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Items: 1 to 50 of 58

1.

Homocysteine Induces Inflammation in Retina and Brain.

Elsherbiny NM, Sharma I, Kira D, Alhusban S, Samra YA, Jadeja R, Martin P, Al-Shabrawey M, Tawfik A.

Biomolecules. 2020 Mar 3;10(3). pii: E393. doi: 10.3390/biom10030393.

2.

Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy.

Shalaby L, Thounaojam M, Tawfik A, Li J, Hussein K, Jahng WJ, Al-Shabrawey M, Kwok HF, Bartoli M, Gutsaeva D.

J Clin Med. 2020 Feb 2;9(2). pii: E400. doi: 10.3390/jcm9020400.

3.

Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity.

Atawia RT, Bunch KL, Fouda AY, Lemtalsi T, Eldahshan W, Xu Z, Saul A, Elmasry K, Al-Shabrawey M, Caldwell RB, Caldwell RW.

J Clin Med. 2020 Jan 22;9(2). pii: E317. doi: 10.3390/jcm9020317.

4.

A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury.

Elmarakby AA, Ibrahim AS, Katary MA, Elsherbiny NM, El-Shafey M, Abd-Elrazik AM, Abdelsayed RA, Maddipati KR, Al-Shabrawey M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Nov;1864(11):1669-1680. doi: 10.1016/j.bbalip.2019.07.009. Epub 2019 Jul 23.

PMID:
31349026
5.

Homocysteine: A Potential Biomarker for Diabetic Retinopathy.

Tawfik A, Mohamed R, Elsherbiny NM, DeAngelis MM, Bartoli M, Al-Shabrawey M.

J Clin Med. 2019 Jan 19;8(1). pii: E121. doi: 10.3390/jcm8010121.

6.

A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse.

Ibrahim AS, Elmasry K, Wan M, Abdulmoneim S, Still A, Khan F, Khalil A, Saul A, Hoda MN, Al-Shabrawey M.

Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5548-5557. doi: 10.1167/iovs.18-24773.

7.

Bioactive lipids and pathological retinal angiogenesis.

Elmasry K, Ibrahim AS, Abdulmoneim S, Al-Shabrawey M.

Br J Pharmacol. 2019 Jan;176(1):93-109. doi: 10.1111/bph.14507. Epub 2018 Nov 19. Review.

8.

Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells.

Valle ML, Dworshak J, Sharma A, Ibrahim AS, Al-Shabrawey M, Sharma S.

Exp Eye Res. 2019 Jan;178:27-36. doi: 10.1016/j.exer.2018.09.009. Epub 2018 Sep 18.

9.

Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration.

Elmasry K, Mohamed R, Sharma I, Elsherbiny NM, Liu Y, Al-Shabrawey M, Tawfik A.

Oncotarget. 2018 Jan 29;9(16):12562-12590. doi: 10.18632/oncotarget.24333. eCollection 2018 Feb 27.

10.

Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.

Elmasry K, Ibrahim AS, Saleh H, Elsherbiny N, Elshafey S, Hussein KA, Al-Shabrawey M.

Diabetologia. 2018 May;61(5):1220-1232. doi: 10.1007/s00125-018-4560-z. Epub 2018 Feb 21.

11.

Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress.

Mohamed R, Sharma I, Ibrahim AS, Saleh H, Elsherbiny NM, Fulzele S, Elmasry K, Smith SB, Al-Shabrawey M, Tawfik A.

Sci Rep. 2017 Sep 20;7(1):11952. doi: 10.1038/s41598-017-09731-y.

12.

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.

Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y.

Nat Commun. 2017 Sep 19;8(1):584. doi: 10.1038/s41467-017-00551-2.

13.

Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.

Ibrahim AS, Saleh H, El-Shafey M, Hussein KA, El-Masry K, Baban B, Sheibani N, Wang MH, Tawfik A, Al-Shabrawey M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jun;1862(6):636-645. doi: 10.1016/j.bbalip.2017.03.010. Epub 2017 Mar 27.

14.

Adenosine Deaminase-2-Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p.

Samra YA, Saleh HM, Hussein KA, Elsherbiny NM, Ibrahim AS, Elmasry K, Fulzele S, El-Shishtawy MM, Eissa LA, Al-Shabrawey M, Liou GI.

Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):933-943. doi: 10.1167/iovs.16-19782.

15.

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration.

Ibrahim AS, Mander S, Hussein KA, Elsherbiny NM, Smith SB, Al-Shabrawey M, Tawfik A.

Oncotarget. 2016 Feb 23;7(8):8532-45. doi: 10.18632/oncotarget.7384.

16.

Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice.

Faulkner J, Pye C, Al-Shabrawey M, Elmarakby AA.

J Diabetes Metab. 2015 Jun;6(6). pii: 555. Epub 2015 May 30.

17.

Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.

Huang H, Al-Shabrawey M, Wang MH.

Prostaglandins Other Lipid Mediat. 2016 Jan;122:45-53. doi: 10.1016/j.prostaglandins.2015.12.007. Epub 2015 Dec 30. Review.

18.

Deletion of SPARC Enhances Retinal Vaso-Obliteration in Mouse Model of Oxygen-Induced Retinopathy.

Sobeih D, Hussein KA, Said N, Motamed K, Al-Shabrawey M.

HSOA J Ophthalmol Clin Res. 2014 Dec;1(1). pii: 002. Epub 2014 Aug 22.

19.

Diabetic retinopathy: mechanism, diagnosis, prevention, and treatment.

Al-Shabrawey M, Zhang W, McDonald D.

Biomed Res Int. 2015;2015:854593. doi: 10.1155/2015/854593. Epub 2015 Mar 19. No abstract available.

20.

The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown.

Abu El-Asrar AM, Mohammad G, Nawaz MI, Abdelsaid M, Siddiquei MM, Alam K, Van den Eynde K, De Hertogh G, Opdenakker G, Al-Shabrawey M, Van Damme J, Struyf S.

Invest Ophthalmol Vis Sci. 2015 Feb 24;56(3):1956-64. doi: 10.1167/iovs.14-16144.

21.

A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase.

Ibrahim AS, Elshafey S, Sellak H, Hussein KA, El-Sherbiny M, Abdelsaid M, Rizk N, Beasley S, Tawfik AM, Smith SB, Al-Shabrawey M.

J Lipid Res. 2015 Mar;56(3):599-611. doi: 10.1194/jlr.M056069. Epub 2015 Jan 17.

22.

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.

Ibrahim AS, Tawfik AM, Hussein KA, Elshafey S, Markand S, Rizk N, Duh EJ, Smith SB, Al-Shabrawey M.

Biochim Biophys Acta. 2015 Mar;1851(3):290-8. doi: 10.1016/j.bbalip.2014.12.017. Epub 2015 Jan 3.

23.

Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema.

Beasley S, El-Sherbiny M, Megyerdi S, El-Shafey S, Choksi K, Kaddour-Djebbar I, Sheibani N, Hsu S, Al-Shabrawey M.

Biomed Res Int. 2014;2014:417986. doi: 10.1155/2014/417986. Epub 2014 Jul 9.

24.

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia.

Tawfik A, Markand S, Al-Shabrawey M, Mayo JN, Reynolds J, Bearden SE, Ganapathy V, Smith SB.

Am J Pathol. 2014 Sep;184(9):2573-85. doi: 10.1016/j.ajpath.2014.05.018. Epub 2014 Jul 10.

25.

Bone morphogenetic protein 2: a potential new player in the pathogenesis of diabetic retinopathy.

Hussein KA, Choksi K, Akeel S, Ahmad S, Megyerdi S, El-Sherbiny M, Nawaz M, Abu El-Asrar A, Al-Shabrawey M.

Exp Eye Res. 2014 Aug;125:79-88. doi: 10.1016/j.exer.2014.05.012. Epub 2014 Jun 6.

26.

Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms.

Pye C, Elsherbiny NM, Ibrahim AS, Liou GI, Chadli A, Al-Shabrawey M, Elmarakby AA.

Pharmacol Res. 2014 Jul;85:45-54. doi: 10.1016/j.phrs.2014.05.004. Epub 2014 May 17.

27.

Effects of tricalcium silicate cements on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells in vitro.

