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Items: 1 to 50 of 150

1.

Survival following rectal cancer surgery: does the age matter?

Al-Abed Y, Parker M, Arulampalam T, Tutton M.

Acta Chir Belg. 2018 Oct 9:1-7. doi: 10.1080/00015458.2018.1515395. [Epub ahead of print]

PMID:
30296927
2.

Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells.

Basile MS, Mazzon E, Krajnovic T, Draca D, Cavalli E, Al-Abed Y, Bramanti P, Nicoletti F, Mijatovic S, Maksimovic-Ivanic D.

Molecules. 2018 Sep 26;23(10). pii: E2463. doi: 10.3390/molecules23102463.

3.

Mechanistic Insights into High Mobility Group Box-1 (HMGb1) induced Toll-like Receptor 4 (TLR4) Dimer Formation.

Sun S, He M, VanPatten S, Al-Abed Y.

J Biomol Struct Dyn. 2018 Sep 21:1-30. doi: 10.1080/07391102.2018.1526712. [Epub ahead of print]

PMID:
30238832
4.

Correction to: Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance.

He M, Bianchi ME, Coleman TR, Tracey KJ, Al-Abed Y.

Mol Med. 2018 Jun 13;24(1):31. doi: 10.1186/s10020-018-0030-9.

5.

Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance.

He M, Bianchi ME, Coleman TR, Tracey KJ, Al-Abed Y.

Mol Med. 2018 May 10;24(1):21. doi: 10.1186/s10020-018-0023-8. Erratum in: Mol Med. 2018 Jun 13;24(1):31.

6.

Contribution of the macrophage migration inhibitory factor superfamily of cytokines in the pathogenesis of preclinical and human multiple sclerosis: In silico and in vivo evidences.

Fagone P, Mazzon E, Cavalli E, Bramanti A, Petralia MC, Mangano K, Al-Abed Y, Bramati P, Nicoletti F.

J Neuroimmunol. 2018 Sep 15;322:46-56. doi: 10.1016/j.jneuroim.2018.06.009. Epub 2018 Jun 15.

7.

Folic acid derived-P5779 mimetics regulate DAMP-mediated inflammation through disruption of HMGB1:TLR4:MD-2 axes.

Sun S, He M, Wang Y, Yang H, Al-Abed Y.

PLoS One. 2018 Feb 15;13(2):e0193028. doi: 10.1371/journal.pone.0193028. eCollection 2018.

8.

Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases.

Li W, Bao G, Chen W, Qiang X, Zhu S, Wang S, He M, Ma G, Ochani M, Al-Abed Y, Yang H, Tracey KJ, Wang P, D'Angelo J, Wang H.

Sci Rep. 2018 Jan 9;8(1):166. doi: 10.1038/s41598-017-18452-1.

9.

High Mobility Group Box-1 (HMGb1): Current Wisdom and Advancement as a Potential Drug Target.

VanPatten S, Al-Abed Y.

J Med Chem. 2018 Jun 28;61(12):5093-5107. doi: 10.1021/acs.jmedchem.7b01136. Epub 2018 Jan 5.

10.

High mobility group box 1 orchestrates tissue regeneration via CXCR4.

Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME, Vénéreau E.

J Exp Med. 2018 Jan 2;215(1):303-318. doi: 10.1084/jem.20160217. Epub 2017 Dec 4.

11.

Activation of the cholinergic anti-inflammatory pathway by GTS-21 attenuates cisplatin-induced acute kidney injury in mice.

Chatterjee PK, Yeboah MM, Solanki MH, Kumar G, Xue X, Pavlov VA, Al-Abed Y, Metz CN.

PLoS One. 2017 Nov 30;12(11):e0188797. doi: 10.1371/journal.pone.0188797. eCollection 2017.

12.

A structural investigation of FISLE-412, a peptidomimetic compound derived from saquinavir that targets lupus autoantibodies.

He M, Cheng KF, VanPatten S, Bloom O, Diamond B, Al-Abed Y.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4725-4729. doi: 10.1016/j.bmcl.2017.08.070. Epub 2017 Sep 17.

PMID:
28927788
13.

β-Hydroxy-tetrahydroquinolines from Quinolines Using Chloroborane: Synthesis of the Peptidomimetic FISLE-412.

Altiti AS, Cheng KF, He M, Al-Abed Y.

