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Items: 41

1.

Left-Right Axis Differentiation and Functional Lateralization: a Haplotype in the Methyltransferase Encoding Gene SETDB2 Might Mediate Handedness in Healthy Adults.

Ocklenburg S, Arning L, Gerding WM, Hengstler JG, Epplen JT, Güntürkün O, Beste C, Akkad DA.

Mol Neurobiol. 2016 Nov;53(9):6355-6361. doi: 10.1007/s12035-015-9534-2. Epub 2015 Nov 16.

PMID:
26572639
2.

A large deletion in RPGR causes XLPRA in Weimaraner dogs.

Kropatsch R, Akkad DA, Frank M, Rosenhagen C, Altmüller J, Nürnberg P, Epplen JT, Dekomien G.

Canine Genet Epidemiol. 2016 Jul 8;3:7. doi: 10.1186/s40575-016-0037-x. eCollection 2016.

3.

Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.

Sadovnick AD, Traboulsee AL, Bernales CQ, Ross JP, Forwell AL, Yee IM, Guillot-Noel L, Fontaine B, Cournu-Rebeix I, Alcina A, Fedetz M, Izquierdo G, Matesanz F, Hilven K, Dubois B, Goris A, Astobiza I, Alloza I, Antigüedad A, Vandenbroeck K, Akkad DA, Aktas O, Blaschke P, Buttmann M, Chan A, Epplen JT, Gerdes LA, Kroner A, Kubisch C, Kümpfel T, Lohse P, Rieckmann P, Zettl UK, Zipp F, Bertram L, Lill CM, Fernandez O, Urbaneja P, Leyva L, Alvarez-Cermeño JC, Arroyo R, Garagorri AM, García-Martínez A, Villar LM, Urcelay E, Malhotra S, Montalban X, Comabella M, Berger T, Fazekas F, Reindl M, Schmied MC, Zimprich A, Vilariño-Güell C.

G3 (Bethesda). 2016 Jul 7;6(7):2073-9. doi: 10.1534/g3.116.030841.

4.

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

Haghikia A, Jörg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thöne J, Demir S, Müller DN, Gold R, Linker RA.

Immunity. 2016 Apr 19;44(4):951-3. doi: 10.1016/j.immuni.2016.04.006. No abstract available.

5.

Multiple sclerosis in families: risk factors beyond known genetic polymorphisms.

Akkad DA, Lee DH, Bruch K, Haghikia A, Epplen JT, Hoffjan S, Linker RA.

Neurogenetics. 2016 Apr;17(2):131-5. doi: 10.1007/s10048-016-0474-4. Epub 2016 Feb 11.

PMID:
26865406
6.

Exome Sequencing Reveals AGBL5 as Novel Candidate Gene and Additional Variants for Retinitis Pigmentosa in Five Turkish Families.

Kastner S, Thiemann IJ, Dekomien G, Petrasch-Parwez E, Schreiber S, Akkad DA, Gerding WM, Hoffjan S, Günes S, Günes S, Bagci H, Epplen JT.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8045-53. doi: 10.1167/iovs.15-17473.

PMID:
26720455
7.

Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.

Schrewe L, Lill CM, Liu T, Salmen A, Gerdes LA, Guillot-Noel L, Akkad DA, Blaschke P, Graetz C, Hoffjan S, Kroner A, Demir S, Böhme A, Rieckmann P, ElAli A, Hagemann N, Hermann DM, Cournu-Rebeix I, Zipp F, Kümpfel T, Buttmann M, Zettl UK, Fontaine B, Bertram L, Gold R, Chan A.

J Neuroinflammation. 2015 Dec 16;12:234. doi: 10.1186/s12974-015-0429-y.

8.

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

Haghikia A, Jörg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thöne J, Demir S, Müller DN, Gold R, Linker RA.

Immunity. 2015 Oct 20;43(4):817-29. doi: 10.1016/j.immuni.2015.09.007. Erratum in: Immunity. 2016 Apr 19;44(4):951-3.

9.

Genome-wide significant association with seven novel multiple sclerosis risk loci.

