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Items: 15

1.

Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial.

Rhein J, Huppler Hullsiek K, Tugume L, Nuwagira E, Mpoza E, Evans EE, Kiggundu R, Pastick KA, Ssebambulidde K, Akampurira A, Williams DA, Bangdiwala AS, Abassi M, Musubire AK, Nicol MR, Muzoora C, Meya DB, Boulware DR; ASTRO-CM team.

Lancet Infect Dis. 2019 Aug;19(8):843-851. doi: 10.1016/S1473-3099(19)30127-6.

PMID:
31345462
2.

Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection.

Gerstein AC, Jackson KM, McDonald TR, Wang Y, Lueck BD, Bohjanen S, Smith KD, Akampurira A, Meya DB, Xue C, Boulware DR, Nielsen K.

MBio. 2019 Jul 16;10(4). pii: e01440-19. doi: 10.1128/mBio.01440-19.

3.

The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential Virulence.

Mukaremera L, McDonald TR, Nielsen JN, Molenaar CJ, Akampurira A, Schutz C, Taseera K, Muzoora C, Meintjes G, Meya DB, Boulware DR, Nielsen K.

Infect Immun. 2019 Apr 23;87(5). pii: e00046-19. doi: 10.1128/IAI.00046-19. Print 2019 Mar.

4.

Evaluation of trypan blue stain in the TC20 automated cell counter as a point-of-care for the enumeration of viable cryptococcal cells in cerebrospinal fluid.

Kwizera R, Akampurira A, Kandole TK, Nabaggala MS, Williams DA, Kambugu A, Meya DB, Rhein J, Boulware DR; ASTRO Team.

Med Mycol. 2018 Jul 1;56(5):559-564. doi: 10.1093/mmy/myx076.

5.

Evaluation of a point-of-care immunoassay test kit 'StrongStep' for cryptococcal antigen detection.

Mpoza E, Mukaremera L, Kundura DA, Akampurira A, Luggya T, Tadeo KK, Pastick KA, Bridge SC, Tugume L, Kiggundu R, Musubire AK, Williams DA, Muzoora C, Nalintya E, Rajasingham R, Rhein J, Boulware DR, Meya DB, Abassi M.

PLoS One. 2018 Jan 5;13(1):e0190652. doi: 10.1371/journal.pone.0190652. eCollection 2018.

6.

Antimicrobial Drug Resistance in Blood Culture Isolates at a Tertiary Hospital, Uganda.

Kajumbula H, Fujita AW, Mbabazi O, Najjuka C, Izale C, Akampurira A, Aisu S, Lamorde M, Walwema R, Bahr NC, Meya DB, Boulware DR, Manabe YC.

Emerg Infect Dis. 2018 Jan;24(1):174-175. doi: 10.3201/eid2401.171112.

7.

Evaluation of trypan blue stain in a haemocytometer for rapid detection of cerebrospinal fluid sterility in HIV patients with cryptococcal meningitis.

Kwizera R, Akampurira A, Kandole TK, Nielsen K, Kambugu A, Meya DB, Boulware DR, Rhein J; ASTRO-CM Study Team.

BMC Microbiol. 2017 Aug 22;17(1):182. doi: 10.1186/s12866-017-1093-4.

8.

Acridine orange fluorescent microscopy is more sensitive than India ink light microscopy in the rapid detection of cryptococcosis among CrAg positive HIV patients.

Kwizera R, Akampurira A, Williams D, Boulware DR, Meya DB; ASTRO-CM Study Team.

PLoS One. 2017 Jul 27;12(7):e0182108. doi: 10.1371/journal.pone.0182108. eCollection 2017.

9.

Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study.

Rhein J, Morawski BM, Hullsiek KH, Nabeta HW, Kiggundu R, Tugume L, Musubire A, Akampurira A, Smith KD, Alhadab A, Williams DA, Abassi M, Bahr NC, Velamakanni SS, Fisher J, Nielsen K, Meya DB, Boulware DR; ASTRO-CM Study Team.

Lancet Infect Dis. 2016 Jul;16(7):809-818. doi: 10.1016/S1473-3099(16)00074-8. Epub 2016 Mar 10.

10.

Human Immune Response Varies by the Degree of Relative Cryptococcal Antigen Shedding.

Boulware DR, von Hohenberg M, Rolfes MA, Bahr NC, Rhein J, Akampurira A, Williams DA, Taseera K, Schutz C, McDonald T, Muzoora C, Meintjes G, Meya DB, Nielsen K, Huppler Hullsiek K.

Open Forum Infect Dis. 2015 Dec 12;3(1):ofv194. doi: 10.1093/ofid/ofv194. eCollection 2016 Jan.

11.

Reproducibility of CSF quantitative culture methods for estimating rate of clearance in cryptococcal meningitis.

Dyal J, Akampurira A, Rhein J, Morawski BM, Kiggundu R, Nabeta HW, Musubire AK, Bahr NC, Williams DA, Bicanic T, Larsen RA, Meya DB, Boulware DR; ASTRO-CM Trial Team.

Med Mycol. 2016 May;54(4):361-9. doi: 10.1093/mmy/myv104. Epub 2016 Jan 14.

12.

Diagnostic performance of a multiplex PCR assay for meningitis in an HIV-infected population in Uganda.

Rhein J, Bahr NC, Hemmert AC, Cloud JL, Bellamkonda S, Oswald C, Lo E, Nabeta H, Kiggundu R, Akampurira A, Musubire A, Williams DA, Meya DB, Boulware DR; ASTRO-CM Team.

Diagn Microbiol Infect Dis. 2016 Mar;84(3):268-73. doi: 10.1016/j.diagmicrobio.2015.11.017. Epub 2015 Dec 1.

13.

Increased Antifungal Drug Resistance in Clinical Isolates of Cryptococcus neoformans in Uganda.

Smith KD, Achan B, Hullsiek KH, McDonald TR, Okagaki LH, Alhadab AA, Akampurira A, Rhein JR, Meya DB, Boulware DR, Nielsen K; ASTRO-CM/COAT Team.

Antimicrob Agents Chemother. 2015 Dec;59(12):7197-204. doi: 10.1128/AAC.01299-15. Epub 2015 Aug 31.

14.

Epidemiology of meningitis in an HIV-infected Ugandan cohort.

Rajasingham R, Rhein J, Klammer K, Musubire A, Nabeta H, Akampurira A, Mossel EC, Williams DA, Boxrud DJ, Crabtree MB, Miller BR, Rolfes MA, Tengsupakul S, Andama AO, Meya DB, Boulware DR.

Am J Trop Med Hyg. 2015 Feb;92(2):274-9. doi: 10.4269/ajtmh.14-0452. Epub 2014 Nov 10.

15.

Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis.

Robertson EJ, Najjuka G, Rolfes MA, Akampurira A, Jain N, Anantharanjit J, von Hohenberg M, Tassieri M, Carlsson A, Meya DB, Harrison TS, Fries BC, Boulware DR, Bicanic T.

J Infect Dis. 2014 Jan 1;209(1):74-82. doi: 10.1093/infdis/jit435. Epub 2013 Aug 14.

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