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From prevention to cure, repurposing anti-viral vaccines for cancer immunotherapy.

Mamai O, Dodagatta-Marri E, Akhurst RJ.

Biotarget. 2018 Dec;2. pii: 20. doi: 10.21037/biotarget.2018.12.03. No abstract available.


α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.

Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza A, Quezada SA, Rosenblum MD, Krummel MF, Balmain A, Akhurst RJ.

J Immunother Cancer. 2019 Mar 4;7(1):62. doi: 10.1186/s40425-018-0493-9.


Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition.

Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R.

Sci Signal. 2019 Feb 26;12(570). pii: eaau8544. doi: 10.1126/scisignal.aau8544.


Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells.

Budi EH, Mamai O, Hoffman S, Akhurst RJ, Derynck R.

iScience. 2019 Jan 25;11:474-491. doi: 10.1016/j.isci.2018.12.038. Epub 2019 Jan 3.


Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition.

Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R.

EMBO Rep. 2018 Jan;19(1):135-155. doi: 10.15252/embr.201744250. Epub 2017 Dec 12.


Targeting TGF-β Signaling for Therapeutic Gain.

Akhurst RJ.

Cold Spring Harb Perspect Biol. 2017 Oct 3;9(10). pii: a022301. doi: 10.1101/cshperspect.a022301. Review.


ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation.

Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R.

PLoS Biol. 2015 Dec 17;13(12):e1002325. doi: 10.1371/journal.pbio.1002325. eCollection 2015 Dec.


Matters of context guide future research in TGFβ superfamily signaling.

Akhurst RJ, Padgett RW.

Sci Signal. 2015 Oct 20;8(399):re10. doi: 10.1126/scisignal.aad0416. Review.


Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.

Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons DM, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ.

Front Genet. 2015 Mar 12;6:67. doi: 10.3389/fgene.2015.00067. eCollection 2015.


Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans.

Kawasaki K, Freimuth J, Meyer DS, Lee MM, Tochimoto-Okamoto A, Benzinou M, Clermont FF, Wu G, Roy R, Letteboer TG, Ploos van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Westermann CJ, Coffey RJ Jr, Akhurst RJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7723-8. doi: 10.1073/pnas.1318761111. Epub 2014 May 8.


BMP-9 balances endothelial cell fate.

Derynck R, Akhurst RJ.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18746-7. doi: 10.1073/pnas.1318346110. Epub 2013 Nov 12. No abstract available.


Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology.

Kang HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A.

J Invest Dermatol. 2013 Jul;133(7):1907-10. doi: 10.1038/jid.2013.45. Epub 2013 Jan 28. No abstract available.


Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.

Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18042-7. doi: 10.1073/pnas.1205374109. Epub 2012 Oct 11.


Targeting the TGFβ signalling pathway in disease.

Akhurst RJ, Hata A.

Nat Rev Drug Discov. 2012 Oct;11(10):790-811. doi: 10.1038/nrd3810. Epub 2012 Sep 24. Review.


The paradoxical TGF-β vasculopathies.

Akhurst RJ.

Nat Genet. 2012 Jul 27;44(8):838-9. doi: 10.1038/ng.2366. No abstract available.


Complexities of TGF-β targeted cancer therapy.

Connolly EC, Freimuth J, Akhurst RJ.

Int J Biol Sci. 2012;8(7):964-78. doi: 10.7150/ijbs.4564. Epub 2012 Jul 12. Review.


TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.

Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R.

J Cell Sci. 2012 Mar 1;125(Pt 5):1259-73. doi: 10.1242/jcs.095299. Epub 2012 Mar 7.


Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β.

Arnold TD, Ferrero GM, Qiu H, Phan IT, Akhurst RJ, Huang EJ, Reichardt LF.

J Neurosci. 2012 Jan 25;32(4):1197-206. doi: 10.1523/JNEUROSCI.5648-11.2012. Erratum in: J Neurosci. 2012 Apr 11;32(15):5351.


Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.

Benzinou M, Clermont FF, Letteboer TG, Kim JH, Espejel S, Harradine KA, Arbelaez J, Luu MT, Roy R, Quigley D, Higgins MN, Zaid M, Aouizerat BE, van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Plauchu H, Hughes CC, Westermann CJ, Akhurst RJ.

Nat Commun. 2012 Jan 10;3:616. doi: 10.1038/ncomms1633. Erratum in: Nat Commun. 2012;3:1148.


TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

Bouquet F, Pal A, Pilones KA, Demaria S, Hann B, Akhurst RJ, Babb JS, Lonning SM, DeWyngaert JK, Formenti SC, Barcellos-Hoff MH.

Clin Cancer Res. 2011 Nov 1;17(21):6754-65. doi: 10.1158/1078-0432.CCR-11-0544. Epub 2011 Oct 25.


The complexities of TGF-β action during mammary and squamous cell carcinogenesis.

Connolly EC, Akhurst RJ.

Curr Pharm Biotechnol. 2011 Dec;12(12):2138-49. Review.


Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761.

Connolly EC, Saunier EF, Quigley D, Luu MT, De Sapio A, Hann B, Yingling JM, Akhurst RJ.

Cancer Res. 2011 Mar 15;71(6):2339-49. doi: 10.1158/0008-5472.CAN-10-2941. Epub 2011 Jan 31.


Taking thalidomide out of rehab.

Akhurst RJ.

Nat Med. 2010 Apr;16(4):370-2. doi: 10.1038/nm0410-370. No abstract available.


Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients.

Harradine KA, Ridd K, Saunier EF, Clermont FF, Perez-Losada J, Moore DH, Epstein EH Jr, Bastian BC, Akhurst RJ.

Clin Cancer Res. 2009 Aug 15;15(16):5101-7. doi: 10.1158/1078-0432.CCR-08-3286. Epub 2009 Aug 11.


Transgenic peas expressing an alpha-amylase inhibitor gene from beans show altered expression and modification of endogenous proteins.

Islam N, Campbell PM, Higgins TJ, Hirano H, Akhurst RJ.

Electrophoresis. 2009 Jun;30(11):1863-8. doi: 10.1002/elps.200800717.


Transforming growth factor-beta in breast cancer: too much, too late.

Barcellos-Hoff MH, Akhurst RJ.

Breast Cancer Res. 2009;11(1):202. doi: 10.1186/bcr2224. Epub 2009 Feb 26. Review.


Use of a Cry1Ac-resistant line of Helicoverpa armigera (Lepidoptera: Noctuidae) to detect novel insecticidal toxin genes in Bacillus thuringiensis.

Beard CE, Court L, Mourant RG, James B, Van Rie J, Masson L, Akhurst RJ.

Curr Microbiol. 2008 Sep;57(3):175-80. doi: 10.1007/s00284-008-9098-8. Epub 2008 Jul 1.


Unusually high frequency of genes encoding vegetative insecticidal proteins in an Australian Bacillus thuringiensis collection.

Beard CE, Court L, Boets A, Mourant R, Van Rie J, Akhurst RJ.

Curr Microbiol. 2008 Sep;57(3):195-9. doi: 10.1007/s00284-008-9173-1. Epub 2008 Jul 1.


Diversity of aminopeptidases, derived from four lepidopteran gene duplications, and polycalins expressed in the midgut of Helicoverpa armigera: identification of proteins binding the delta-endotoxin, Cry1Ac of Bacillus thuringiensis.

Angelucci C, Barrett-Wilt GA, Hunt DF, Akhurst RJ, East PD, Gordon KH, Campbell PM.

Insect Biochem Mol Biol. 2008 Jul;38(7):685-96. doi: 10.1016/j.ibmb.2008.03.010. Epub 2008 Apr 4.


The type I TGF-beta receptor is covalently modified and regulated by sumoylation.

Kang JS, Saunier EF, Akhurst RJ, Derynck R.

