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Items: 16


Loss-of-function of EBP50 is a new cause of hereditary peripheral neuropathy: EBP50 functions in peripheral nerve system.

Song GJ, Gupta DP, Rahman MH, Park HT, Al Ghouleh I, Bisello A, Lee MG, Park JY, Park HH, Jun JH, Chung KW, Choi BO, Suk K.

Glia. 2020 Feb 20. doi: 10.1002/glia.23805. [Epub ahead of print]


Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development.

Rafikova O, Al Ghouleh I, Rafikov R.

Antioxid Redox Signal. 2019 Nov 1;31(13):933-953. doi: 10.1089/ars.2018.7673. Epub 2019 Jul 2.


The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.

Meijles DN, Sahoo S, Al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.

Sci Signal. 2017 Oct 17;10(501). pii: eaaj1784. doi: 10.1126/scisignal.aaj1784.


CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL.

Csányi G, Feck DM, Ghoshal P, Singla B, Lin H, Nagarajan S, Meijles DN, Al Ghouleh I, Cantu-Medellin N, Kelley EE, Mateuszuk L, Isenberg JS, Watkins S, Pagano PJ.

Antioxid Redox Signal. 2017 Jun 1;26(16):886-901. doi: 10.1089/ars.2016.6834. Epub 2017 Jan 31.


Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype.

Al Ghouleh I, Meijles DN, Mutchler S, Zhang Q, Sahoo S, Gorelova A, Henrich Amaral J, Rodríguez AI, Mamonova T, Song GJ, Bisello A, Friedman PA, Cifuentes-Pagano ME, Pagano PJ.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5308-17. doi: 10.1073/pnas.1514161113. Epub 2016 Aug 18.


MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension.

Sahoo S, Meijles DN, Al Ghouleh I, Tandon M, Cifuentes-Pagano E, Sembrat J, Rojas M, Goncharova E, Pagano PJ.

PLoS One. 2016 May 4;11(5):e0153780. doi: 10.1371/journal.pone.0153780. eCollection 2016.


Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4.

Frazziano G, Al Ghouleh I, Baust J, Shiva S, Champion HC, Pagano PJ.

Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H197-205. doi: 10.1152/ajpheart.00977.2012. Epub 2013 Nov 8.


Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration.

Al Ghouleh I, Rodríguez A, Pagano PJ, Csányi G.

Int J Mol Sci. 2013 Oct 11;14(10):20220-35. doi: 10.3390/ijms141020220.


Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1.

Csányi G, Yao M, Rodríguez AI, Al Ghouleh I, Sharifi-Sanjani M, Frazziano G, Huang X, Kelley EE, Isenberg JS, Pagano PJ.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2966-73. doi: 10.1161/ATVBAHA.112.300031. Epub 2012 Oct 18.


Aquaporin 1, Nox1, and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy.

Al Ghouleh I, Frazziano G, Rodriguez AI, Csányi G, Maniar S, St Croix CM, Kelley EE, Egaña LA, Song GJ, Bisello A, Lee YJ, Pagano PJ.

Cardiovasc Res. 2013 Jan 1;97(1):134-42. doi: 10.1093/cvr/cvs295. Epub 2012 Sep 20.


Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.

Al Ghouleh I, Khoo NK, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, Pagano PJ.

Free Radic Biol Med. 2011 Oct 1;51(7):1271-88. doi: 10.1016/j.freeradbiomed.2011.06.011. Epub 2011 Jun 14. Review.


Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2.

Csányi G, Cifuentes-Pagano E, Al Ghouleh I, Ranayhossaini DJ, Egaña L, Lopes LR, Jackson HM, Kelley EE, Pagano PJ.

Free Radic Biol Med. 2011 Sep 15;51(6):1116-25. doi: 10.1016/j.freeradbiomed.2011.04.025. Epub 2011 Apr 17.


Endosomal ClC-3 and Nox1: moving marksmen of redox signaling?

Al Ghouleh I, Pagano PJ.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):240-2. doi: 10.1161/ATVBAHA.110.220053. No abstract available.


Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase.

Cascino T, Csanyi G, Al Ghouleh I, Montezano AC, Touyz RM, Haurani MJ, Pagano PJ.

Antioxid Redox Signal. 2011 Sep 15;15(6):1507-15. doi: 10.1089/ars.2010.3631. Epub 2011 Apr 8.


Nicotinamide adenine dinucleotide phosphate (reduced form) oxidase is important for LPS-induced endothelial cell activation.

Al Ghouleh I, Magder S.

Shock. 2008 May;29(5):553-9. doi: 10.1097/SHK.0b013e318157ebc8.


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