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Items: 24


The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.

Zhang W, Li Q, Li D, Li J, Aki D, Liu YC.

J Exp Med. 2018 Dec 3;215(12):3180-3193. doi: 10.1084/jem.20181211. Epub 2018 Nov 21.


Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch.

Aki D, Li Q, Li H, Liu YC, Lee JH.

Protein Cell. 2018 Nov 9. doi: 10.1007/s13238-018-0586-8. [Epub ahead of print] Review.


The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.

Aki D, Li H, Zhang W, Zheng M, Elly C, Lee JH, Zou W, Liu YC.

Nat Immunol. 2018 Jul;19(7):766-775. doi: 10.1038/s41590-018-0137-8. Epub 2018 Jun 20.


The E3 ligase Itch in immune regulation and beyond.

Aki D, Zhang W, Liu YC.

Immunol Rev. 2015 Jul;266(1):6-26. doi: 10.1111/imr.12301. Review.


The ubiquitin system in immune regulation.

Park Y, Jin HS, Aki D, Lee J, Liu YC.

Adv Immunol. 2014;124:17-66. doi: 10.1016/B978-0-12-800147-9.00002-9. Review.


Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.

Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T.

Cancer Cell. 2013 Sep 9;24(3):305-17. doi: 10.1016/j.ccr.2013.08.011.


Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.

Ozaki Y, Matsui H, Asou H, Nagamachi A, Aki D, Honda H, Yasunaga S, Takihara Y, Yamamoto T, Izumi S, Ohsugi M, Inaba T.

Mol Cell. 2012 Sep 14;47(5):694-706. doi: 10.1016/j.molcel.2012.06.033. Epub 2012 Aug 2.


To go or not to go: the "itchy" effect on the destiny of hematopoietic stem cells.

Aki D, Liu YC.

Cell Res. 2011 Aug;21(8):1161-3. doi: 10.1038/cr.2011.95. Epub 2011 Jun 7. No abstract available.


The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase.

Ozaki Y, Matsui H, Nagamachi A, Asou H, Aki D, Inaba T.

J Biol Chem. 2011 Feb 18;286(7):5589-98. doi: 10.1074/jbc.M110.167742. Epub 2010 Dec 16.


Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.

Okuya M, Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura RA, Sugita K, Arisaka O, Look AT, Inaba T.

J Biol Chem. 2010 Jan 15;285(3):1850-60. doi: 10.1074/jbc.M109.023762. Epub 2009 Nov 2.


A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.

Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A.

J Immunol. 2009 May 15;182(10):5929-37. doi: 10.4049/jimmunol.0802672.


Identification of a common microdeletion cluster in 7q21.3 subband among patients with myeloid leukemia and myelodysplastic syndrome.

Asou H, Matsui H, Ozaki Y, Nagamachi A, Nakamura M, Aki D, Inaba T.

Biochem Biophys Res Commun. 2009 May 29;383(2):245-51. doi: 10.1016/j.bbrc.2009.04.004. Epub 2009 Apr 7.


Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.

Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, Chinen T, Inaba T, Hikida M, Kurosaki T, Saeki K, Yoshimura A.

Genes Cells. 2008 Feb;13(2):199-208. doi: 10.1111/j.1365-2443.2007.01159.x.


A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.

Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30. Epub 2006 Apr 19. Erratum in: Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121.


FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.

Mashima R, Saeki K, Aki D, Minoda Y, Takaki H, Sanada T, Kobayashi T, Aburatani H, Yamanashi Y, Yoshimura A.

J Biol Chem. 2005 Dec 16;280(50):41289-97. Epub 2005 Oct 12.


Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages.

Aki D, Mashima R, Saeki K, Minoda Y, Yamauchi M, Yoshimura A.

Genes Cells. 2005 Apr;10(4):357-68.


Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines.

Ohishi M, Matsumura Y, Aki D, Mashima R, Taniguchi K, Kobayashi T, Kukita T, Iwamoto Y, Yoshimura A.

J Immunol. 2005 Mar 1;174(5):3024-31.


Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.

Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A.

Nat Med. 2004 Jul;10(7):739-43. Epub 2004 Jun 20.


Regulation of TLR signaling and inflammation by SOCS family proteins.

Yoshimura A, Ohishi HM, Aki D, Hanada T.

J Leukoc Biol. 2004 Mar;75(3):422-7. Epub 2004 Jan 14. Review.


Negative regulation of cytokine signaling influences inflammation.

Yoshimura A, Mori H, Ohishi M, Aki D, Hanada T.

Curr Opin Immunol. 2003 Dec;15(6):704-8. Review.


IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.

Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A.

Nat Immunol. 2003 Jun;4(6):551-6. Epub 2003 May 18.


STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.

Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A.

J Biol Chem. 2003 Mar 28;278(13):11182-9. Epub 2003 Jan 22.


SOCS1/JAB is a negative regulator of LPS-induced macrophage activation.

Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A.

Immunity. 2002 Nov;17(5):583-91.

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