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Items: 1 to 50 of 105

1.

Multiple Cellular Transport and Binding Processes of Unesterified Docosahexaenoic Acid in Outer Blood-Retinal Barrier Retinal Pigment Epithelial Cells.

Tachikawa M, Akanuma SI, Imai T, Okayasu S, Tomohiro T, Hatanaka Y, Hosoya KI.

Biol Pharm Bull. 2018;41(9):1384-1392. doi: 10.1248/bpb.b18-00185.

2.

Impact of Nicotine Transport across the Blood-Brain Barrier: Carrier-Mediated Transport of Nicotine and Interaction with Central Nervous System Drugs.

Tega Y, Yamazaki Y, Akanuma SI, Kubo Y, Hosoya KI.

Biol Pharm Bull. 2018;41(9):1330-1336. doi: 10.1248/bpb.b18-00134. Review.

3.

Investigation of Receptor-Mediated Cyanocobalamin (Vitamin B12) Transport across the Inner Blood-Retinal Barrier Using Fluorescence-Labeled Cyanocobalamin.

Kinoshita Y, Nogami K, Jomura R, Akanuma SI, Abe H, Inouye M, Kubo Y, Hosoya KI.

Mol Pharm. 2018 Aug 6;15(8):3583-3594. doi: 10.1021/acs.molpharmaceut.8b00617. Epub 2018 Jul 17.

PMID:
29966424
4.

Recent advances in drug and nutrient transport across the blood-retinal barrier.

Kubo Y, Akanuma SI, Hosoya KI.

Expert Opin Drug Metab Toxicol. 2018 May;14(5):513-531. doi: 10.1080/17425255.2018.1472764. Epub 2018 May 10. Review.

PMID:
29719158
5.

Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin.

Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI.

Mol Pharm. 2018 Jun 4;15(6):2327-2337. doi: 10.1021/acs.molpharmaceut.8b00179. Epub 2018 May 2.

PMID:
29688723
6.

Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier.

Kubo Y, Nakazawa A, Akanuma SI, Hosoya KI.

Pharm Res. 2018 Mar 12;35(5):93. doi: 10.1007/s11095-018-2384-7.

PMID:
29532174
7.
8.

Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins.

Akanuma SI, Higashi H, Maruyama S, Murakami K, Tachikawa M, Kubo Y, Hosoya KI.

Exp Eye Res. 2018 Mar;168:128-137. doi: 10.1016/j.exer.2018.01.016. Epub 2018 Jan 31.

PMID:
29366904
9.

Comprehensive reduction of amino acid set in a protein suggests the importance of prebiotic amino acids for stable proteins.

Shibue R, Sasamoto T, Shimada M, Zhang B, Yamagishi A, Akanuma S.

Sci Rep. 2018 Jan 19;8(1):1227. doi: 10.1038/s41598-018-19561-1.

10.

Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain.

Akanuma SI, Yamazaki Y, Kubo Y, Hosoya KI.

Fluids Barriers CNS. 2018 Jan 8;15(1):1. doi: 10.1186/s12987-017-0087-9.

11.

Activation of macrophages by a laccase-polymerized polyphenol is dependent on phosphorylation of Rac1.

Tajima K, Akanuma S, Matsumoto-Akanuma A, Yamanaka D, Ishibashi KI, Adachi Y, Ohno N.

Biochem Biophys Res Commun. 2018 Jan 15;495(3):2209-2213. doi: 10.1016/j.bbrc.2017.12.095. Epub 2017 Dec 18.

PMID:
29269293
12.

Developmental changes of l-arginine transport at the blood-brain barrier in rats.

Tachikawa M, Hirose S, Akanuma SI, Matsuyama R, Hosoya KI.

Microvasc Res. 2018 May;117:16-21. doi: 10.1016/j.mvr.2017.12.003. Epub 2017 Dec 14.

PMID:
29247719
13.

Creation of artificial protein-protein interactions using α-helices as interfaces.

Yagi S, Akanuma S, Yamagishi A.

Biophys Rev. 2018 Apr;10(2):411-420. doi: 10.1007/s12551-017-0352-9. Epub 2017 Dec 6. Review.

14.

Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.

Tachikawa M, Yashiki A, Akanuma SI, Matsukawa H, Ide S, Minami M, Hosoya KI.

Neurochem Int. 2018 Feb;113:1-7. doi: 10.1016/j.neuint.2017.11.013. Epub 2017 Nov 24.

PMID:
29175673
15.

Selection of a platinum-binding sequence in a loop of a four-helix bundle protein.

Yagi S, Akanuma S, Kaji A, Niiro H, Akiyama H, Uchida T, Yamagishi A.

J Biosci Bioeng. 2018 Feb;125(2):192-198. doi: 10.1016/j.jbiosc.2017.09.006. Epub 2017 Oct 17.

PMID:
29050803
16.

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma SI, Hosoya KI, Urtti A, Terasaki T, Tachikawa M.

Mol Pharm. 2017 Nov 6;14(11):3729-3738. doi: 10.1021/acs.molpharmaceut.7b00493. Epub 2017 Oct 12.