Chemistry. 2017 Aug 10;23(45):10738-10743. doi: 10.1002/chem.201701944. Epub 2017 Jul 26.

14.

The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation.

Yang H, Wang H, Wang Y, Addorisio M, Li J, Postiglione MJ, Chavan SS, Al-Abed Y, Antoine DJ, Andersson U, Tracey KJ.

J Intern Med. 2017 Jul;282(1):76-93. doi: 10.1111/joim.12619. Epub 2017 May 31.

15.

Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.

Ahmed M, VanPatten S, Lakshminrusimha S, Patel H, Coleman TR, Al-Abed Y.

Physiol Rep. 2016 Dec;4(24). pii: e13069. doi: 10.14814/phy2.13069.

16.

The multi-target effects of CNI-1493: convergence of anti-amylodogenic and anti-inflammatory properties in animal models of Alzheimer's disease.

Sankowski R, Herring A, Keyvani K, Frenzel K, Wu J, Röskam S, Noelker C, Bacher M, Al-Abed Y.

Mol Med. 2016 Dec;22:776-788. doi: 10.2119/molmed.2016.00163. Epub 2016 Nov 15.

17.

C1q and HMGB1 reciprocally regulate human macrophage polarization.

Son M, Porat A, He M, Suurmond J, Santiago-Schwarz F, Andersson U, Coleman TR, Volpe BT, Tracey KJ, Al-Abed Y, Diamond B.

Blood. 2016 Nov 3;128(18):2218-2228. Epub 2016 Sep 28.

18.

MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development.

Bloom J, Sun S, Al-Abed Y.

Expert Opin Ther Targets. 2016 Dec;20(12):1463-1475. Epub 2016 Nov 1. Review.

PMID:
27762152
19.

Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential.

Bloom J, Metz C, Nalawade S, Casabar J, Cheng KF, He M, Sherry B, Coleman T, Forsthuber T, Al-Abed Y.

J Biol Chem. 2016 Dec 16;291(51):26502-26514. Epub 2016 Oct 28.

20.

The challenges of modulating the 'rest and digest' system: acetylcholine receptors as drug targets.

VanPatten S, Al-Abed Y.

Drug Discov Today. 2017 Jan;22(1):97-104. doi: 10.1016/j.drudis.2016.09.011. Epub 2016 Sep 22. Review.

PMID:
27666193
21.

Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies.

VanPatten S, Sun S, He M, Cheng KF, Altiti A, Papatheodorou A, Kowal C, Jeganathan V, Crawford JM, Bloom O, Volpe BT, Grant C, Meurice N, Coleman TR, Diamond B, Al-Abed Y.

J Med Chem. 2016 Oct 13;59(19):8859-8867. Epub 2016 Sep 20.

22.

Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice.

Hudson LK, Dancho ME, Li J, Bruchfeld JB, Ragab AA, He MM, Bragg M, Lenaghan D, Quinn MD, Fritz JR, Tanzi MV, Silverman HA, Hanes WM, Levine YA, Pavlov VA, Olofsson PS, Roth J, Al-Abed Y, Andersson U, Tracey KJ, Chavan SS.

Mol Med. 2016 Oct;22:585-596. doi: 10.2119/molmed.2016.00082. Epub 2016 Jun 10.

23.

Chronic biliary colic associated with ketamine abuse.

Al-Nowfal A, Al-Abed YA.

Int Med Case Rep J. 2016 Jun 2;9:135-7. doi: 10.2147/IMCRJ.S100648. eCollection 2016.

24.

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, Zhu S, Li W, Li J, de Kleijn DP, Olofsson PS, Warren HS, He M, Al-Abed Y, Roth J, Antoine DJ, Chavan SS, Andersson U, Tracey KJ.

JCI Insight. 2016;1(7). pii: e85375. Epub 2016 May 19.

25.

Safety and Efficacy of Permacol Injection in the Treatment of Fecal Incontinence.

Al-Abed YA, Ayers J, Ayantunde A, Praveen BV.

Ann Coloproctol. 2016 Apr;32(2):73-8. doi: 10.3393/ac.2016.32.2.73. Epub 2016 Apr 30.

26.

Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma.

Markowitz D, Powell C, Tran NL, Berens ME, Ryken TC, Vanan M, Rosen L, He M, Sun S, Symons M, Al-Abed Y, Ruggieri R.

