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Items: 8


Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo.

Meshram CD, Lukash T, Phillips AT, Akhrymuk I, Frolova EI, Frolov I.

Virology. 2019 Aug;534:14-24. doi: 10.1016/j.virol.2019.05.016. Epub 2019 May 28.


Novel Mutations in nsP2 Abolish Chikungunya Virus-Induced Transcriptional Shutoff and Make the Virus Less Cytopathic without Affecting Its Replication Rates.

Akhrymuk I, Lukash T, Frolov I, Frolova EI.

J Virol. 2019 Feb 5;93(4). pii: e02062-18. doi: 10.1128/JVI.02062-18. Print 2019 Feb 15.


Sindbis Virus Infection Causes Cell Death by nsP2-Induced Transcriptional Shutoff or by nsP3-Dependent Translational Shutoff.

Akhrymuk I, Frolov I, Frolova EI.

J Virol. 2018 Nov 12;92(23). pii: e01388-18. doi: 10.1128/JVI.01388-18. Print 2018 Dec 1.


New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.

Kim DY, Reynaud JM, Rasalouskaya A, Akhrymuk I, Mobley JA, Frolov I, Frolova EI.

PLoS Pathog. 2016 Aug 10;12(8):e1005810. doi: 10.1371/journal.ppat.1005810. eCollection 2016 Aug.


Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode.

Akhrymuk I, Frolov I, Frolova EI.

Virology. 2016 Jan;487:230-41. doi: 10.1016/j.virol.2015.09.023. Epub 2015 Nov 6.


Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes.

Foy NJ, Akhrymuk M, Akhrymuk I, Atasheva S, Bopda-Waffo A, Frolov I, Frolova EI.

J Virol. 2013 Feb;87(4):1997-2010. doi: 10.1128/JVI.02853-12. Epub 2012 Dec 5.


Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II.

Akhrymuk I, Kulemzin SV, Frolova EI.

J Virol. 2012 Jul;86(13):7180-91. doi: 10.1128/JVI.00541-12. Epub 2012 Apr 18.


Early events in alphavirus replication determine the outcome of infection.

Frolov I, Akhrymuk M, Akhrymuk I, Atasheva S, Frolova EI.

J Virol. 2012 May;86(9):5055-66. doi: 10.1128/JVI.07223-11. Epub 2012 Feb 15.

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