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Items: 1 to 50 of 91

1.

Experimental colitis enhances the rate of antinociceptive tolerance to morphine via peripheral opioid receptors.

Komla E, Stevens DL, Zheng Y, Zhang Y, Dewey WL, Akbarali HI.

J Pharmacol Exp Ther. 2019 Jun 27. pii: jpet.119.256941. doi: 10.1124/jpet.119.256941. [Epub ahead of print]

2.

Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?

Akbarali HI, Dewey WL.

Nat Rev Gastroenterol Hepatol. 2019 Jun;16(6):323-324. doi: 10.1038/s41575-019-0150-x. Review. No abstract available.

PMID:
31024090
3.

Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment.

Obeng S, Jali A, Zheng Y, Wang H, Schwienteck KL, Chen C, Stevens DL, Akbarali HI, Dewey WL, Banks ML, Liu-Chen LY, Selley DE, Zhang Y.

ACS Chem Neurosci. 2019 May 15;10(5):2518-2532. doi: 10.1021/acschemneuro.9b00038. Epub 2019 Feb 21.

PMID:
30758946
4.

Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands.

Zheng Y, Obeng S, Wang H, Jali AM, Peddibhotla B, Williams DA, Zou C, Stevens DL, Dewey WL, Akbarali HI, Selley DE, Zhang Y.

J Med Chem. 2019 Jan 24;62(2):561-574. doi: 10.1021/acs.jmedchem.8b01158. Epub 2019 Jan 11.

5.

Analysis of carbenoxolone by ultra-high-performance liquid chromatography tandem mass spectrometry in mouse brain and blood after systemic administration.

Poklis JL, Gonek MM, Wolf CE, Akbarali HI, Dewey WL.

Biomed Chromatogr. 2019 Apr;33(4):e4465. doi: 10.1002/bmc.4465. Epub 2019 Jan 7.

PMID:
30548295
6.

Structure-Activity Relationship Studies of 6α- and 6β-Indolylacetamidonaltrexamine Derivatives as Bitopic Mu Opioid Receptor Modulators and Elaboration of the "Message-Address Concept" To Comprehend Their Functional Conversion.

Obeng S, Wang H, Jali A, Stevens DL, Akbarali HI, Dewey WL, Selley DE, Zhang Y.

ACS Chem Neurosci. 2019 Mar 20;10(3):1075-1090. doi: 10.1021/acschemneuro.8b00349. Epub 2018 Sep 7.

PMID:
30156823
7.

Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.

Zheng Y, Obeng S, Wang H, Stevens DL, Komla E, Selley DE, Dewey WL, Akbarali HI, Zhang Y.

ACS Chem Neurosci. 2018 Dec 19;9(12):3028-3037. doi: 10.1021/acschemneuro.8b00234. Epub 2018 Jul 23.

PMID:
30001114
8.

Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators.

Mischel RA, Dewey WL, Akbarali HI.

iScience. 2018 Apr 27;2:193-209. doi: 10.1016/j.isci.2018.03.003.

9.

Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons.

Jacob JC, Sakakibara K, Mischel RA, Henderson G, Dewey WL, Akbarali HI.

Mol Pharmacol. 2018 May;93(5):417-426. doi: 10.1124/mol.117.110775. Epub 2018 Feb 21.

10.

Culture of Neurons and Smooth Muscle Cells from the Myenteric Plexus of Adult Mice.

Brun P, Akbarali HI.

Methods Mol Biol. 2018;1727:119-125. doi: 10.1007/978-1-4939-7571-6_9.

PMID:
29222777
11.

CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward.

Gonek M, McLane VD, Stevens DL, Lippold K, Akbarali HI, Knapp PE, Dewey WL, Hauser KF, Paris JJ.

Brain Behav Immun. 2018 Mar;69:124-138. doi: 10.1016/j.bbi.2017.11.006. Epub 2017 Nov 13.

12.

The gut-brain interaction in opioid tolerance.

Akbarali HI, Dewey WL.

Curr Opin Pharmacol. 2017 Dec;37:126-130. doi: 10.1016/j.coph.2017.10.012. Epub 2017 Nov 13. Review.

