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Items: 13

1.

Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.

Akan DT, Howes JE, Sai J, Arnold AL, Beesetty Y, Phan J, Olejniczak ET, Waterson AG, Fesik SW.

ACS Chem Biol. 2019 Mar 15;14(3):325-331. doi: 10.1021/acschembio.8b00869. Epub 2019 Feb 18.

PMID:
30735352
2.

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.

Abbott JR, Patel PA, Howes JE, Akan DT, Kennedy JP, Burns MC, Browning CF, Sun Q, Rossanese OW, Phan J, Waterson AG, Fesik SW.

ACS Med Chem Lett. 2018 Aug 8;9(9):941-946. doi: 10.1021/acsmedchemlett.8b00296. eCollection 2018 Sep 13.

3.

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.

Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D, Stadtmueller H, Rossanese OW, Phan J, Waterson AG, McConnell DB, Fesik SW.

J Med Chem. 2018 Oct 11;61(19):8875-8894. doi: 10.1021/acs.jmedchem.8b01108. Epub 2018 Sep 28.

PMID:
30205005
4.

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.

Abbott JR, Hodges TR, Daniels RN, Patel PA, Kennedy JP, Howes JE, Akan DT, Burns MC, Sai J, Sobolik T, Beesetty Y, Lee T, Rossanese OW, Phan J, Waterson AG, Fesik SW.

J Med Chem. 2018 Jul 26;61(14):6002-6017. doi: 10.1021/acs.jmedchem.8b00360. Epub 2018 Jul 11.

PMID:
29856609
5.

Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1.

Howes JE, Akan DT, Burns MC, Rossanese OW, Waterson AG, Fesik SW.

Mol Cancer Ther. 2018 May;17(5):1051-1060. doi: 10.1158/1535-7163.MCT-17-0666. Epub 2018 Feb 13.

6.
7.

Effects of totally extraperitoneal (TEP) and Lichtenstein hernia repair on testicular blood flow and volume.

Gürbulak EK, Gürbulak B, Akgün İE, Özel A, Akan D, Ömeroğlu S, Öz A, Mihmanlı M, Bektaş H.

Surgery. 2015 Nov;158(5):1297-303. doi: 10.1016/j.surg.2015.03.028. Epub 2015 Apr 30.

PMID:
25937159
8.

Oseltamivir treatment and prophylaxis in a neonatal intensive care unit during a 2009 H1N1 influenza outbreak.

Pannaraj PS, Tam B, Akan D.

J Perinatol. 2011 Jul;31(7):487-93. doi: 10.1038/jp.2010.159. Epub 2011 Jan 13.

PMID:
21233797
9.

Electronic screening for mental health in rural primary care: implementation.

Farrell SP, Mahone IH, Zerull LM, Guerlain S, Akan D, Hauenstein E, Schorling J.

Issues Ment Health Nurs. 2009 Mar;30(3):165-73. doi: 10.1080/01612840802694411.

PMID:
19291493
10.

Electronic screening for mental health in rural primary care: feasibility and user testing.

Farrell SP, Zerull LM, Mahone IH, Guerlain S, Akan D, Hauenstein E, Schorling J.

Comput Inform Nurs. 2009 Mar-Apr;27(2):93-8. doi: 10.1097/NCN.0b013e3181972a0d.

11.

Genome of the opportunistic pathogen Streptococcus sanguinis.

Xu P, Alves JM, Kitten T, Brown A, Chen Z, Ozaki LS, Manque P, Ge X, Serrano MG, Puiu D, Hendricks S, Wang Y, Chaplin MD, Akan D, Paik S, Peterson DL, Macrina FL, Buck GA.

J Bacteriol. 2007 Apr;189(8):3166-75. Epub 2007 Feb 2.

12.

[A case of temporal lobe abscess with an unusual course].

Altuğ H, Akan D.

Tip Fak Mecm. 1966;29(1):119-26. Turkish. No abstract available.

PMID:
5926830
13.

[Management of disabilities as sequelae of chest surgery].

RUSK H, HAAS A, AKAN D.

Tip Fak Mecm. 1959;22:380-4. Turkish. No abstract available.

PMID:
14440260

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