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Items: 1 to 50 of 171

1.

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.

Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J, Akbar AN.

Nat Commun. 2019 Jun 3;10(1):2387. doi: 10.1038/s41467-019-10335-5.

2.

Human natural killer cells mediate adaptive immunity to viral antigens.

Nikzad R, Angelo LS, Aviles-Padilla K, Le DT, Singh VK, Bimler L, Vukmanovic-Stejic M, Vendrame E, Ranganath T, Simpson L, Haigwood NL, Blish CA, Akbar AN, Paust S.

Sci Immunol. 2019 May 10;4(35). pii: eaat8116. doi: 10.1126/sciimmunol.aat8116.

PMID:
31076527
3.

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS.

Gut. 2019 Aug;68(8):1430-1438. doi: 10.1136/gutjnl-2019-318424. Epub 2019 Apr 10.

4.

CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age.

Müller-Durovic B, Grählert J, Devine OP, Akbar AN, Hess C.

Aging (Albany NY). 2019 Jan 27;11(2):724-740. doi: 10.18632/aging.101774.

5.

Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis.

Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR, de Matos Guedes HL, Falqueto A, Akbar AN, Gomes DCO.

Front Immunol. 2019 Jan 4;9:3001. doi: 10.3389/fimmu.2018.03001. eCollection 2018.

6.

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence.

Xu W, Monaco G, Wong EH, Tan WLW, Kared H, Simoni Y, Tan SW, How WZY, Tan CTY, Lee BTK, Carbajo D, K G S, Low ICH, Mok EWH, Foo S, Lum J, Tey HL, Tan WP, Poidinger M, Newell E, Ng TP, Foo R, Akbar AN, Fülöp T, Larbi A.

EBioMedicine. 2019 Jan;39:44-58. doi: 10.1016/j.ebiom.2018.11.053. Epub 2018 Dec 7.

7.

Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge.

Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA, Krueger J, Akbar AN.

J Infect Dis. 2018 Sep 22;218(suppl_2):S88-S98. doi: 10.1093/infdis/jiy420.

8.

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo.

Holm LL, Vukmanovic-Stejic M, Blauenfeldt T, Benfield T, Andersen P, Akbar AN, Ruhwald M.

J Vis Exp. 2018 Aug 11;(138). doi: 10.3791/57554.

9.

The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease.

Chambers ES, Byrne CS, Rugyendo A, Morrison DJ, Preston T, Tedford C, Bell JD, Thomas L, Akbar AN, Riddell NE, Sharma R, Thursz MR, Manousou P, Frost G.

Diabetes Obes Metab. 2019 Feb;21(2):372-376. doi: 10.1111/dom.13500. Epub 2018 Sep 16.

10.

Skin resident memory CD8+ T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function.

Seidel JA, Vukmanovic-Stejic M, Muller-Durovic B, Patel N, Fuentes-Duculan J, Henson SM, Krueger JG, Rustin MHA, Nestle FO, Lacy KE, Akbar AN.

Clin Exp Immunol. 2018 Oct;194(1):79-92. doi: 10.1111/cei.13189. Epub 2018 Sep 12.

PMID:
30030847
11.

Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation.

Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE, Turner CT, Larbi A, Birault V, Noursadeghi M, Mabbott NA, Rustin MHA, Krueger JG, Akbar AN.

J Allergy Clin Immunol. 2018 Sep;142(3):844-856. doi: 10.1016/j.jaci.2017.10.032. Epub 2017 Nov 17.

12.

Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK.

Callender LA, Carroll EC, Beal RWJ, Chambers ES, Nourshargh S, Akbar AN, Henson SM.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12675. Epub 2017 Oct 12.

13.

A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.

Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN.

Nat Immunol. 2017 Mar;18(3):354-363. doi: 10.1038/ni.3665. Epub 2017 Jan 23.

14.

Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders.

Shih BB, Nirmal AJ, Headon DJ, Akbar AN, Mabbott NA, Freeman TC.

J Pathol. 2017 Apr;241(5):600-613. doi: 10.1002/path.4864. Epub 2017 Feb 24.

15.

Convergence of Innate and Adaptive Immunity during Human Aging.

Pereira BI, Akbar AN.

Front Immunol. 2016 Nov 4;7:445. eCollection 2016. Review.

16.

The convergence of senescence and nutrient sensing during lymphocyte ageing.

Akbar AN.

Clin Exp Immunol. 2017 Jan;187(1):4-5. doi: 10.1111/cei.12876. Epub 2016 Oct 28. Review.

17.

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity.

Akbar AN, Henson SM, Lanna A.

Trends Immunol. 2016 Dec;37(12):866-876. doi: 10.1016/j.it.2016.09.002. Epub 2016 Oct 4. Review.

PMID:
27720177
18.

Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase.

Müller-Durovic B, Lanna A, Covre LP, Mills RS, Henson SM, Akbar AN.

