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Items: 48


The neuroinflammatory component of negative affect in patients with chronic pain.

Albrecht DS, Kim M, Akeju O, Torrado-Carvajal A, Edwards RR, Zhang Y, Bergan C, Protsenko E, Kucyi A, Wasan AD, Hooker JM, Napadow V, Loggia ML.

Mol Psychiatry. 2019 May 28. doi: 10.1038/s41380-019-0433-1. [Epub ahead of print]


Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study.

Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Loggia ML, Hadjikhani N.

Neurology. 2019 Apr 23;92(17):e2038-e2050. doi: 10.1212/WNL.0000000000007371. Epub 2019 Mar 27.


Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl.

Nozari A, Akeju O, Mirzakhani H, Eskandar E, Ma Z, Hossain MA, Wang Q, Greenblatt DJ, Martyn JAJ.

J Pharm Pharmacol. 2019 Jun;71(6):982-987. doi: 10.1111/jphp.13079. Epub 2019 Feb 21.


Electroencephalogram dynamics during general anesthesia predict the later incidence and duration of burst-suppression during cardiopulmonary bypass.

Plummer GS, Ibala R, Hahm E, An J, Gitlin J, Deng H, Shelton KT, Solt K, Qu JZ, Akeju O.

Clin Neurophysiol. 2019 Jan;130(1):55-60. doi: 10.1016/j.clinph.2018.11.003. Epub 2018 Nov 16.


Brain age from the electroencephalogram of sleep.

Sun H, Paixao L, Oliva JT, Goparaju B, Carvalho DZ, van Leeuwen KG, Akeju O, Thomas RJ, Cash SS, Bianchi MT, Westover MB.

Neurobiol Aging. 2019 Feb;74:112-120. doi: 10.1016/j.neurobiolaging.2018.10.016. Epub 2018 Oct 19.


Brain Monitoring of Sedation in the Intensive Care Unit Using a Recurrent Neural Network.

Sun H, Nagaraj SB, Akeju O, Purdon PL, Westover BM.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513185.


Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial.

Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C.

J Affect Disord. 2019 Jan 15;243:516-524. doi: 10.1016/j.jad.2018.09.037. Epub 2018 Sep 17.


Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation.

Albrecht DS, Forsberg A, Sandström A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, Taylor N, Kim M, Hooker JM, Edwards RR, Napadow V, Kosek E, Loggia ML.

Brain Behav Immun. 2019 Jan;75:72-83. doi: 10.1016/j.bbi.2018.09.018. Epub 2018 Sep 14.


A Systematic Review and Meta-Analysis Examining the Impact of Sleep Disturbance on Postoperative Delirium.

Fadayomi AB, Ibala R, Bilotta F, Westover MB, Akeju O.

Crit Care Med. 2018 Dec;46(12):e1204-e1212. doi: 10.1097/CCM.0000000000003400.


A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans.

Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL.

Elife. 2018 Aug 10;7. pii: e33250. doi: 10.7554/eLife.33250.


Anesthesia for stroke rescue.

Fadayomi AB, Akeju O.

Curr Opin Anaesthesiol. 2018 Oct;31(5):544-548. doi: 10.1097/ACO.0000000000000631. Review.


Electroencephalogram Based Detection of Deep Sedation in ICU Patients Using Atomic Decomposition.

Nagaraj SB, McClain LM, Boyle EJ, Zhou DW, Ramaswamy SM, Biswal S, Akeju O, Purdon PL, Westover MB.

IEEE Trans Biomed Eng. 2018 Dec;65(12):2684-2691. doi: 10.1109/TBME.2018.2813265. Epub 2018 Mar 7.


Using EEG markers to make inferences about anaesthetic-induced altered states of arousal.

Brown EN, Purdon PL, Akeju O, An J.

Br J Anaesth. 2018 Jul;121(1):325-327. doi: 10.1016/j.bja.2017.12.034. Epub 2018 Mar 14. No abstract available.


Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial.

Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O.

BMJ Open. 2018 Apr 20;8(4):e020316. doi: 10.1136/bmjopen-2017-020316.


Breaking the rules: is it the neurointensivists' turn?

Gritti P, Akeju O, Lorini FL, Lanterna A, Brembilla C, Bilotta F.

Crit Care. 2018 Jan 29;22(1):21. doi: 10.1186/s13054-017-1919-3. No abstract available.


Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study.

Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN.

Clin Neurophysiol. 2018 Jan;129(1):69-78. doi: 10.1016/j.clinph.2017.10.005. Epub 2017 Oct 20.


Hierarchy in disruption of large-scale networks across altered arousal states.

Lewis LD, Akeju O.

Br J Anaesth. 2017 Oct 1;119(4):566-568. doi: 10.1093/bja/aex297. No abstract available.


Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts.

Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zürcher NR, Barth VN, Guehl NJ, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML.

J Nucl Med. 2018 Jan;59(1):107-114. doi: 10.2967/jnumed.116.178335. Epub 2017 Aug 17.


A Narrative Review of Adherence to Subarachnoid Hemorrhage Guidelines.

Gritti P, Akeju O, Lorini FL, Lanterna LA, Brembilla C, Bilotta F.

J Neurosurg Anesthesiol. 2018 Jul;30(3):203-216. doi: 10.1097/ANA.0000000000000453. Review.


A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children.

Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL.

Anesthesiology. 2017 Aug;127(2):293-306. doi: 10.1097/ALN.0000000000001717.


Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans.

Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O.

J Neurosci. 2017 Jul 19;37(29):6938-6945. doi: 10.1523/JNEUROSCI.0446-17.2017. Epub 2017 Jun 16.


Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power.

Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O.

Front Syst Neurosci. 2017 May 30;11:38. doi: 10.3389/fnsys.2017.00038. eCollection 2017.


Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep.

Akeju O, Brown EN.

Curr Opin Neurobiol. 2017 Jun;44:178-185. doi: 10.1016/j.conb.2017.04.011. Epub 2017 May 22. Review.


Patient-Specific Classification of ICU Sedation Levels From Heart Rate Variability.

Nagaraj SB, Biswal S, Boyle EJ, Zhou DW, McClain LM, Bajwa EK, Quraishi SA, Akeju O, Barbieri R, Purdon PL, Westover MB.

Crit Care Med. 2017 Jul;45(7):e683-e690. doi: 10.1097/CCM.0000000000002364.


Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks.

Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O.

Anesthesiology. 2017 Mar;126(3):419-430. doi: 10.1097/ALN.0000000000001509.


Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis.

Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Chonde DB, Izquierdo Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N.

Neurology. 2016 Dec 13;87(24):2554-2561. Epub 2016 Nov 11.


Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations.

Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN.

PLoS One. 2016 Oct 6;11(10):e0163431. doi: 10.1371/journal.pone.0163431. eCollection 2016.


Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study.

Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C.

J Clin Psychiatry. 2016 Jun;77(6):e719-25. doi: 10.4088/JCP.15m10056.


GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness.

Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN.

Clin Neurophysiol. 2016 Jun;127(6):2472-81. doi: 10.1016/j.clinph.2016.02.012. Epub 2016 Feb 27.


Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness.

Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL.

Clin Neurophysiol. 2016 Jun;127(6):2414-22. doi: 10.1016/j.clinph.2016.03.005. Epub 2016 Mar 16.


Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation.

Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M.

Aust N Z J Psychiatry. 2017 Jan;51(1):55-64. doi: 10.1177/0004867416631828.


Clustering analysis to identify distinct spectral components of encephalogram burst suppression in critically ill patients.

Zhou DW, Westover MB, McClain LM, Nagaraj SB, Bajwa EK, Quraishi SA, Akeju O, Cobb JP, Purdon PL.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:7258-61. doi: 10.1109/EMBC.2015.7320067.


In reply.

Purdon PL, Zhou DW, Akeju O, Brown EN.

Anesthesiology. 2015 Sep;123(3):725-8. doi: 10.1097/ALN.0000000000000794. No abstract available.


Age-dependency of sevoflurane-induced electroencephalogram dynamics in children.

Akeju O, Pavone KJ, Thum JA, Firth PG, Westover MB, Puglia M, Shank ES, Brown EN, Purdon PL.

Br J Anaesth. 2015 Jul;115 Suppl 1:i66-i76. doi: 10.1093/bja/aev114.


The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.

Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN.

Br J Anaesth. 2015 Jul;115 Suppl 1:i46-i57. doi: 10.1093/bja/aev213.


Nitrous oxide-induced slow and delta oscillations.

Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN.

Clin Neurophysiol. 2016 Jan;127(1):556-564. doi: 10.1016/j.clinph.2015.06.001. Epub 2015 Jun 10.


Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.

Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N.

Neuroimage Clin. 2015 Jan 19;7:409-14. doi: 10.1016/j.nicl.2015.01.009. eCollection 2015.


Evidence for brain glial activation in chronic pain patients.

Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, Rosen BR, Napadow V, Hooker JM.

Brain. 2015 Mar;138(Pt 3):604-15. doi: 10.1093/brain/awu377. Epub 2015 Jan 12.


Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness.

Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL.

Elife. 2014 Nov 28;3:e04499. doi: 10.7554/eLife.04499.


Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence.

Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL.

Anesthesiology. 2014 Nov;121(5):990-8. doi: 10.1097/ALN.0000000000000436.


A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis.

Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Pierce ET, Walsh JL, Brown EN, Purdon PL.

Anesthesiology. 2014 Nov;121(5):978-89. doi: 10.1097/ALN.0000000000000419. Erratum in: Anesthesiology. 2015 Apr;122(4):958. Lei, Gao [corrected to Gao, Lei].


Ketamine exposure in early development impairs specification of the primary germ cell layers.

Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K.

Neurotoxicol Teratol. 2014 May-Jun;43:59-68. doi: 10.1016/ Epub 2014 Apr 16.


Awakened by a sleeping pill.

Akeju O, Brown EN.

Elife. 2013 Nov 19;2:e01658. doi: 10.7554/eLife.01658.


Stemming electrical outage in myocardial infarction.

Akeju O, Alston TA.

Crit Care Med. 2011 May;39(5):1222-3. doi: 10.1097/CCM.0b013e31820a838a. No abstract available.


The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas.

Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK.

J Natl Cancer Inst. 2007 Apr 18;99(8):639-52.


N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation.

Park DM, Li J, Okamoto H, Akeju O, Kim SH, Lubensky I, Vortmeyer A, Dambrosia J, Weil RJ, Oldfield EH, Park JK, Zhuang Z.

Cell Cycle. 2007 Feb 15;6(4):467-70. Epub 2007 Feb 12.


Short hairpin RNA loop design for the facilitation of sequence verification.

Akeju O, Peng T, Park JK.

Biotechniques. 2006 Feb;40(2):154, 156, 158. No abstract available.


High voltage electrical stimulation in the augmentation of muscle strength: effects of pulse frequency.

Balogun JA, Onilari OO, Akeju OA, Marzouk DK.

Arch Phys Med Rehabil. 1993 Sep;74(9):910-6.


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