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Items: 1 to 50 of 62

1.

Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity.

Dufailu OA, Mahdavi J, Ala'Aldeen DAA, Wooldridge KG, Oldfield NJ.

Microb Pathog. 2018 Nov;124:70-75. doi: 10.1016/j.micpath.2018.08.001. Epub 2018 Aug 4.

PMID:
30081080
2.

Genomic Analysis of Serogroup Y Neisseria meningitidis Isolates Reveals Extensive Similarities Between Carriage-Associated and Disease-Associated Organisms.

Oldfield NJ, Harrison OB, Bayliss CD, Maiden MC, Ala'Aldeen DA, Turner DP.

J Infect Dis. 2016 Jun 1;213(11):1777-85. doi: 10.1093/infdis/jiw008. Epub 2016 Jan 7.

3.

Optimization of Molecular Approaches to Genogroup Neisseria meningitidis Carriage Isolates and Implications for Monitoring the Impact of New Serogroup B Vaccines.

Rojas E, Hoyos J, Oldfield NJ, Lee P, Flint M, Jones CH, Ala'Aldeen DA, Jansen KU, Anderson AS.

PLoS One. 2015 Jul 6;10(7):e0132140. doi: 10.1371/journal.pone.0132140. eCollection 2015.

4.

Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters.

Khairalla AS, Omer SA, Mahdavi J, Aslam A, Dufailu OA, Self T, Jonsson AB, Geörg M, Sjölinder H, Royer PJ, Martinez-Pomares L, Ghaemmaghami AM, Wooldridge KG, Oldfield NJ, Ala'Aldeen DA.

Cell Microbiol. 2015 Jul;17(7):1008-20. doi: 10.1111/cmi.12417. Epub 2015 Feb 8.

5.

Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis.

Alqahtani F, Mahdavi J, Wheldon LM, Vassey M, Pirinccioglu N, Royer PJ, Qarani SM, Morroll S, Stoof J, Holliday ND, Teo SY, Oldfield NJ, Wooldridge KG, Ala'Aldeen DA.

Open Biol. 2014 Oct;4(10). pii: 140053. doi: 10.1098/rsob.140053.

6.

Phase variation mediates reductions in expression of surface proteins during persistent meningococcal carriage.

Alamro M, Bidmos FA, Chan H, Oldfield NJ, Newton E, Bai X, Aidley J, Care R, Mattick C, Turner DP, Neal KR, Ala'aldeen DA, Feavers I, Borrow R, Bayliss CD.

Infect Immun. 2014 Jun;82(6):2472-84. doi: 10.1128/IAI.01521-14. Epub 2014 Mar 31.

7.

A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization.

Mahdavi J, Pirinccioglu N, Oldfield NJ, Carlsohn E, Stoof J, Aslam A, Self T, Cawthraw SA, Petrovska L, Colborne N, Sihlbom C, Borén T, Wooldridge KG, Ala'Aldeen DA.

Open Biol. 2014 Jan 22;4:130202. doi: 10.1098/rsob.130202.

8.

Epidemiological investigation of Pseudomonas aeruginosa isolates from a six-year-long hospital outbreak using high-throughput whole genome sequencing.

Snyder LA, Loman NJ, Faraj LA, Levi K, Weinstock G, Boswell TC, Pallen MJ, Ala'Aldeen DA.

Euro Surveill. 2013 Oct 17;18(42). pii: 20611.

9.

Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence.

Mahdavi J, Royer PJ, Sjölinder HS, Azimi S, Self T, Stoof J, Wheldon LM, Brännström K, Wilson R, Moreton J, Moir JW, Sihlbom C, Borén T, Jonsson AB, Soultanas P, Ala'Aldeen DA.

Open Biol. 2013 Oct 9;3(10):130048. doi: 10.1098/rsob.130048.

10.

Prevalence and phase variable expression status of two autotransporters, NalP and MspA, in carriage and disease isolates of Neisseria meningitidis.

Oldfield NJ, Matar S, Bidmos FA, Alamro M, Neal KR, Turner DP, Bayliss CD, Ala'aldeen DA.