Lill CM, Luessi F, Alcina A, Sokolova EA, Ugidos N, de la Hera B, Guillot-Noël L, Malhotra S, Reinthaler E, Schjeide BM, Mescheriakova JY, Mashychev A, Wohlers I, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Astobiza I, Blaschke P, Boyko AN, Buttmann M, Chan A, Dörner T, Epplen JT, Favorova OO, Fedetz M, Fernández O, García-Martínez A, Gerdes LA, Graetz C, Hartung HP, Hoffjan S, Izquierdo G, Korobko DS, Kroner A, Kubisch C, Kümpfel T, Leyva L, Lohse P, Malkova NA, Montalban X, Popova EV, Rieckmann P, Rozhdestvenskii AS, Schmied C, Smagina IV, Tsareva EY, Winkelmann A, Zettl UK, Binder H, Cournu-Rebeix I, Hintzen R, Zimprich A, Comabella M, Fontaine B, Urcelay E, Vandenbroeck K, Filipenko M, Matesanz F, Zipp F, Bertram L.

J Med Genet. 2015 Dec;52(12):848-55. doi: 10.1136/jmedgenet-2015-103442. Epub 2015 Oct 16.

PMID:
26475045
10.

Homozygosity mapping and sequencing identify two genes that might contribute to pointing behavior in hunting dogs.

Akkad DA, Gerding WM, Gasser RB, Epplen JT.

Canine Genet Epidemiol. 2015 Apr 18;2:5. doi: 10.1186/s40575-015-0018-5. eCollection 2015.

11.

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.

Gu BJ, Field J, Dutertre S, Ou A, Kilpatrick TJ, Lechner-Scott J, Scott R, Lea R, Taylor BV, Stankovich J, Butzkueven H, Gresle M, Laws SM, Petrou S, Hoffjan S, Akkad DA, Graham CA, Hawkins S, Glaser A, Bedri SK, Hillert J, Matute C, Antiguedad A; ANZgene Consortium, Wiley JS.

Hum Mol Genet. 2015 Oct 1;24(19):5644-54. doi: 10.1093/hmg/ddv278. Epub 2015 Jul 17.

PMID:
26188005
12.

Combinations of susceptibility genes are associated with higher risk for multiple sclerosis and imply disease course specificity.

Akkad DA, Olischewsky A, Reiner F, Hellwig K, Esser S, Epplen JT, Curk T, Gold R, Haghikia A.

PLoS One. 2015 May 26;10(5):e0127632. doi: 10.1371/journal.pone.0127632. eCollection 2015.

13.

Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case-control cohort.

Hoffjan S, Okur A, Epplen JT, Wieczorek S, Chan A, Akkad DA.

Int J Immunogenet. 2015 Apr;42(2):106-10. doi: 10.1111/iji.12183. Epub 2015 Feb 12.

PMID:
25684197
14.

Multiple sclerosis risk loci correlate with cervical cord atrophy and may explain the course of disability.

Akkad DA, Bellenberg B, Esser S, Weiler F, Epplen JT, Gold R, Lukas C, Haghikia A.

Neurogenetics. 2015 Jul;16(3):161-8. doi: 10.1007/s10048-015-0438-0. Epub 2015 Jan 27.

PMID:
25620546
15.

Interferon-beta affects mitochondrial activity in CD4+ lymphocytes: Implications for mechanism of action in multiple sclerosis.

Haghikia A, Faissner S, Pappas D, Pula B, Akkad DA, Arning L, Ruhrmann S, Duscha A, Gold R, Baranzini SE, Malhotra S, Montalban X, Comabella M, Chan A.

Mult Scler. 2015 Sep;21(10):1262-70. doi: 10.1177/1352458514561909. Epub 2014 Dec 5.

PMID:
25480861
16.

Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis.

Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BM, Mashychev A, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Zipp F, Bertram L.

Neurogenetics. 2014 May;15(2):129-34. doi: 10.1007/s10048-014-0396-y. Epub 2014 Mar 18.

PMID:
24638856
17.

Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R.

Kloster E, Saft C, Akkad DA, Epplen JT, Arning L.

J Mol Med (Berl). 2014 Feb;92(2):177-84.

PMID:
24121255
18.

SOX9 duplication linked to intersex in deer.

Kropatsch R, Dekomien G, Akkad DA, Gerding WM, Petrasch-Parwez E, Young ND, Altmüller J, Nürnberg P, Gasser RB, Epplen JT.

