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Items: 19


Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.

Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC.

EMBO Rep. 2018 Sep 20. pii: e46193. doi: 10.15252/embr.201846193. [Epub ahead of print]


Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.

Freihofer P, Akbergenov R, Teo Y, Juskeviciene R, Andersson DI, Böttger EC.

RNA. 2016 Dec;22(12):1836-1843. Epub 2016 Oct 3.


Biochemical requirements for two Dicer-like activities from wheat germ.

Shivaprasad PV, Hohn T, Akbergenov R.

PLoS One. 2015 Jan 23;10(1):e0116736. doi: 10.1371/journal.pone.0116736. eCollection 2015.


Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.

Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC.

MBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14.


4'-O-substitutions determine selectivity of aminoglycoside antibiotics.

Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC.

Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112.


Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ.

Nat Med. 2014 Feb;20(2):152-158. doi: 10.1038/nm.3458. Epub 2014 Jan 26.


Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups.

Salian S, Matt T, Akbergenov R, Harish S, Meyer M, Duscha S, Shcherbakov D, Bernet BB, Vasella A, Westhof E, Böttger EC.

Antimicrob Agents Chemother. 2012 Dec;56(12):6104-8. doi: 10.1128/AAC.01326-12. Epub 2012 Sep 4.


Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.

Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10984-9. doi: 10.1073/pnas.1204073109. Epub 2012 Jun 14.


Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.

Akbergenov R, Shcherbakov D, Matt T, Duscha S, Meyer M, Wilson DN, Böttger EC.

Antimicrob Agents Chemother. 2011 Oct;55(10):4712-7. doi: 10.1128/AAC.00628-11. Epub 2011 Jul 18.


Suppressors of RNA silencing encoded by the components of the cotton leaf curl begomovirus-betasatellite complex.

Amin I, Hussain K, Akbergenov R, Yadav JS, Qazi J, Mansoor S, Hohn T, Fauquet CM, Briddon RW.

Mol Plant Microbe Interact. 2011 Aug;24(8):973-83. doi: 10.1094/MPMI-01-11-0001.


Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis.

Akshay S, Bertea M, Hobbie SN, Oettinghaus B, Shcherbakov D, Böttger EC, Akbergenov R.

Antimicrob Agents Chemother. 2011 Sep;55(9):4096-102. doi: 10.1128/AAC.01398-10. Epub 2011 Jul 5.


Directed mutagenesis of Mycobacterium smegmatis 16S rRNA to reconstruct the in vivo evolution of aminoglycoside resistance in Mycobacterium tuberculosis.

Shcherbakov D, Akbergenov R, Matt T, Sander P, Andersson DI, Böttger EC.

Mol Microbiol. 2010 Aug;77(4):830-40. doi: 10.1111/j.1365-2958.2010.07218.x. Epub 2010 Jun 1.


Modification of small RNAs associated with suppression of RNA silencing by tobamovirus replicase protein.

Vogler H, Akbergenov R, Shivaprasad PV, Dang V, Fasler M, Kwon MO, Zhanybekova S, Hohn T, Heinlein M.

J Virol. 2007 Oct;81(19):10379-88. Epub 2007 Jul 18.


Transgenic cassava resistance to African cassava mosaic virus is enhanced by viral DNA-A bidirectional promoter-derived siRNAs.

Vanderschuren H, Akbergenov R, Pooggin MM, Hohn T, Gruissem W, Zhang P.

Plant Mol Biol. 2007 Jul;64(5):549-57. Epub 2007 May 10.


Molecular characterization of geminivirus-derived small RNAs in different plant species.

Akbergenov R, Si-Ammour A, Blevins T, Amin I, Kutter C, Vanderschuren H, Zhang P, Gruissem W, Meins F Jr, Hohn T, Pooggin MM.

Nucleic Acids Res. 2006 Jan 18;34(2):462-71. Print 2006.


Promoters, transcripts, and regulatory proteins of Mungbean yellow mosaic geminivirus.

Shivaprasad PV, Akbergenov R, Trinks D, Rajeswaran R, Veluthambi K, Hohn T, Pooggin MM.

J Virol. 2005 Jul;79(13):8149-63.


Suppression of RNA silencing by a geminivirus nuclear protein, AC2, correlates with transactivation of host genes.

Trinks D, Rajeswaran R, Shivaprasad PV, Akbergenov R, Oakeley EJ, Veluthambi K, Hohn T, Pooggin MM.

J Virol. 2005 Feb;79(4):2517-27.


ARC-1, a sequence element complementary to an internal 18S rRNA segment, enhances translation efficiency in plants when present in the leader or intercistronic region of mRNAs.

Akbergenov RZh, Zhanybekova SSh, Kryldakov RV, Zhigailov A, Polimbetova NS, Hohn T, Iskakov BK.

Nucleic Acids Res. 2004 Jan 12;32(1):239-47. Print 2004.

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