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Prediction of extraprostatic extension by MRI tumor contact length: difference between anterior and posterior prostate cancer.

Matsumoto K, Akita H, Narita K, Hashiguchi A, Takamatsu K, Takeda T, Kosaka T, Mizuno R, Kikuchi E, Oya M, Jinzaki M.

Prostate Cancer Prostatic Dis. 2019 Feb 27. doi: 10.1038/s41391-019-0136-3. [Epub ahead of print]


Behavioral responses to anxiogenic tasks in young adult rats with neonatal dopamine depletion.

Ogata M, Akita H, Ishibashi H.

Physiol Behav. 2019 Feb 6;204:10-19. doi: 10.1016/j.physbeh.2019.02.006. [Epub ahead of print]


Pre-donation BMI and preserved kidney volume can predict the cohort with unfavorable renal functional compensation at 1-year after kidney donation.

Shinoda K, Morita S, Akita H, Tamaki S, Takahashi R, Kono H, Asanuma H, Kikuchi E, Jinzaki M, Nakagawa K, Oya M.

BMC Nephrol. 2019 Feb 8;20(1):46. doi: 10.1186/s12882-019-1242-0.


Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles.

Ohto T, Konishi M, Tanaka H, Onomoto K, Yoneyama M, Nakai Y, Tange K, Yoshioka H, Akita H.

Biol Pharm Bull. 2019;42(2):299-302. doi: 10.1248/bpb.b18-00783.


Clinical usefulness of a perioperative bacteriological culture to treat patients with postoperative pneumonia after esophagectomy.

Matsunaga T, Miyata H, Sugimura K, Asukai K, Yanagimoto Y, Takahashi Y, Tomokuni A, Yamamoto K, Akita H, Nishimura J, Wada H, Takahashi H, Yasui M, Omori T, Oue M, Yano M.

Ann Gastroenterol Surg. 2018 Sep 21;3(1):57-64. doi: 10.1002/ags3.12210. eCollection 2019 Jan.


Prognostic Significance of Sarcopenia and Systemic Inflammatory Response in Patients With Esophageal Cancer.

Matsunaga T, Miyata H, Sugimura K, Motoori M, Asukai K, Yanagimoto Y, Takahashi Y, Tomokuni A, Yamamoto K, Akita H, Nishimura J, Wada H, Takahashi H, Yasui M, Omori T, Oue M, Yano M.

Anticancer Res. 2019 Jan;39(1):449-458. doi: 10.21873/anticanres.13133.


Outcomes and Complications of Simultaneous Laparoscopic Cystectomy and Laparoscopic Nephroureterectomy with Umbilical Reduced Port Surgery

Tanaka Y, Okamura T, Chaya R, Nagai T, Kobayashi D, Kobayashi T, Akita H, Yasui T.

Asian Pac J Cancer Prev. 2018 Dec 25;19(12):3495-3500.


Comparison of the hepatic metabolism of triazolam in wild-type and Cyp3a-knockout mice for understanding CYP3A-mediated metabolism in CYP3A-humanized mice in vivo.

Minegishi G, Kazuki Y, Yamasaki Y, Okuya F, Akita H, Oshimura M, Kobayashi K.

Xenobiotica. 2018 Dec 18:1-37. doi: 10.1080/00498254.2018.1560516. [Epub ahead of print]


Two cases of pneumococcal spondylitis in the same household: a case report.

Goda K, Kenzaka T, Chang B, Akita H.

BMC Infect Dis. 2018 Dec 17;18(1):666. doi: 10.1186/s12879-018-3588-5.


The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.

Tanaka H, Watanabe A, Konishi M, Nakai Y, Yoshioka H, Ohkawara T, Takeda H, Harashima H, Akita H.

Heliyon. 2018 Dec 3;4(12):e00959. doi: 10.1016/j.heliyon.2018.e00959. eCollection 2018 Dec.


