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Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species.

Thompson CG, Rosen EP, Prince HMA, White N, Sykes C, de la Cruz G, Mathews M, Deleage C, Estes JD, Charlins P, Mulder LR, Kovarova M, Adamson L, Arora S, Dellon ES, Peery AF, Shaheen NJ, Gay C, Muddiman DC, Akkina R, Garcia JV, Luciw P, Kashuba ADM.

Sci Transl Med. 2019 Jul 3;11(499). pii: eaap8758. doi: 10.1126/scitranslmed.aap8758.


Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

Burgunder E, Fallon JK, White N, Schauer AP, Sykes C, Remling-Mulder L, Kovarova M, Adamson L, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

J Pharmacol Exp Ther. 2019 Sep;370(3):360-368. doi: 10.1124/jpet.119.259150. Epub 2019 Jun 24.


Generation of High-Titer Pseudotyped Lentiviral Vectors.

Hu S, Li M, Akkina R.

Methods Mol Biol. 2019;1937:125-134. doi: 10.1007/978-1-4939-9065-8_7.


Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species.

Srinivas N, Rosen EP, Gilliland WM Jr, Kovarova M, Remling-Mulder L, De La Cruz G, White N, Adamson L, Schauer AP, Sykes C, Luciw P, Garcia JV, Akkina R, Kashuba ADM.

Xenobiotica. 2019 Oct;49(10):1192-1201. doi: 10.1080/00498254.2018.1539278. Epub 2018 Dec 17.


SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.

Schmitt K, Curlin J, Kumar DM, Remling-Mulder L, Feely S, Stenglein M, O'Connor S, Marx P, Akkina R.

J Med Primatol. 2018 Oct;47(5):298-301. doi: 10.1111/jmp.12380.


Stable Transcriptional Repression and Parasitism of HIV-1.

Shrivastava S, Charlins P, Ackley A, Embree H, Dropulic B, Akkina R, Weinberg MS, Morris KV.

Mol Ther Nucleic Acids. 2018 Sep 7;12:12-18. doi: 10.1016/j.omtn.2018.04.011. Epub 2018 May 1.


Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1.

Zhou J, Lazar D, Li H, Xia X, Satheesan S, Charlins P, O'Mealy D, Akkina R, Saayman S, Weinberg MS, Rossi JJ, Morris KV.

Theranostics. 2018 Feb 7;8(6):1575-1590. doi: 10.7150/thno.23085. eCollection 2018.


Ultra-Sensitive HIV-1 Latency Viral Outgrowth Assays Using Humanized Mice.

Schmitt K, Akkina R.

Front Immunol. 2018 Mar 5;9:344. doi: 10.3389/fimmu.2018.00344. eCollection 2018. Review.


Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model.

Schmitt K, Charlins P, Veselinovic M, Kinner-Bibeau L, Hu S, Curlin J, Remling-Mulder L, Olson KE, Aboellail T, Akkina R.

Virology. 2018 Feb;515:235-242. doi: 10.1016/j.virol.2017.12.026. Epub 2018 Jan 6.


Modeling the evolution of SIV sooty mangabey progenitor virus towards HIV-2 using humanized mice.

Schmitt K, Mohan Kumar D, Curlin J, Remling-Mulder L, Stenglein M, O'Connor S, Marx P, Akkina R.

Virology. 2017 Oct;510:175-184. doi: 10.1016/j.virol.2017.07.005. Epub 2017 Jul 24.


Multimodal analysis of drug transporter expression in gastrointestinal tissue.

Thompson CG, Fallon JK, Mathews M, Charlins P, Remling-Mulder L, Kovarova M, Adamson L, Srinivas N, Schauer A, Sykes C, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

AIDS. 2017 Jul 31;31(12):1669-1678. doi: 10.1097/QAD.0000000000001554.


A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads.

Charlins P, Schmitt K, Remling-Mulder L, Hogan LE, Hanhauser E, Hobbs KS, Hecht F, Deeks SG, Henrich TJ, Akkina R.

Virology. 2017 Jul;507:135-139. doi: 10.1016/j.virol.2017.04.011. Epub 2017 Apr 19.


