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Items: 1 to 50 of 248

1.

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab.

Kato D, Yaguchi T, Iwata T, Katoh Y, Morii K, Tsubota K, Takise Y, Tamiya M, Kamada H, Akiba H, Tsumoto K, Serada S, Naka T, Nishimura R, Nakagawa T, Kawakami Y.

Elife. 2020 Mar 31;9. pii: e49392. doi: 10.7554/eLife.49392.

2.

Computer-guided library generation applied to the optimization of single-domain antibodies.

Akiba H, Tamura H, Caaveiro JMM, Tsumoto K.

Protein Eng Des Sel. 2019 Dec 31;32(9):423-431. doi: 10.1093/protein/gzaa006.

PMID:
32167147
3.

Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher.

Akiba H, Takayanagi K, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K.

Biotechnol Rep (Amst). 2020 Jan 11;25:e00418. doi: 10.1016/j.btre.2020.e00418. eCollection 2020 Mar.

4.

Rational Synthesis for a Noble Metal Carbide.

Wakisaka T, Kusada K, Wu D, Yamamoto T, Toriyama T, Matsumura S, Akiba H, Yamamuro O, Ikeda K, Otomo T, Palina N, Chen Y, Kumara LSR, Song C, Sakata O, Xie W, Koyama M, Kubota Y, Kawaguchi S, Arevalo RL, Aspera SM, Arguelles EF, Nakanishi H, Kitagawa H.

J Am Chem Soc. 2020 Jan 22;142(3):1247-1253. doi: 10.1021/jacs.9b09219. Epub 2019 Nov 21.

PMID:
31750648
5.

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody.

Akiba H, Tamura H, Kiyoshi M, Yanaka S, Sugase K, Caaveiro JMM, Tsumoto K.

Sci Rep. 2019 Oct 29;9(1):15481. doi: 10.1038/s41598-019-50722-y.

6.

111In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis.

Fujiwara K, Tsuji AB, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T, Higashi T.

Ann Nucl Med. 2020 Jan;34(1):13-23. doi: 10.1007/s12149-019-01408-y. Epub 2019 Oct 12.

7.

Transcranial direct current stimulation (tDCS) in elderly with mild cognitive impairment: A pilot study.

Gomes MA, Akiba HT, Gomes JS, Trevizol AP, de Lacerda ALT, Dias ÁM.

Dement Neuropsychol. 2019 Apr-Jun;13(2):187-195. doi: 10.1590/1980-57642018dn13-020007.

8.

Neural Correlates of Preference: A Transmodal Validation Study.

Akiba HT, Costa MF, Gomes JS, Oda E, Simurro PB, Dias AM.

Front Hum Neurosci. 2019 Mar 18;13:73. doi: 10.3389/fnhum.2019.00073. eCollection 2019.

9.

Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition.

Matsuno K, Harada N, Harada S, Takeshige T, Ishimori A, Itoigawa Y, Katsura Y, Kodama Y, Makino F, Ito J, Atsuta R, Akiba H, Takahashi K.

Exp Lung Res. 2018 Sep;44(7):332-343. doi: 10.1080/01902148.2018.1522558. Epub 2019 Jan 24.

PMID:
30676129
10.

Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E.

Yasuda M, Harada N, Harada S, Ishimori A, Katsura Y, Itoigawa Y, Matsuno K, Makino F, Ito J, Ono J, Tobino K, Akiba H, Atsuta R, Izuhara K, Takahashi K.

Allergy Asthma Clin Immunol. 2018 Nov 19;14:72. doi: 10.1186/s13223-018-0300-7. eCollection 2018.

11.

Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody.

Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K.

J Struct Biol. 2018 Nov;204(2):207-214. doi: 10.1016/j.jsb.2018.08.011. Epub 2018 Aug 18.

PMID:
30125694
12.

Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody.

Miyanabe K, Yamashita T, Abe Y, Akiba H, Takamatsu Y, Nakakido M, Hamakubo T, Ueda T, Caaveiro JMM, Tsumoto K.