PLoS One. 2013 Jul 25;8(7):e69746. doi: 10.1371/journal.pone.0069746. Print 2013.

11.

Naturally occurring IgG antibody levels to the Staphylococcus aureus protein IsdB in humans.

Zorman JK, Esser M, Raedler M, Kreiswirth BN, Ala'Aldeen DA, Kartsonis N, Smugar SS, Anderson AS, McNeely T, Arduino JM.

Hum Vaccin Immunother. 2013 Sep;9(9):1857-64. doi: 10.4161/hv.25253. Epub 2013 Jun 18.

12.

Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2.

Abouseada NM, Assafi MS, Mahdavi J, Oldfield NJ, Wheldon LM, Wooldridge KG, Ala'Aldeen DA.

PLoS One. 2012;7(9):e46233. doi: 10.1371/journal.pone.0046233. Epub 2012 Sep 25.

13.

Carriage of meningococci by university students, United Kingdom.

Ala'aldeen DA, Oldfield NJ, Bidmos FA, Abouseada NM, Ahmed NW, Turner DP, Neal KR, Bayliss CD.

Emerg Infect Dis. 2011 Sep;17(9):1762-3. doi: 10.3201/eid1709.101762. No abstract available.

14.

Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence.

Tauseef I, Harrison OB, Wooldridge KG, Feavers IM, Neal KR, Gray SJ, Kriz P, Turner DP, Ala'Aldeen DA, Maiden MC, Bayliss CD.

Microbiology. 2011 May;157(Pt 5):1446-56. doi: 10.1099/mic.0.046946-0. Epub 2011 Feb 10.

15.

Persistence, replacement, and rapid clonal expansion of meningococcal carriage isolates in a 2008 university student cohort.

Bidmos FA, Neal KR, Oldfield NJ, Turner DP, Ala'Aldeen DA, Bayliss CD.

J Clin Microbiol. 2011 Feb;49(2):506-12. doi: 10.1128/JCM.01322-10. Epub 2010 Dec 1.

16.

The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells.

Tunio SA, Oldfield NJ, Ala'Aldeen DA, Wooldridge KG, Turner DP.

BMC Microbiol. 2010 Nov 9;10:280. doi: 10.1186/1471-2180-10-280.

17.

Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage.

Ala'aldeen DA, Flint M, Oldfield NJ, Omer SA, McNeil LK, Jiang Q, Murphy E, Giardina PC, Novikova EG, Dodge-Scully IL, Bayliss CD, Turner DP, Neal KR, Hoiseth SK, Jansen KU, Anderson AS.

Vaccine. 2010 Nov 10;28(48):7667-75. doi: 10.1016/j.vaccine.2010.09.038. Epub 2010 Sep 25.

PMID:
20875489
18.

The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion.

Tunio SA, Oldfield NJ, Berry A, Ala'Aldeen DA, Wooldridge KG, Turner DP.

Mol Microbiol. 2010 May;76(3):605-15. doi: 10.1111/j.1365-2958.2010.07098.x. Epub 2010 Feb 28.

19.

AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge.

Oldfield NJ, Worrall KE, Rycroft AN, Ali T, Wooldridge KG, Ala'Aldeen DA.

Vaccine. 2009 Aug 20;27(38):5278-83. doi: 10.1016/j.vaccine.2009.06.047. Epub 2009 Jun 27.

PMID:
19563888
20.

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models.

Orihuela CJ, Mahdavi J, Thornton J, Mann B, Wooldridge KG, Abouseada N, Oldfield NJ, Self T, Ala'Aldeen DA, Tuomanen EI.

J Clin Invest. 2009 Jun;119(6):1638-46. doi: 10.1172/JCI36759. Epub 2009 May 11.

21.

Secreted proteins of Neisseria meningitidis protect mice against infection.

Li Y, Wooldridge KG, Javed MA, Tang CM, Ala'aldeen DA.

Vaccine. 2009 Apr 14;27(17):2320-5. doi: 10.1016/j.vaccine.2009.02.034. Epub 2009 Feb 20.

