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Items: 30


Enhanced avidity from a multivalent fluorescent antimicrobial peptide enables pathogen detection in a human lung model.

Akram AR, Avlonitis N, Scholefield E, Vendrell M, McDonald N, Aslam T, Craven TH, Gray C, Collie DS, Fisher AJ, Corris PA, Walsh T, Haslett C, Bradley M, Dhaliwal K.

Sci Rep. 2019 Jun 10;9(1):8422. doi: 10.1038/s41598-019-44804-0.


In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A.

Akram AR, Chankeshwara SV, Scholefield E, Aslam T, McDonald N, Megia-Fernandez A, Marshall A, Mills B, Avlonitis N, Craven TH, Smyth AM, Collie DS, Gray C, Hirani N, Hill AT, Govan JR, Walsh T, Haslett C, Bradley M, Dhaliwal K.

Sci Transl Med. 2018 Oct 24;10(464). pii: eaal0033. doi: 10.1126/scitranslmed.aal0033.


Super-silent FRET Sensor Enables Live Cell Imaging and Flow Cytometric Stratification of Intracellular Serine Protease Activity in Neutrophils.

Craven TH, Avlonitis N, McDonald N, Walton T, Scholefield E, Akram AR, Walsh TS, Haslett C, Bradley M, Dhaliwal K.

Sci Rep. 2018 Sep 10;8(1):13490. doi: 10.1038/s41598-018-31391-9.


Low-cost high sensitivity pulsed endomicroscopy to visualize tricolor optical signatures.

Krstajić N, Mills B, Murray I, Marshall A, Norberg D, Craven TH, Emanuel P, Choudhary TR, Williams GOS, Scholefield E, Akram AR, Davie A, Hirani N, Bruce A, Moore A, Bradley M, Dhaliwal K.

J Biomed Opt. 2018 Jul;23(7):1-12. doi: 10.1117/1.JBO.23.7.076005.


Optical Screening of Novel Bacteria-specific Probes on Ex Vivo Human Lung Tissue by Confocal Laser Endomicroscopy.

Mills B, Akram AR, Scholefield E, Bradley M, Dhaliwal K.

J Vis Exp. 2017 Nov 29;(129). doi: 10.3791/56284.


Assessing the utility of autofluorescence-based pulmonary optical endomicroscopy to predict the malignant potential of solitary pulmonary nodules in humans.

Seth S, Akram AR, McCool P, Westerfeld J, Wilson D, McLaughlin S, Dhaliwal K, Williams CK.

Sci Rep. 2016 Aug 23;6:31372. doi: 10.1038/srep31372.


Two-color widefield fluorescence microendoscopy enables multiplexed molecular imaging in the alveolar space of human lung tissue.

Krstajic N, Akram AR, Choudhary TR, McDonald N, Tanner MG, Pedretti E, Dalgarno PA, Scholefield E, Girkin JM, Moore A, Bradley M, Dhaliwal K.

J Biomed Opt. 2016 Apr 30;21(4):46009. doi: 10.1117/1.JBO.21.4.046009.


Risk factors for Clostridium difficile infection in hospitalized patients with community-acquired pneumonia.

Chalmers JD, Akram AR, Singanayagam A, Wilcox MH, Hill AT.

J Infect. 2016 Jul;73(1):45-53. doi: 10.1016/j.jinf.2016.04.008. Epub 2016 Apr 19.


Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue.

Mendive-Tapia L, Zhao C, Akram AR, Preciado S, Albericio F, Lee M, Serrels A, Kielland N, Read ND, Lavilla R, Vendrell M.

Nat Commun. 2016 Mar 9;7:10940. doi: 10.1038/ncomms10940.


A labelled-ubiquicidin antimicrobial peptide for immediate in situ optical detection of live bacteria in human alveolar lung tissue.

Akram AR, Avlonitis N, Lilienkampf A, Perez-Lopez AM, McDonald N, Chankeshwara SV, Scholefield E, Haslett C, Bradley M, Dhaliwal K.

Chem Sci. 2015 Dec 1;6(12):6971-6979. doi: 10.1039/c5sc00960j. Epub 2015 Jun 29.


Optical molecular imaging of lysyl oxidase activity - detection of active fibrogenesis in human lung tissue.

Aslam T, Miele A, Chankeshwara SV, Megia-Fernandez A, Michels C, Akram AR, McDonald N, Hirani N, Haslett C, Bradley M, Dhaliwal K.

Chem Sci. 2015 Aug 1;6(8):4946-4953. doi: 10.1039/c5sc01258a. Epub 2015 Jun 8.


British Thoracic Society guidelines for the investigation and management of pulmonary nodules.

Callister ME, Baldwin DR, Akram AR, Barnard S, Cane P, Draffan J, Franks K, Gleeson F, Graham R, Malhotra P, Prokop M, Rodger K, Subesinghe M, Waller D, Woolhouse I; British Thoracic Society Pulmonary Nodule Guideline Development Group; British Thoracic Society Standards of Care Committee.

Thorax. 2015 Aug;70 Suppl 2:ii1-ii54. doi: 10.1136/thoraxjnl-2015-207168. No abstract available. Erratum in: Thorax. 2015 Dec;70(12):1188.


An evaluation of clinical stability criteria to predict hospital course in community-acquired pneumonia.

Akram AR, Chalmers JD, Taylor JK, Rutherford J, Singanayagam A, Hill AT.