PLoS One. 2013 Sep 6;8(9):e73734. doi: 10.1371/journal.pone.0073734. eCollection 2013.

19.

MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.

International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F.

Brain. 2013 Jun;136(Pt 6):1778-82. doi: 10.1093/brain/awt101.

20.

Spotted Weimaraner dog due to de novo KIT mutation.

Gerding WM, Akkad DA, Epplen JT.

Anim Genet. 2013 Aug;44(5):605-6. doi: 10.1111/age.12056. Epub 2013 May 9. No abstract available.

PMID:
23659249
21.

Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk.

Lill CM, Schjeide BM, Graetz C, Liu T, Damotte V, Akkad DA, Blaschke P, Gerdes LA, Kroner A, Luessi F, Cournu-Rebeix I, Hoffjan S, Winkelmann A, Touze E, Pico F, Corcia P, Otaegui D, Antigüedad A, Alcina A, Comabella M, Montalban X, Olascoaga J, Matesanz F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Rieckmann P, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Fontaine B, Zipp F, Vandenbroeck K, Bertram L.

J Med Genet. 2013 Mar;50(3):140-3. doi: 10.1136/jmedgenet-2012-101411. Epub 2013 Jan 12. No abstract available.

PMID:
23315543
22.

Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.

Lill CM, Liu T, Schjeide BM, Roehr JT, Akkad DA, Damotte V, Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes LA, Luessi F, Fernadez O, Izquierdo G, Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S, Faber H, Liebsch M, Meissner E, Chanvillard C, Touze E, Pico F, Corcia P; ANZgene Consortium,{dagger}, Dörner T, Steinhagen-Thiessen E, Baeckman L, Heekeren HR, Li SC, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Fontaine B, Vandenbroeck K, Matesanz F, Urcelay E, Bertram L, Zipp F.

J Med Genet. 2012 Sep;49(9):558-62. doi: 10.1136/jmedgenet-2012-101175. Erratum in: J Med Genet. 2012 Oct;49(10):668.

PMID:
22972946
23.

Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.

Lill CM, Schjeide BM, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Bertram L, Zipp F.

Neurogenetics. 2012 Feb;13(1):83-6. doi: 10.1007/s10048-011-0305-6. Epub 2011 Nov 18.

PMID:
22095036
24.

IL28B polymorphisms are not associated with the response to interferon-β in multiple sclerosis.

Malhotra S, Morcillo-Suárez C, Brassat D, Goertsches R, Lechner-Scott J, Urcelay E, Fernández O, Drulovic J, García-Merino A, Martinelli Boneschi F, Chan A, Vandenbroeck K, Navarro A, Bustamante MF, Río J, Akkad DA, Giacalone G, Sánchez AJ, Leyva L, Alvarez-Lafuente R, Zettl UK, Oksenberg J, Montalban X, Comabella M.

J Neuroimmunol. 2011 Oct 28;239(1-2):101-4. doi: 10.1016/j.jneuroim.2011.08.004. Epub 2011 Sep 1.

PMID:
21889215
25.

Ccdc66 null mutation causes retinal degeneration and dysfunction.

Gerding WM, Schreiber S, Schulte-Middelmann T, de Castro Marques A, Atorf J, Akkad DA, Dekomien G, Kremers J, Dermietzel R, Gal A, Rülicke T, Ibrahim S, Epplen JT, Petrasch-Parwez E.

Hum Mol Genet. 2011 Sep 15;20(18):3620-31. doi: 10.1093/hmg/ddr282. Epub 2011 Jun 16.

PMID:
21680557
26.

Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients.

Rey LK, Wieczorek S, Akkad DA, Linker RA, Chan A, Hoffjan S.

Mol Cell Probes. 2011 Oct-Dec;25(5-6):255-9. doi: 10.1016/j.mcp.2011.05.004. Epub 2011 Jun 12.

PMID:
21664965
27.

PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease.

Taherzadeh-Fard E, Saft C, Akkad DA, Wieczorek S, Haghikia A, Chan A, Epplen JT, Arning L.

Mol Neurodegener. 2011 May 19;6(1):32. doi: 10.1186/1750-1326-6-32.

28.

Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene.

Kropatsch R, Petrasch-Parwez E, Seelow D, Schlichting A, Gerding WM, Akkad DA, Epplen JT, Dekomien G.

