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Items: 13

1.

Lysine Ethylation by Histone Lysine Methyltransferases.

Al Temimi AHK, Martin M, Meng Q, Lenstra DC, Qian P, Guo H, Weinhold E, Mecinovic J.

Chembiochem. 2019 Jul 9. doi: 10.1002/cbic.201900359. [Epub ahead of print]

PMID:
31287209
2.

Importance of the main chain of lysine for histone lysine methyltransferase catalysis.

Al Temimi AHK, Teeuwen RS, Tran V, Altunc AJ, Lenstra DC, Ren W, Qian P, Guo H, Mecinović J.

Org Biomol Chem. 2019 Jun 12;17(23):5693-5697. doi: 10.1039/c9ob01038f.

PMID:
31134245
3.

γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones.

Al Temimi AHK, van der Wekken-de Bruijne R, Proietti G, Guo H, Qian P, Mecinović J.

Bioconjug Chem. 2019 Jun 19;30(6):1798-1804. doi: 10.1021/acs.bioconjchem.9b00313. Epub 2019 Jun 5.

PMID:
31117351
4.

Investigating the active site of human trimethyllysine hydroxylase.

Wang Y, Reddy YV, Al Temimi AHK, Venselaar H, Nelissen FHT, Lenstra DC, Mecinović J.

Biochem J. 2019 Apr 10;476(7):1109-1119. doi: 10.1042/BCJ20180857.

PMID:
30898847
5.

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation.

Pieters BJGE, Hintzen JCJ, Grobben Y, Al Temimi AHK, Kamps JJAG, Mecinović J.

Bioconjug Chem. 2019 Mar 20;30(3):952-958. doi: 10.1021/acs.bioconjchem.9b00065. Epub 2019 Mar 7.

PMID:
30794748
6.

LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2.

Wang H, Jiang D, Axelsson E, Lorković ZJ, Montgomery S, Holec S, Pieters BJGE, Al Temimi AHK, Mecinović J, Berger F.

Mol Plant. 2018 Aug 6;11(8):1038-1052. doi: 10.1016/j.molp.2018.05.004. Epub 2018 May 21.

7.

Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II).

Lenstra DC, Al Temimi AHK, Mecinović J.

Bioorg Med Chem Lett. 2018 Apr 15;28(7):1234-1238. doi: 10.1016/j.bmcl.2018.02.043. Epub 2018 Feb 24.

8.

Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins.

Al Temimi AHK, Belle R, Kumar K, Poater J, Betlem P, Pieters BJGE, Paton RS, Bickelhaupt FM, Mecinović J.

Chem Commun (Camb). 2018 Mar 7;54(19):2409-2412. doi: 10.1039/c8cc01009a. Epub 2018 Feb 19.

PMID:
29457186
9.

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

Belle R, Al Temimi AHK, Kumar K, Pieters BJGE, Tumber A, Dunford JE, Johansson C, Oppermann U, Brown T, Schofield CJ, Hopkinson RJ, Paton RS, Kawamura A, Mecinović J.

Chem Commun (Camb). 2017 Dec 12;53(99):13264-13267. doi: 10.1039/c7cc08028j.

10.

Peptide-Appended Permethylated β-Cyclodextrins with Hydrophilic and Hydrophobic Spacers.

Al Temimi AHK, Boltje TJ, Zollinger D, Rutjes FPJT, Feiters MC.

Bioconjug Chem. 2017 Aug 16;28(8):2160-2166. doi: 10.1021/acs.bioconjchem.7b00319. Epub 2017 Jul 26.

11.

Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis.

Vijayendar Reddy Y, Al Temimi AH, Mecinović J.

Org Biomol Chem. 2017 Feb 7;15(6):1350-1354. doi: 10.1039/c6ob02683d.

PMID:
28116387
12.

Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine.

Reddy YV, Al Temimi AH, White PB, Mecinović J.

Org Lett. 2017 Jan 20;19(2):400-403. doi: 10.1021/acs.orglett.6b03608. Epub 2017 Jan 3.

PMID:
28045275
13.

Substrate scope for trimethyllysine hydroxylase catalysis.

Al Temimi AH, Pieters BJ, Reddy YV, White PB, Mecinović J.

Chem Commun (Camb). 2016 Oct 25;52(87):12849-12852.

PMID:
27730239

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