PMID:
19428846
22.

Functional characterization of AasP, a maturation protease autotransporter protein of Actinobacillus pleuropneumoniae.

Ali T, Oldfield NJ, Wooldridge KG, Turner DP, Ala'Aldeen DA.

Infect Immun. 2008 Dec;76(12):5608-14. doi: 10.1128/IAI.00085-08. Epub 2008 Oct 13.

23.

Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae.

Oldfield NJ, Donovan EA, Worrall KE, Wooldridge KG, Langford PR, Rycroft AN, Ala'Aldeen DA.

Vaccine. 2008 Apr 7;26(16):1942-54. doi: 10.1016/j.vaccine.2008.02.022. Epub 2008 Feb 27.

PMID:
18342410
24.

Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity.

Maiden MC, Ibarz-Pavón AB, Urwin R, Gray SJ, Andrews NJ, Clarke SC, Walker AM, Evans MR, Kroll JS, Neal KR, Ala'aldeen DA, Crook DW, Cann K, Harrison S, Cunningham R, Baxter D, Kaczmarski E, Maclennan J, Cameron JC, Stuart JM.

J Infect Dis. 2008 Mar 1;197(5):737-43. doi: 10.1086/527401.

25.

CapA, an autotransporter protein of Campylobacter jejuni, mediates association with human epithelial cells and colonization of the chicken gut.

Ashgar SS, Oldfield NJ, Wooldridge KG, Jones MA, Irving GJ, Turner DP, Ala'Aldeen DA.

J Bacteriol. 2007 Mar;189(5):1856-65. Epub 2006 Dec 15.

26.

T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells.

Oldfield NJ, Bland SJ, Taraktsoglou M, Dos Ramos FJ, Robinson K, Wooldridge KG, Ala'Aldeen DA.

Cell Microbiol. 2007 Feb;9(2):463-78. Epub 2006 Sep 11.

PMID:
16965515
27.

Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis.

Turner DP, Marietou AG, Johnston L, Ho KK, Rogers AJ, Wooldridge KG, Ala'Aldeen DA.

Infect Immun. 2006 May;74(5):2957-64.

28.

Unusual genetic organization of a functional type I protein secretion system in Neisseria meningitidis.

Wooldridge KG, Kizil M, Wells DB, Ala'aldeen DA.

Infect Immun. 2005 Sep;73(9):5554-67.

29.

T-cell-stimulating protein A elicits immune responses during meningococcal carriage and human disease.

Robinson K, Wooldridge KG, Wells DB, Hasan A, Todd I, Robins A, James R, Ala'Aldeen DA.

Infect Immun. 2005 Aug;73(8):4684-93.

30.

Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation.

Robinson K, Taraktsoglou M, Rowe KS, Wooldridge KG, Ala'Aldeen DA.

Cell Microbiol. 2004 Oct;6(10):927-38.

PMID:
15339268
31.
32.

Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice.

Loughlin MF, Ala'Aldeen DA, Jenks PJ.

J Antimicrob Chemother. 2003 Feb;51(2):367-71.

PMID:
12562704
33.

Independent subsets of amplified fragments from the genome of Neisseria meningitidis identify the same invasive clones of ET37 and ET5.

Goulding JN, Stanley J, Olver W, Neal KR, Ala'Aldeen DA, Arnold C.

J Med Microbiol. 2003 Feb;52(Pt 2):151-4.

PMID:
12543921
34.
35.

Isolation of a serogroup 29E meningococcal strain carrying Group-C siaD capsular gene.

Ala'Aldeen DA, Neil K, English A, Hawkey P.

J Infect. 2002 Jan;44(1):56-7. No abstract available.

PMID:
11972426
36.

Characterization of humoral and cellular immune responses elicited by meningococcal carriage.

Robinson K, Neal KR, Howard C, Stockton J, Atkinson K, Scarth E, Moran J, Robins A, Todd I, Kaczmarski E, Gray S, Muscat I, Slack R, Ala'Aldeen DA.

