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Items: 1 to 50 of 162

1.

[Effects of drug treatment on the surviral-time in patients with dementia].

Manabe T, Mizukami K, Matsuoka T, Ogawa N, Kanesaka T, Taniguchi C, Yamamoto S, Hashizume Y, Ohara H, Yamamoto T, Akatsu H.

Nihon Ronen Igakkai Zasshi. 2019;56(2):171-180. doi: 10.3143/geriatrics.56.171. Japanese.

2.

Pneumonia-associated death in patients with dementia: A systematic review and meta-analysis.

Manabe T, Fujikura Y, Mizukami K, Akatsu H, Kudo K.

PLoS One. 2019 Mar 14;14(3):e0213825. doi: 10.1371/journal.pone.0213825. eCollection 2019.

3.

Isotope Corrected Chiral and Achiral Nontargeted Metabolomics: An Approach for High Accuracy and Precision Metabolomics Based on Derivatization and Its Application to Cerebrospinal Fluid of Patients with Alzheimer's Disease.

Takayama T, Mizuno H, Toyo'oka T, Akatsu H, Inoue K, Todoroki K.

Anal Chem. 2019 Apr 2;91(7):4396-4404. doi: 10.1021/acs.analchem.8b04852. Epub 2019 Mar 15.

PMID:
30831026
4.

Factors influencing hospital admission among patients with autopsy-confirmed dementia.

Matsuoka T, Manabe T, Akatsu H, Hashizume Y, Yamamoto S, Ogawa N, Kanesaka T, Taniguchi C, Yamamoto T, Mizukami K.

Psychogeriatrics. 2019 May;19(3):255-263. doi: 10.1111/psyg.12393. Epub 2019 Jan 24.

PMID:
30675966
5.

Serum levels of proteins involved in amyloid-β clearance are related to cognitive decline and neuroimaging changes in mild cognitive impairment.

Liu S, Suzuki H, Ito H, Korenaga T, Akatsu H, Meno K, Uchida K.

Alzheimers Dement (Amst). 2019 Jan 12;11:85-97. doi: 10.1016/j.dadm.2018.11.003. eCollection 2019 Dec.

6.

Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome.

Nishitsuji K, Watanabe S, Xiao J, Nagatomo R, Ogawa H, Tsunematsu T, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K.

Sci Rep. 2018 Nov 1;8(1):16173. doi: 10.1038/s41598-018-34571-9.

7.

Diagnostic 123I Whole Body Scan Prior to Ablation of Thyroid Remnant in Patients With Papillary Thyroid Cancer: Implications for Clinical Management.

Song H, Mosci C, Akatsu H, Basina M, Dosiou C, Iagaru A.

Clin Nucl Med. 2018 Oct;43(10):705-709. doi: 10.1097/RLU.0000000000002246.

PMID:
30153149
8.

[The consciousness survey and the effect of educational intervention of Advance Care Planning (ACP) including post-mortem to elderly residents living in old New Town of big city].

Akatsu H, Manabe T, Takeo J, Kawade Y, Kimura Y, Kondo M, Ito S, Nagano K, Nozaki Y, Dhoi M, Masaki Y, Tanaka H, Kanematsu T, Kojima M, Akashi K, Iwata A, Suzuki T, Kimura K, Asai K, Ohara H.

Nihon Ronen Igakkai Zasshi. 2018;55(3):358-366. doi: 10.3143/geriatrics.55.358. Japanese.

9.

Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.

Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T.

Hum Genet. 2018 Jul;137(6-7):521-533. doi: 10.1007/s00439-018-1906-z. Epub 2018 Jul 13.

10.

Widely targeted metabolomics of Alzheimer's disease postmortem cerebrospinal fluid based on 9-fluorenylmethyl chloroformate derivatized ultra-high performance liquid chromatography tandem mass spectrometry.

Muguruma Y, Tsutsui H, Noda T, Akatsu H, Inoue K.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 1;1091:53-66. doi: 10.1016/j.jchromb.2018.05.031. Epub 2018 May 23.

PMID:
29852382
11.

TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration.

Endo R, Takashima N, Nekooki-Machida Y, Komi Y, Hui KK, Takao M, Akatsu H, Murayama S, Sawa A, Tanaka M.

