Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1987 1
1988 1
1990 1
1992 1
1993 2
1994 3
1995 5
1996 8
1997 27
1998 58
1999 115
2000 229
2001 403
2002 542
2003 681
2004 832
2005 711
2006 167
2007 215
2008 270
2009 304
2010 323
2011 338
2012 408
2013 454
2014 476
2015 502
2016 494
2017 481
2018 492
2019 631
2020 772
2021 834
2022 848
2023 844
2024 339

Text availability

Article attribute

Article type

Publication date

Search Results

11,520 results

Results by year

Filters applied: . Clear all
Page 1
Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer.
Tian X, Wang R, Gu T, Ma F, Laster KV, Li X, Liu K, Lee MH, Dong Z. Tian X, et al. Mol Cancer. 2022 Oct 6;21(1):193. doi: 10.1186/s12943-022-01662-1. Mol Cancer. 2022. PMID: 36203195 Free PMC article.
Likewise, EGFR inhibition by osimertinib induced activation of MEK1 and AKT1/2, which weakened osimertinib sensitivity in NSCLC cells. Consequently, this study aimed to identify a novel inhibitor which could suppress resistant cell growth by dual targeting of MEK1 and A …
Likewise, EGFR inhibition by osimertinib induced activation of MEK1 and AKT1/2, which weakened osimertinib sensitivity in NSCLC cells …
DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer.
Zhang Y, Kong R, Yang W, Hu K, Zhao Z, Li L, Geng X, Liu L, Chen H, Xiao P, Liu D, Luo Y, Chen H, Hu J, Sun B. Zhang Y, et al. Cancer Lett. 2023 Aug 1;568:216288. doi: 10.1016/j.canlet.2023.216288. Epub 2023 Jun 29. Cancer Lett. 2023. PMID: 37390887
DUSP2 significantly promoted apoptosis in PDAC both in vitro and in vivo, mainly through AKT1 rather than ERK1/2. Mechanistically, DUSP2 competed with AKT1 to bind to casein kinase 2 alpha 1 (CSNK2A1) and inhibited the phosphorylation of AKT1, which plays a c …
DUSP2 significantly promoted apoptosis in PDAC both in vitro and in vivo, mainly through AKT1 rather than ERK1/2. Mechanistically, DU …
AKT1 Transcriptomic Landscape in Breast Cancer Cells.
George B, Gui B, Raguraman R, Paul AM, Nakshatri H, Pillai MR, Kumar R. George B, et al. Cells. 2022 Jul 25;11(15):2290. doi: 10.3390/cells11152290. Cells. 2022. PMID: 35892586 Free PMC article.
We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, in turn, imply resulting AKT1 cellular functions. ...We found that depletion of AKT1 leads to upregulation of a subset of genes- …
We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, in …
Akt1-dependent expression of angiopoietin 1 and 2 in vascular smooth muscle cells leads to vascular stabilization.
Ha JM, Jin SY, Lee HS, Kum HJ, Vafaeinik F, Ha HK, Song SH, Kim CD, Bae SS. Ha JM, et al. Exp Mol Med. 2022 Aug;54(8):1133-1145. doi: 10.1038/s12276-022-00819-8. Epub 2022 Aug 5. Exp Mol Med. 2022. PMID: 35931736 Free PMC article.
Retinal angiogenesis was delayed in VSMC-specific Akt1-deficient mice (Akt1(SMC)) but not in Akt2(SMC) mice. The proliferation of ECs, recruitment of pericytes, and coverage of VSMCs to the endothelium were defective in Akt1(SMC). ...The activation of Notch3 …
Retinal angiogenesis was delayed in VSMC-specific Akt1-deficient mice (Akt1(SMC)) but not in Akt2(SMC) mice. The proliferation …
miRNA-Dependent Regulation of AKT1 Phosphorylation.
Frederick MI, Siddika T, Zhang P, Balasuriya N, Turk MA, O'Donoghue P, Heinemann IU. Frederick MI, et al. Cells. 2022 Feb 26;11(5):821. doi: 10.3390/cells11050821. Cells. 2022. PMID: 35269443 Free PMC article.
We then used mechanistic studies to investigate the impact of let-7 miRNAs on AKT1 phosphorylation status and activity in cells. In growth factor-stimulated HEK 293T cells supplemented with let-7a, we found increased phosphorylation of AKT1 at T308, decreased phosph …
