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Items: 1 to 50 of 439

1.

Engineering Photorhabdus luminescens toxin complex (PTC) into a recombinant injection nanomachine.

Ng Ang A PN, Ebner JK, Plessner M, Aktories K, Schmidt G.

Life Sci Alliance. 2019 Sep 20;2(5). pii: e201900485. doi: 10.26508/lsa.201900485. Print 2019 Oct.

2.

Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva.

Ebner JK, König GM, Kostenis E, Siegert P, Aktories K, Orth JHC.

Bone. 2019 Oct;127:592-601. doi: 10.1016/j.bone.2019.07.031. Epub 2019 Jul 31.

PMID:
31376533
3.

cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs.

Aktories K, Gierschik P, Heringdorf DMZ, Schmidt M, Schultz G, Wieland T.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392(8):887-911. doi: 10.1007/s00210-019-01650-1. Epub 2019 May 17. Review.

PMID:
31101932
4.

Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.

Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H.

FASEB J. 2019 Apr;33(4):5755-5771. doi: 10.1096/fj.201802453R. Epub 2019 Jan 30.

PMID:
30699302
5.

Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K.

FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28.

PMID:
30592645
6.

The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase.

Levanova N, Mattheis C, Carson D, To KN, Jank T, Frankel G, Aktories K, Schroeder GN.

J Biol Chem. 2019 Feb 22;294(8):2862-2879. doi: 10.1074/jbc.RA118.005952. Epub 2018 Dec 20.

7.

A cysteine protease-like domain enhances the cytotoxic effects of the Photorhabdus asymbiotica toxin PaTox.

Bogdanovic X, Schneider S, Levanova N, Wirth C, Trillhaase C, Steinemann M, Hunte C, Aktories K, Jank T.

J Biol Chem. 2019 Jan 18;294(3):1035-1044. doi: 10.1074/jbc.RA118.005043. Epub 2018 Nov 26.

PMID:
30478175
8.

Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells.

Ost GS, Ng'ang'a PN, Lang AE, Aktories K.

Cell Microbiol. 2019 Mar;21(3):e12978. doi: 10.1111/cmi.12978. Epub 2018 Dec 2.

PMID:
30431706
9.

Characterization of the glucosyltransferase activity of Legionella pneumophila effector SetA.

Levanova N, Steinemann M, Böhmer KE, Schneider S, Belyi Y, Schlosser A, Aktories K, Jank T.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Jan;392(1):69-79. doi: 10.1007/s00210-018-1562-9. Epub 2018 Sep 17.

PMID:
30225797
10.

The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B.

Steinemann M, Schlosser A, Jank T, Aktories K.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585. doi: 10.1073/pnas.1807658115. Epub 2018 Sep 4.

11.

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin.

Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C.

Nat Commun. 2018 Aug 30;9(1):3524. doi: 10.1038/s41467-018-05850-w.

12.

Involvement of Osteocytes in the Action of Pasteurella multocida Toxin.

Heni H, Ebner JK, Schmidt G, Aktories K, Orth JHC.

Toxins (Basel). 2018 Aug 13;10(8). pii: E328. doi: 10.3390/toxins10080328.

13.

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins.

Brink T, Leiss V, Siegert P, Jehle D, Ebner JK, Schwan C, Shymanets A, Wiese S, Nürnberg B, Hensel M, Aktories K, Orth JHC.

PLoS Pathog. 2018 Aug 13;14(8):e1007248. doi: 10.1371/journal.ppat.1007248. eCollection 2018 Aug.

14.

Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL.

Schorch B, Heni H, Zahaf NI, Brummer T, Mione M, Schmidt G, Papatheodorou P, Aktories K.

Oncotarget. 2018 Mar 27;9(23):16489-16500. doi: 10.18632/oncotarget.24740. eCollection 2018 Mar 27.

15.

Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton.

Aktories K, Papatheodorou P, Schwan C.

Anaerobe. 2018 Oct;53:21-29. doi: 10.1016/j.anaerobe.2018.03.001. Epub 2018 Mar 7. Review.

PMID:
29524654
16.

Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins.

Papatheodorou P, Barth H, Minton N, Aktories K.

Adv Exp Med Biol. 2018;1050:77-96. doi: 10.1007/978-3-319-72799-8_6. Review.

PMID:
29383665
17.

Specific role of RhoC in tumor invasion and metastasis.

Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K, Schmidt G.

