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Comprehensive functional genomic resource and integrative model for the human brain.

Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüş ZH, Crawford GE; PsychENCODE Consortium, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB.

Science. 2018 Dec 14;362(6420). pii: eaat8464. doi: 10.1126/science.aat8464.


Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.

Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, Ho SM, MacDonald M, Hoffman GE, Roussos P, Zhang B, Hahn CG, Weng Z, Brennand KJ, Akbarian S.

Science. 2018 Dec 14;362(6420). pii: eaat4311. doi: 10.1126/science.aat4311.


Intravitreal injection of a Rho-kinase inhibitor (fasudil) combined with bevacizumab versus bevacizumab monotherapy for diabetic macular oedema: a pilot randomised clinical trial.

Ahmadieh H, Nourinia R, Hafezi-Moghadam A, Sabbaghi H, Nakao S, Zandi S, Yaseri M, Tofighi Z, Akbarian S.

Br J Ophthalmol. 2018 Aug 27. pii: bjophthalmol-2018-312244. doi: 10.1136/bjophthalmol-2018-312244. [Epub ahead of print]


Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

Boks MP, Houtepen LC, Xu Z, He Y, Ursini G, Maihofer AX, Rajarajan P, Yu Q, Xu H, Wu Y, Wang S, Shi JP, Hulshoff Pol HE, Strengman E, Rutten BPF, Jaffe AE, Kleinman JE, Baker DG, Hol EM, Akbarian S, Nievergelt CM, De Witte LD, Vinkers CH, Weinberger DR, Yu J, Kahn RS.

NPJ Schizophr. 2018 Aug 21;4(1):16. doi: 10.1038/s41537-018-0058-4.


Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders.

Yu Q, He Z, Zubkov D, Huang S, Kurochkin I, Yang X, Halene T, Willmitzer L, Giavalisco P, Akbarian S, Khaitovich P.

Mol Psychiatry. 2018 Aug 8. doi: 10.1038/s41380-018-0200-8. [Epub ahead of print]


Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia.

Bryois J, Garrett ME, Song L, Safi A, Giusti-Rodriguez P, Johnson GD, Shieh AW, Buil A, Fullard JF, Roussos P, Sklar P, Akbarian S, Haroutunian V, Stockmeier CA, Wray GA, White KP, Liu C, Reddy TE, Ashley-Koch A, Sullivan PF, Crawford GE.

Nat Commun. 2018 Aug 7;9(1):3121. doi: 10.1038/s41467-018-05379-y.


Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome.

Girdhar K, Hoffman GE, Jiang Y, Brown L, Kundakovic M, Hauberg ME, Francoeur NJ, Wang YC, Shah H, Kavanagh DH, Zharovsky E, Jacobov R, Wiseman JR, Park R, Johnson JS, Kassim BS, Sloofman L, Mattei E, Weng Z, Sieberts SK, Peters MA, Harris BT, Lipska BK, Sklar P, Roussos P, Akbarian S.

Nat Neurosci. 2018 Aug;21(8):1126-1136. doi: 10.1038/s41593-018-0187-0. Epub 2018 Jul 23.


Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.

Rajarajan P, Jiang Y, Kassim BS, Akbarian S.

Prog Mol Biol Transl Sci. 2018;157:21-40. doi: 10.1016/bs.pmbts.2017.11.022. Epub 2018 Mar 30.


Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1.

Mao W, Salzberg AC, Uchigashima M, Hasegawa Y, Hock H, Watanabe M, Akbarian S, Kawasawa YI, Futai K.

Cell Rep. 2018 Jun 12;23(11):3209-3222. doi: 10.1016/j.celrep.2018.05.028.


Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS.

Dobbyn A, Huckins LM, Boocock J, Sloofman LG, Glicksberg BS, Giambartolomei C, Hoffman GE, Perumal TM, Girdhar K, Jiang Y, Raj T, Ruderfer DM, Kramer RS, Pinto D; CommonMind Consortium, Akbarian S, Roussos P, Domenici E, Devlin B, Sklar P, Stahl EA, Sieberts SK.

Am J Hum Genet. 2018 Jun 7;102(6):1169-1184. doi: 10.1016/j.ajhg.2018.04.011. Epub 2018 May 24.


Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells.

LaMarca EA, Powell SK, Akbarian S, Brennand KJ.

Front Pediatr. 2018 Apr 3;6:82. doi: 10.3389/fped.2018.00082. eCollection 2018. Review.


Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes.

Lin CY, Chang KW, Lin CY, Wu JY, Coon H, Huang PH, Ho HN, Akbarian S, Gau SS, Huang HS.

Sci Rep. 2018 Mar 9;8(1):4277. doi: 10.1038/s41598-018-22753-4.


Association of Brain-derived neurotrophic factor gene polymorphisms with body mass index: A systematic review and meta-analysis.

Akbarian SA, Salehi-Abargouei A, Pourmasoumi M, Kelishadi R, Nikpour P, Heidari-Beni M.