13.

Reversal of oxycodone and hydrocodone tolerance by diazepam.

Gonek M, Akbarali HI, Henderson G, Dewey WL.

Brain Res. 2017 Nov 1;1674:84-90. doi: 10.1016/j.brainres.2017.08.017. Epub 2017 Aug 19.

14.

Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone.

Jacob JC, Poklis JL, Akbarali HI, Henderson G, Dewey WL.

J Pharmacol Exp Ther. 2017 Jul;362(1):45-52. doi: 10.1124/jpet.117.241083. Epub 2017 Apr 25.

15.

Connexin-purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation.

Bhave S, Gade A, Kang M, Hauser KF, Dewey WL, Akbarali HI.

FASEB J. 2017 Jun;31(6):2649-2660. doi: 10.1096/fj.201601068R. Epub 2017 Mar 9.

16.

The effect of gut microbiome on tolerance to morphine mediated antinociception in mice.

Kang M, Mischel RA, Bhave S, Komla E, Cho A, Huang C, Dewey WL, Akbarali HI.

Sci Rep. 2017 Feb 17;7:42658. doi: 10.1038/srep42658.

17.

Nanoconjugated NAP as a Potent and Periphery Selective Mu Opioid Receptor Modulator To Treat Opioid-Induced Constipation.

Xu GG, Zolotarskaya OY, Williams DA, Yuan Y, Selley DE, Dewey WL, Akbarali HI, Yang H, Zhang Y.

ACS Med Chem Lett. 2016 Nov 21;8(1):78-83. doi: 10.1021/acsmedchemlett.6b00382. eCollection 2017 Jan 12.

18.

Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.

AlSharari SD, Bagdas D, Akbarali HI, Lichtman PA, Raborn ES, Cabral GA, Carroll FI, McGee EA, Damaj MI.

Nicotine Tob Res. 2017 Apr 1;19(4):460-468. doi: 10.1093/ntr/ntw245.

PMID:
27639096
19.

HIV-1 Tat exacerbates lipopolysaccharide-induced cytokine release via TLR4 signaling in the enteric nervous system.

Guedia J, Brun P, Bhave S, Fitting S, Kang M, Dewey WL, Hauser KF, Akbarali HI.

Sci Rep. 2016 Aug 5;6:31203. doi: 10.1038/srep31203.

20.

6β-N-Heterocyclic Substituted Naltrexamine Derivative BNAP: A Peripherally Selective Mixed MOR/KOR Ligand.

Williams DA, Zheng Y, David BG, Yuan Y, Zaidi SA, Stevens DL, Scoggins KL, Selley DE, Dewey WL, Akbarali HI, Zhang Y.

ACS Chem Neurosci. 2016 Aug 17;7(8):1120-9. doi: 10.1021/acschemneuro.6b00075. Epub 2016 Jun 15.

21.

Enhanced Sensitivity of α3β4 Nicotinic Receptors in Enteric Neurons after Long-Term Morphine: Implication for Opioid-Induced Constipation.

Gade AR, Kang M, Khan F, Grider JR, Damaj MI, Dewey WL, Akbarali HI.

J Pharmacol Exp Ther. 2016 Jun;357(3):520-8. doi: 10.1124/jpet.116.233304. Epub 2016 Apr 11.

22.

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion.

Zhang Y, Williams DA, Zaidi SA, Yuan Y, Braithwaite A, Bilsky EJ, Dewey WL, Akbarali HI, Streicher JM, Selley DE.

ACS Chem Neurosci. 2016 Mar 16;7(3):297-304. doi: 10.1021/acschemneuro.5b00245. Epub 2016 Jan 8.

23.

Postranslational Modification of Ion Channels in Colonic Inflammation.

Akbarali HI, Kang M.

Curr Neuropharmacol. 2015;13(2):234-8. Review.

24.

Stimulation of synthesis and release of brain-derived neurotropic factor from intestinal smooth muscle cells by substance P and pituitary adenylate cyclase-activating peptide.

Al-Qudah M, Alkahtani R, Akbarali HI, Murthy KS, Grider JR.