2016 International meeting of the Global Virus Network.

Akkina R, Ellerbrok H, Hall W, Hasegawa H, Kawaguchi Y, Kleanthous H, McSweegan E, Mercer N, Romanowski V, Sawa H, Vahlne A.

Antiviral Res. 2017 Jun;142:21-29. doi: 10.1016/j.antiviral.2017.03.005. Epub 2017 Mar 16.


A humanized mouse model for HIV-2 infection and efficacy testing of a single-pill triple-drug combination anti-retroviral therapy.

Hu S, Neff CP, Kumar DM, Habu Y, Akkina SR, Seki T, Akkina R.

Virology. 2017 Jan 15;501:115-118. doi: 10.1016/j.virol.2016.11.013. Epub 2016 Nov 30.


Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis.

Veselinovic M, Yang KH, Sykes C, Remling-Mulder L, Kashuba AD, Akkina R.

Virology. 2016 Feb;489:173-8. doi: 10.1016/j.virol.2015.12.014. Epub 2016 Jan 6.


Modeling HIV-1 Mucosal Transmission and Prevention in Humanized Mice.

Veselinovic M, Charlins P, Akkina R.

Methods Mol Biol. 2016;1354:203-20. doi: 10.1007/978-1-4939-3046-3_14.


Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.

Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA.

AIDS Res Hum Retroviruses. 2016 Feb;32(2):109-19. doi: 10.1089/AID.2015.0258.


Pseudotyping of lentiviral vector with novel vesiculovirus envelope glycoproteins derived from Chandipura and Piry viruses.

Hu S, Mohan Kumar D, Sax C, Schuler C, Akkina R.

Virology. 2016 Jan 15;488:162-8. doi: 10.1016/j.virol.2015.11.012. Epub 2015 Nov 30.


HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model.

Veselinovic M, Yang KH, LeCureux J, Sykes C, Remling-Mulder L, Kashuba ADM, Akkina R.

Virology. 2014 Sep;464-465:253-263. doi: 10.1016/j.virol.2014.07.008. Epub 2014 Aug 7.


Humanized Mice for Studying Human Immune Responses and Generating Human Monoclonal Antibodies.

Akkina R.

Microbiol Spectr. 2014 Apr;2(2). doi: 10.1128/microbiolspec.AID-0003-2012. Review.


Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice.

Bennett MS, Akkina R.

Viruses. 2013 Dec 12;5(12):3119-41. doi: 10.3390/v5123119. Review.


New insights into HIV impact on hematopoiesis.

Akkina R.

Blood. 2013 Sep 26;122(13):2144-6. doi: 10.1182/blood-2013-08-518274. No abstract available.


A mouse model for human norovirus.

Taube S, Kolawole AO, Höhne M, Wilkinson JE, Handley SA, Perry JW, Thackray LB, Akkina R, Wobus CE.

MBio. 2013 Jul 16;4(4). pii: e00450-13. doi: 10.1128/mBio.00450-13.


Human immune responses and potential for vaccine assessment in humanized mice.

Akkina R.

Curr Opin Immunol. 2013 Jun;25(3):403-9. doi: 10.1016/j.coi.2013.03.009. Epub 2013 Apr 27. Review.


Identification of novel influenza A virus proteins translated from PA mRNA.

Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y.

J Virol. 2013 Mar;87(5):2455-62. doi: 10.1128/JVI.02656-12. Epub 2012 Dec 12.


New generation humanized mice for virus research: comparative aspects and future prospects.

Akkina R.

Virology. 2013 Jan 5;435(1):14-28. doi: 10.1016/j.virol.2012.10.007. Review.


In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice.

Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R.

J Immunol. 2013 Jan 1;190(1):211-9. doi: 10.4049/jimmunol.1201108. Epub 2012 Dec 3.


Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge.

Zhou J, Neff CP, Swiderski P, Li H, Smith DD, Aboellail T, Remling-Mulder L, Akkina R, Rossi JJ.

Mol Ther. 2013 Jan;21(1):192-200. doi: 10.1038/mt.2012.226. Epub 2012 Nov 20.


Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model.

Veselinovic M, Neff CP, Mulder LR, Akkina R.

Virology. 2012 Oct 25;432(2):505-10. doi: 10.1016/j.virol.2012.06.025. Epub 2012 Jul 24.