Adv Med Sci. 2018 Mar;63(1):43-56. doi: 10.1016/j.advms.2017.07.002. Epub 2017 Dec 1. Review.


Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.

Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, López-Giménez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J.

Nat Neurosci. 2017 Sep;20(9):1247-1259. doi: 10.1038/nn.4616. Epub 2017 Aug 7.


Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes.

Ho SM, Hartley BJ, Flaherty E, Rajarajan P, Abdelaal R, Obiorah I, Barretto N, Muhammad H, Phatnani HP, Akbarian S, Brennand KJ.

Stem Cell Reports. 2017 Aug 8;9(2):615-628. doi: 10.1016/j.stemcr.2017.06.012. Epub 2017 Jul 27.


The epigenomics of schizophrenia, in the mouse.

Javidfar B, Park R, Kassim BS, Bicks LK, Akbarian S.

Am J Med Genet B Neuropsychiatr Genet. 2017 Sep;174(6):631-640. doi: 10.1002/ajmg.b.32566. Epub 2017 Jul 12. Review.


The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S.

Nat Genet. 2017 Aug;49(8):1239-1250. doi: 10.1038/ng.3906. Epub 2017 Jul 3.


Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2.

Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ.

Biol Psychiatry. 2017 Dec 1;82(11):794-805. doi: 10.1016/j.biopsych.2017.04.013. Epub 2017 May 5.


Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease.

Powell SK, Gregory J, Akbarian S, Brennand KJ.

Mol Cell Neurosci. 2017 Jul;82:157-166. doi: 10.1016/j.mcn.2017.05.007. Epub 2017 May 23. Review.


Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K.

Nat Commun. 2017 May 9;8:15142. doi: 10.1038/ncomms15142.


Effect of timing of repair on repair bond strength of methacrylate- and silorane-based composite resins.

Shafiei F, Akbarian S, Asadi F.

Gen Dent. 2017 May-Jun;65(3):45-49.


Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network.

Science. 2017 Apr 28;356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review.


Children with ADHD and symptoms of oppositional defiant disorder improved in behavior when treated with methylphenidate and adjuvant risperidone, though weight gain was also observed - Results from a randomized, double-blind, placebo-controlled clinical trial.

Jahangard L, Akbarian S, Haghighi M, Ahmadpanah M, Keshavarzi A, Bajoghli H, Sadeghi Bahmani D, Holsboer-Trachsler E, Brand S.

Psychiatry Res. 2017 May;251:182-191. doi: 10.1016/j.psychres.2016.12.010. Epub 2016 Dec 10.


Knowledge and Attitude toward Epilepsy of Close Family Members of People with Epilepsy in North of Iran.

Karimi N, Akbarian SA.

Adv Med. 2016;2016:8672853. doi: 10.1155/2016/8672853. Epub 2016 Dec 26.


MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice.

Mitchell AC, Javidfar B, Pothula V, Ibi D, Shen EY, Peter CJ, Bicks LK, Fehr T, Jiang Y, Brennand KJ, Neve RL, Gonzalez-Maeso J, Akbarian S.

Mol Psychiatry. 2018 Jan;23(1):123-132. doi: 10.1038/mp.2016.254. Epub 2017 Jan 24.


Association of Socio-Economic Status and Visual Impairment: A Population-Based Study in Iran.

Katibeh M, Rajavi Z, Yaseri M, Hosseini S, Hosseini S, Akbarian S, Sehat M.

Arch Iran Med. 2017 Jan;20(1):43-48. doi: 0172001/AIM.0010.


Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms.

Schmitt A, Martins-de-Souza D, Akbarian S, Cassoli JS, Ehrenreich H, Fischer A, Fonteh A, Gattaz WF, Gawlik M, Gerlach M, Grünblatt E, Halene T, Hasan A, Hashimoto K, Kim YK, Kirchner SK, Kornhuber J, Kraus TFJ, Malchow B, Nascimento JM, Rossner M, Schwarz M, Steiner J, Talib L, Thibaut F, Riederer P, Falkai P; Members of the WFSBP Task Force on Biological Markers.

World J Biol Psychiatry. 2017 Aug;18(5):330-356. doi: 10.1080/15622975.2016.1224929. Epub 2016 Oct 26. Review.


DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition.

Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S.

Biol Psychiatry. 2016 Nov 15;80(10):765-774. doi: 10.1016/j.biopsych.2016.03.2100. Epub 2016 Mar 26.


Spatial genome organization and cognition.

Rajarajan P, Gil SE, Brennand KJ, Akbarian S.

Nat Rev Neurosci. 2016 Nov;17(11):681-691. doi: 10.1038/nrn.2016.124. Epub 2016 Oct 6. Review.


Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism.

Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell A, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S, Akbarian S, Khaitovich P.

PLoS Biol. 2016 Sep 29;14(9):e1002558. doi: 10.1371/journal.pbio.1002558. eCollection 2016 Sep.


Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex.

Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood MA, Jiang Y, Gaisler-Salomon I, Akbarian S.

Nat Commun. 2016 Sep 6;7:12743. doi: 10.1038/ncomms12743.


The effects of conjugated linoleic acids on breast cancer: A systematic review.

Arab A, Akbarian SA, Ghiyasvand R, Miraghajani M.

Adv Biomed Res. 2016 Jul 6;5:115. doi: 10.4103/2277-9175.185573. eCollection 2016. Review.


Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.

Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S.

Neuropsychopharmacology. 2016 Dec;41(13):3103-3113. doi: 10.1038/npp.2016.144. Epub 2016 Aug 3.


Insulin-like Growth Factor 1 for Healthy Spines and Healthy Minds?

Chandrasekaran S, Akbarian S.

Biol Psychiatry. 2016 Aug 15;80(4):260-262. doi: 10.1016/j.biopsych.2016.06.002. No abstract available.


Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH.

PLoS One. 2016 Jul 25;11(7):e0160295. doi: 10.1371/journal.pone.0160295. eCollection 2016.


Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK.

Biol Psychiatry. 2016 Jul 15;80(2):84-86. doi: 10.1016/j.biopsych.2016.05.004. No abstract available.


Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue.

Kundakovic M, Jiang Y, Kavanagh DH, Dincer A, Brown L, Pothula V, Zharovsky E, Park R, Jacobov R, Magro I, Kassim B, Wiseman J, Dang K, Sieberts SK, Roussos P, Fromer M, Harris B, Lipska BK, Peters MA, Sklar P, Akbarian S.

Biol Psychiatry. 2017 Jan 15;81(2):162-170. doi: 10.1016/j.biopsych.2016.03.1048. Epub 2016 Mar 9.


Evaluation of enamel damages following orthodontic bracket debonding in fluorosed teeth bonded with adhesion promoter.

Baherimoghadam T, Akbarian S, Rasouli R, Naseri N.

Eur J Dent. 2016 Apr-Jun;10(2):193-8. doi: 10.4103/1305-7456.178296.


Prevalence of Amblyopia and Refractive Errors Among Primary School Children.

Rajavi Z, Sabbaghi H, Baghini AS, Yaseri M, Moein H, Akbarian S, Behradfar N, Hosseini S, Rabei HM, Sheibani K.

J Ophthalmic Vis Res. 2015 Oct-Dec;10(4):408-16. doi: 10.4103/2008-322X.176909.


Understanding the genetic liability to schizophrenia through the neuroepigenome.

Fullard JF, Halene TB, Giambartolomei C, Haroutunian V, Akbarian S, Roussos P.

Schizophr Res. 2016 Nov;177(1-3):115-124. doi: 10.1016/j.schres.2016.01.039. Epub 2016 Jan 27. Review.


NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure.

Halene TB, Kozlenkov A, Jiang Y, Mitchell AC, Javidfar B, Dincer A, Park R, Wiseman J, Croxson PL, Giannaris EL, Hof PR, Roussos P, Dracheva S, Hemby SE, Akbarian S.

Schizophr Res. 2016 Feb;170(2-3):235-44. doi: 10.1016/j.schres.2015.12.016. Epub 2016 Jan 6.


Back to the past in schizophrenia genomics.

Sharp AJ, Akbarian S.

Nat Neurosci. 2016 Jan;19(1):1-2. doi: 10.1038/nn.4203. No abstract available.


Effect of Adhesive Pretreatments on Marginal Sealing of Aged Nano-ionomer Restorations.

Shafiei F, Akbarian S, Karim Etminan M.

J Dent Res Dent Clin Dent Prospects. 2015 Summer;9(3):144-50. doi: 10.15171/joddd.2015.028. Epub 2015 Sep 16.


RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.

Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH.

PLoS One. 2015 Dec 4;10(12):e0143563. doi: 10.1371/journal.pone.0143563. eCollection 2015. Erratum in: PLoS One. 2016;11(7):e0160295.


The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease.

Dong X, Tsuji J, Labadorf A, Roussos P, Chen JF, Myers RH, Akbarian S, Weng Z.

PLoS One. 2015 Dec 4;10(12):e0144398. doi: 10.1371/journal.pone.0144398. eCollection 2015.


Prefrontal Cortex and Social Cognition in Mouse and Man.

Bicks LK, Koike H, Akbarian S, Morishita H.

Front Psychol. 2015 Nov 26;6:1805. doi: 10.3389/fpsyg.2015.01805. eCollection 2015. Review.


The PsychENCODE project.

PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N.

Nat Neurosci. 2015 Dec;18(12):1707-12. doi: 10.1038/nn.4156. Review. No abstract available.


CHRNA7 and CHRFAM7A: psychosis and smoking? Blame the neighbors!

Akbarian S, Kundakovic M.

Am J Psychiatry. 2015 Nov 1;172(11):1054-6. doi: 10.1176/appi.ajp.2015.15081018. No abstract available.


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