Mol Cancer Ther. 2016 Aug;15(8):1799-808. doi: 10.1158/1535-7163.MCT-15-0849. Epub 2016 May 20.

27.

Novel strategies for targeting innate immune responses to influenza.

Shirey KA, Lai W, Patel MC, Pletneva LM, Pang C, Kurt-Jones E, Lipsky M, Roger T, Calandra T, Tracey KJ, Al-Abed Y, Bowie AG, Fasano A, Dinarello CA, Gusovsky F, Blanco JC, Vogel SN.

Mucosal Immunol. 2016 Sep;9(5):1173-82. doi: 10.1038/mi.2015.141. Epub 2016 Jan 27.

28.

Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.

Cai J, Zhong H, Wu J, Chen RF, Yang H, Al-Abed Y, Li Y, Li X, Jiang W, Montenegro MF, Yuan H, Billiar T, Chen AF.

Mol Med. 2017 Jun;23:92-100. doi: 10.2119/molmed.2016.00222. Epub 2016 Mar 20.

29.

The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation.

Hesketh AJ, Maloney C, Behr CA, Edelman MC, Glick RD, Al-Abed Y, Symons M, Soffer SZ, Steinberg BM.

PLoS One. 2015 Dec 28;10(12):e0145197. doi: 10.1371/journal.pone.0145197. eCollection 2015.

30.

Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors.

Dulmovits BM, Appiah-Kubi AO, Papoin J, Hale J, He M, Al-Abed Y, Didier S, Gould M, Husain-Krautter S, Singh SA, Chan KW, Vlachos A, Allen SL, Taylor N, Marambaud P, An X, Gallagher PG, Mohandas N, Lipton JM, Liu JM, Blanc L.

Blood. 2016 Mar 17;127(11):1481-92. doi: 10.1182/blood-2015-09-667923. Epub 2015 Dec 17.

31.

HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4.

Cai J, Yuan H, Wang Q, Yang H, Al-Abed Y, Hua Z, Wang J, Chen D, Wu J, Lu B, Pribis JP, Jiang W, Yang K, Hackam DJ, Tracey KJ, Billiar TR, Chen AF.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2579-93. doi: 10.1161/ATVBAHA.115.305789. Epub 2015 Oct 29.

32.

Cholinergic anti-inflammatory pathway activity in dialysis patients: a role for neuroimmunomodulation?

Hilderman M, Qureshi AR, Al-Abed Y, Abtahi F, Lindecrantz K, Anderstam B, Bruchfeld A.

Clin Kidney J. 2015 Oct;8(5):599-605. doi: 10.1093/ckj/sfv074. Epub 2015 Aug 25.

33.

The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88.

Pribis JP, Al-Abed Y, Yang H, Gero D, Xu H, Montenegro MF, Bauer EM, Kim S, Chavan SS, Cai C, Li T, Szoleczky P, Szabo C, Tracey KJ, Billiar TR.

Mol Med. 2015 Dec;21(1):749-757. doi: 10.2119/molmed.2015.00197. Epub 2015 Sep 2.

34.

Effects of NO-Hybridization on the Immunomodulatory Properties of the HIV Protease Inhibitors Lopinavir and Ritonavir.

Fagone P, Mangano K, Quattrocchi C, Cavalli E, Mammana S, Lombardo GA, Pennisi V, Zocca MB, He M, Al-Abed Y, Nicoletti F.

Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):306-15. doi: 10.1111/bcpt.12414. Epub 2015 May 25.

35.

Rodent models of neuroinflammation for Alzheimer's disease.

Nazem A, Sankowski R, Bacher M, Al-Abed Y.

J Neuroinflammation. 2015 Apr 17;12:74. doi: 10.1186/s12974-015-0291-y. Review.

36.

The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion.

Laragione T, Cheng KF, Tanner MR, He M, Beeton C, Al-Abed Y, Gulko PS.

Clin Immunol. 2015 Jun;158(2):183-92. doi: 10.1016/j.clim.2015.04.001. Epub 2015 Apr 11.

37.

MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.

Yang H, Wang H, Ju Z, Ragab AA, Lundbäck P, Long W, Valdes-Ferrer SI, He M, Pribis JP, Li J, Lu B, Gero D, Szabo C, Antoine DJ, Harris HE, Golenbock DT, Meng J, Roth J, Chavan SS, Andersson U, Billiar TR, Tracey KJ, Al-Abed Y.