J Immunol. 2016 Oct 1;197(7):2891-2899. doi: 10.4049/jimmunol.1600590. Epub 2016 Aug 26.

19.

The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis.

Di Mitri D, Sambucci M, Loiarro M, De Bardi M, Volpe E, Cencioni MT, Gasperini C, Centonze D, Sette C, Akbar AN, Borsellino G, Battistini L.

Immunology. 2015 Oct;146(2):251-63. doi: 10.1111/imm.12497. Epub 2015 Jul 6.

20.

Virus-specific T lymphocytes home to the skin during natural dengue infection.

Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA.

Sci Transl Med. 2015 Mar 11;7(278):278ra35. doi: 10.1126/scitranslmed.aaa0526.

PMID:
25761891
21.

The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging.

Vukmanovic-Stejic M, Sandhu D, Seidel JA, Patel N, Sobande TO, Agius E, Jackson SE, Fuentes-Duculan J, Suárez-Fariñas M, Mabbott NA, Lacy KE, Ogg G, Nestle FO, Krueger JG, Rustin MHA, Akbar AN.

J Invest Dermatol. 2015 Jul;135(7):1752-1762. doi: 10.1038/jid.2015.63. Epub 2015 Mar 3.

22.

Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways.

Henson SM, Macaulay R, Riddell NE, Nunn CJ, Akbar AN.

Eur J Immunol. 2015 May;45(5):1441-51. doi: 10.1002/eji.201445312. Epub 2015 Mar 30.

23.

Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults.

Riddell NE, Griffiths SJ, Rivino L, King DC, Teo GH, Henson SM, Cantisan S, Solana R, Kemeny DM, MacAry PA, Larbi A, Akbar AN.

Immunology. 2015 Apr;144(4):549-60. doi: 10.1111/imm.12409.

24.

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.

Lanna A, Henson SM, Escors D, Akbar AN.

Nat Immunol. 2014 Oct;15(10):965-72. doi: 10.1038/ni.2981. Epub 2014 Aug 24.

25.

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells.

Henson SM, Lanna A, Riddell NE, Franzese O, Macaulay R, Griffiths SJ, Puleston DJ, Watson AS, Simon AK, Tooze SA, Akbar AN.

J Clin Invest. 2014 Sep;124(9):4004-16. doi: 10.1172/JCI75051. Epub 2014 Aug 1.

26.

Lost in translation: mice, men and cutaneous immunity in old age.

Smithey MJ, Uhrlaub JL, Li G, Vukmanovic-Stejic M, Akbar AN, Nikolich-Zugich J.

Biogerontology. 2015 Apr;16(2):203-8. doi: 10.1007/s10522-014-9517-0. Epub 2014 Jul 16. Review.

PMID:
25027761
27.

IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling.

Lanna A, Coutavas E, Levati L, Seidel J, Rustin MH, Henson SM, Akbar AN, Franzese O.

J Immunol. 2013 Oct 1;191(7):3744-52. doi: 10.4049/jimmunol.1301409. Epub 2013 Aug 30.

28.

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S, Rivino L, Larbi A, Kemeny DM, Nikolich-Zugich J, Kern F, Klenerman P, Emery VC, Akbar AN.

J Immunol. 2013 Jun 1;190(11):5363-72. doi: 10.4049/jimmunol.1203267. Epub 2013 May 1.

29.

Investigation of the cutaneous response to recall antigen in humans in vivo.

Akbar AN, Reed JR, Lacy KE, Jackson SE, Vukmanovic-Stejic M, Rustin MH.

Clin Exp Immunol. 2013 Aug;173(2):163-72. doi: 10.1111/cei.12107.

30.

Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.

Comandini A, Naro C, Adamo R, Akbar AN, Lanna A, Bonmassar E, Franzese O.

Mol Immunol. 2013 Jun;54(2):181-92. doi: 10.1016/j.molimm.2012.12.003. Epub 2012 Dec 31.

PMID:
23287597
31.

Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans.

Vukmanovic-Stejic M, Sandhu D, Sobande TO, Agius E, Lacy KE, Riddell N, Montez S, Dintwe OB, Scriba TJ, Breuer J, Nikolich-Zugich J, Ogg G, Rustin MH, Akbar AN.

J Immunol. 2013 Feb 1;190(3):977-86. doi: 10.4049/jimmunol.1201331. Epub 2013 Jan 2.

32.

Differing HLA types influence inhibitory receptor signalling in CMV-specific CD8+ T cells.

Macaulay R, Riddell NE, Griffiths SJ, Akbar AN, Henson SM.

Hum Immunol. 2013 Mar;74(3):302-9. doi: 10.1016/j.humimm.2012.11.014. Epub 2012 Dec 5.

33.

CMV and Immunosenescence: from basics to clinics.

Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zieliński M, Pawelec G.

Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23.

34.

Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells.

Havenith SH, Yong SL, Henson SM, Piet B, Idu MM, Koch SD, Jonkers RE, Kragten NA, Akbar AN, van Lier RA, ten Berge IJ.

Int Immunol. 2012 Oct;24(10):625-36. Epub 2012 Jul 26.

PMID:
22836020
35.

Editorial overview.

Akbar AN, Hodes RJ.

Curr Opin Immunol. 2012 Aug;24(4):467-9. doi: 10.1016/j.coi.2012.07.002. Epub 2012 Jul 23. No abstract available.

PMID:
22832007
36.

Translational research in immune senescence: assessing the relevance of current models.

High KP, Akbar AN, Nikolich-Zugich J.

Semin Immunol. 2012 Oct;24(5):373-82. doi: 10.1016/j.smim.2012.04.007. Epub 2012 May 23. Review.

37.

Properties of end-stage human T cells defined by CD45RA re-expression.

Henson SM, Riddell NE, Akbar AN.

Curr Opin Immunol. 2012 Aug;24(4):476-81. doi: 10.1016/j.coi.2012.04.001. Epub 2012 May 1. Review.

38.

The role of the T cell in age-related inflammation.

Macaulay R, Akbar AN, Henson SM.

Age (Dordr). 2013 Jun;35(3):563-72. doi: 10.1007/s11357-012-9381-2. Epub 2012 Jan 15. Review.

39.

Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade.

Henson SM, Macaulay R, Franzese O, Akbar AN.

Immunology. 2012 Apr;135(4):355-63. doi: 10.1111/j.1365-2567.2011.03550.x.

40.

Reversible senescence in human CD4+CD45RA+CD27- memory T cells.

Di Mitri D, Azevedo RI, Henson SM, Libri V, Riddell NE, Macaulay R, Kipling D, Soares MV, Battistini L, Akbar AN.

J Immunol. 2011 Sep 1;187(5):2093-100. doi: 10.4049/jimmunol.1100978. Epub 2011 Jul 25.

41.

Immune responses in the skin in old age.

Vukmanovic-Stejic M, Rustin MH, Nikolich-Zugich J, Akbar AN.

Curr Opin Immunol. 2011 Aug;23(4):525-31. doi: 10.1016/j.coi.2011.05.008. Epub 2011 Jun 22. Review.

PMID:
21703840
42.

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

Akbar AN, Henson SM.

Nat Rev Immunol. 2011 Apr;11(4):289-95. doi: 10.1038/nri2959.

PMID:
21436838
43.

Measurement of proliferation and disappearance of regulatory T cells in human studies using deuterium-labeled glucose.

Vukmanovic-Stejic M, Zhang Y, Akbar AN, Macallan DC.

Methods Mol Biol. 2011;707:243-61. doi: 10.1007/978-1-61737-979-6_16.

PMID:
21287340
44.

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process.

Libri V, Azevedo RI, Jackson SE, Di Mitri D, Lachmann R, Fuhrmann S, Vukmanovic-Stejic M, Yong K, Battistini L, Kern F, Soares MV, Akbar AN.

Immunology. 2011 Mar;132(3):326-39. doi: 10.1111/j.1365-2567.2010.03386.x. Epub 2011 Jan 7.

45.

The silent war against CMV in CLL.

Akbar AN.

Blood. 2010 Oct 21;116(16):2869-70. doi: 10.1182/blood-2010-07-293431. No abstract available.

46.

Memory T-cell homeostasis and senescence during aging.

Henson SM, Akbar AN.

Adv Exp Med Biol. 2010;684:189-97.

PMID:
20795550
47.

Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects.

Wallace DL, Masters JE, De Lara CM, Henson SM, Worth A, Zhang Y, Kumar SR, Beverley PC, Akbar AN, Macallan DC.

Immunology. 2011 Jan;132(1):27-38. doi: 10.1111/j.1365-2567.2010.03334.x. Epub 2010 Aug 25.

48.

CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection.

Hoare M, Gelson WT, Das A, Fletcher JM, Davies SE, Curran MD, Vowler SL, Maini MK, Akbar AN, Alexander GJ.

J Hepatol. 2010 Aug;53(2):252-60. doi: 10.1016/j.jhep.2010.03.005. Epub 2010 Apr 22.

49.

Features of immune senescence in liver transplant recipients with established grafts.

Gelson W, Hoare M, Vowler S, Shankar A, Gibbs P, Akbar AN, Alexander GJ.

Liver Transpl. 2010 May;16(5):577-87. doi: 10.1002/lt.22033.

50.

Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset.

Hayhoe RP, Henson SM, Akbar AN, Palmer DB.

Hum Immunol. 2010 Jul;71(7):676-81. doi: 10.1016/j.humimm.2010.03.014. Epub 2010 Apr 23.

PMID:
20394788

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