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Items: 42

1.

Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons.

Chapelle J, Sorokina O, McLean C, Salemme V, Alfieri A, Angelini C, Morellato A, Adrait A, Menna E, Matteoli M, Couté Y, Ala U, Turco E, Defilippi P, Armstrong JD.

Front Cell Dev Biol. 2019 Oct 15;7:222. doi: 10.3389/fcell.2019.00222. eCollection 2019.

2.

Choice of Alternative Polyadenylation Sites, Mediated by the RNA-Binding Protein Elavl3, Plays a Role in Differentiation of Inhibitory Neuronal Progenitors.

Grassi E, Santoro R, Umbach A, Grosso A, Oliviero S, Neri F, Conti L, Ala U, Provero P, DiCunto F, Merlo GR.

Front Cell Neurosci. 2019 Jan 10;12:518. doi: 10.3389/fncel.2018.00518. eCollection 2018.

3.

Biological relevance of Cytomegalovirus genetic variability in congenitally and postnatally infected children.

Galitska G, Biolatti M, De Andrea M, Leone A, Coscia A, Bertolotti L, Ala U, Bertino E, Dell'Oste V, Landolfo S.

J Clin Virol. 2018 Nov;108:132-140. doi: 10.1016/j.jcv.2018.09.019. Epub 2018 Oct 2.

PMID:
30312910
4.

Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.

Pallavicini G, Sgrò F, Garello F, Falcone M, Bitonto V, Berto GE, Bianchi FT, Gai M, Chiotto AMA, Filippi M, Cutrin JC, Ala U, Terreno E, Turco E, Cunto FD.

Cancer Res. 2018 Aug 15;78(16):4599-4612. doi: 10.1158/0008-5472.CAN-17-4060. Epub 2018 Jun 19.

5.

Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy.

Boido M, De Amicis E, Valsecchi V, Trevisan M, Ala U, Ruegg MA, Hettwer S, Vercelli A.

Front Cell Neurosci. 2018 Jan 30;12:17. doi: 10.3389/fncel.2018.00017. eCollection 2018.

6.

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

Gulluni F, Martini M, De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Fan F, Meraldi P, Marchiò C, Pece S, Sapino A, Chiarle R, Di Fiore PP, Hirsch E.

Cancer Cell. 2017 Oct 9;32(4):444-459.e7. doi: 10.1016/j.ccell.2017.09.002.

7.

Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders.

Alfieri A, Sorokina O, Adrait A, Angelini C, Russo I, Morellato A, Matteoli M, Menna E, Boeri Erba E, McLean C, Armstrong JD, Ala U, Buxbaum JD, Brusco A, Couté Y, De Rubeis S, Turco E, Defilippi P.

Front Mol Neurosci. 2017 Jun 30;10:212. doi: 10.3389/fnmol.2017.00212. eCollection 2017.

8.

Copy number variants analysis in a cohort of isolated and syndromic developmental delay/intellectual disability reveals novel genomic disorders, position effects and candidate disease genes.

Di Gregorio E, Riberi E, Belligni EF, Biamino E, Spielmann M, Ala U, Calcia A, Bagnasco I, Carli D, Gai G, Giordano M, Guala A, Keller R, Mandrile G, Arduino C, Maffè A, Naretto VG, Sirchia F, Sorasio L, Ungari S, Zonta A, Zacchetti G, Talarico F, Pappi P, Cavalieri S, Giorgio E, Mancini C, Ferrero M, Brussino A, Savin E, Gandione M, Pelle A, Giachino DF, De Marchi M, Restagno G, Provero P, Cirillo Silengo M, Grosso E, Buxbaum JD, Pasini B, De Rubeis S, Brusco A, Ferrero GB.

Clin Genet. 2017 Oct;92(4):415-422. doi: 10.1111/cge.13009. Epub 2017 Jul 25.

PMID:
28295210
9.

Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.

Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E.

Cell Death Differ. 2017 Apr;24(4):731-746. doi: 10.1038/cdd.2017.8. Epub 2017 Feb 17.

10.

Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.

Bianchi FT, Tocco C, Pallavicini G, Liu Y, Vernì F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AM, Sgrò F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F.

Cell Rep. 2017 Feb 14;18(7):1674-1686. doi: 10.1016/j.celrep.2017.01.054.

11.

An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates.

Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, Santoro MM.

Development. 2017 Feb 1;144(3):464-478. doi: 10.1242/dev.133926. Epub 2017 Jan 3.

12.

DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk.

Baglietto L, Ponzi E, Haycock P, Hodge A, Bianca Assumma M, Jung CH, Chung J, Fasanelli F, Guida F, Campanella G, Chadeau-Hyam M, Grankvist K, Johansson M, Ala U, Provero P, Wong EM, Joo J, English DR, Kazmi N, Lund E, Faltus C, Kaaks R, Risch A, Barrdahl M, Sandanger TM, Southey MC, Giles GG, Johansson M, Vineis P, Polidoro S, Relton CL, Severi G.