J Exp Med. 2015 Jan 12;212(1):5-14. doi: 10.1084/jem.20141318. Epub 2015 Jan 5.

38.

Pharmacological inhibition of MIF interferes with trophoblast cell migration and invasiveness.

Jovanović Krivokuća M, Stefanoska I, Abu Rabi T, Al-Abed Y, Stošić-Grujičić S, Vićovac Lj.

Placenta. 2015 Feb;36(2):150-9. doi: 10.1016/j.placenta.2014.12.003. Epub 2014 Dec 15.

PMID:
25530499
39.

A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.

Kaku H, Cheng KF, Al-Abed Y, Rothstein TL.

J Immunol. 2014 Dec 15;193(12):5904-13. doi: 10.4049/jimmunol.1400336. Epub 2014 Nov 12.

40.

Diagnostic markers in acute appendicitis.

Al-Abed YA, Alobaid N, Myint F.

Am J Surg. 2015 Jun;209(6):1043-7. doi: 10.1016/j.amjsurg.2014.05.024. Epub 2014 Jul 29.

PMID:
25172166
41.

Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis.

Ju Z, Chavan SS, Antoine DJ, Dancho M, Tsaava T, Li J, Lu B, Levine YA, Stiegler A, Tamari Y, Al-Abed Y, Roth J, Tracey KJ, Yang H.

PLoS One. 2014 Aug 15;9(8):e103992. doi: 10.1371/journal.pone.0103992. eCollection 2014.

42.

Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation.

Rosas-Ballina M, Valdés-Ferrer SI, Dancho ME, Ochani M, Katz D, Cheng KF, Olofsson PS, Chavan SS, Al-Abed Y, Tracey KJ, Pavlov VA.

Brain Behav Immun. 2015 Feb;44:19-27. doi: 10.1016/j.bbi.2014.07.010. Epub 2014 Jul 23.

43.

ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.

Ioannou K, Cheng KF, Crichlow GV, Birmpilis AI, Lolis EJ, Tsitsilonis OE, Al-Abed Y.

Int J Oncol. 2014 Oct;45(4):1457-68. doi: 10.3892/ijo.2014.2551. Epub 2014 Jul 22.

44.

Novel inhibitors of macrophage migration inhibitory factor prevent cytokine-induced beta cell death.

Vujicic M, Nikolic I, Krajnovic T, Cheng KF, VanPatten S, He M, Stosic-Grujicic S, Stojanovic I, Al-Abed Y, Saksida T.

Eur J Pharmacol. 2014 Oct 5;740:683-9. doi: 10.1016/j.ejphar.2014.06.009. Epub 2014 Jun 23.

PMID:
24967533
45.

Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia.

Miller IS, Didier S, Murray DW, Turner TH, Issaivanan M, Ruggieri R, Al-Abed Y, Symons M.

PLoS One. 2014 May 9;9(5):e95885. doi: 10.1371/journal.pone.0095885. eCollection 2014.

46.

MIF: mood improving/inhibiting factor?

Bloom J, Al-Abed Y.

J Neuroinflammation. 2014 Jan 21;11:11. doi: 10.1186/1742-2094-11-11. Review.

47.

Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor.

He M, Metz C, Cheng KF, Ling J, Coleman T, VanPatten S, Al-Abed Y.

Arch Pharm (Weinheim). 2014 Feb;347(2):104-7. doi: 10.1002/ardp.201300243. Epub 2013 Nov 18.

PMID:
24243226
48.

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis.

Dhruv H, Loftus JC, Narang P, Petit JL, Fameree M, Burton J, Tchegho G, Chow D, Yin H, Al-Abed Y, Berens ME, Tran NL, Meurice N.

J Biol Chem. 2013 Nov 8;288(45):32261-76. doi: 10.1074/jbc.M113.493536. Epub 2013 Sep 20.

49.
50.

Identification of pharmacological modulators of HMGB1-induced inflammatory response by cell-based screening.

Gerö D, Szoleczky P, Módis K, Pribis JP, Al-Abed Y, Yang H, Chevan S, Billiar TR, Tracey KJ, Szabo C.

PLoS One. 2013 Jun 14;8(6):e65994. doi: 10.1371/journal.pone.0065994. Print 2013.

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