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Items: 32

1.

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Krämer BK, Kronenberg F, Kubo M, Kühnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimäki T, Lieb W; Lifelines Cohort Study, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikäinen LP, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP; V. A. Million Veteran Program, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell J, O'Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx BWJH, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tönjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Völker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Böger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C.

Nat Genet. 2019 Jun;51(6):957-972. doi: 10.1038/s41588-019-0407-x. Epub 2019 May 31.

PMID:
31152163
2.

Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells.

Chu T, Ni M, Chen C, Akilesh S, Hamerman JA.

J Immunol. 2019 May 1;202(9):2529-2534. doi: 10.4049/jimmunol.1801267. Epub 2019 Apr 1.

PMID:
30936294
3.

Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma.

Siebenthall KT, Miller CP, Vierstra JD, Mathieu J, Tretiakova M, Reynolds A, Sandstrom R, Rynes E, Haugen E, Johnson A, Nelson J, Bates D, Diegel M, Dunn D, Frerker M, Buckley M, Kaul R, Zheng Y, Himmelfarb J, Ruohola-Baker H, Akilesh S.

EBioMedicine. 2019 Mar;41:427-442. doi: 10.1016/j.ebiom.2019.01.063. Epub 2019 Mar 1.

4.

Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci.

Sieber KB, Batorsky A, Siebenthall K, Hudkins KL, Vierstra JD, Sullivan S, Sur A, McNulty M, Sandstrom R, Reynolds A, Bates D, Diegel M, Dunn D, Nelson J, Buckley M, Kaul R, Sampson MG, Himmelfarb J, Alpers CE, Waterworth D, Akilesh S.

J Am Soc Nephrol. 2019 Feb 13. pii: ASN.2018030309. doi: 10.1681/ASN.2018030309. [Epub ahead of print]

PMID:
30760496
5.

IgA-dominant glomerulonephritis with a membranoproliferative pattern of injury.

Andeen NK, Jefferson JA, Akilesh S, Alpers CE, Bissonnette ML, Finn LS, Higgins J, Houghton DC, Kambham N, Magil A, Najafian B, Nicosia RF, Troxell ML, Smith KD.

Hum Pathol. 2018 Nov;81:272-280. doi: 10.1016/j.humpath.2018.06.031. Epub 2018 Jul 3.

PMID:
30420049
6.

A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis.

Miller CP, Tsuchida C, Zheng Y, Himmelfarb J, Akilesh S.

Neoplasia. 2018 Jun;20(6):610-620. doi: 10.1016/j.neo.2018.02.011. Epub 2018 May 7.

7.

B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.

Kim AH, Chung JJ, Akilesh S, Koziell A, Jain S, Hodgin JB, Miller MJ, Stappenbeck TS, Miner JH, Shaw AS.

JCI Insight. 2017 Nov 2;2(21). pii: 81836. doi: 10.1172/jci.insight.81836.

8.

Cross-Platform DNA Encoding for Single-Cell Imaging of Gene Expression.

Zrazhevskiy P, Akilesh S, Tai W, Queitsch K, True LD, Fromm J, Wu D, Nelson P, Stamatoyannopoulos JA, Gao X.

Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8975-8. doi: 10.1002/anie.201603945. Epub 2016 Jun 7.

9.

Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine.

Shiue Z, McNicholas B, Cormack F, Akilesh S.

Clin Nephrol Case Stud. 2014 Dec 15;3:37-41. doi: 10.5414/CNCS108385. eCollection 2015.

10.

Chronic Ifosfamide toxicity: kidney pathology and pathophysiology.

Akilesh S, Juaire N, Duffield JS, Smith KD.

Am J Kidney Dis. 2014 May;63(5):843-50. doi: 10.1053/j.ajkd.2013.11.028. Epub 2014 Feb 8. Erratum in: Am J Kidney Dis. 2014 Oct;64(4):666.

PMID:
24518127
11.

Combined crystalline podocytopathy and tubulopathy associated with multiple myeloma.

Akilesh S, Alem A, Nicosia RF.

Hum Pathol. 2014 Apr;45(4):875-9. doi: 10.1016/j.humpath.2013.10.007. Epub 2013 Oct 19.

PMID:
24439928
12.

Rac1 activation in podocytes induces rapid foot process effacement and proteinuria.

Yu H, Suleiman H, Kim AH, Miner JH, Dani A, Shaw AS, Akilesh S.

Mol Cell Biol. 2013 Dec;33(23):4755-64. doi: 10.1128/MCB.00730-13. Epub 2013 Sep 23.

13.

Monoclonal antibodies directed against human FcRn and their applications.

Christianson GJ, Sun VZ, Akilesh S, Pesavento E, Proetzel G, Roopenian DC.