Biol Psychiatry. 2018 Oct 1;84(7):509-521. doi: 10.1016/j.biopsych.2018.03.008. Epub 2018 Mar 29.

PMID:
29752072
12.

Complement Activation in Capillary Cerebral Amyloid Angiopathy.

Matsuo K, Shindo A, Niwa A, Tabei KI, Akatsu H, Hashizume Y, Akiyama H, Ayaki T, Maki T, Sawamoto N, Takahashi R, Oikawa S, Tomimoto H.

Dement Geriatr Cogn Disord. 2017;44(5-6):343-353. doi: 10.1159/000486091. Epub 2018 Feb 8.

PMID:
29421784
13.

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.

Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H.

Nat Commun. 2018 Jan 30;9(1):433. doi: 10.1038/s41467-018-02821-z.

14.

Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome.

Nishitsuji K, Xiao J, Nagatomo R, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K.

Sci Rep. 2017 Nov 20;7(1):15876. doi: 10.1038/s41598-017-16189-5.

15.

Comparative Analysis of Cortical Microinfarcts and Microbleeds using 3.0-Tesla Postmortem Magnetic Resonance Images and Histopathology.

Niwa A, Ii Y, Shindo A, Matsuo K, Ishikawa H, Taniguchi A, Takase S, Maeda M, Sakuma H, Akatsu H, Hashizume Y, Tomimoto H.

J Alzheimers Dis. 2017;59(3):951-959. doi: 10.3233/JAD-161242.

16.

Factors Associated with Pneumonia-caused Death in Older Adults with Autopsy-confirmed Dementia.

Manabe T, Mizukami K, Akatsu H, Hashizume Y, Ohkubo T, Kudo K, Hizawa N.

Intern Med. 2017;56(8):907-914. doi: 10.2169/internalmedicine.56.7879. Epub 2017 Apr 15.

17.

Lysophosphatidylcholine export by human ABCA7.

Tomioka M, Toda Y, Mañucat NB, Akatsu H, Fukumoto M, Kono N, Arai H, Kioka N, Ueda K.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jul;1862(7):658-665. doi: 10.1016/j.bbalip.2017.03.012. Epub 2017 Mar 31.

PMID:
28373057
18.

Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.

Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H.

Sci Rep. 2017 Mar 23;7:45050. doi: 10.1038/srep45050.

19.

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.

Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2947-E2954. doi: 10.1073/pnas.1615036114. Epub 2017 Mar 20.

20.

Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.

Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S.

J Proteomics. 2017 Mar 31;158:31-42. doi: 10.1016/j.jprot.2017.02.009. Epub 2017 Feb 16.

PMID:
28214564
21.
22.

Histopathology and Florbetaben PET in Patients Incorrectly Diagnosed with Alzheimer's Disease.

Sabbagh MN, Schäuble B, Anand K, Richards D, Murayama S, Akatsu H, Takao M, Rowe CC, Masters CL, Barthel H, Gertz HJ, Peters O, Rasgon N, Jovalekic A, Sabri O, Schulz-Schaeffer WJ, Seibyl J.

J Alzheimers Dis. 2017;56(2):441-446. doi: 10.3233/JAD-160821.

PMID:
27983552
23.

A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression.

Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim TS, Gao N, Dong Y, Zhang S, Fujinawa Y, Yamamoto O, Ito H, Tomita Y, Naruse Y, Sakamaki A, Ishii Y, Tsuneyama K, Inoue M, Itoh J, Yasuda M, Sakata N, Jung CG, Kanazawa S, Akatsu H, Minato H, Nojima T, Asai K, Miura Y.

BMC Cancer. 2016 Oct 18;16(1):805.

24.

Prognostic Factors Related to Dementia with Lewy Bodies Complicated with Pneumonia: An Autopsy Study.

Manabe T, Mizukami K, Akatsu H, Hashizume Y, Teramoto S, Nakamura S, Kudo K, Hizawa N.

Intern Med. 2016;55(19):2771-2776. Epub 2016 Oct 1.

25.

Development of prognostic signatures for intermediate-risk papillary thyroid cancer.