Oncotarget. 2017 Sep 16;8(50):87364-87378. doi: 10.18632/oncotarget.20957. eCollection 2017 Oct 20.

18.

Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells.

Østevold K, Meléndez AV, Lehmann F, Schmidt G, Aktories K, Schwan C.

Oncotarget. 2017 Sep 11;8(44):76686-76698. doi: 10.18632/oncotarget.20805. eCollection 2017 Sep 29.

19.

Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.

Jank T, Belyi Y, Wirth C, Rospert S, Hu Z, Dengjel J, Tzivelekidis T, Andersen GR, Hunte C, Schlosser A, Aktories K.

J Biol Chem. 2017 Sep 29;292(39):16014-16023. doi: 10.1074/jbc.M117.801035. Epub 2017 Aug 11.

20.

Clostridium difficile Toxin Biology.

Aktories K, Schwan C, Jank T.

Annu Rev Microbiol. 2017 Sep 8;71:281-307. doi: 10.1146/annurev-micro-090816-093458. Epub 2017 Jun 28. Review.

PMID:
28657883
21.

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells.

Ernst K, Schmid J, Beck M, Hägele M, Hohwieler M, Hauff P, Ückert AK, Anastasia A, Fauler M, Jank T, Aktories K, Popoff MR, Schiene-Fischer C, Kleger A, Müller M, Frick M, Barth H.

Sci Rep. 2017 Jun 2;7(1):2724. doi: 10.1038/s41598-017-02882-y.

22.

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells.

Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, Carle S, Langer S, Tippel F, Buchner J, Fischer G, Hausch F, Frick M, Schwan C, Aktories K, Schiene-Fischer C, Barth H.

Sci Rep. 2017 Apr 4;7(1):613. doi: 10.1038/s41598-017-00780-x.

23.

Insecticidal Toxin Complexes from Photorhabdus luminescens.

Sheets J, Aktories K.

Curr Top Microbiol Immunol. 2017;402:3-23. doi: 10.1007/82_2016_55.

PMID:
28233068
24.

Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells.

Zahaf NI, Lang AE, Kaiser L, Fichter CD, Lassmann S, McCluskey A, Augspach A, Aktories K, Schmidt G.

Sci Rep. 2017 Jan 27;7:41252. doi: 10.1038/srep41252.

25.

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication.

Carle S, Brink T, Orth JH, Aktories K, Barth H.

Toxins (Basel). 2017 Jan 13;9(1). pii: E32. doi: 10.3390/toxins9010032.

26.

Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins.

Papatheodorou P, Aktories K.

Curr Top Microbiol Immunol. 2017;406:119-133. doi: 10.1007/82_2016_46. Review.

PMID:
27817176
28.

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia.

Cowardin CA, Buonomo EL, Saleh MM, Wilson MG, Burgess SL, Kuehne SA, Schwan C, Eichhoff AM, Koch-Nolte F, Lyras D, Aktories K, Minton NP, Petri WA Jr.

Nat Microbiol. 2016 Jul 11;1(8):16108. doi: 10.1038/nmicrobiol.2016.108.

29.

Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells.

Czulkies BA, Mastroianni J, Lutz L, Lang S, Schwan C, Schmidt G, Lassmann S, Zeiser R, Aktories K, Papatheodorou P.

Oncotarget. 2017 Jun 6;8(23):37009-37022. doi: 10.18632/oncotarget.10425.

30.

Actin ADP-ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F-actin.

Lang AE, Qu Z, Schwan C, Silvan U, Unger A, Schoenenberger CA, Aktories K, Mannherz HG.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12636. Epub 2016 Jul 15.

PMID:
27341322
31.

Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT).

Nölke T, Schwan C, Lehmann F, Østevold K, Pertz O, Aktories K.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7870-5. doi: 10.1073/pnas.1522717113. Epub 2016 Jun 23.

32.

ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins.

Aktories K, Schwan C, Lang AE.

Handb Exp Pharmacol. 2017;235:179-206. doi: 10.1007/164_2016_26. Review.

PMID:
27316913
33.

Preface for Anaerobe - Special issue on Clostpath9.

Papatheodorou P, Aktories K.

Anaerobe. 2016 Oct;41:1. doi: 10.1016/j.anaerobe.2016.04.008. Epub 2016 Apr 11. No abstract available.

PMID:
27079796
34.

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin.