Infect Immun. 2002 Mar;70(3):1301-9.

37.

Identification and characterization of App: an immunogenic autotransporter protein of Neisseria meningitidis.

Hadi HA, Wooldridge KG, Robinson K, Ala'Aldeen DA.

Mol Microbiol. 2001 Aug;41(3):611-23.

38.

Unveiling of genetic basis of resistance of S aureus to antibiotics.

Ala'Aldeen DA, Grundmann H.

Lancet. 2001 Apr 21;357(9264):1218-9. No abstract available.

PMID:
11418140
39.

Neisserial TonB-dependent outer-membrane proteins: detection, regulation and distribution of three putative candidates identified from the genome sequences.

Turner PC, Thomas CE, Stojiljkovic I, Elkins C, Kizel G, Ala'Aldeen DA, Sparling PF.

Microbiology. 2001 May;147(Pt 5):1277-90.

PMID:
11320131
40.

Fluorescent amplified-fragment length polymorphism genotyping of Neisseria meningitidis identifies clones associated with invasive disease.

Goulding JN, Hookey JV, Stanley J, Olver W, Neal KR, Ala'Aldeen DA, Arnold C.

J Clin Microbiol. 2000 Dec;38(12):4580-5.

41.

Auto-transporter A protein of Neisseria meningitidis: a potent CD4+ T-cell and B-cell stimulating antigen detected by expression cloning.

Ait-Tahar K, Wooldridge KG, Turner DP, Atta M, Todd I, Ala'Aldeen DA.

Mol Microbiol. 2000 Sep;37(5):1094-105.

42.

Detection and characterisation of the genes encoding glyoxalase I and II from Neisseria meningitidis.

Kizil G, Wilks K, Wells D, Ala'Aldeen DA.

J Med Microbiol. 2000 Jul;49(7):669-73.

PMID:
10882093
43.

Dynamics of meningococcal long-term carriage among university students and their implications for mass vaccination.

Ala'Aldeen DA, Neal KR, Ait-Tahar K, Nguyen-Van-Tam JS, English A, Falla TJ, Hawkey PM, Slack RC.

J Clin Microbiol. 2000 Jun;38(6):2311-6.

44.

Changing carriage rate of Neisseria meningitidis among university students during the first week of term: cross sectional study.

Neal KR, Nguyen-Van-Tam JS, Jeffrey N, Slack RC, Madeley RJ, Ait-Tahar K, Job K, Wale MC, Ala'Aldeen DA.

BMJ. 2000 Mar 25;320(7238):846-9.

45.

Seven-week interval between acquisition of a meningococcus and the onset of invasive disease. A case report.

Neal KR, Nguyen-van-Tam JS, Slack RC, Kaczmarski EB, White A, Ala'Aldeen DA.

Epidemiol Infect. 1999 Dec;123(3):507-9.

46.

Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen.

Kizil G, Todd I, Atta M, Borriello SP, Ait-Tahar K, Ala'Aldeen DA.

Infect Immun. 1999 Jul;67(7):3533-41.

47.

Mastic gum kills Helicobacter pylori.

Huwez FU, Thirlwell D, Cockayne A, Ala'Aldeen DA.

N Engl J Med. 1998 Dec 24;339(26):1946. No abstract available.

PMID:
9874617
48.

Differential binding of apo and holo human transferrin to meningococci and co-localisation of the transferrin-binding proteins (TbpA and TbpB).

Powell NB, Bishop K, Palmer HM, Ala'Aldeen DA, Gorringe AR, Borriello SP.

J Med Microbiol. 1998 Mar;47(3):257-64.

PMID:
9511831
49.

A microbiologist's guide to travellers abroad: do as I say not as I do.

Ala'Aldeen DA.

J Hosp Infect. 1997 Apr;35(4):255-7.

PMID:
9152817
50.

Neisseria meningitidis: clinical aspects.

Cartwright KA, Ala'Aldeen DA.

J Infect. 1997 Jan;34(1):15-9. Review. No abstract available.

PMID:
9120319

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