Neurogastroenterol Motil. 2015 Aug;27(8):1162-74. doi: 10.1111/nmo.12604. Epub 2015 Jun 18.

25.

Sensitization of enteric neurons to morphine by HIV-1 Tat protein.

Fitting S, Ngwainmbi J, Kang M, Khan FA, Stevens DL, Dewey WL, Knapp PE, Hauser KF, Akbarali HI.

Neurogastroenterol Motil. 2015 Apr;27(4):468-80. doi: 10.1111/nmo.12514. Epub 2015 Feb 19.

26.

Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.

Kang M, Hashimoto A, Gade A, Akbarali HI.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G532-9. doi: 10.1152/ajpgi.00281.2014. Epub 2014 Dec 31.

27.

Effects of HIV-1 Tat on enteric neuropathogenesis.

Ngwainmbi J, De DD, Smith TH, El-Hage N, Fitting S, Kang M, Dewey WL, Hauser KF, Akbarali HI.

J Neurosci. 2014 Oct 22;34(43):14243-51. doi: 10.1523/JNEUROSCI.2283-14.2014.

28.

Site and mechanism of morphine tolerance in the gastrointestinal tract.

Akbarali HI, Inkisar A, Dewey WL.

Neurogastroenterol Motil. 2014 Oct;26(10):1361-7. doi: 10.1111/nmo.12443. Review.

29.

Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na⁺ influx, mitochondrial instability, and Ca²⁺ overload.

Fitting S, Knapp PE, Zou S, Marks WD, Bowers MS, Akbarali HI, Hauser KF.

J Neurosci. 2014 Sep 17;34(38):12850-64. doi: 10.1523/JNEUROSCI.5351-13.2014.

30.

Molecular physiology of enteric opioid receptors.

Galligan JJ, Akbarali HI.

Am J Gastroenterol Suppl. 2014 Sep 10;2(1):17-21. doi: 10.1038/ajgsup.2014.5. Review.

31.

Morphine dependence in single enteric neurons from the mouse colon requires deletion of β-arrestin2.

Smith TH, Ngwainmbi J, Hashimoto A, Dewey WL, Akbarali HI.

Physiol Rep. 2014 Sep 4;2(9). pii: e12140. doi: 10.14814/phy2.12140. Print 2014 Sep 1.

32.

Specific localization of β-Arrestin2 in myenteric plexus of mouse gastrointestinal tract.

Maguma HT, Datta De D, Bhave S, Dewey WL, Akbarali HI.

PLoS One. 2014 Aug 1;9(8):e103894. doi: 10.1371/journal.pone.0103894. eCollection 2014.

33.

Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.

Al-Qudah M, Anderson CD, Mahavadi S, Bradley ZL, Akbarali HI, Murthy KS, Grider JR.

Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G328-37. doi: 10.1152/ajpgi.00203.2013. Epub 2013 Dec 19.

34.

Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.

Mahavadi S, Bhattacharya S, Kumar DP, Clay C, Ross G, Akbarali HI, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G964-74. doi: 10.1152/ajpgi.00165.2013. Epub 2013 Oct 24.

35.

An in-vitro preparation of isolated enteric neurons and glia from the myenteric plexus of the adult mouse.

Smith TH, Ngwainmbi J, Grider JR, Dewey WL, Akbarali HI.

J Vis Exp. 2013 Aug 7;(78). doi: 10.3791/50688.

36.

Sepiapterin ameliorates chemically induced murine colitis and azoxymethane-induced colon cancer.

Cardnell RJ, Rabender CS, Ross GR, Guo C, Howlett EL, Alam A, Wang XY, Akbarali HI, Mikkelsen RB.

J Pharmacol Exp Ther. 2013 Oct;347(1):117-25. doi: 10.1124/jpet.113.203828. Epub 2013 Aug 2.

37.

Electrophysiological characteristics of enteric neurons isolated from the immortomouse.

Hawkins EG, Dewey WL, Anitha M, Srinivasan S, Grider JR, Akbarali HI.

Dig Dis Sci. 2013 Jun;58(6):1516-27. doi: 10.1007/s10620-013-2557-5. Epub 2013 Jan 31.