Brennan K, Holsinger C, Dosiou C, Sunwoo JB, Akatsu H, Haile R, Gevaert O.

BMC Cancer. 2016 Sep 15;16(1):736. doi: 10.1186/s12885-016-2771-6.

26.

Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.

Hino M, Kunii Y, Matsumoto J, Wada A, Nagaoka A, Niwa S, Takahashi H, Kakita A, Akatsu H, Hashizume Y, Yamamoto S, Yabe H.

J Psychiatr Res. 2016 Nov;82:100-8. doi: 10.1016/j.jpsychires.2016.07.018. Epub 2016 Jul 25.

PMID:
27484635
27.

Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.

Liu L, Watanabe N, Akatsu H, Nishimura M.

Neuroscience. 2016 Aug 25;330:236-46. doi: 10.1016/j.neuroscience.2016.05.050. Epub 2016 May 30.

PMID:
27256505
28.

Amyloid-β sequester proteins as blood-based biomarkers of cognitive decline.

Uchida K, Shan L, Suzuki H, Tabuse Y, Nishimura Y, Hirokawa Y, Mizukami K, Akatsu H, Meno K, Asada T.

Alzheimers Dement (Amst). 2015 Jun 15;1(2):270-80. doi: 10.1016/j.dadm.2015.04.003. eCollection 2015 Jun.

29.

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.

Kametani F, Obi T, Shishido T, Akatsu H, Murayama S, Saito Y, Yoshida M, Hasegawa M.

Sci Rep. 2016 Mar 16;6:23281. doi: 10.1038/srep23281.

30.

Impact of Training Method on the Robustness of the Visual Assessment of 18F-Florbetaben PET Scans: Results from a Phase-3 Study.

Seibyl J, Catafau AM, Barthel H, Ishii K, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Takao M, Akatsu H, Murayama S, Bullich S, Mueller A, Koglin N, Schulz-Schaeffer WJ, Hoffmann A, Sabbagh MN, Stephens AW, Sabri O.

J Nucl Med. 2016 Jun;57(6):900-6. doi: 10.2967/jnumed.115.161927. Epub 2016 Jan 28.

31.

Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates.

Ochiishi T, Itakura A, Liu L, Akatsu H, Kohno H, Nishimura M, Yoshimune K.

Genes Cells. 2016 Feb;21(2):200-11. doi: 10.1111/gtc.12332. Epub 2016 Jan 25.

32.

A novel approach for LC-MS/MS-based chiral metabolomics fingerprinting and chiral metabolomics extraction using a pair of enantiomers of chiral derivatization reagents.

Takayama T, Mochizuki T, Todoroki K, Min JZ, Mizuno H, Inoue K, Akatsu H, Noge I, Toyo'oka T.

Anal Chim Acta. 2015 Oct 22;898:73-84. doi: 10.1016/j.aca.2015.10.010. Epub 2015 Oct 22.

PMID:
26526912
33.

Influence of pneumonia complications on the prognosis of patients with autopsy-confirmed Alzheimer's disease, dementia with Lewy bodies, and vascular dementia.

Manabe T, Mizukami K, Akatsu H, Teramoto S, Yamaoka K, Nakamura S, Ohkubo T, Kudo K, Hizawa N.

Psychogeriatrics. 2016 Sep;16(5):305-14. doi: 10.1111/psyg.12163. Epub 2015 Oct 29.

34.

Operational Assistance for Elderly People by Using Audio Rhythms.

Akatsu H, Komatsubara A.

Stud Health Technol Inform. 2015;217:539-45.

PMID:
26294525
35.

Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.

Mizukami K, Akatsu H, Abrahamson EE, Mi Z, Ikonomovic MD.

Neuropathology. 2016 Apr;36(2):135-45. doi: 10.1111/neup.12241. Epub 2015 Aug 21.

36.
37.

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.

Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.

Psychiatr Genet. 2015 Aug;25(4):139-46. doi: 10.1097/YPG.0000000000000090.

PMID:
26049409
38.

Atypia of undetermined significance and follicular lesions of undetermined significance: sonographic assessment for prediction of the final diagnosis.

Kamaya A, Lewis GH, Liu Y, Akatsu H, Kong C, Desser TS.