Clin Microbiol Infect. 2013 Dec;19(12):1174-80. doi: 10.1111/1469-0691.12173. Epub 2013 Feb 26.


Thrombus load and acute right ventricular failure in pulmonary embolism: correlation and demonstration of a "tipping point" on CT pulmonary angiography.

Wong LF, Akram AR, McGurk S, Van Beek EJ, Reid JH, Murchison JT.

Br J Radiol. 2012 Nov;85(1019):1471-6. doi: 10.1259/bjr/22397455. Epub 2012 Jun 20.


Seven-day antibiotic courses have similar efficacy to prolonged courses in severe community-acquired pneumonia--a propensity-adjusted analysis.

Choudhury G, Mandal P, Singanayagam A, Akram AR, Chalmers JD, Hill AT.

Clin Microbiol Infect. 2011 Dec;17(12):1852-8. doi: 10.1111/j.1469-0691.2011.03542.x. Epub 2011 Sep 15.


Predicting mortality with severity assessment tools in out-patients with community-acquired pneumonia.

Akram AR, Chalmers JD, Hill AT.

QJM. 2011 Oct;104(10):871-9. doi: 10.1093/qjmed/hcr088. Epub 2011 Jul 18.


Epidemiology, antibiotic therapy, and clinical outcomes in health care-associated pneumonia: a UK cohort study.

Chalmers JD, Taylor JK, Singanayagam A, Fleming GB, Akram AR, Mandal P, Choudhury G, Hill AT.

Clin Infect Dis. 2011 Jul 15;53(2):107-13. doi: 10.1093/cid/cir274.


Severity assessment tools to guide ICU admission in community-acquired pneumonia: systematic review and meta-analysis.

Chalmers JD, Mandal P, Singanayagam A, Akram AR, Choudhury G, Short PM, Hill AT.

Intensive Care Med. 2011 Sep;37(9):1409-20. doi: 10.1007/s00134-011-2261-x. Epub 2011 Jun 10. Review.


Impact of inhaled corticosteroid use on outcome in COPD patients admitted with pneumonia.

Singanayagam A, Chalmers JD, Akram AR, Hill AT.

Eur Respir J. 2011 Jul;38(1):36-41. doi: 10.1183/09031936.00077010. Epub 2011 Mar 23.


Physician judgement is a crucial adjunct to pneumonia severity scores in low-risk patients.

Choudhury G, Chalmers JD, Mandal P, Akram AR, Murray MP, Short P, Singanayagam A, Hill AT.

Eur Respir J. 2011 Sep;38(3):643-8. doi: 10.1183/09031936.00172910. Epub 2011 Mar 15.


Vascular complications are associated with poor outcome in community-acquired pneumonia.

Mandal P, Chalmers JD, Choudhury G, Akram AR, Hill AT.

QJM. 2011 Jun;104(6):489-95. doi: 10.1093/qjmed/hcq247. Epub 2011 Jan 7.


Safety and efficacy of CURB65-guided antibiotic therapy in community-acquired pneumonia.

Chalmers JD, Singanayagam A, Akram AR, Choudhury G, Mandal P, Hill AT.

J Antimicrob Chemother. 2011 Feb;66(2):416-23. doi: 10.1093/jac/dkq426. Epub 2010 Nov 16.


Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis.

Chalmers JD, Singanayagam A, Akram AR, Mandal P, Short PM, Choudhury G, Wood V, Hill AT.

Thorax. 2010 Oct;65(10):878-83. doi: 10.1136/thx.2009.133280. Epub 2010 Aug 20. Review.


Increasing outpatient treatment of mild community-acquired pneumonia: systematic review and meta-analysis.

Chalmers JD, Akram AR, Hill AT.

Eur Respir J. 2011 Apr;37(4):858-64. doi: 10.1183/09031936.00065610. Epub 2010 Aug 20. Review.


Statins in community acquired pneumonia: Evidence from experimental and clinical studies.

Chalmers JD, Short PM, Mandal P, Akram AR, Hill AT.

Respir Med. 2010 Aug;104(8):1081-91. doi: 10.1016/j.rmed.2010.04.005. Epub 2010 May 5. Review.


Incidence and prognostic implications of acute kidney injury on admission in patients with community-acquired pneumonia.

Akram AR, Singanayagam A, Choudhury G, Mandal P, Chalmers JD, Hill AT.

Chest. 2010 Oct;138(4):825-32. doi: 10.1378/chest.09-3071. Epub 2010 Apr 30.


Right ventricular dilation on CT pulmonary angiogram independently predicts mortality in pulmonary embolism.

Singanayagam A, Chalmers JD, Scally C, Akram AR, Al-Khairalla MZ, Leitch L, Hill LE, Hill AT.

Respir Med. 2010 Jul;104(7):1057-62. doi: 10.1016/j.rmed.2010.02.004. Epub 2010 Mar 3.


Clinically suspected acute pulmonary embolism: a comparison of presentation, radiological features and outcome in patients with and without PE.

Akram AR, Cowell GW, Logan LJ, Macdougall M, Reid JH, Murchison JT, Simpson AJ.

QJM. 2009 Jun;102(6):407-14. doi: 10.1093/qjmed/hcp041. Epub 2009 Apr 17.


Pain assessment in the paediatric Emergency Department: whose view counts?

Maciocia PM, Strachan EM, Akram AR, Hendrie RE, Kelly DN, Kemp A, McLuckie AM, Smith LM, Beattie TF.

Eur J Emerg Med. 2003 Dec;10(4):264-7.


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