Biochemistry. 2018 Jul 17;57(28):4177-4185. doi: 10.1021/acs.biochem.8b00592. Epub 2018 Jul 5.

PMID:
29936828
13.

Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody.

Miyanabe K, Akiba H, Kuroda D, Nakakido M, Kusano-Arai O, Iwanari H, Hamakubo T, Caaveiro JMM, Tsumoto K.

J Biochem. 2018 Jul 1;164(1):65-76. doi: 10.1093/jb/mvy032.

PMID:
29924367
14.

Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity.

Kawade R, Akiba H, Entzminger K, Maruyama T, Okumura CJ, Tsumoto K.

Protein Eng Des Sel. 2018 Jul 1;31(7-8):243-247. doi: 10.1093/protein/gzy008.

PMID:
29850878
15.

Effects of transcranial direct current stimulation on working memory and negative symptoms in schizophrenia: a phase II randomized sham-controlled trial.

Gomes JS, Trevizol AP, Ducos DV, Gadelha A, Ortiz BB, Fonseca AO, Akiba HT, Azevedo CC, Guimaraes LSP, Shiozawa P, Cordeiro Q, Lacerda A, Dias AM.

Schizophr Res Cogn. 2018 Feb 20;12:20-28. doi: 10.1016/j.scog.2018.02.003. eCollection 2018 Jun.

16.

Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17.

Kusano-Arai O, Iwanari H, Kudo S, Kikuchi C, Yui A, Akiba H, Matsusaka K, Kaneda A, Fukayama M, Tsumoto K, Hamakubo T.

Monoclon Antib Immunodiagn Immunother. 2018 Feb;37(1):1-11. doi: 10.1089/mab.2017.0043.

PMID:
29474162
17.

Cutting Edge: Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice.

Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S.

J Immunol. 2017 Dec 1;199(11):3733-3737. doi: 10.4049/jimmunol.1700059. Epub 2017 Oct 23.

18.

Thermodynamic analyses of amino acid residues at the interface of an antibody B2212A and its antigen roundabout homolog 1.

Yui A, Akiba H, Kudo S, Nakakido M, Nagatoishi S, Tsumoto K.

J Biochem. 2017 Oct 1;162(4):255-258. doi: 10.1093/jb/mvx050.

PMID:
28981752
19.

Hemoencephalography self-regulation training and its impact on cognition: A study with schizophrenia and healthy participants.

Gomes JS, Ducos DV, Gadelha A, Ortiz BB, Van Deusen AM, Akiba HT, Guimaraes LSP, Cordeiro Q, Trevizol AP, Lacerda A, Dias AM.

Schizophr Res. 2018 May;195:591-593. doi: 10.1016/j.schres.2017.08.044. Epub 2017 Sep 5.

PMID:
28882685
20.

Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen.

Yumura K, Akiba H, Nagatoishi S, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K.

J Biochem. 2017 Sep 1;162(3):203-210. doi: 10.1093/jb/mvx023.

PMID:
28637250
21.

Transcranial direct current stimulation for refractory major depressive disorder temporal lobe epilepsy: A quantitative electroencephalography study.

Gomes JS, Dias ÁM, Scorza FA, Cordeiro Q, Sato IA, Akiba H, Barros MD, Trevizol AP.

Epilepsy Behav. 2017 Jul;72:205-207. doi: 10.1016/j.yebeh.2017.04.012. Epub 2017 Jun 10. No abstract available.

PMID:
28606691
22.

Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.

Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J.

Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6815-6823. doi: 10.1167/iovs.16-20644.

PMID:
28002569
23.

Transcranial Direct Current Stimulation Effects on Athletes' Cognitive Performance: An Exploratory Proof of Concept Trial.

Borducchi DM, Gomes JS, Akiba H, Cordeiro Q, Borducchi JH, Valentin LS, Borducchi GM, Dias ÁM.

Front Psychiatry. 2016 Nov 30;7:183. eCollection 2016.

24.