Nat Cell Biol. 2008 Jun;10(6):654-64. doi: 10.1038/ncb1728. Epub 2008 May 11.


A pair of adjacent genes, cry5Ad and orf2-5Ad, encode the typical N- and C-terminal regions of a Cry5Adelta-endotoxin as two separate proteins in Bacillus thuringiensis strain L366.

Lenane IJ, Bagnall NH, Josh PF, Pearson RD, Akhurst RJ, Kotze AC.

FEMS Microbiol Lett. 2008 Jan;278(1):115-20. Epub 2007 Nov 19.


The requirement for early exposure of Haemonchus contortus larvae to Bacillus thuringiensis for effective inhibition of larval development.

O'Grady J, Akhurst RJ, Kotze AC.

Vet Parasitol. 2007 Nov 30;150(1-2):97-103. Epub 2007 Oct 22.


Differentiation plasticity regulated by TGF-beta family proteins in development and disease.

Derynck R, Akhurst RJ.

Nat Cell Biol. 2007 Sep;9(9):1000-4.


TGF beta inhibition for cancer therapy.

Saunier EF, Akhurst RJ.

Curr Cancer Drug Targets. 2006 Nov;6(7):565-78. Review.


Mutations of TGFbeta signaling molecules in human disease.

Harradine KA, Akhurst RJ.

Ann Med. 2006;38(6):403-14. Review. Erratum in: Ann Med. 2007;39(1):79.


Large- and small-molecule inhibitors of transforming growth factor-beta signaling.

Akhurst RJ.

Curr Opin Investig Drugs. 2006 Jun;7(6):513-21. Review.


Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.

Mao JH, Saunier EF, de Koning JP, McKinnon MM, Higgins MN, Nicklas K, Yang HT, Balmain A, Akhurst RJ.

Proc Natl Acad Sci U S A. 2006 May 23;103(21):8125-30. Epub 2006 May 15.


A sweet link between TGFbeta and vascular disease?

Akhurst RJ.

Nat Genet. 2006 Apr;38(4):400-1. No abstract available.


Txp40, a ubiquitous insecticidal toxin protein from Xenorhabdus and Photorhabdus bacteria.

Brown SE, Cao AT, Dobson P, Hines ER, Akhurst RJ, East PD.

Appl Environ Microbiol. 2006 Feb;72(2):1653-62.


Identification and characterization of proteins from Bacillus thuringiensis with high toxic activity against the sheep blowfly, Lucilia cuprina.

Gough JM, Kemp DH, Akhurst RJ, Pearson RD, Kongsuwan K.

J Invertebr Pathol. 2005 Sep;90(1):39-46. Epub 2005 Aug 11.


Toxicity of Bacillus thuringiensis to parasitic and free-living life-stages of nematode parasites of livestock.

Kotze AC, O'Grady J, Gough JM, Pearson R, Bagnall NH, Kemp DH, Akhurst RJ.

Int J Parasitol. 2005 Aug;35(9):1013-22. Erratum in: Int J Parasitol. 2007 Apr;37(5):577.


Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis.

Tang Y, Lee KS, Yang H, Logan DW, Wang S, McKinnon ML, Holt LJ, Condie A, Luu MT, Akhurst RJ.

Genomics. 2005 Jan;85(1):60-70.


TGF beta signaling in health and disease.

Akhurst RJ.

Nat Genet. 2004 Aug;36(8):790-2. No abstract available. Erratum in: Nat Genet. 2004 Sep;36(9):1024.


Taxonomy of Australian clinical isolates of the genus Photorhabdus and proposal of Photorhabdus asymbiotica subsp. asymbiotica subsp. nov. and P. asymbiotica subsp. australis subsp. nov.

Akhurst RJ, Boemare NE, Janssen PH, Peel MM, Alfredson DA, Beard CE.

Int J Syst Evol Microbiol. 2004 Jul;54(Pt 4):1301-10.


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