MAbs. 2012 Mar-Apr;4(2):208-16. doi: 10.4161/mabs.4.2.19397. Epub 2012 Mar 1.

14.

Infectious pseudotumors: red herrings in head and neck pathology.

El-Mofty SK, Akilesh S.

Head Neck Pathol. 2012 Mar;6(1):58-63. doi: 10.1007/s12105-012-0340-0. Epub 2012 Mar 20.

15.

Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.

Akilesh S, Suleiman H, Yu H, Stander MC, Lavin P, Gbadegesin R, Antignac C, Pollak M, Kopp JB, Winn MP, Shaw AS.

J Clin Invest. 2011 Oct;121(10):4127-37. doi: 10.1172/JCI46458. Epub 2011 Sep 12.

16.

Pseudotumor of the tracheal-laryngeal junction with unusual morphologic features caused by Rhodococcus equi infection.

Akilesh S, Cross S, Kimmelshue K, Kirmani N, Dehner LP, El-Mofty SK.

Head Neck Pathol. 2011 Dec;5(4):395-400. doi: 10.1007/s12105-011-0259-x. Epub 2011 Apr 26. Review.

17.

Expression profiles of podocytes exposed to high glucose reveal new insights into early diabetic glomerulopathy.

Jain S, De Petris L, Hoshi M, Akilesh S, Chatterjee R, Liapis H.

Lab Invest. 2011 Apr;91(4):488-98. doi: 10.1038/labinvest.2010.188. Epub 2010 Nov 22.

18.

Acute renal allograft thrombosis in 'seronegative' antiphospholipid syndrome.

Akilesh S, Jendrisak M, Zhang L, Lewis JS Jr, Liapis H.

NDT Plus. 2009 Apr;2(2):181-2. doi: 10.1093/ndtplus/sfn193. No abstract available.

19.

Podocytes use FcRn to clear IgG from the glomerular basement membrane.

Akilesh S, Huber TB, Wu H, Wang G, Hartleben B, Kopp JB, Miner JH, Roopenian DC, Unanue ER, Shaw AS.

Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):967-72. doi: 10.1073/pnas.0711515105. Epub 2008 Jan 15.

20.

An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.

Graham DB, Stephenson LM, Lam SK, Brim K, Lee HM, Bautista J, Gilfillan S, Akilesh S, Fujikawa K, Swat W.

J Exp Med. 2007 Nov 26;204(12):2889-97. Epub 2007 Nov 5.

21.

Basic science meets clinical medicine: identification of a CD2AP-deficient patient.

Akilesh S, Koziell A, Shaw AS.

Kidney Int. 2007 Nov;72(10):1181-3.

22.

Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism.

Akilesh S, Christianson GJ, Roopenian DC, Shaw AS.

J Immunol. 2007 Oct 1;179(7):4580-8.

23.

FcRn: the neonatal Fc receptor comes of age.

Roopenian DC, Akilesh S.

Nat Rev Immunol. 2007 Sep;7(9):715-25. Epub 2007 Aug 17. Review.

PMID:
17703228
24.

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC.

Int Immunol. 2006 Dec;18(12):1759-69. Epub 2006 Oct 31.

PMID:
17077181
25.

Metal-binding thermodynamics of the histidine-rich sequence from the metal-transport protein IRT1 of Arabidopsis thaliana.

Grossoehme NE, Akilesh S, Guerinot ML, Wilcox DE.

Inorg Chem. 2006 Oct 16;45(21):8500-8. Erratum in: Inorg Chem. 2006 oCT 16;45(21):8812.

PMID:
17029360
26.

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.

Ozaki K, Spolski R, Ettinger R, Kim HP, Wang G, Qi CF, Hwu P, Shaffer DJ, Akilesh S, Roopenian DC, Morse HC 3rd, Lipsky PE, Leonard WJ.

J Immunol. 2004 Nov 1;173(9):5361-71.

27.

Quantitative gene expression profiling implicates genes for susceptibility and resistance to alveolar bone loss.

Hart GT, Shaffer DJ, Akilesh S, Brown AC, Moran L, Roopenian DC, Baker PJ.

Infect Immun. 2004 Aug;72(8):4471-9.

28.

The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease.

Akilesh S, Petkova S, Sproule TJ, Shaffer DJ, Christianson GJ, Roopenian D.

J Clin Invest. 2004 May;113(9):1328-33.

29.
30.

The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs.

Roopenian DC, Christianson GJ, Sproule TJ, Brown AC, Akilesh S, Jung N, Petkova S, Avanessian L, Choi EY, Shaffer DJ, Eden PA, Anderson CL.

J Immunol. 2003 Apr 1;170(7):3528-33.

31.

Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection.

Akilesh S, Dudley ME, Eden PA, Roopenian DC.

J Immunol. 2001 Nov 1;167(9):5143-9.

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