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Items: 28


"Methotrexate and NSAIDs in rheumatoid arthritis-Confirmation of a known NSAIDs adverse effect rather than a dangerous combination".

Al-Khalili O, Mikuls TR, O'Dell JR, England BR.

Pharmacoepidemiol Drug Saf. 2018 Dec;27(12):1429. doi: 10.1002/pds.4670. Epub 2018 Nov 13. No abstract available.


IgG-4 Related Disease: An Introduction.

Al-Khalili OM, Erickson AR.

Mo Med. 2018 May-Jun;115(3):253-256. Review.


Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport.

Zou L, Linck V, Zhai YJ, Galarza-Paez L, Li L, Yue Q, Al-Khalili O, Bao HF, Ma HP, Thai TL, Jiao J, Eaton DC.

J Biol Chem. 2018 Feb 2;293(5):1666-1675. doi: 10.1074/jbc.M117.798645. Epub 2017 Nov 27.


Aldosterone Modulates the Association between NCC and ENaC.

Wynne BM, Mistry AC, Al-Khalili O, Mallick R, Theilig F, Eaton DC, Hoover RS.

Sci Rep. 2017 Jun 23;7(1):4149. doi: 10.1038/s41598-017-03510-5.


ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins.

Montgomery DS, Yu L, Ghazi ZM, Thai TL, Al-Khalili O, Ma HP, Eaton DC, Alli AA.

Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C42-C53. doi: 10.1152/ajpcell.00244.2016. Epub 2017 May 3.


Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC.

Trac PT, Thai TL, Linck V, Zou L, Greenlee M, Yue Q, Al-Khalili O, Alli AA, Eaton AF, Eaton DC.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L797-L811. doi: 10.1152/ajplung.00379.2016. Epub 2017 Mar 10.


The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.

Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I.

J Biol Chem. 2016 Nov 4;291(45):23440-23451. Epub 2016 Sep 19.


The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate.

Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS.

Biochem J. 2016 Oct 1;473(19):3237-52. doi: 10.1042/BCJ20160312. Epub 2016 Jul 15.


The Polarized Effect of Intracellular Calcium on the Renal Epithelial Sodium Channel Occurs as a Result of Subcellular Calcium Signaling Domains Maintained by Mitochondria.

Thai TL, Yu L, Galarza-Paez L, Wu MM, Lam HY, Bao HF, Duke BJ, Al-Khalili O, Ma HP, Liu B, Eaton DC.

J Biol Chem. 2015 Nov 27;290(48):28805-11. doi: 10.1074/jbc.M115.668293. Epub 2015 Oct 8.


A new approach for decreasing the detection limit for a ketamine(I) ion-selective electrode.

Abu Shawish HM, Tamous H, Saadeh SM, Abed-Almonem KI, Al Khalili O.

Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:445-451. doi: 10.1016/j.msec.2015.01.010. Epub 2015 Jan 6.


Prolactin stimulates sodium and chloride ion channels in A6 renal epithelial cells.

Greenlee MM, Mitzelfelt JD, Duke BJ, Al-Khalili O, Bao HF, Eaton DC.

Am J Physiol Renal Physiol. 2015 Apr 1;308(7):F697-705. doi: 10.1152/ajprenal.00270.2014. Epub 2015 Jan 13.


Basolateral P2X₄channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells.

Thai TL, Yu L, Eaton DC, Duke BJ, Al-Khalili O, Lam HY, Ma H, Bao HF.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F806-13. doi: 10.1152/ajprenal.00350.2013. Epub 2014 Aug 6.


The inhibitory effect of Gβγ and Gβ isoform specificity on ENaC activity.

Yu L, Al-Khalili O, Duke BJ, Stockand JD, Eaton DC, Bao HF.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1365-73. doi: 10.1152/ajprenal.00009.2013. Epub 2013 Jul 17.


WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.

Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF, Eaton DC.

Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F31-41. doi: 10.1152/ajprenal.00652.2012. Epub 2013 Apr 17.


Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein.