Schnell L, Mittler AK, Sadi M, Popoff MR, Schwan C, Aktories K, Mattarei A, Azarnia Tehran D, Montecucco C, Barth H.

Toxins (Basel). 2016 Apr 1;8(4):101. doi: 10.3390/toxins8040101.

35.

Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin.

Belyy A, Tabakova I, Lang AE, Jank T, Belyi Y, Aktories K.

PLoS One. 2015 Dec 29;10(12):e0145708. doi: 10.1371/journal.pone.0145708. eCollection 2015.

36.

Rho-modifying bacterial protein toxins.

Aktories K.

Pathog Dis. 2015 Dec;73(9):ftv091. doi: 10.1093/femspd/ftv091. Epub 2015 Oct 9. Review.

PMID:
26454272
37.

Bacterial glycosyltransferase toxins.

Jank T, Belyi Y, Aktories K.

Cell Microbiol. 2015 Dec;17(12):1752-65. doi: 10.1111/cmi.12533. Epub 2015 Nov 4. Review.

PMID:
26445410
38.

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.

Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L.

Circ Res. 2015 Sep 11;117(7):622-33. doi: 10.1161/CIRCRESAHA.115.306721. Epub 2015 Jul 20.

39.

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.

Jank T, Eckerle S, Steinemann M, Trillhaase C, Schimpl M, Wiese S, van Aalten DM, Driever W, Aktories K.

Nat Commun. 2015 Jul 20;6:7807. doi: 10.1038/ncomms8807.

40.

Rho-modifying bacterial protein toxins from Photorhabdus species.

Jank T, Lang AE, Aktories K.

Toxicon. 2016 Jun 15;116:17-22. doi: 10.1016/j.toxicon.2015.05.017. Epub 2015 May 28.

PMID:
26026623
41.

Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR).

Hemmasi S, Czulkies BA, Schorch B, Veit A, Aktories K, Papatheodorou P.

J Biol Chem. 2015 May 29;290(22):14031-44. doi: 10.1074/jbc.M115.650523. Epub 2015 Apr 16.

42.

Intracellular plasma membrane guidance of Photorhabdus asymbiotica toxin is crucial for cell toxicity.

Jank T, Trillhaase C, Brozda N, Steinemann M, Schwan C, Süss R, Aktories K.

FASEB J. 2015 Jul;29(7):2789-802. doi: 10.1096/fj.14-269381. Epub 2015 Mar 17.

PMID:
25782990
43.

A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice.

Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JH.

Cell Microbiol. 2015 Sep;17(9):1320-31. doi: 10.1111/cmi.12436. Epub 2015 Mar 30.

PMID:
25759205
44.

Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.

Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA.

J Biol Chem. 2015 Apr 10;290(15):9363-76. doi: 10.1074/jbc.M114.575217. Epub 2015 Feb 9.

45.

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT.

Unger M, Eichhoff AM, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker HW, Goldbaum F, Aktories K, Koch-Nolte F.

Sci Rep. 2015 Jan 19;5:7850. doi: 10.1038/srep07850.

46.

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation.

Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G.

Nat Commun. 2014 Dec 19;5:5887. doi: 10.1038/ncomms6887.

47.

Novel receptors for bacterial protein toxins.

Schmidt G, Papatheodorou P, Aktories K.

Curr Opin Microbiol. 2015 Feb;23:55-61. doi: 10.1016/j.mib.2014.11.003. Epub 2014 Nov 22. Review.

PMID:
25461573
48.

Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin.

Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth JH.

MBio. 2014 Nov 11;5(6):e02190. doi: 10.1128/mBio.02190-14.

49.

The actin and Rho-modifying toxins PTC3 and PTC5 of Photorhabdus luminescens: enzyme characterization and induction of MAL/SRF-dependent transcription.

Pfaumann V, Lang AE, Schwan C, Schmidt G, Aktories K.

Cell Microbiol. 2015 Apr;17(4):579-94. doi: 10.1111/cmi.12386. Epub 2014 Nov 22.

PMID:
25338512
50.

Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins.

Ernst K, Langer S, Kaiser E, Osseforth C, Michaelis J, Popoff MR, Schwan C, Aktories K, Kahlert V, Malesevic M, Schiene-Fischer C, Barth H.

J Mol Biol. 2015 Mar 27;427(6 Pt A):1224-38. doi: 10.1016/j.jmb.2014.07.013. Epub 2014 Jul 21.

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