Case of a giant gauzeoma diagnosed 21 years after an inguinal hernia surgery.

Chaya R, Okamura T, Nagai T, Kobayashi D, Kobayashi T, Akita H, Yasui T.

J Rural Med. 2018 Nov;13(2):177-180. doi: 10.2185/jrm.2963. Epub 2018 Nov 29.


Pseudomonas humi sp. nov., isolated from leaf soil.

Akita H, Kimura ZI, Hoshino T.

Arch Microbiol. 2019 Mar;201(2):245-251. doi: 10.1007/s00203-018-1588-x. Epub 2018 Nov 26.


Short- and long-term outcomes of choledochojejunostomy during pancreaticoduodenectomy and total pancreatectomy: interrupted suture versus continuous suture.

Tatsuguchi T, Takahashi H, Akita H, Kobayashi S, Tomokuni A, Gotoh K, Eguchi H, Ohigashi H, Yanagimoto Y, Miyoshi N, Sugimura K, Moon JH, Omori T, Yasui M, Miyata H, Ohue M, Fujiwara Y, Yano M, Sakon M, Ishikawa O.

Langenbecks Arch Surg. 2018 Dec;403(8):959-966. doi: 10.1007/s00423-018-1733-7. Epub 2018 Nov 24.


Ureteral pseudodiverticulosis accompanied by urothelial carcinoma diagnosed by CT urography: a case report and review of the literature.

Sugiura H, Akita H, Kikuchi E, Mikami S, Hayakawa N, Narita K, Jinzaki M.

BJR Case Rep. 2018 Jan 18;4(2):20170111. doi: 10.1259/bjrcr.20170111. eCollection 2018.


DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy.

Kawai M, Nakamura T, Miura N, Maeta M, Tanaka H, Ueda K, Higashi K, Moribe K, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

Nanomedicine. 2018 Nov;14(8):2587-2597. doi: 10.1016/j.nano.2018.08.006. Epub 2018 Aug 29.


Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies.

Kitamura K, Ito R, Umehara K, Morio H, Saito K, Suzuki S, Hashimoto M, Saito Y, Anzai N, Akita H, Chiba K, Furihata T.

J Pharmacol Sci. 2018 Aug;137(4):350-358. doi: 10.1016/j.jphs.2018.06.013. Epub 2018 Aug 9.


Subclinical cancer cell dissemination in peritoneal lavage fluid detected by reverse-transcription polymerase chain reaction identifies patients at high risk for peritoneal recurrence and consequent impaired survival in the setting of preoperative chemoradiation therapy for pancreatic cancer.

Takahashi H, Akita H, Wada H, Tomokuni A, Asukai K, Takahashi Y, Yanagimoto Y, Matsunaga T, Sugimura K, Yamamoto K, Nishimura J, Yasui M, Omori T, Miyata H, Yamamoto T, Nakanishi M, Shirayanagi M, Yamasaki T, Ohue M, Yano M, Sakon M, Ishikawa O.

Surgery. 2018 Dec;164(6):1168-1177. doi: 10.1016/j.surg.2018.06.047. Epub 2018 Aug 24.


Phase I Trial Evaluating the Safety of Preoperative Gemcitabine/nab-Paclitaxel With Concurrent Radiation Therapy for Borderline Resectable Pancreatic Cancer.

Takahashi H, Akita H, Ioka T, Wada H, Tomokoni A, Asukai K, Ohue M, Yano M, Ishikawa O.

Pancreas. 2018 Oct;47(9):1135-1141. doi: 10.1097/MPA.0000000000001140.


Performance of diffusion-weighted MRI post-CT urography for the diagnosis of upper tract urothelial carcinoma: Comparison with selective urine cytology sampling.

Akita H, Kikuchi E, Hayakawa N, Mikami S, Sugiura H, Oya M, Jinzaki M.