Eid AA, Hussein KA, Niu LN, Li GH, Watanabe I, Al-Shabrawey M, Pashley DH, Tay FR.

Acta Biomater. 2014 Jul;10(7):3327-34. doi: 10.1016/j.actbio.2014.04.006. Epub 2014 Apr 13.

28.

New developments in the pathophysiology and management of diabetic retinopathy.

Abu El-Asrar AM, Midena E, Al-Shabrawey M, Mohammad G.

J Diabetes Res. 2013;2013:424258. doi: 10.1155/2013/424258. Epub 2013 Dec 10. No abstract available.

29.

Targeting Neovascularization in Ischemic Retinopathy: Recent Advances.

Al-Shabrawey M, Elsherbiny M, Nussbaum J, Othman A, Megyerdi S, Tawfik A.

Expert Rev Ophthalmol. 2013 Jun;8(3):267-286.

30.

12/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: contribution of NADPH oxidase.

Othman A, Ahmad S, Megyerdi S, Mussell R, Choksi K, Maddipati KR, Elmarakby A, Rizk N, Al-Shabrawey M.

PLoS One. 2013;8(2):e57254. doi: 10.1371/journal.pone.0057254. Epub 2013 Feb 20.

31.

Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia.

Tawfik A, Al-Shabrawey M, Roon P, Sonne S, Covar JA, Matragoon S, Ganapathy PS, Atherton SS, El-Remessy A, Ganapathy V, Smith SB.

Invest Ophthalmol Vis Sci. 2013 Feb 1;54(2):939-49. doi: 10.1167/iovs.12-10536.

32.

High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina.

Mohammad G, Siddiquei MM, Othman A, Al-Shabrawey M, Abu El-Asrar AM.

Exp Eye Res. 2013 Feb;107:101-9. doi: 10.1016/j.exer.2012.12.009. Epub 2012 Dec 21.

PMID:
23261684
33.

Caspase-14: a novel caspase in the retina with a potential role in diabetic retinopathy.

Al-Shabrawey M, Ahmad S, Megyerdi S, Othman A, Baban B, Palenski TL, Shin ES, Gurel Z, Hsu S, Sheibani N.

Mol Vis. 2012;18:1895-906. Epub 2012 Jul 14.

34.

Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death.

Kaddour-Djebbar I, Choudhary V, Lakshmikanthan V, Shirley R, El Gaish M, Al-Shabrawey M, Al-Husein B, Zhong R, Davis M, Dong Z, Bollag WB, Kumar MV.

J Pharmacol Exp Ther. 2012 Jun;341(3):646-55. doi: 10.1124/jpet.111.188151. Epub 2012 Mar 5.

PMID:
22393247
35.

Recombinant bone morphogenetic protein-2 induces up-regulation of vascular endothelial growth factor and interleukin 6 in human pre-osteoblasts: role of reactive oxygen species.

Akeel S, El-Awady A, Hussein K, El-Refaey M, Elsalanty M, Sharawy M, Al-Shabrawey M.

Arch Oral Biol. 2012 May;57(5):445-52. doi: 10.1016/j.archoralbio.2011.10.002. Epub 2011 Oct 29.

PMID:
22041018
36.

Difference in soft tissue response between immediate and delayed delivery suggests a new mechanism for recombinant human bone morphogenetic protein 2 action in large segmental bone defects.

Hussein KA, Zakhary IE, Elawady AR, Emam HA, Sharawy M, Baban B, Akeel S, Al-Shabrawey M, Elsalanty ME.

Tissue Eng Part A. 2012 Mar;18(5-6):665-75. doi: 10.1089/ten.TEA.2011.0148. Epub 2011 Dec 5.

PMID:
21981405
37.

High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy.

El-Asrar AM, Nawaz MI, Kangave D, Geboes K, Ola MS, Ahmad S, Al-Shabrawey M.

Mol Vis. 2011;17:1829-38. Epub 2011 Jul 6.

38.

Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes.

Elmarakby AA, Faulkner J, Al-Shabrawey M, Wang MH, Maddipati KR, Imig JD.

Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1307-17. doi: 10.1152/ajpregu.00759.2010. Epub 2011 Aug 10.

39.

Inflammation and diabetic retinal microvascular complications.

