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Items: 17


Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice.

Williams DK, Parham SG, Schryver E, Akel NS, Shelton RS, Webber J, Swain FL, Schmidt J, Suva LJ, Gaddy D.

JBMR Plus. 2017 Dec 29;2(1):47-54. doi: 10.1002/jbm4.10025. eCollection 2018 Jan.


PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan.

Kamalakar A, Washam CL, Akel NS, Allen BJ, Williams DK, Swain FL, Leitzel K, Lipton A, Gaddy D, Suva LJ.

J Bone Miner Res. 2017 Jul;32(7):1421-1431. doi: 10.1002/jbmr.3142. Epub 2017 Apr 19.


Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures.

Fowler TW, Kamalakar A, Akel NS, Kurten RC, Suva LJ, Gaddy D.

J Cell Sci. 2015 Feb 15;128(4):683-94. doi: 10.1242/jcs.157834. Epub 2015 Jan 20.


Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans.

Kamalakar A, Bendre MS, Washam CL, Fowler TW, Carver A, Dilley JD, Bracey JW, Akel NS, Margulies AG, Skinner RA, Swain FL, Hogue WR, Montgomery CO, Lahiji P, Maher JJ, Leitzel KE, Ali SM, Lipton A, Nicholas RW, Gaddy D, Suva LJ.

Bone. 2014 Apr;61:176-85. doi: 10.1016/j.bone.2014.01.015. Epub 2014 Jan 28.


Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis.

Gruenwald K, Castagnola P, Besio R, Dimori M, Chen Y, Akel NS, Swain FL, Skinner RA, Eyre DR, Gaddy D, Suva LJ, Morello R.

J Bone Miner Res. 2014 Mar;29(3):666-75. doi: 10.1002/jbmr.2075.


Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment.

Fowler TW, McKelvey KD, Akel NS, Vander Schilden J, Bacon AW, Bracey JW, Sowder T, Skinner RA, Swain FL, Hogue WR, Leblanc DB, Gaddy D, Wenger GR, Suva LJ.

PLoS One. 2012;7(8):e42967. doi: 10.1371/journal.pone.0042967. Epub 2012 Aug 14.


Low bone turnover and low bone density in a cohort of adults with Down syndrome.

McKelvey KD, Fowler TW, Akel NS, Kelsay JA, Gaddy D, Wenger GR, Suva LJ.

Osteoporos Int. 2013 Apr;24(4):1333-8. doi: 10.1007/s00198-012-2109-4. Epub 2012 Aug 18.


Pressure hyperalgesia in hind limb suspended rats.

Chowdhury P, Soulsby ME, Jayroe J, Akel NS, Gaddy D, Dobretsov M.

Aviat Space Environ Med. 2011 Oct;82(10):988-91.


Inhibin A enhances bone formation during distraction osteogenesis.

Perrien DS, Nicks KM, Liu L, Akel NS, Bacon AW, Skinner RA, Swain FL, Aronson J, Suva LJ, Gaddy D.

J Orthop Res. 2012 Feb;30(2):288-95. doi: 10.1002/jor.21501. Epub 2011 Aug 1.


Bone turnover across the menopause transition : The role of gonadal inhibins.

Nicks KM, Fowler TW, Akel NS, Perrien DS, Suva LJ, Gaddy D.

Ann N Y Acad Sci. 2010 Mar;1192:153-60. doi: 10.1111/j.1749-6632.2009.05349.x. Review.


Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin.

Nicks KM, Perrien DS, Akel NS, Suva LJ, Gaddy D.

Mol Cell Endocrinol. 2009 Oct 30;310(1-2):11-20. doi: 10.1016/j.mce.2009.07.001. Epub 2009 Jul 15. Review.


Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease.

Suva LJ, Hartman E, Dilley JD, Russell S, Akel NS, Skinner RA, Hogue WR, Budde U, Varughese KI, Kanaji T, Ware J.

Am J Pathol. 2008 Feb;172(2):430-9. doi: 10.2353/ajpath.2008.070417. Epub 2008 Jan 10.


Inhibin A is an endocrine stimulator of bone mass and strength.

Perrien DS, Akel NS, Edwards PK, Carver AA, Bendre MS, Swain FL, Skinner RA, Hogue WR, Nicks KM, Pierson TM, Suva LJ, Gaddy D.

Endocrinology. 2007 Apr;148(4):1654-65. Epub 2006 Dec 28.


Aging alters the skeletal response to disuse in the rat.

Perrien DS, Akel NS, Dupont-Versteegden EE, Skinner RA, Siegel ER, Suva LJ, Gaddy D.

Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R988-96. Epub 2006 Oct 26.


Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway.

Bendre MS, Margulies AG, Walser B, Akel NS, Bhattacharrya S, Skinner RA, Swain F, Ramani V, Mohammad KS, Wessner LL, Martinez A, Guise TA, Chirgwin JM, Gaddy D, Suva LJ.

Cancer Res. 2005 Dec 1;65(23):11001-9.


Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo.

Bendre MS, Gaddy-Kurten D, Mon-Foote T, Akel NS, Skinner RA, Nicholas RW, Suva LJ.

Cancer Res. 2002 Oct 1;62(19):5571-9.

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