Clin Imaging. 2018 Nov - Dec;52:208-215. doi: 10.1016/j.clinimag.2018.08.012. Epub 2018 Aug 16.


Artificial Thermostable D-Amino Acid Dehydrogenase: Creation and Application.

Akita H, Hayashi J, Sakuraba H, Ohshima T.

Front Microbiol. 2018 Aug 3;9:1760. doi: 10.3389/fmicb.2018.01760. eCollection 2018. Review.


Magnetic compression anastomosis for the complete dehiscence of hepaticojejunostomy in a patient after living-donor liver transplantation.

Kubo M, Wada H, Eguchi H, Gotoh K, Iwagami Y, Yamada D, Akita H, Asaoka T, Noda T, Kobayashi S, Nakamura M, Ono Y, Osuga K, Yamanouchi E, Doki Y, Mori M.

Surg Case Rep. 2018 Aug 15;4(1):95. doi: 10.1186/s40792-018-0504-6.


Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA.

Shirane D, Tanaka H, Nakai Y, Yoshioka H, Akita H.

Biol Pharm Bull. 2018;41(8):1291-1294. doi: 10.1248/bpb.b18-00208.


c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.

Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.

Oncol Lett. 2018 Aug;16(2):1892-1898. doi: 10.3892/ol.2018.8793. Epub 2018 May 24.


Clinical Features and Prognosis of Patients With the Bone Metastasis of Pancreatic Cancer: A Single-Institutional Cohort Study.

Outani H, Akita H, Nakai T, Takada R, Imura Y, Tanaka T, Tamiya H, Oshima K, Takahashi H, Ohkawa K, Katayama K, Araki N, Naka N.

Pancreas. 2018 Aug;47(7):e43-e46. doi: 10.1097/MPA.0000000000001098. No abstract available.


A case report of myocarditis combined with hepatitis caused by herpes simplex virus.

Yamamoto T, Kenzaka T, Matsumoto M, Nishio R, Kawasaki S, Akita H.

BMC Cardiovasc Disord. 2018 Jul 3;18(1):134. doi: 10.1186/s12872-018-0869-2.


Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.

Sun Y, Piñón Hofbauer J, Harada M, Wöss K, Koller U, Morio H, Stierschneider A, Kitamura K, Hashimoto M, Chiba K, Akita H, Anzai N, Reichelt J, Bauer JW, Guttmann-Gruber C, Furihata T.

Cancer Lett. 2018 Oct 1;433:107-116. doi: 10.1016/j.canlet.2018.06.032. Epub 2018 Jun 27.


Analysis of genotype/phenotype correlations in Japanese patients with dyschromatosis symmetrica hereditaria.

Kobayashi T, Kono M, Suganuma M, Akita H, Takai A, Tsutsui K, Inasaka Y, Takeichi T, Muro Y, Akiyama M.

Nagoya J Med Sci. 2018 May;80(2):267-277. doi: 10.18999/nagjms.80.2.267.


Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Nitta SI, Hashimoto M, Kazuki Y, Takehara S, Suzuki H, Oshimura M, Akita H, Chiba K, Kobayashi K.

AAPS J. 2018 Apr 9;20(3):61. doi: 10.1208/s12248-018-0186-9.


Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y.

Drug Metab Dispos. 2018 Nov;46(11):1756-1766. doi: 10.1124/dmd.118.081216. Epub 2018 May 18.


Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies.

Ishizaki Y, Furihata T, Oyama Y, Ohura K, Imai T, Hosokawa M, Akita H, Chiba K.

Biol Pharm Bull. 2018;41(5):697-706. doi: 10.1248/bpb.b17-00880.


A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E-scaffold lipid-like material with the aid of an anti-inflammatory drug.

Togashi R, Tanaka H, Nakamura S, Yokota H, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

J Control Release. 2018 Jun 10;279:262-270. doi: 10.1016/j.jconrel.2018.04.022. Epub 2018 Apr 17.