Alli AA, Bao HF, Alli AA, Aldrugh Y, Song JZ, Ma HP, Yu L, Al-Khalili O, Eaton DC.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F800-11. doi: 10.1152/ajprenal.00703.2011. Epub 2012 Jul 11.


Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity.

Alli AA, Song JZ, Al-Khalili O, Bao HF, Ma HP, Alli AA, Eaton DC.

J Biol Chem. 2012 Aug 31;287(36):30073-83. doi: 10.1074/jbc.M111.338574. Epub 2012 Jul 10.


Protein-protein interaction between cPLA2 and splice variants of alpha-subunit of BK channels.

Li J, Al-Khalili O, Ramosevac S, Eaton DC, Denson DD.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C251-62. doi: 10.1152/ajpcell.00221.2009. Epub 2009 Nov 25.


Oxidative signaling in renal epithelium: Critical role of cytosolic phospholipase A2 and p38(SAPK).

Cui XL, Ding Y, Alexander LD, Bao C, Al-Khalili OK, Simonson M, Eaton DC, Douglas JG.

Free Radic Biol Med. 2006 Jul 15;41(2):213-21. Epub 2006 Feb 28.


Phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (ENaC) and interacts with gamma-ENaC.

Helms MN, Liu L, Liang YY, Al-Khalili O, Vandewalle A, Saxena S, Eaton DC, Ma HP.

J Biol Chem. 2005 Dec 9;280(49):40885-91. Epub 2005 Oct 4.


Steroids and exogenous gamma-ENaC subunit modulate cation channels formed by alpha-ENaC in human B lymphocytes.

Ma HP, Al-Khalili O, Ramosevac S, Saxena S, Liang YY, Warnock DG, Eaton DC.

J Biol Chem. 2004 Aug 6;279(32):33206-12. Epub 2004 Jun 8.


Phosphatase inhibitors increase the open probability of ENaC in A6 cells.

Becchetti A, Malik B, Yue G, Duchatelle P, Al-Khalili O, Kleyman TR, Eaton DC.

Am J Physiol Renal Physiol. 2002 Nov;283(5):F1030-45.


Cloning of the proto-oncogene c-src from rat testis.

Al-Khalili O, Duke BJ, Zeltwanger S, Eaton DC, Spier B, Stockand JD.

DNA Seq. 2001 Dec;12(5-6):425-9.


Mechanisms of aldosterone's action on epithelial Na + transport.

Eaton DC, Malik B, Saxena NC, Al-Khalili OK, Yue G.

J Membr Biol. 2001 Dec 1;184(3):313-9. Epub 2002 Feb 5. Review.


Enac degradation in A6 cells by the ubiquitin-proteosome proteolytic pathway.

Malik B, Schlanger L, Al-Khalili O, Bao HF, Yue G, Price SR, Mitch WE, Eaton DC.

J Biol Chem. 2001 Apr 20;276(16):12903-10. Epub 2001 Jan 26.


Aldosterone induces ras methylation in A6 epithelia.

Al-Baldawi NF, Stockand JD, Al-Khalili OK, Yue G, Eaton DC.

Am J Physiol Cell Physiol. 2000 Aug;279(2):C429-39.


Isoprenylcysteine-O-carboxyl methyltransferase regulates aldosterone-sensitive Na(+) reabsorption.

Stockand JD, Edinger RS, Al-Baldawi N, Sariban-Sohraby S, Al-Khalili O, Eaton DC, Johnson JP.

J Biol Chem. 1999 Sep 17;274(38):26912-6.


Antisense oligonucleotides against the alpha-subunit of ENaC decrease lung epithelial cation-channel activity.

Jain L, Chen XJ, Malik B, Al-Khalili O, Eaton DC.

Am J Physiol. 1999 Jun;276(6):L1046-51. doi: 10.1152/ajplung.1999.276.6.L1046.


S-adenosyl-L-homocysteine hydrolase regulates aldosterone-induced Na+ transport.

Stockand JD, Al-Baldawi NF, Al-Khalili OK, Worrell RT, Eaton DC.

J Biol Chem. 1999 Feb 5;274(6):3842-50.

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