Int J Cancer. 2017 Jan 1;140(1):50-61. doi: 10.1002/ijc.30431. Epub 2016 Oct 11.

13.

Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma.

Bersani F, Lingua MF, Morena D, Foglizzo V, Miretti S, Lanzetti L, Carrà G, Morotti A, Ala U, Provero P, Chiarle R, Singer S, Ladanyi M, Tuschl T, Ponzetto C, Taulli R.

Cancer Res. 2016 Oct 15;76(20):6095-6106. Epub 2016 Aug 28.

14.

Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes.

Morena D, Maestro N, Bersani F, Forni PE, Lingua MF, Foglizzo V, Šćepanović P, Miretti S, Morotti A, Shern JF, Khan J, Ala U, Provero P, Sala V, Crepaldi T, Gasparini P, Casanova M, Ferrari A, Sozzi G, Chiarle R, Ponzetto C, Taulli R.

Elife. 2016 Mar 17;5. pii: e12116. doi: 10.7554/eLife.12116.

15.

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.

Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P.

Nat Commun. 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192.

16.

Corrigendum: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.

Procopio MG, Laszlo C, Al Labban D, Kim DE, Bordignon P, Jo SH, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski WW, Swartz MA, Brisken C, Lefort K, Dotto GP.

Nat Cell Biol. 2015 Oct;17(10):1370. doi: 10.1038/ncb3242. No abstract available.

PMID:
26419803
17.

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.

Procopio MG, Laszlo C, Al Labban D, Kim DE, Bordignon P, Jo SH, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski WW, Swartz MA, Brisken C, Lefort K, Dotto GP.

Nat Cell Biol. 2015 Sep;17(9):1193-204. doi: 10.1038/ncb3228. Epub 2015 Aug 24. Erratum in: Nat Cell Biol. 2015 Oct;17(10):1370.

18.

The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

Karreth FA, Reschke M, Ruocco A, Ng C, Chapuy B, Léopold V, Sjoberg M, Keane TM, Verma A, Ala U, Tay Y, Wu D, Seitzer N, Velasco-Herrera Mdel C, Bothmer A, Fung J, Langellotto F, Rodig SJ, Elemento O, Shipp MA, Adams DJ, Chiarle R, Pandolfi PP.

Cell. 2015 Apr 9;161(2):319-32. doi: 10.1016/j.cell.2015.02.043. Epub 2015 Apr 2.

19.

Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.

Lunardi A, Varmeh S, Chen M, Taulli R, Guarnerio J, Ala U, Seitzer N, Ishikawa T, Carver BS, Hobbs RM, Quarantotti V, Ng C, Berger AH, Nardella C, Poliseno L, Montironi R, Castillo-Martin M, Cordon-Cardo C, Signoretti S, Pandolfi PP.

Cancer Discov. 2015 May;5(5):550-63. doi: 10.1158/2159-8290.CD-13-1050. Epub 2015 Feb 4.

20.

SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma.

Coda DM, Lingua MF, Morena D, Foglizzo V, Bersani F, Ala U, Ponzetto C, Taulli R.

Cell Cycle. 2015;14(9):1389-402. doi: 10.1080/15384101.2015.1005993.

21.

Bone marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis.

Guarnerio J, Coltella N, Ala U, Tonon G, Pandolfi PP, Bernardi R.

Stem Cell Reports. 2014 May 15;2(6):794-809. doi: 10.1016/j.stemcr.2014.04.002. eCollection 2014 Jun 3.

22.

Pseudogenes as competitive endogenous RNAs: target prediction and validation.

Karreth FA, Ala U, Provero P, Pandolfi PP.

Methods Mol Biol. 2014;1167:199-212. doi: 10.1007/978-1-4939-0835-6_13.

PMID:
24823779
23.

Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs).

Molineris I, Ala U, Provero P, Di Cunto F.

BMC Bioinformatics. 2013 Oct 2;14:288. doi: 10.1186/1471-2105-14-288.

24.

Characterization and analysis of the composition and dynamics of the mammalian riboproteome.

Reschke M, Clohessy JG, Seitzer N, Goldstein DP, Breitkopf SB, Schmolze DB, Ala U, Asara JM, Beck AH, Pandolfi PP.

Cell Rep. 2013 Sep 26;4(6):1276-87. doi: 10.1016/j.celrep.2013.08.014. Epub 2013 Sep 19.

25.

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

Song SJ, Poliseno L, Song MS, Ala U, Webster K, Ng C, Beringer G, Brikbak NJ, Yuan X, Cantley LC, Richardson AL, Pandolfi PP.

Cell. 2013 Jul 18;154(2):311-324. doi: 10.1016/j.cell.2013.06.026. Epub 2013 Jul 3.

26.

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.

Song SJ, Ito K, Ala U, Kats L, Webster K, Sun SM, Jongen-Lavrencic M, Manova-Todorova K, Teruya-Feldstein J, Avigan DE, Delwel R, Pandolfi PP.

Cell Stem Cell. 2013 Jul 3;13(1):87-101. doi: 10.1016/j.stem.2013.06.003.