Mol Cell Probes. 2010 Dec;24(6):357-63. doi: 10.1016/j.mcp.2010.07.007. Epub 2010 Aug 4.

PMID:
20691256
29.

The genetics of multiple sclerosis: an update 2010.

Hoffjan S, Akkad DA.

Mol Cell Probes. 2010 Oct;24(5):237-43. doi: 10.1016/j.mcp.2010.04.006. Epub 2010 May 5. Review.

PMID:
20450971
30.

Mitochondrial haplogroup H correlates with ATP levels and age at onset in Huntington disease.

Arning L, Haghikia A, Taherzadeh-Fard E, Saft C, Andrich J, Pula B, Höxtermann S, Wieczorek S, Akkad DA, Perrech M, Gold R, Epplen JT, Chan A.

J Mol Med (Berl). 2010 Apr;88(4):431-6. doi: 10.1007/s00109-010-0589-2. Epub 2010 Jan 29.

PMID:
20108082
31.

Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene.

Dekomien G, Vollrath C, Petrasch-Parwez E, Boevé MH, Akkad DA, Gerding WM, Epplen JT.

Neurogenetics. 2010 May;11(2):163-74. doi: 10.1007/s10048-009-0223-z. Epub 2009 Sep 24.

PMID:
19777273
32.

Analysis of variation in the IL7RA and IL2RA genes in atopic dermatitis.

Hoffjan S, Beygo J, Akkad DA, Parwez Q, Petrasch-Parwez E, Epplen JT.

J Dermatol Sci. 2009 Aug;55(2):138-40. doi: 10.1016/j.jdermsci.2009.05.001. Epub 2009 Jun 11. No abstract available.

PMID:
19523791
33.

Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients.

Akkad DA, Hoffjan S, Petrasch-Parwez E, Beygo J, Gold R, Epplen JT.

J Autoimmun. 2009 Mar;32(2):110-5. doi: 10.1016/j.jaut.2009.01.002. Epub 2009 Feb 23.

PMID:
19231135
34.

Genomic NGFB variation and multiple sclerosis in a case control study.

Akkad DA, Kruse N, Arning L, Gold R, Epplen JT.

BMC Med Genet. 2008 Dec 8;9:107. doi: 10.1186/1471-2350-9-107.

35.

ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.

Arning L, Monté D, Hansen W, Wieczorek S, Jagiello P, Akkad DA, Andrich J, Kraus PH, Saft C, Epplen JT.

J Mol Med (Berl). 2008 Apr;86(4):485-90. doi: 10.1007/s00109-007-0299-6. Epub 2008 Mar 8.

PMID:
18327563
36.

mtDNA nt13708A variant increases the risk of multiple sclerosis.

Yu X, Koczan D, Sulonen AM, Akkad DA, Kroner A, Comabella M, Costa G, Corongiu D, Goertsches R, Camina-Tato M, Thiesen HJ, Nyland HI, Mørk SJ, Montalban X, Rieckmann P, Marrosu MG, Myhr KM, Epplen JT, Saarela J, Ibrahim SM.

PLoS One. 2008 Feb 13;3(2):e1530. doi: 10.1371/journal.pone.0001530.

37.

Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels.

Akkad DA, Arning L, Ibrahim SM, Epplen JT.

Genes Immun. 2007 Dec;8(8):703-6. Epub 2007 Sep 13.

PMID:
17855802
38.

No association between synapsin III gene promoter polymorphisms and multiple sclerosis in German patients.

Akkad DA, Gödde R, Epplen JT.

J Neurol. 2006 Oct;253(10):1365-6. Epub 2006 Sep 13.

PMID:
16972123
39.

Electrophoresis of DNA in human genetic diagnostics - state-of-the-art, alternatives and future prospects.

Gödde R, Akkad DA, Arning L, Dekomien G, Herchenbach J, Kunstmann E, Meins M, Wieczorek S, Epplen JT, Hoffjan S.

Electrophoresis. 2006 Mar;27(5-6):939-46. Review.

PMID:
16470775
40.

Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups.

Akkad DA, Jagiello P, Szyld P, Goedde R, Wieczorek S, Gross WL, Epplen JT.

Int J Immunogenet. 2006 Feb;33(1):59-61.

PMID:
16426246
41.

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