38.

Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.

Yuan Y, Elbegdorj O, Chen J, Akubathini SK, Zhang F, Stevens DL, Beletskaya IO, Scoggins KL, Zhang Z, Gerk PM, Selley DE, Akbarali HI, Dewey WL, Zhang Y.

J Med Chem. 2012 Nov 26;55(22):10118-29. doi: 10.1021/jm301247n. Epub 2012 Nov 9.

39.

Hydrogen sulfide as an allosteric modulator of ATP-sensitive potassium channels in colonic inflammation.

Gade AR, Kang M, Akbarali HI.

Mol Pharmacol. 2013 Jan;83(1):294-306. doi: 10.1124/mol.112.081596. Epub 2012 Oct 31.

40.

Novel insights on the effect of nicotine in a murine colitis model.

AlSharari SD, Akbarali HI, Abdullah RA, Shahab O, Auttachoat W, Ferreira GA, White KL, Lichtman AH, Cabral GA, Damaj MI.

J Pharmacol Exp Ther. 2013 Jan;344(1):207-17. doi: 10.1124/jpet.112.198796. Epub 2012 Oct 31.

41.

Morphine decreases enteric neuron excitability via inhibition of sodium channels.

Smith TH, Grider JR, Dewey WL, Akbarali HI.

PLoS One. 2012;7(9):e45251. doi: 10.1371/journal.pone.0045251. Epub 2012 Sep 21. Erratum in: PLoS One. 2013;8(5). doi: 10.1371/annotation/c2d0d839-3fea-4dfd-ad78-4e4fb1271b20.

42.

Evidence for the putative cannabinoid receptor (GPR55)-mediated inhibitory effects on intestinal contractility in mice.

Ross GR, Lichtman A, Dewey WL, Akbarali HI.

Pharmacology. 2012;90(1-2):55-65. doi: 10.1159/000339076. Epub 2012 Jun 28.

43.

6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists.

Yuan Y, Stevens DL, Braithwaite A, Scoggins KL, Bilsky EJ, Akbarali HI, Dewey WL, Zhang Y.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4731-4. doi: 10.1016/j.bmcl.2012.05.075. Epub 2012 May 26.

44.

Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice.

Maguma HT, Dewey WL, Akbarali HI.

Eur J Pharmacol. 2012 Jun 15;685(1-3):133-40. doi: 10.1016/j.ejphar.2012.04.001. Epub 2012 Apr 11.

45.

Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat.

Xia CM, Gulick MA, Yu SJ, Grider JR, Murthy KS, Kuemmerle JF, Akbarali HI, Qiao LY.

J Neuroinflammation. 2012 Feb 15;9:30. doi: 10.1186/1742-2094-9-30.

46.

Nicotine suppresses hyperexcitability of colonic sensory neurons and visceral hypersensivity in mouse model of colonic inflammation.

Abdrakhmanova GR, Kang M, Imad Damaj M, Akbarali HI.

Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G740-7. doi: 10.1152/ajpgi.00411.2011. Epub 2012 Jan 12.

47.

Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia.

Ross GR, Gade AR, Dewey WL, Akbarali HI.

Am J Physiol Cell Physiol. 2012 Apr 15;302(8):C1152-61. doi: 10.1152/ajpcell.00171.2011. Epub 2011 Dec 21.

48.

The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract.

Kang M, Maguma HT, Smith TH, Ross GR, Dewey WL, Akbarali HI.

J Pharmacol Exp Ther. 2012 Mar;340(3):567-76. doi: 10.1124/jpet.111.186320. Epub 2011 Nov 30.

49.

Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice.

Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. doi: 10.1124/jpet.111.181370. Epub 2011 Jun 30.

50.

Prolonged sympathetic innervation of sensory neurons in rat thoracolumbar dorsal root ganglia during chronic colitis.

Xia CM, Colomb DG Jr, Akbarali HI, Qiao LY.

Neurogastroenterol Motil. 2011 Aug;23(8):801-e339. doi: 10.1111/j.1365-2982.2011.01728.x. Epub 2011 May 24.

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