

39.

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex.

Gandin V, Gutierrez GJ, Brill LM, Varsano T, Feng Y, Aza-Blanc P, Au Q, McLaughlan S, Ferreira TA, Alain T, Sonenberg N, Topisirovic I, Ronai ZA.

Mol Cell Biol. 2013 Jul;33(13):2510-26. doi: 10.1128/MCB.01362-12. Epub 2013 Apr 22.

40.

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio.

Alain T, Sonenberg N, Topisirovic I.

Oncotarget. 2012 Dec;3(12):1491-2. No abstract available.

41.

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.

Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N.

Cancer Res. 2012 Dec 15;72(24):6468-76. doi: 10.1158/0008-5472.CAN-12-2395. Epub 2012 Oct 24.

42.

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N.

Mol Cell Biol. 2012 Sep;32(17):3585-93. doi: 10.1128/MCB.00455-12. Epub 2012 Jul 2.

43.

Distinct perturbation of the translatome by the antidiabetic drug metformin.

Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8977-82. doi: 10.1073/pnas.1201689109. Epub 2012 May 18.

44.

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

Herdy B, Jaramillo M, Svitkin YV, Rosenfeld AB, Kobayashi M, Walsh D, Alain T, Sean P, Robichaud N, Topisirovic I, Furic L, Dowling RJO, Sylvestre A, Rong L, Colina R, Costa-Mattioli M, Fritz JH, Olivier M, Brown E, Mohr I, Sonenberg N.

Nat Immunol. 2012 Apr 29;13(6):543-550. doi: 10.1038/ni.2291.

45.

Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.

Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C, Tee AR, Duong F, Andersen RJ, Orlowski J, Numata M, Sonenberg N, Roberge M.

J Biol Chem. 2012 May 18;287(21):17530-45. doi: 10.1074/jbc.M112.359638. Epub 2012 Apr 2.

46.

IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.

Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA.

J Immunol. 2012 May 1;188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23.

47.

Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.

Mahoney DJ, Lefebvre C, Allan K, Brun J, Sanaei CA, Baird S, Pearce N, Grönberg S, Wilson B, Prakesh M, Aman A, Isaac M, Mamai A, Uehling D, Al-Awar R, Falls T, Alain T, Stojdl DF.

Cancer Cell. 2011 Oct 18;20(4):443-56. doi: 10.1016/j.ccr.2011.09.005.

48.

Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.

Fonseca BD, Alain T, Finestone LK, Huang BP, Rolfe M, Jiang T, Yao Z, Hernandez G, Bennett CF, Proud CG.

J Biol Chem. 2011 Aug 5;286(31):27111-22. doi: 10.1074/jbc.M111.260794. Epub 2011 Jun 9.

49.

Attenuated reovirus displays oncolysis with reduced host toxicity.

Kim M, Garant KA, zur Nieden NI, Alain T, Loken SD, Urbanski SJ, Forsyth PA, Rancourt DE, Lee PW, Johnston RN.

Br J Cancer. 2011 Jan 18;104(2):290-9. doi: 10.1038/sj.bjc.6606053. Epub 2010 Dec 21.

50.

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.

Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N.

Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532.

Supplemental Content

Support Center