Zhang W, Liu H, Al-Shabrawey M, Caldwell RW, Caldwell RB.

J Cardiovasc Dis Res. 2011 Apr;2(2):96-103. doi: 10.4103/0975-3583.83035.

40.

Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization.

Al-Shabrawey M, Mussell R, Kahook K, Tawfik A, Eladl M, Sarthy V, Nussbaum J, El-Marakby A, Park SY, Gurel Z, Sheibani N, Maddipati KR.

Diabetes. 2011 Feb;60(2):614-24. doi: 10.2337/db10-0008. Epub 2011 Jan 12. Erratum in: Diabetes. 2013 Mar;62(3):998.

41.

Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers.

Al-Shabrawey M, Smith S.

EPMA J. 2010 Mar;1(1):56-72. doi: 10.1007/s13167-010-0002-9. Epub 2010 Mar 23.

42.

Exogenous expression of caspase-14 induces tumor suppression in human salivary cancer cells by inhibiting tumor vascularization.

Wu M, Kodani I, Dickinson D, Huff F, Ogbureke KU, Qin H, Arun S, Dulebohn R, Al-Shabrawey M, Tawfik A, Prater S, Lewis J, Wataha J, Messer R, Hsu S.

Anticancer Res. 2009 Oct;29(10):3811-8.

43.

Role of IL-6 in angiotensin II-induced retinal vascular inflammation.

Rojas M, Zhang W, Lee DL, Romero MJ, Nguyen DT, Al-Shabrawey M, Tsai NT, Liou GI, Brands MW, Caldwell RW, Caldwell RB.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1709-18. doi: 10.1167/iovs.09-3375. Epub 2009 Oct 15.

44.

Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy.

Abdelsaid MA, Pillai BA, Matragoon S, Prakash R, Al-Shabrawey M, El-Remessy AB.

J Pharmacol Exp Ther. 2010 Jan;332(1):125-34. doi: 10.1124/jpet.109.157941. Epub 2009 Oct 8.

PMID:
19815813
45.

HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy.

Bartoli M, Al-Shabrawey M, Labazi M, Behzadian MA, Istanboli M, El-Remessy AB, Caldwell RW, Marcus DM, Caldwell RB.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4934-40. doi: 10.1167/iovs.08-2158. Epub 2008 Dec 20.

46.

Suppression of retinal peroxisome proliferator-activated receptor gamma in experimental diabetes and oxygen-induced retinopathy: role of NADPH oxidase.

Tawfik A, Sanders T, Kahook K, Akeel S, Elmarakby A, Al-Shabrawey M.

Invest Ophthalmol Vis Sci. 2009 Feb;50(2):878-84. doi: 10.1167/iovs.08-2005. Epub 2008 Sep 20.

PMID:
18806296
47.

Role of NADPH oxidase in retinal vascular inflammation.

Al-Shabrawey M, Rojas M, Sanders T, Behzadian A, El-Remessy A, Bartoli M, Parpia AK, Liou G, Caldwell RB.

Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3239-44. doi: 10.1167/iovs.08-1755. Epub 2008 Mar 31.

48.

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.

Al-Shabrawey M, Bartoli M, El-Remessy AB, Ma G, Matragoon S, Lemtalsi T, Caldwell RW, Caldwell RB.

Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3231-8. doi: 10.1167/iovs.08-1754. Epub 2008 Mar 31.

49.

Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells.

El-Remessy AB, Al-Shabrawey M, Platt DH, Bartoli M, Behzadian MA, Ghaly N, Tsai N, Motamed K, Caldwell RB.

FASEB J. 2007 Aug;21(10):2528-39. Epub 2007 Mar 23. Retraction in: FASEB J. 2017 Jan;31(1):421.

PMID:
17384142
50.

Protection against myocardial ischemia/reperfusion injury by short-term diabetes: enhancement of VEGF formation, capillary density, and activation of cell survival signaling.

Ma G, Al-Shabrawey M, Johnson JA, Datar R, Tawfik HE, Guo D, Caldwell RB, Caldwell RW.

Naunyn Schmiedebergs Arch Pharmacol. 2006 Sep;373(6):415-27. Epub 2006 Sep 6.

PMID:
16955284

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