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Items: 1 to 50 of 88

1.

Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.

Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10488-10493. doi: 10.1073/pnas.1816911116. Epub 2019 May 8.

2.

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.

Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, Zhang XM, Harris RA, Cooter M, Berger M, Maddipati KR, Akassoglou K, Terrando N.

Br J Anaesth. 2019 Mar;122(3):350-360. doi: 10.1016/j.bja.2018.10.062. Epub 2018 Dec 28.

3.

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.

Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K.

Neuron. 2019 Mar 20;101(6):1099-1108.e6. doi: 10.1016/j.neuron.2019.01.014. Epub 2019 Feb 5.

PMID:
30737131
4.

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.

Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K.

Nat Immunol. 2018 Nov;19(11):1212-1223. doi: 10.1038/s41590-018-0232-x. Epub 2018 Oct 15.

5.

Pericytes: The Brain's Very First Responders?

Rafalski VA, Merlini M, Akassoglou K.

Neuron. 2018 Oct 10;100(1):11-13. doi: 10.1016/j.neuron.2018.09.033.

PMID:
30308164
6.

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.

Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10172-10177. doi: 10.1073/pnas.1811411115. Epub 2018 Sep 19.

7.

Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1.

Pathak A, Stanley EM, Hickman FE, Wallace N, Brewer B, Li D, Gluska S, Perlson E, Fuhrmann S, Akassoglou K, Bronfman F, Casaccia P, Burnette DT, Carter BD.

Dev Cell. 2018 Aug 6;46(3):376-387.e7. doi: 10.1016/j.devcel.2018.07.001.

PMID:
30086304
8.

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.

Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS.

Brain. 2018 Jun 1;141(6):1637-1649. doi: 10.1093/brain/awy082.

9.

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.

Petersen MA, Ryu JK, Akassoglou K.

Nat Rev Neurosci. 2018 May;19(5):283-301. doi: 10.1038/nrn.2018.13. Epub 2018 Apr 5. Review.

PMID:
29618808
10.

In Vivo Imaging of CNS Injury and Disease.

Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B.

J Neurosci. 2017 Nov 8;37(45):10808-10816. doi: 10.1523/JNEUROSCI.1826-17.2017. Review.

11.

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K.

Neuron. 2017 Dec 6;96(5):1003-1012.e7. doi: 10.1016/j.neuron.2017.10.008. Epub 2017 Nov 2.

12.

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.

Xu T, Stewart KM, Wang X, Liu K, Xie M, Ryu JK, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S.

Nature. 2017 Aug 10;548(7666):228-233. doi: 10.1038/nature23475. Epub 2017 Aug 2.

PMID:
28783731
13.

Alzheimer disease makes new blood contacts.

Merlini M, Akassoglou K.

Blood. 2017 May 4;129(18):2462-2463. doi: 10.1182/blood-2017-03-772087. No abstract available.

14.

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):5029-5034. doi: 10.1073/pnas.1700477114. Epub 2017 Apr 24.

15.

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T.

J Exp Med. 2017 Apr 3;214(4):1081-1092. doi: 10.1084/jem.20162011. Epub 2017 Mar 15.

16.

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease.

Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Ryu JK, Akassoglou K, Mullins ES.

J Neurosci. 2017 Apr 5;37(14):3776-3788. doi: 10.1523/JNEUROSCI.2932-15.2017. Epub 2017 Mar 8.

17.

Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy.

Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE.

Front Cell Neurosci. 2017 Jan 10;10:303. doi: 10.3389/fncel.2016.00303. eCollection 2016.

18.

Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation.

Bardehle S, Rafalski V, Akassoglou K.

Nat Immunol. 2016 Dec 16;18(1):7-8. doi: 10.1038/ni.3633. No abstract available.

19.

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.

Zhang MD, Barde S, Yang T, Lei B, Eriksson LI, Mathew JP, Andreska T, Akassoglou K, Harkany T, Hökfelt TG, Terrando N.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6686-E6695. Epub 2016 Oct 10.

20.

Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.

Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.

21.

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K.

Cell Rep. 2016 Jan 12;14(2):255-68. doi: 10.1016/j.celrep.2015.12.028. Epub 2015 Dec 31.

22.

Breaking boundaries-coagulation and fibrinolysis at the neurovascular interface.

Bardehle S, Rafalski VA, Akassoglou K.

Front Cell Neurosci. 2015 Sep 16;9:354. doi: 10.3389/fncel.2015.00354. eCollection 2015. Review.

23.

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.

Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K.

Nat Commun. 2015 Sep 10;6:8164. doi: 10.1038/ncomms9164.

24.

Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease

Le Moan N, Baeten KM, Rafalski VA, Ryu JK, Rios Coronado PE, Bedard C, Syme C, Davalos D, Akassoglou K.

eNeuro. 2015 Mar-Apr;2(2). pii: e0050.

25.

Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.

Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K.

Nat Neurosci. 2015 Aug;18(8):1077-80. doi: 10.1038/nn.4054. Epub 2015 Jun 29.

26.

SIRT1 deacetylates RORγt and enhances Th17 cell generation.

Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E.

J Exp Med. 2015 Jun 1;212(6):973. doi: 10.1084/jem.2013237805062015c. Epub 2015 May 18. No abstract available.

27.