RS3PE syndrome developing during the course of probable toxic shock syndrome: a case report.

Kyotani M, Kenzaka T, Nishio R, Akita H.

BMC Infect Dis. 2018 Apr 13;18(1):174. doi: 10.1186/s12879-018-3089-6.


Development of a mouse model for the visual and quantitative assessment of lymphatic trafficking and function by in vivo imaging.

Yamaji Y, Akita S, Akita H, Miura N, Gomi M, Manabe I, Kubota Y, Mitsukawa N.

Sci Rep. 2018 Apr 12;8(1):5921. doi: 10.1038/s41598-018-23693-9.


[A Case of Isolated Lateral Pelvic Lymph Node Recurrence after TME for Early Lower Rectal Cancer Treated with Laparoscopic Lateral Lymph Node Dissection].

Kimura R, Yasui M, Ohue M, Takahashi Y, Miyoshi N, Yanagimoto Y, Sugimura K, Tomokuni A, Akita H, Jeong-Ho M, Kobayashi S, Takahashi H, Omori T, Fujiwara Y, Miyata H, Yano M, Sakon M.

Gan To Kagaku Ryoho. 2018 Apr;45(4):734-736. Review. Japanese.


In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration.

Tanaka H, Nakatani T, Furihata T, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

Mol Pharm. 2018 May 7;15(5):2060-2067. doi: 10.1021/acs.molpharmaceut.7b01084. Epub 2018 Apr 11.


Prospective study of removing solar lentigines in Asians using a novel dual-wavelength and dual-pulse width picosecond laser.

Negishi K, Akita H, Matsunaga Y.

Lasers Surg Med. 2018 Oct;50(8):851-858. doi: 10.1002/lsm.22820. Epub 2018 Apr 2.


Early abiraterone acetate treatment is beneficial in Japanese castration-resistant prostate cancer after failure of primary combined androgen blockade.

Nagai T, Naiki T, Iida K, Etani T, Ando R, Hamamoto S, Sugiyama Y, Akita H, Kubota H, Hashimoto Y, Kawai N, Yasui T.

Prostate Int. 2018 Mar;6(1):18-23. doi: 10.1016/j.prnil.2017.07.001. Epub 2017 Aug 9.


Late Onset of Non-islet Cell Tumor Hypoglycemia Managed via Multidisciplinary Treatment in a Patient with a Solitary Fibrous Tumor.

Takeuchi S, Goda T, Taguchi J, Douhata Y, Honma R, Ariga S, Ohhara Y, Shimizu Y, Kinoshita I, Fukuda I, Nagashima Y, Akita H.

Intern Med. 2018 Aug 15;57(16):2431-2436. doi: 10.2169/internalmedicine.0231-17. Epub 2018 Mar 9.


Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker.

Morio H, Sun Y, Harada M, Ide H, Shimozato O, Zhou X, Higashi K, Yuki R, Yamaguchi N, Hofbauer JP, Guttmann-Gruber C, Anzai N, Akita H, Chiba K, Furihata T.

Biol Pharm Bull. 2018;41(3):445-449. doi: 10.1248/bpb.b17-00743.


Development of a New Conditionally Immortalized Human Liver Sinusoidal Endothelial Cells.

Zhu M, Koibuchi A, Ide H, Morio H, Shibuya M, Kamiichi A, Tsubota A, Anzai N, Akita H, Chiba K, Furihata T.

Biol Pharm Bull. 2018;41(3):440-444. doi: 10.1248/bpb.b17-00661.


The POU5F1 gene expression in colorectal cancer: a novel prognostic marker.

Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Sugimura K, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Omori T, Miyata H, Yano M.

Surg Today. 2018 Jul;48(7):709-715. doi: 10.1007/s00595-018-1644-9. Epub 2018 Feb 27.


18F-fluorodeoxyglucose positron emission tomography/computed tomography for the prediction of survival in patients with advanced esophageal cancer who have undergone neoadjuvant chemotherapy.