PMID:
28954515
17.

Involvement of Carrier-Mediated Transport at the Blood-Cerebrospinal Fluid Barrier in Spermine Clearance from Rat Brain.

Akanuma SI, Shimada H, Kubo Y, Hosoya KI.

Biol Pharm Bull. 2017;40(9):1599-1603. doi: 10.1248/bpb.b17-00394.

18.

Characterization of a thermostable mutant of Agaricus brasiliensis laccase created by phylogeny-based design.

Hamuro Y, Tajima K, Matsumoto-Akanuma A, Sakamoto S, Furukawa R, Yamagishi A, Ohno N, Akanuma S.

J Biosci Bioeng. 2017 Dec;124(6):623-629. doi: 10.1016/j.jbiosc.2017.07.004. Epub 2017 Aug 26.

PMID:
28847577
19.

Characterization of Reconstructed Ancestral Proteins Suggests a Change in Temperature of the Ancient Biosphere.

Akanuma S.

Life (Basel). 2017 Aug 6;7(3). pii: E33. doi: 10.3390/life7030033. Review.

20.

Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants.

Kubo Y, Akanuma SI, Hosoya KI.

Biol Pharm Bull. 2017;40(8):1139-1145. doi: 10.1248/bpb.b17-00090. Review.

21.

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts.

Inagaki M, Nishimura T, Akanuma SI, Nakanishi T, Tachikawa M, Tamai I, Hosoya KI, Nakashima E, Tomi M.

Placenta. 2017 May;53:76-82. doi: 10.1016/j.placenta.2017.04.002. Epub 2017 Apr 6.

PMID:
28487024
22.

Retina-to-Blood Transport of 1-Methyl-4-Phenylpyridinium Involves Carrier-Mediated Process at the Blood-Retinal Barrier.

Kubo Y, Yamamoto M, Matsunaga K, Usui T, Akanuma SI, Hosoya KI.

J Pharm Sci. 2017 Sep;106(9):2583-2591. doi: 10.1016/j.xphs.2017.04.028. Epub 2017 Apr 25.

PMID:
28454745
23.

Reconstructed ancestral enzymes suggest long-term cooling of Earth's photic zone since the Archean.

Garcia AK, Schopf JW, Yokobori SI, Akanuma S, Yamagishi A.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4619-4624. doi: 10.1073/pnas.1702729114. Epub 2017 Apr 17.

24.

Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier.

Kubo Y, Yahata S, Miki S, Akanuma SI, Hosoya KI.

Drug Metab Pharmacokinet. 2017 Feb;32(1):92-99. doi: 10.1016/j.dmpk.2016.09.006. Epub 2016 Oct 8.

PMID:
27964953
25.

Impact of SLC6A Transporters in Physiological Taurine Transport at the Blood-Retinal Barrier and in the Liver.

Kubo Y, Akanuma SI, Hosoya KI.

Biol Pharm Bull. 2016;39(12):1903-1911. Review.

27.

Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4).

Usui T, Nakazawa A, Okura T, Deguchi Y, Akanuma SI, Kubo Y, Hosoya KI.

J Neurochem. 2016 Nov;139(3):408-418. doi: 10.1111/jnc.13758. Epub 2016 Sep 15.

28.
29.

De novo design of protein-protein interactions through modification of inter-molecular helix-helix interface residues.

Yagi S, Akanuma S, Yamagishi M, Uchida T, Yamagishi A.

Biochim Biophys Acta. 2016 May;1864(5):479-87. doi: 10.1016/j.bbapap.2016.02.008. Epub 2016 Feb 9.

PMID:
26867971
30.

Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells.

Tega Y, Yuzurihara C, Kubo Y, Akanuma SI, Ehrhardt C, Hosoya KI.

Drug Metab Pharmacokinet. 2016 Feb;31(1):99-101. doi: 10.1016/j.dmpk.2015.11.006. Epub 2015 Dec 9.

PMID:
26830082
31.

Epistasis effects of multiple ancestral-consensus amino acid substitutions on the thermal stability of glycerol kinase from Cellulomonas sp. NT3060.

Fukuda Y, Abe A, Tamura T, Kishimoto T, Sogabe A, Akanuma S, Yokobori S, Yamagishi A, Imada K, Inagaki K.

J Biosci Bioeng. 2016 May;121(5):497-502. doi: 10.1016/j.jbiosc.2015.09.011. Epub 2015 Oct 20.

PMID:
26493633
32.

Robustness of predictions of extremely thermally stable proteins in ancient organisms.

Akanuma S, Yokobori S, Nakajima Y, Bessho M, Yamagishi A.

Evolution. 2015 Nov;69(11):2954-62. doi: 10.1111/evo.12779. Epub 2015 Oct 6.

PMID:
26404857
33.

Impact of Cationic Amino Acid Transporter 1 on Blood-Retinal Barrier Transport of L-Ornithine.

Kubo Y, Obata A, Akanuma S, Hosoya K.

Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5925-32. doi: 10.1167/iovs.15-17398.

PMID:
26377079
34.

Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood-Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina.