Modeling HIV infection and therapies in humanized mice.

Nischang M, Gers-Huber G, Audigé A, Akkina R, Speck RF.

Swiss Med Wkly. 2012 Jul 9;142:w13618. doi: 10.4414/smw.2012.13618. eCollection 2012. Review.


Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice.

Zhou J, Neff CP, Liu X, Zhang J, Li H, Smith DD, Swiderski P, Aboellail T, Huang Y, Du Q, Liang Z, Peng L, Akkina R, Rossi JJ.

Mol Ther. 2011 Dec;19(12):2228-38. doi: 10.1038/mt.2011.207. Epub 2011 Sep 27.


Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes.

Akkina R, Berges BK, Palmer BE, Remling L, Neff CP, Kuruvilla J, Connick E, Folkvord J, Gagliardi K, Kassu A, Akkina SR.

PLoS One. 2011;6(6):e20169. doi: 10.1371/journal.pone.0020169. Epub 2011 Jun 14.


A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice.

Neff CP, Kurisu T, Ndolo T, Fox K, Akkina R.

PLoS One. 2011;6(6):e20209. doi: 10.1371/journal.pone.0020209. Epub 2011 Jun 1.


Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro.

Evans VA, Lal L, Akkina R, Solomon A, Wright E, Lewin SR, Cameron PU.

Retrovirology. 2011 Jun 3;8:43. doi: 10.1186/1742-4690-8-43.


An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice.

Neff CP, Zhou J, Remling L, Kuruvilla J, Zhang J, Li H, Smith DD, Swiderski P, Rossi JJ, Akkina R.

Sci Transl Med. 2011 Jan 19;3(66):66ra6. doi: 10.1126/scitranslmed.3001581.


Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model.

Neff CP, Ndolo T, Tandon A, Habu Y, Akkina R.

PLoS One. 2010 Dec 21;5(12):e15257. doi: 10.1371/journal.pone.0015257.


Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection.

Kassu A, Marcus RA, D'Souza MB, Kelly-McKnight EA, Golden-Mason L, Akkina R, Fontenot AP, Wilson CC, Palmer BE.

J Immunol. 2010 Sep 1;185(5):3007-18. doi: 10.4049/jimmunol.1000156. Epub 2010 Jul 23.


Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year.

Berges BK, Akkina SR, Remling L, Akkina R.

Virology. 2010 Feb 5;397(1):100-3. doi: 10.1016/j.virol.2009.10.034. Epub 2009 Nov 18.


Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production.

Kassu A, D'Souza M, O'Connor BP, Kelly-McKnight E, Akkina R, Fontenot AP, Palmer BE.

Clin Immunol. 2009 Aug;132(2):234-45. doi: 10.1016/j.clim.2009.03.531. Epub 2009 Apr 29.


Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells.

Zhou J, Swiderski P, Li H, Zhang J, Neff CP, Akkina R, Rossi JJ.

Nucleic Acids Res. 2009 May;37(9):3094-109. doi: 10.1093/nar/gkp185. Epub 2009 Mar 21.


Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance.

Tamhane M, Akkina R.

AIDS Res Ther. 2008 Jul 30;5:16. doi: 10.1186/1742-6405-5-16.


Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice.

Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R.

Virology. 2008 Apr 10;373(2):342-51. doi: 10.1016/j.virol.2007.11.020. Epub 2008 Jan 18.


Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice.

Kuruvilla JG, Troyer RM, Devi S, Akkina R.

Virology. 2007 Dec 5;369(1):143-52. Epub 2007 Aug 16.


Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells.

Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R.

Mol Ther. 2007 Jun;15(6):1182-1188. doi: 10.1038/ Epub 2016 Dec 7.


Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells.

Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R.

Mol Ther. 2007 Jun;15(6):1182-8. Epub 2007 Apr 3.


Short-hairpin RNA expressed from polymerase III promoters mediates RNA interference in mosquito cells.

Konet DS, Anderson J, Piper J, Akkina R, Suchman E, Carlson J.

Insect Mol Biol. 2007 Apr;16(2):199-206. Epub 2007 Feb 6.


HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model.

Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R.

Retrovirology. 2006 Nov 1;3:76.

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