27.

Failure to downregulate the BAF53a subunit of the SWI/SNF chromatin remodeling complex contributes to the differentiation block in rhabdomyosarcoma.

Taulli R, Foglizzo V, Morena D, Coda DM, Ala U, Bersani F, Maestro N, Ponzetto C.

Oncogene. 2014 May 1;33(18):2354-62. doi: 10.1038/onc.2013.188. Epub 2013 Jun 3.

PMID:
23728344
28.

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.

Wang G, Lunardi A, Zhang J, Chen Z, Ala U, Webster KA, Tay Y, Gonzalez-Billalabeitia E, Egia A, Shaffer DR, Carver B, Liu XS, Taulli R, Kuo WP, Nardella C, Signoretti S, Cordon-Cardo C, Gerald WL, Pandolfi PP.

Nat Genet. 2013 Jul;45(7):739-746. doi: 10.1038/ng.2654. Epub 2013 Jun 2.

29.

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA, Wang G, Mazzucchelli R, Bianconi M, Stack EC, Lis R, Patnaik A, Cantley LC, Bubley G, Cordon-Cardo C, Gerald WL, Montironi R, Signoretti S, Loda M, Nardella C, Pandolfi PP.

Nat Genet. 2013 Jul;45(7):747-55. doi: 10.1038/ng.2650. Epub 2013 Jun 2.

30.

Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.

Ala U, Karreth FA, Bosia C, Pagnani A, Taulli R, Léopold V, Tay Y, Provero P, Zecchina R, Pandolfi PP.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7154-9. doi: 10.1073/pnas.1222509110. Epub 2013 Mar 27.

31.

Early versus delayed laparoscopic cholecystectomy for acute cholecystitis.

Solej M, Martino V, Mao P, Enrico S, Rosa R, Fornari M, Destefano I, Ferrarese AG, Gibin E, Bindi F, Falcone A, Ala U, Nano M.

Minerva Chir. 2012 Oct;67(5):381-7.

PMID:
23232475
32.

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.

Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.

Nat Med. 2012 Sep;18(9):1350-8.

33.

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.

Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP.

Cell. 2011 Oct 14;147(2):382-95. doi: 10.1016/j.cell.2011.09.032. Erratum in: Cell. 2011 Nov 11;147(4):948.

34.

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP.

Cell. 2011 Oct 14;147(2):344-57. doi: 10.1016/j.cell.2011.09.029.

35.

Evaluation of candidate genes from orphan FEB and GEFS+ loci by analysis of human brain gene expression atlases.

Piro RM, Molineris I, Ala U, Di Cunto F.

PLoS One. 2011;6(8):e23149. doi: 10.1371/journal.pone.0023149. Epub 2011 Aug 17.

36.

The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides.

Bianchi FT, Camera P, Ala U, Imperiale D, Migheli A, Boda E, Tempia F, Berto G, Bosio Y, Oddo S, LaFerla FM, Taraglio S, Dotti CG, Di Cunto F.

PLoS One. 2011;6(7):e22370. doi: 10.1371/journal.pone.0022370. Epub 2011 Jul 28.

37.

An atlas of tissue-specific conserved coexpression for functional annotation and disease gene prediction.

Piro RM, Ala U, Molineris I, Grassi E, Bracco C, Perego GP, Provero P, Di Cunto F.

Eur J Hum Genet. 2011 Nov;19(11):1173-80. doi: 10.1038/ejhg.2011.96. Epub 2011 Jun 8.

38.

Evolution of promoter affinity for transcription factors in the human lineage.

Molineris I, Grassi E, Ala U, Di Cunto F, Provero P.

Mol Biol Evol. 2011 Aug;28(8):2173-83. doi: 10.1093/molbev/msr027. Epub 2011 Feb 18.

PMID:
21335606
39.

Candidate gene prioritization based on spatially mapped gene expression: an application to XLMR.

Piro RM, Molineris I, Ala U, Provero P, Di Cunto F.

Bioinformatics. 2010 Sep 15;26(18):i618-24. doi: 10.1093/bioinformatics/btq396.

40.

The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.

Forlani G, Giarda E, Ala U, Di Cunto F, Salani M, Tupler R, Kilstrup-Nielsen C, Landsberger N.

Hum Mol Genet. 2010 Aug 15;19(16):3114-23. doi: 10.1093/hmg/ddq214. Epub 2010 May 26.

41.

Functional annotation and identification of candidate disease genes by computational analysis of normal tissue gene expression data.

Miozzi L, Piro RM, Rosa F, Ala U, Silengo L, Di Cunto F, Provero P.

PLoS One. 2008 Jun 18;3(6):e2439. doi: 10.1371/journal.pone.0002439.

42.

Prediction of human disease genes by human-mouse conserved coexpression analysis.

Ala U, Piro RM, Grassi E, Damasco C, Silengo L, Oti M, Provero P, Di Cunto F.

PLoS Comput Biol. 2008 Mar 28;4(3):e1000043. doi: 10.1371/journal.pcbi.1000043.

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