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Items: 25

1.

TRP53 Mutants Drive Neuroendocrine Lung Cancer Through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response.

Akeno N, Reece AL, Callahan M, Miller AL, Kim RG, He D, Lane A, Moulton JS, Wikenheiser-Brokamp KA.

Mol Cancer Ther. 2017 Dec;16(12):2913-2926. doi: 10.1158/1535-7163.MCT-17-0353. Epub 2017 Aug 28.

2.

p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function.

Sen M, Akeno N, Reece A, Miller AL, Simpson DS, Wikenheiser-Brokamp KA.

Oncogenesis. 2017 Apr 17;6(4):e320. doi: 10.1038/oncsis.2017.5.

3.

p53 suppresses carcinoma progression by inhibiting mTOR pathway activation.

Akeno N, Miller AL, Ma X, Wikenheiser-Brokamp KA.

Oncogene. 2015 Jan 29;34(5):589-99. doi: 10.1038/onc.2013.589. Epub 2014 Jan 27.

4.

IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms.

Akeno N, Smith EP, Stefan M, Huber AK, Zhang W, Keddache M, Tomer Y.

J Immunol. 2011 Apr 15;186(8):4693-706. doi: 10.4049/jimmunol.1002631. Epub 2011 Mar 14.

5.

Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.

Chen X, Mitsutake N, LaPerle K, Akeno N, Zanzonico P, Longo VA, Mitsutake S, Kimura ET, Geiger H, Santos E, Wendel HG, Franco A, Knauf JA, Fagin JA.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7979-84. doi: 10.1073/pnas.0900343106. Epub 2009 Apr 29.

6.

HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity.

Akeno N, Blackard JT, Tomer Y.

J Autoimmun. 2008 Dec;31(4):339-44. doi: 10.1016/j.jaut.2008.08.001. Epub 2008 Sep 16.

7.

RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR.

Croyle M, Akeno N, Knauf JA, Fabbro D, Chen X, Baumgartner JE, Lane HA, Fagin JA.

Cancer Res. 2008 Jun 1;68(11):4183-91. doi: 10.1158/0008-5472.CAN-08-0413.

8.

Interferon alpha treatment and thyroid dysfunction.

Tomer Y, Blackard JT, Akeno N.

Endocrinol Metab Clin North Am. 2007 Dec;36(4):1051-66; x-xi. Review.

9.

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression.

Jacobson EM, Huber AK, Akeno N, Sivak M, Li CW, Concepcion E, Ho K, Tomer Y.

Genes Immun. 2007 Apr;8(3):205-14. Epub 2007 Mar 8.

PMID:
17344890
10.

BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis.

Mitsutake N, Miyagishi M, Mitsutake S, Akeno N, Mesa C Jr, Knauf JA, Zhang L, Taira K, Fagin JA.

Endocrinology. 2006 Feb;147(2):1014-9. Epub 2005 Oct 27.

PMID:
16254036
11.

Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9.

Robins JC, Akeno N, Mukherjee A, Dalal RR, Aronow BJ, Koopman P, Clemens TL.

Bone. 2005 Sep;37(3):313-22.

PMID:
16023419
12.

Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5.

Rutter MM, Markoff E, Clayton L, Akeno N, Zhao G, Clemens TL, Chernausek SD.

Bone. 2005 Feb;36(2):224-31.

PMID:
15780948
13.

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization.

Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL.

J Biol Chem. 2002 Nov 15;277(46):44005-12. Epub 2002 Sep 4.

14.
15.

Selected Contribution: Osteocytes upregulate HIF-1alpha in response to acute disuse and oxygen deprivation.

Gross TS, Akeno N, Clemens TL, Komarova S, Srinivasan S, Weimer DA, Mayorov S.

J Appl Physiol (1985). 2001 Jun;90(6):2514-9.

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17.

Regulation of vitamin D-1alpha-hydroxylase and -24-hydroxylase expression by dexamethasone in mouse kidney.

Akeno N, Matsunuma A, Maeda T, Kawane T, Horiuchi N.

J Endocrinol. 2000 Mar;164(3):339-48.

PMID:
10694374
18.

Regulation of small intestinal transit by central nervous calcitonin receptor.

Hamada S, Kawane T, Akeno N, Igarashi H, Horiuchi N.

Horm Metab Res. 1999 Sep;31(9):499-504.

PMID:
10569250
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Matrix metalloproteinases-1 and -8 and TIMP-1 mRNA levels in normal and diseased human gingivae.

Aiba T, Akeno N, Kawane T, Okamoto H, Horiuchi N.

Eur J Oral Sci. 1996 Oct-Dec;104(5-6):562-9.

PMID:
9021326
23.

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