We then used mechanistic studies to investigate the impact of let-7 miRNAs on AKT1 phosphorylation status and activity in cells. In g …
AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer.
Shi Z, Yuan H, Cao L, Lin Y. Shi Z, et al. Biochem Cell Biol. 2023 Oct 1;101(5):422-431. doi: 10.1139/bcb-2022-0361. Epub 2023 Apr 3. Biochem Cell Biol. 2023. PMID: 37011414
DDP-resistant ovarian cancer cells maintain a high level of autophagy to escape the pressure of chemotherapy, which ultimately leads to increased autophagic degradation of FTH1. We further revealed that the loss of AKT1 was the reason for the increased autophagy level of D …
DDP-resistant ovarian cancer cells maintain a high level of autophagy to escape the pressure of chemotherapy, which ultimately leads to incr …
Delivery of Active AKT1 to Human Cells.
Siddika T, Balasuriya N, Frederick MI, Rozik P, Heinemann IU, O'Donoghue P. Siddika T, et al. Cells. 2022 Nov 29;11(23):3834. doi: 10.3390/cells11233834. Cells. 2022. PMID: 36497091 Free PMC article.
To produce cells with specific AKT1 activity, we developed a novel system to deliver active AKT1 to human cells. ...The data demonstrate efficient delivery of AKT1 with programmed phosphorylation to human cells, thus establishing a cell-based model system to …
To produce cells with specific AKT1 activity, we developed a novel system to deliver active AKT1 to human cells. ...The data d …
AKT1 is positively regulated by G-quadruplexes in its promoter and 3'-UTR.
Zhang L, Yan T, Wang W, Wu Q, Li G, Li D, Stovall DB, Wang Y, Li Y, Sui G. Zhang L, et al. Biochem Biophys Res Commun. 2021 Jul 5;561:93-100. doi: 10.1016/j.bbrc.2021.05.029. Epub 2021 May 18. Biochem Biophys Res Commun. 2021. PMID: 34020144
AKT1 plays a key role in cell growth and survival, and its activation in cancers is mediated by different mechanisms. ...In reporter assays, mutations of the G-tracts in either the promoter or the 3'-UTR of AKT1 reduced expression mediated by these G-rich regions, s …
AKT1 plays a key role in cell growth and survival, and its activation in cancers is mediated by different mechanisms. ...In reporter …
Akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition.
Kim IY, Song SH, Seong EY, Lee DW, Bae SS, Lee SB. Kim IY, et al. Exp Cell Res. 2023 Mar 15;424(2):113509. doi: 10.1016/j.yexcr.2023.113509. Epub 2023 Feb 10. Exp Cell Res. 2023. PMID: 36773738
The levels of phosphorylated glycogen synthase kinase (GSK)-3beta, Snail, and beta-catenin in the Akt1(-/-) mice were lower than those in the WT mice. The number of apoptotic tubular cells and the expression of cleaved caspase-3/Bax were both lower in Akt1(-/-) mice …
The levels of phosphorylated glycogen synthase kinase (GSK)-3beta, Snail, and beta-catenin in the Akt1(-/-) mice were lower than thos …
AKT1 and genetic vulnerability to bipolar disorder.
Millischer V, Matheson GJ, Martinsson L, Römer Ek I, Schalling M, Lavebratt C, Backlund L. Millischer V, et al. Psychiatry Res. 2020 Feb;284:112677. doi: 10.1016/j.psychres.2019.112677. Epub 2019 Nov 4. Psychiatry Res. 2020. PMID: 31810747 Free article.
AKT1 has been previously been implicated as a vulnerability gene for bipolar disorder (BD). ...Analysis of genome wide association data did not reveal any association between BD and the AKT1 region. We conclude AKT1 is less likely to be a vulnerability gene i …
AKT1 has been previously been implicated as a vulnerability gene for bipolar disorder (BD). ...Analysis of genome wide association da …
11,520 results
You have reached the last available page of results. Please see the User Guide for more information.