SIRT1 deacetylates RORγt and enhances Th17 cell generation.

Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E.

J Exp Med. 2015 May 4;212(5):607-17. doi: 10.1084/jem.20132378. Epub 2015 Apr 27. Erratum in: J Exp Med. 2015 Jun 1;212(6):973.

28.

Coagulation takes center stage in inflammation.

Akassoglou K.

Blood. 2015 Jan 15;125(3):419-20. doi: 10.1182/blood-2014-11-609222. No abstract available.

29.

Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M.

Mol Med. 2015 Mar 17;20:667-75. doi: 10.2119/molmed.2014.00143.

30.

Systemic inflammation regulates microglial responses to tissue damage in vivo.

Gyoneva S, Davalos D, Biswas D, Swanger SA, Garnier-Amblard E, Loth F, Akassoglou K, Traynelis SF.

Glia. 2014 Aug;62(8):1345-60. doi: 10.1002/glia.22686. Epub 2014 May 7.

31.

Early detection of thrombin activity in neuroinflammatory disease.

Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K.

Ann Neurol. 2014 Feb;75(2):303-8. doi: 10.1002/ana.24078. Epub 2014 Feb 24.

32.

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

Baeza-Raja B, Eckel-Mahan K, Zhang L, Vagena E, Tsigelny IF, Sassone-Corsi P, Ptácek LJ, Akassoglou K.

J Neurosci. 2013 Jun 19;33(25):10221-34. doi: 10.1523/JNEUROSCI.2757-12.2013.

33.

Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain.

Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):305-10. doi: 10.1161/ATVBAHA.112.300485. Epub 2012 Dec 13.

34.

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.

Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E.

Science. 2013 Jan 11;339(6116):211-4. doi: 10.1126/science.1227166. Epub 2012 Dec 6.

35.

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.

Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY.

Nat Chem Biol. 2013 Feb;9(2):97-104. doi: 10.1038/nchembio.1136. Epub 2012 Dec 2.

36.

In vivo imaging of the neurovascular unit in CNS disease.

Merlini M, Davalos D, Akassoglou K.

Intravital. 2012 Dec 1;1(2):87-94.

37.

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.

Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K.

Nat Commun. 2012;3:1227. doi: 10.1038/ncomms2230.

38.

Mutant huntingtin impairs immune cell migration in Huntington disease.

Kwan W, Träger U, Davalos D, Chou A, Bouchard J, Andre R, Miller A, Weiss A, Giorgini F, Cheah C, Möller T, Stella N, Akassoglou K, Tabrizi SJ, Muchowski PJ.

J Clin Invest. 2012 Dec;122(12):4737-47. doi: 10.1172/JCI64484. Epub 2012 Nov 19.

39.

Glucose homeostasis and p75NTR: the sweet side of neurotrophin receptor signaling.

Baeza-Raja B, Akassoglou K.

Cell Cycle. 2012 Sep 1;11(17):3151-2. doi: 10.4161/cc.21590. Epub 2012 Aug 16. No abstract available.

40.

p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.

Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5838-43. doi: 10.1073/pnas.1103638109. Epub 2012 Mar 28.

41.

p75 (NTR) and hypoxia: a breath of fresh air in neurotrophin receptor signaling.

Le Moan N, Baeza-Raja B, Akassoglou K.

Cell Cycle. 2012 Mar 1;11(5):829-30. doi: 10.4161/cc.11.5.19436. Epub 2012 Mar 1.

PMID:
22333586
42.

In vivo imaging of the mouse spinal cord using two-photon microscopy.

Davalos D, Akassoglou K.

J Vis Exp. 2012 Jan 5;(59):e2760. doi: 10.3791/2760.

43.

Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.

Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP.

Anesthesiology. 2012 Feb;116(2):352-61. doi: 10.1097/ALN.0b013e318242a48c.

44.

Resolving postoperative neuroinflammation and cognitive decline.

Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M.

Ann Neurol. 2011 Dec;70(6):986-995. doi: 10.1002/ana.22664.

45.

Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

Le Moan N, Houslay DM, Christian F, Houslay MD, Akassoglou K.

Mol Cell. 2011 Nov 4;44(3):476-90. doi: 10.1016/j.molcel.2011.08.033.

46.

Fibrinogen as a key regulator of inflammation in disease.

Davalos D, Akassoglou K.

Semin Immunopathol. 2012 Jan;34(1):43-62. doi: 10.1007/s00281-011-0290-8. Epub 2011 Oct 31. Review.

PMID:
22037947
47.

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke.

Baeten KM, Akassoglou K.

Dev Neurobiol. 2011 Nov;71(11):1018-39. doi: 10.1002/dneu.20954. Review.

48.

Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair.

Schachtrup C, Le Moan N, Passino MA, Akassoglou K.

Cell Cycle. 2011 Jun 1;10(11):1764-71. Epub 2011 Jun 1. Review.

49.

Chronic optical access through a polished and reinforced thinned skull.

Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D.

Nat Methods. 2010 Dec;7(12):981-4. doi: 10.1038/nmeth.1530. Epub 2010 Oct 21.

50.

Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage.

Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K.

J Neurosci. 2010 Apr 28;30(17):5843-54. doi: 10.1523/JNEUROSCI.0137-10.2010.

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