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Items: 22

1.

Senescent breast luminal cells promote carcinogenesis through IL-8-dependent activation of stromal fibroblasts.

Al-Khalaf HH, Ghebeh H, Inass R, Aboussekhra A.

Mol Cell Biol. 2018 Nov 5. pii: MCB.00359-18. doi: 10.1128/MCB.00359-18. [Epub ahead of print]

PMID:
30397077
2.

IL-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenic and Tumorigenic Promoting Effects.

Al-Khalaf HH, Al-Harbi B, Al-Sayed A, Arafah M, Tulbah A, Jarman A, Al-Mohanna F, Aboussekhra A.

Mol Cell Biol. 2018 Nov 5. pii: MCB.00332-18. doi: 10.1128/MCB.00332-18. [Epub ahead of print]

PMID:
30397072
3.

p16 Controls p53 Protein Expression Through miR-dependent Destabilization of MDM2.

Al-Khalaf HH, Aboussekhra A.

Mol Cancer Res. 2018 Aug;16(8):1299-1308. doi: 10.1158/1541-7786.MCR-18-0017. Epub 2018 May 8.

PMID:
29739873
4.

Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity.

Al-Khalaf HH, Amir M, Al-Mohanna F, Tulbah A, Al-Sayed A, Aboussekhra A.

Mol Cell Biol. 2017 Aug 11;37(17). pii: e00101-17. doi: 10.1128/MCB.00101-17. Print 2017 Sep 1.

5.

p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction.

Al-Khalaf HH, Nallar SC, Kalvakolanu DV, Aboussekhra A.

Mol Carcinog. 2017 Jul;56(7):1687-1702. doi: 10.1002/mc.22627. Epub 2017 Mar 6.

PMID:
28218424
6.

p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1.

Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2017 Mar;56(3):985-999. doi: 10.1002/mc.22564. Epub 2016 Sep 21.

PMID:
27596953
7.

PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells.

Al-Howail HA, Hakami HA, Al-Otaibi B, Al-Mazrou A, Daghestani MH, Al-Jammaz I, Al-Khalaf HH, Aboussekhra A.

BMC Cancer. 2016 Jul 27;16:540. doi: 10.1186/s12885-016-2583-8.

8.

TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.

Zou M, Baitei EY, Al-Rijjal RA, Parhar RS, Al-Mohanna FA, Kimura S, Pritchard C, Binessa HA, Alzahrani AS, Al-Khalaf HH, Hawwari A, Akhtar M, Assiri AM, Meyer BF, Shi Y.

Oncogene. 2016 Apr 14;35(15):1909-18. doi: 10.1038/onc.2015.253. Epub 2015 Oct 19.

PMID:
26477313
9.

PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.

Al-Qasem A, Al-Howail HA, Al-Swailem M, Al-Mazrou A, Al-Otaibi B, Al-Jammaz I, Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2016 Mar;55(3):233-44. doi: 10.1002/mc.22271. Epub 2015 Jan 16.

PMID:
25641341
10.
11.

The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1.

Hendrayani SF, Al-Khalaf HH, Aboussekhra A.

J Biol Chem. 2014 Nov 7;289(45):30962-76. doi: 10.1074/jbc.M114.594044. Epub 2014 Sep 17.

12.
13.

p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.

Al-Khalaf HH, Aboussekhra A.

PLoS One. 2013 Jul 23;8(7):e70133. doi: 10.1371/journal.pone.0070133. Print 2013.

14.

ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner.

Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2014 Dec;53(12):979-87. doi: 10.1002/mc.22066. Epub 2013 Jun 29.

PMID:
23813879
16.

Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress.

Al-Khalaf HH, Aboussekhra A.

Age (Dordr). 2013 Jun;35(3):549-62. doi: 10.1007/s11357-011-9378-2. Epub 2012 Jan 15.

17.

ATR controls the p21(WAF1/Cip1) protein up-regulation and apoptosis in response to low UV fluences.

Al-Khalaf HH, Hendrayani SF, Aboussekhra A.

Mol Carcinog. 2012 Dec;51(12):930-8. doi: 10.1002/mc.20864. Epub 2011 Oct 4.

PMID:
21976111
18.

p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.

Al-Khalaf HH, Colak D, Al-Saif M, Al-Bakheet A, Hendrayani SF, Al-Yousef N, Kaya N, Khabar KS, Aboussekhra A.

PLoS One. 2011;6(7):e21111. doi: 10.1371/journal.pone.0021111. Epub 2011 Jul 20.

19.

The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation.

Al-Khalaf HH, Hendrayani SF, Aboussekhra A.

Mol Cancer Res. 2011 Mar;9(3):311-9. doi: 10.1158/1541-7786.MCR-10-0506. Epub 2011 Jan 26.

20.

Expression of survivin and p16(INK4a)/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells.

Al-Khalaf HH, Lach B, Allam A, Hassounah M, Alkhani A, Elkum N, Alrokayan SA, Aboussekhra A.

Brain Res. 2008 Jan 10;1188:25-34. Epub 2007 Nov 4.

PMID:
18048012
21.

The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells.

Al-Khalaf HH, Lach B, Allam A, AlKhani A, Alrokayan SA, Aboussekhra A.

J Neurooncol. 2007 May;83(1):9-15. Epub 2007 Jan 24.

PMID:
17245624
22.

The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light.

Al-Mohanna MA, Al-Khalaf HH, Al-Yousef N, Aboussekhra A.

Nucleic Acids Res. 2007;35(1):223-33. Epub 2006 Dec 7.

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