Sakurai T, Akanuma S, Usui T, Kubo Y, Tachikawa M, Hosoya K.

Biol Pharm Bull. 2015;38(7):1087-91. doi: 10.1248/bpb.b15-00226.

35.
36.
37.

Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.

Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma S, Hosoya K, Tamai I.

PLoS One. 2015 Apr 29;10(4):e0123895. doi: 10.1371/journal.pone.0123895. eCollection 2015.

38.

Carrier-Mediated Transport of Nicotine Across the Inner Blood-Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H(+) Gradient.

Tega Y, Kubo Y, Yuzurihara C, Akanuma S, Hosoya K.

J Pharm Sci. 2015 Sep;104(9):3069-75. doi: 10.1002/jps.24453. Epub 2015 Apr 17.

PMID:
25892000
39.

Involvement of cationic amino acid transporter 1 in L-arginine transport in rat retinal pericytes.

Zakoji N, Akanuma S, Tachikawa M, Hosoya K.

Biol Pharm Bull. 2015;38(2):257-62. doi: 10.1248/bpb.b14-00637.

40.

Involvement of the H+/organic cation antiporter in nicotine transport in rat liver.

Tega Y, Akanuma S, Kubo Y, Hosoya K.

Drug Metab Dispos. 2015 Jan;43(1):89-92. doi: 10.1124/dmd.114.061002. Epub 2014 Oct 28.

PMID:
25352656
41.

Cloning and characterization of laccase DNA from the Royal Sun medicinal mushroom, Agaricus brasiliensis (higher Basidiomycetes).

Matsumoto-Akanuma A, Akanuma S, Motoi M, Yamagishi A, Ohno N.

Int J Med Mushrooms. 2014;16(4):375-93.

PMID:
25271866
42.

Involvement of carrier-mediated transport in the retinal uptake of clonidine at the inner blood-retinal barrier.

Kubo Y, Tsuchiyama A, Shimizu Y, Akanuma S, Hosoya K.

Mol Pharm. 2014 Oct 6;11(10):3747-53. doi: 10.1021/mp500516j. Epub 2014 Sep 26.

PMID:
25222277
43.

Involvement of the carrier-mediated process in the retina-to-blood transport of spermine at the inner blood-retinal barrier.

Kubo Y, Tomise A, Tsuchiyama A, Akanuma S, Hosoya K.

Exp Eye Res. 2014 Jul;124:17-23. doi: 10.1016/j.exer.2014.05.002. Epub 2014 May 14.

PMID:
24836980
44.

Amino acid residues involved in the substrate specificity of TauT/SLC6A6 for taurine and γ-aminobutyric acid.

Yahara T, Tachikawa M, Akanuma S, Kubo Y, Hosoya K.

Biol Pharm Bull. 2014;37(5):817-25.

45.

Characterization of the low-temperature activity of Sulfolobus tokodaii glucose-1-dehydrogenase mutants.

Sugii T, Akanuma S, Yagi S, Yagyu K, Shimoda Y, Yamagishi A.

J Biosci Bioeng. 2014 Oct;118(4):367-71. doi: 10.1016/j.jbiosc.2014.03.002. Epub 2014 Apr 16.

PMID:
24742629
46.

Effect of amplitude and duration of impulsive pressure on endothelial permeability in in vitro fluid percussion trauma.

Nakadate H, Inuzuka K, Akanuma S, Kakuta A, Aomura S.

Biomed Eng Online. 2014 Apr 16;13:44. doi: 10.1186/1475-925X-13-44.

47.

Transporter-mediated prostaglandin E₂ elimination across the rat blood-brain barrier and its attenuation by the activation of N-methyl-D-aspartate receptors.

Akanuma S, Higuchi T, Higashi H, Ozeki G, Tachikawa M, Kubo Y, Hosoya K.

Drug Metab Pharmacokinet. 2014;29(5):387-93. Epub 2014 Apr 8.

48.

Preparation of Phi29 DNA polymerase free of amplifiable DNA using ethidium monoazide, an ultraviolet-free light-emitting diode lamp and trehalose.

Takahashi H, Yamazaki H, Akanuma S, Kanahara H, Saito T, Chimuro T, Kobayashi T, Ohtani T, Yamamoto K, Sugiyama S, Kobori T.

PLoS One. 2014 Feb 5;9(2):e82624. doi: 10.1371/journal.pone.0082624. eCollection 2014.

49.

N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization.

Abe T, Kojima M, Akanuma S, Iwashita H, Yamazaki T, Okuyama R, Ichikawa K, Umemura M, Nakano H, Takahashi S, Takahashi Y.

J Biol Chem. 2014 Feb 14;289(7):3888-900. doi: 10.1074/jbc.M113.491217. Epub 2013 Dec 30.

50.

Addition of negatively charged residues can reverse the decrease in the solubility of an acidic protein caused by an artificially introduced non-polar surface patch.

Yagi S, Akanuma S, Yamagishi A.

Biochim Biophys Acta. 2014 Mar;1844(3):553-60. doi: 10.1016/j.bbapap.2013.12.011. Epub 2013 Dec 27.

PMID:
24373877

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