Improved Brain Expression of Anti-Amyloid β scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer.

Perche F, Uchida S, Akiba H, Lin CY, Ikegami M, Dirisala A, Nakashima T, Itaka K, Tsumoto K, Kataoka K.

Curr Alzheimer Res. 2017;14(3):295-302. doi: 10.2174/1567205013666161108110031.

PMID:
27829339
25.

Effect of transcranial direct current stimulation (tDCS) over the prefrontal cortex combined with cognitive training for treating schizophrenia: a sham-controlled randomized clinical trial.

Shiozawa P, Gomes JS, Ducos DV, Akiba HT, Dias ÁM, Trevizol AP, Uchida RR, Orlov N, Cordeiro Q.

Trends Psychiatry Psychother. 2016 Jul-Sep;38(3):175-177. doi: 10.1590/2237-6089-2015-0043.

26.

A neurofeedback protocol to improve mild anxiety and sleep quality.

Gomes JS, Ducos DV, Akiba H, Dias ÁM.

Braz J Psychiatry. 2016 Jul-Sep;38(3):264-5. doi: 10.1590/1516-4446-2015-1811. No abstract available.

27.

Trigeminal Nerve Stimulation for olfactory hallucinations in schizophrenia: case study.

Gomes JS, Akiba H, Dias ÁM, Soares A, Taiar I, Gadelha AA, Cordeiro Q, Shiozawa P.

Schizophr Res. 2016 Oct;176(2-3):203-205. doi: 10.1016/j.schres.2016.08.002. Epub 2016 Aug 9. No abstract available.

PMID:
27515987
28.

Nanometer-Size Effect on Hydrogen Sites in Palladium Lattice.

Akiba H, Kofu M, Kobayashi H, Kitagawa H, Ikeda K, Otomo T, Yamamuro O.

J Am Chem Soc. 2016 Aug 17;138(32):10238-43. doi: 10.1021/jacs.6b04970. Epub 2016 Aug 8.

PMID:
27462875
29.

Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes.

Sumaoka J, Akiba H, Komiyama M.

Int J Anal Chem. 2016;2016:3216523. doi: 10.1155/2016/3216523. Epub 2016 Jun 8. Review.

30.

OX40L blockade protects against inflammation-driven fibrosis.

Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Fréchet M, Burgevin A, Pezet S, Sadoine J, Guilbert T, Nicco C, Akiba H, Heissmeyer V, Subramaniam A, Resnick R, Molberg Ø, Kahan A, Chiocchia G, Allanore Y.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3901-10. doi: 10.1073/pnas.1523512113. Epub 2016 Jun 13.

31.

Neuropsychological correlates of remission in chronic schizophrenia subjects: The role of general and task-specific executive processes.

Rabanea-Souza T, Akiba HT, Berberian AA, Bressan RA, Dias ÁM, Lacerda ALT.

Schizophr Res Cogn. 2016 Feb 16;3:39-46. doi: 10.1016/j.scog.2015.12.001. eCollection 2016 Mar.

32.

Left Dorsolateral Prefrontal Cortex Anodal tDCS Effects on Negative Symptoms in Schizophrenia.

Gomes JS, Shiozawa P, Dias ÁM, Valverde Ducos D, Akiba H, Trevizol AP, Bikson M, Aboseria M, Gadelha A, de Lacerda AL, Cordeiro Q.

Brain Stimul. 2015 Sep-Oct;8(5):989-91. doi: 10.1016/j.brs.2015.07.033. Epub 2015 Aug 3. No abstract available.

PMID:
26279407
33.

Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation.

Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K.

Exp Lung Res. 2015;41(7):370-82. doi: 10.3109/01902148.2015.1044137.

PMID:
26151756
34.

ICOS promotes group 2 innate lymphoid cell activation in lungs.

Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):739-45. doi: 10.1016/j.bbrc.2015.06.005. Epub 2015 Jun 4.

PMID:
26049110
35.

Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions.

Akiba H, Tsumoto K.