Yano M, Miyata H, Sugimura K, Motoori M, Omori T, Fujiwara Y, Miyoshi N, Yasui M, Ohue M, Akita H, Tomokuni A, Takahashi H, Kobayashi S, Sakon M.

Mol Clin Oncol. 2018 Mar;8(3):434-440. doi: 10.3892/mco.2018.1546. Epub 2018 Jan 10.


Reply to 'Influenza follicles and their buds as early diagnostic markers of influenza: typical images' and demonstration of lymphoid follicles in the posterior pharyngeal walls of patients with mycoplasmal pneumonia.

Kenzaka T, Kyotani M, Goda K, Akita H.

Postgrad Med J. 2018 May;94(1111):311-312. doi: 10.1136/postgradmedj-2017-135540. Epub 2018 Feb 12. No abstract available.


[A Case of Laparoscopic Low Anterior Dissection for Rectal Carcinoma with Left-Sided Inferior Vena Cava].

Takenaka Y, Yasui M, Ohue M, Takahashi Y, Miyoshi H, Yanagimoto Y, Tomokuni A, Sugimura K, Yamamoto K, Akita H, Takahashi H, Wada H, Omori T, Miyata H, Yano M.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1701-1703. Japanese.


[Surgical Resection of Peritoneal Recurrence of Hepatocellular Carcinoma with Endoscopic Fluorescence Imaging System].

Nishimura S, Tomokuni A, Kobayashi S, Asukai K, Akita H, Takahashi H, Yanagimoto Y, Takahashi Y, Miyoshi N, Sugimura K, Yamamoto K, Ohmori T, Ohue M, Yano M, Sakon M.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1665-1667. Japanese.


[A Case of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis Treated Successfully with Multidisciplinary Therapy Including Preoperative Stereotactic Body Radiotherapy(SBRT)].

Nishimura S, Tomokuni A, Kobayashi S, Asukai K, Akita H, Takahashi H, Yanagimoto Y, Takahashi Y, Miyoshi N, Sugimura K, Yamamoto K, Ohmori T, Ohue M, Yano M, Sakon M.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1650-1652. Japanese.


Laparoscopic Hilar Lymph Node Sampling in Patients With Biliary Tract Cancers That are Rarely Associated With Nodal Metastasis.

Kobayashi S, Tomokuni A, Takahashi H, Akita H, Marubashi S, Gotoh K, Yanagimoto Y, Takahashi Y, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Miyata H, Ohue M, Fujiwara Y, Yano M, Sakon M.

Surg Laparosc Endosc Percutan Tech. 2018 Apr;28(2):90-95. doi: 10.1097/SLE.0000000000000510.


A pilot study of gemcitabine and paclitaxel as third-line chemotherapy in metastatic urothelial carcinoma.

Naiki T, Iida K, Kawai N, Etani T, Ando R, Nagai T, Tanaka Y, Hamamoto S, Hamakawa T, Akita H, Sugiyama Y, Yasui T.

J Rural Med. 2017 Nov;12(2):105-111. doi: 10.2185/jrm.2940. Epub 2017 Nov 30.


Carbonylated proteins contribute to the darkness around facial pores.

Masaki H, Mizutani T, Ogawa N, Suzuki H, Okano Y, Akita H.

J Dermatol Sci. 2018 Mar;89(3):299-301. doi: 10.1016/j.jdermsci.2017.11.016. Epub 2017 Dec 5. No abstract available.


A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies.

Umehara K, Sun Y, Hiura S, Hamada K, Itoh M, Kitamura K, Oshima M, Iwama A, Saito K, Anzai N, Chiba K, Akita H, Furihata T.

Mol Neurobiol. 2018 Jul;55(7):5993-6006. doi: 10.1007/s12035-017-0815-9. Epub 2017 Nov 11.


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