J Ultrasound Med. 2015 May;34(5):767-74. doi: 10.7863/ultra.34.5.767.

PMID:
25911708
39.

Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.

Jin JK, Jang B, Jin HT, Choi EK, Jung CG, Akatsu H, Kim JI, Carp RI, Kim YS.

PLoS One. 2015 Apr 13;10(4):e0122120. doi: 10.1371/journal.pone.0122120. eCollection 2015.

40.

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: phase 3 study.

Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, Senda K, Murayama S, Ishii K, Takao M, Beach TG, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Catafau AM, Stephens AW, Mueller A, Koglin N, Hoffmann A, Roth K, Reininger C, Schulz-Schaeffer WJ; Florbetaben Phase 3 Study Group.

Alzheimers Dement. 2015 Aug;11(8):964-74. doi: 10.1016/j.jalz.2015.02.004. Epub 2015 Mar 28.

41.

Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.

Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I.

Neurosci Lett. 2015 Mar 30;591:19-24. doi: 10.1016/j.neulet.2015.02.013. Epub 2015 Feb 9.

42.

Enhanced vaccination effect against influenza by prebiotics in elderly patients receiving enteral nutrition.

Akatsu H, Nagafuchi S, Kurihara R, Okuda K, Kanesaka T, Ogawa N, Kanematsu T, Takasugi S, Yamaji T, Takami M, Yamamoto T, Ohara H, Maruyama M.

Geriatr Gerontol Int. 2016 Feb;16(2):205-13. doi: 10.1111/ggi.12454. Epub 2015 Jan 22.

PMID:
25613751
43.

Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis.

Inoue K, Tsuchiya H, Takayama T, Akatsu H, Hashizume Y, Yamamoto T, Matsukawa N, Toyo'oka T.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:24-34. doi: 10.1016/j.jchromb.2014.10.022. Epub 2014 Oct 27.

PMID:
25463194
44.

DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.

Yuki D, Sugiura Y, Zaima N, Akatsu H, Takei S, Yao I, Maesako M, Kinoshita A, Yamamoto T, Kon R, Sugiyama K, Setou M.

Sci Rep. 2014 Nov 20;4:7130. doi: 10.1038/srep07130.

45.

Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathies.

Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M.

Ann Clin Transl Neurol. 2014 Jul 3;1(7):479-489.

46.

ATBF1 is a novel amyloid-β protein precursor (AβPP) binding protein that affects AβPP expression.

Uhm KO, Kim MJ, Kawaguchi M, Akatsu H, Miura Y, Misumi S, Hida H, Choi EK, Kim YS, Michikawa M, Jung CG.

J Alzheimers Dis. 2015;43(1):243-57. doi: 10.3233/JAD-140612.

PMID:
25079792
47.

Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.

Miyashita A, Wen Y, Kitamura N, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Furukawa K, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Nishizawa M, Suga M, Kawase Y, Akatsu H, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Yamaguchi H, Akazawa K, Kanazawa I, Ihara Y, Ikeuchi T, Kuwano R.

J Alzheimers Dis. 2014;41(4):1031-8. doi: 10.3233/JAD-140225.

PMID:
24762945
48.

Distinction between mild cognitive impairment and Alzheimer's disease by CSF amyloid β40 and β42, and protein-conjugated acrolein.

Mizoi M, Yoshida M, Saiki R, Waragai M, Uemura K, Akatsu H, Kashiwagi K, Igarashi K.

Clin Chim Acta. 2014 Mar 20;430:150-5. doi: 10.1016/j.cca.2014.01.007. Epub 2014 Feb 6.

PMID:
24508996
49.

Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.

Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2638-43. doi: 10.1073/pnas.1307345111. Epub 2014 Feb 4.

50.

Association Between Thyroid Function and Objective and Subjective Sleep Quality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study.

Akatsu H, Ewing SK, Stefanick ML, Fink HA, Stone KL, Barrett-Connor E, Mehra R, Ancoli-Israel S, Redline S, Hoffman AR; Osteoporotic Fractures In Men MrOS Research Group.

Endocr Pract. 2014 Jun;20(6):576-86. doi: 10.4158/EP13282.OR.

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