J Biochem. 2015 Jul;158(1):1-13. doi: 10.1093/jb/mvv049. Epub 2015 May 7. Review.

PMID:
25956164
36.

Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells.

Tripathi S, Chabtini L, Dakle PJ, Smith B, Akiba H, Yagita H, Guleria I.

PLoS One. 2015 Apr 21;10(4):e0123439. doi: 10.1371/journal.pone.0123439. eCollection 2015.

37.

Click conjugation of a binuclear terbium(III) complex for real-time detection of tyrosine phosphorylation.

Akiba H, Sumaoka J, Tsumoto K, Komiyama M.

Anal Chem. 2015 Apr 7;87(7):3834-40. doi: 10.1021/ac5045466. Epub 2015 Mar 24.

PMID:
25757507
38.

Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex.

Akiba H, Sumaoka J, Hamakubo T, Komiyama M.

Anal Bioanal Chem. 2014 May;406(12):2957-64. doi: 10.1007/s00216-014-7707-x. Epub 2014 Mar 21.

PMID:
24652149
39.

Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice.

Nozaki Y, Kitching AR, Akiba H, Yagita H, Kinoshita K, Funauchi M, Matsumura I.

Am J Physiol Renal Physiol. 2014 May 15;306(10):F1210-21. doi: 10.1152/ajprenal.00570.2013. Epub 2014 Mar 12.

40.

The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease.

Kaneyama T, Tomiki H, Tsugane S, Inaba Y, Ichikawa M, Akiba H, Yagita H, Kim BS, Koh CS.

Int Immunol. 2014 Jul;26(7):369-81. doi: 10.1093/intimm/dxt056. Epub 2014 Jan 31.

PMID:
24486565
41.

OX40 ligand regulates splenic CD8⁻ dendritic cell-induced Th2 responses in vivo.

Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H.

Biochem Biophys Res Commun. 2014 Feb 7;444(2):235-40. doi: 10.1016/j.bbrc.2014.01.060. Epub 2014 Jan 22.

PMID:
24462862
42.

TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.

Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M.

Immunity. 2013 Dec 12;39(6):1070-81. doi: 10.1016/j.immuni.2013.09.014. Epub 2013 Dec 5.

43.

TIM-4 has dual function in the induction and effector phases of murine arthritis.

Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H.

J Immunol. 2013 Nov 1;191(9):4562-72. doi: 10.4049/jimmunol.1203035. Epub 2013 Sep 25.

44.

Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.

Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N.

J Immunol. 2013 Oct 15;191(8):4447-55. doi: 10.4049/jimmunol.1300992. Epub 2013 Sep 13.

45.

Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.

Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Müller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, Ohteki T.

Immunity. 2013 Sep 19;39(3):584-98. doi: 10.1016/j.immuni.2013.06.019. Epub 2013 Sep 12.

46.

T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis.

Foks AC, Ran IA, Wasserman L, Frodermann V, Ter Borg MN, de Jager SC, van Santbrink PJ, Yagita H, Akiba H, Bot I, Kuiper J, van Puijvelde GH.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2558-65. doi: 10.1161/ATVBAHA.113.301879. Epub 2013 Aug 29.

PMID:
23990206
47.

Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.

Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J.

PLoS One. 2013 May 7;8(5):e63620. doi: 10.1371/journal.pone.0063620. Print 2013.

48.

TIM-3 regulates innate immune cells to induce fetomaternal tolerance.

Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, Smith BD, Boenisch O, Najafian N, Akiba H, Yagita H, Guleria I.

J Immunol. 2013 Jan 1;190(1):88-96. doi: 10.4049/jimmunol.1202176. Epub 2012 Nov 23.

49.

Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.

Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M.

Cancer Immunol Immunother. 2013 Apr;62(4):629-37. doi: 10.1007/s00262-012-1371-9. Epub 2012 Nov 10.

PMID:
23143694
50.

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.

Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M.

Nat Immunol. 2012 Sep;13(9):832-42. doi: 10.1038/ni.2376. Epub 2012 Jul 29.

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