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Items: 46


Late Onset of Estrogen Therapy Impairs Carotid Function of Senescent Females in Association with Altered Prostanoid Balance and Upregulation of the Variant ERα36.

Costa TJ, Jiménez-Altayó F, Echem C, Akamine EH, Tostes R, Vila E, Dantas AP, Carvalho MHC.

Cells. 2019 Oct 8;8(10). pii: E1217. doi: 10.3390/cells8101217.


Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats.

Colli LG, Belardin LB, Echem C, Akamine EH, Antoniassi MP, Andretta RR, Mathias LS, Rodrigues SFP, Bertolla RP, de Carvalho MHC.

Sci Rep. 2019 Jul 30;9(1):11047. doi: 10.1038/s41598-019-47157-w.


Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension.

Echem C, Costa TJD, Oliveira V, Giglio Colli L, Landgraf MA, Rodrigues SF, Franco MDCP, Landgraf RG, Santos-Eichler RA, Bomfim GF, Akamine EH, de Carvalho MHC.

Pharmacol Res. 2019 Jun;144:142-150. doi: 10.1016/j.phrs.2019.04.008. Epub 2019 Apr 6.


Detrimental Impact of Low Birth Weight on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Healthy Children: Role of Angiogenic Factors.

Souza LV, De Meneck F, Oliveira V, Higa EM, Akamine EH, Franco MDC.

J Pediatr. 2019 Mar;206:72-77.e1. doi: 10.1016/j.jpeds.2018.10.040.


Beneficial Impact of Moderate to Vigorous Physical Activity Program on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Children: The Crucial Role of Nitric Oxide and VEGF-A.

Souza LV, De Meneck F, Oliveira V, Higa EM, Akamine EH, Franco MDC.

Pediatr Exerc Sci. 2019 Aug 1;31(3):322-329. doi: 10.1123/pes.2018-0178.


Involvement of inducible nitric oxide synthase and estrogen receptor ESR2 (ERβ) in the vascular dysfunction in female type 1 diabetic rats.

Sartoretto SM, Santos FF, Costa BP, Ceravolo GS, Santos-Eichler R, Carvalho MHC, Fortes ZB, Akamine EH.

Life Sci. 2019 Jan 1;216:279-286. doi: 10.1016/j.lfs.2018.11.030. Epub 2018 Nov 14.


Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension.

Costa TJ, Ceravolo GS, Echem C, Hashimoto CM, Costa BP, Santos-Eichler RA, Oliveira MA, Jiménez-Altayó F, Akamine EH, Dantas AP, Carvalho MHC.

Front Physiol. 2018 May 8;9:490. doi: 10.3389/fphys.2018.00490. eCollection 2018.


Intrauterine exposure to metformin: Evaluation of endothelial and perivascular adipose tissue function in abdominal aorta of adult offspring.

Vidigal CB, Novi DRBS, Moura KF, Picinin R, Montagnini BG, Silva RNOD, da Silva MDV, de Andrade FG, Akamine EH, Gerardin DCC, Ceravolo GS.

Life Sci. 2018 Aug 15;207:72-79. doi: 10.1016/j.lfs.2018.05.050. Epub 2018 May 29.


Intrauterine and lactational exposure to fluoxetine enhances endothelial modulation of aortic contractile response in adult female rats.

Higashi CM, Sartoretto SM, Echem C, Lucchetti BFC, Carvalho MHC, Pelosi GG, Pinge-Filho P, Gerardin DCC, Moreira EG, Akamine EH, Ceravolo GS.

Vascul Pharmacol. 2018 Sep;108:67-73. doi: 10.1016/j.vph.2018.04.004. Epub 2018 Apr 11.


Intrauterine growth restriction-induced deleterious adaptations in endothelial progenitor cells: possible mechanism to impair endothelial function.

Oliveira V, de Souza LV, Fernandes T, Junior SDS, de Carvalho MHC, Akamine EH, Michelini LC, de Oliveira EM, Franco MDC.

J Dev Orig Health Dis. 2017 Dec;8(6):665-673. doi: 10.1017/S2040174417000484. Epub 2017 Jul 10.


Treatment with Standard and Low Dose of Conjugated Equine Estrogen Differentially Modulates Estrogen Receptor Expression and Response to Angiotensin II in Mesenteric Venular Bed of Surgically Postmenopausal Hypertensive Rats.

Araujo PX, Costa TJ, Echem C, Aparecida de Oliveira M, Santos-Eichler RA, Colli LG, Jiménez-Altayó F, Vila E, Akamine EH, Dantas AP, Ceravolo GS, de Carvalho MHC.

J Pharmacol Exp Ther. 2017 Jul;362(1):98-107. doi: 10.1124/jpet.117.240465. Epub 2017 May 22.


Intrauterine growth restriction increases circulating mitochondrial DNA and Toll-like receptor 9 expression in adult offspring: could aerobic training counteract these adaptations?

Oliveira V, Silva Junior SD, de Carvalho MH, Akamine EH, Michelini LC, Franco MC.

J Dev Orig Health Dis. 2017 Apr;8(2):236-243. doi: 10.1017/S2040174416000714. Epub 2016 Dec 22.


H2O2 generated from mitochondrial electron transport chain in thoracic perivascular adipose tissue is crucial for modulation of vascular smooth muscle contraction.

Costa RM, Filgueira FP, Tostes RC, Carvalho MH, Akamine EH, Lobato NS.

Vascul Pharmacol. 2016 Sep;84:28-37. doi: 10.1016/j.vph.2016.05.008. Epub 2016 May 29.


Endothelial dysfunction in rats with ligature-induced periodontitis: Participation of nitric oxide and cycloxygenase-2-derived products.

Campi P, Herrera BS, de Jesus FN, Napolitano M, Teixeira SA, Maia-Dantas A, Spolidorio LC, Akamine EH, Mayer MPA, de Carvalho MHC, Costa SKP, Muscara MN.

Arch Oral Biol. 2016 Mar;63:66-74. doi: 10.1016/j.archoralbio.2015.11.022. Epub 2015 Dec 4.


Anti-toll like receptor 4 (TLR4) therapy diminishes cardiac remodeling regardless of changes in blood pressure in spontaneously hypertensive rats (SHR).

Echem C, Bomfim GF, Ceravolo GS, Oliveira MA, Santos-Eichler RA, Bechara LR, Veras MM, Saldiva PH, Ferreira JC, Akamine EH, Fortes ZB, Dantas AP, de Carvalho MH.

Int J Cardiol. 2015;187:243-5. doi: 10.1016/j.ijcard.2015.03.190. Epub 2015 Mar 18. No abstract available.


Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells.

Costa TJ, Ceravolo GS, dos Santos RA, de Oliveira MA, Araújo PX, Giaquinto LR, Tostes RC, Akamine EH, Fortes ZB, Dantas AP, Carvalho MH.

Am J Physiol Heart Circ Physiol. 2015 Apr 1;308(7):H723-32. doi: 10.1152/ajpheart.00681.2014. Epub 2015 Jan 30.


Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats.

Bomfim GF, Echem C, Martins CB, Costa TJ, Sartoretto SM, Dos Santos RA, Oliveira MA, Akamine EH, Fortes ZB, Tostes RC, Webb RC, Carvalho MH.

Life Sci. 2015 Feb 1;122:1-7. doi: 10.1016/j.lfs.2014.12.001. Epub 2014 Dec 11.


Metformin reduces the Walker-256 tumor development in obese-MSG rats via AMPK and FOXO3a.

de Queiroz EA, Akamine EH, de Carvalho MH, Sampaio SC, Fortes ZB.

Life Sci. 2015 Jan 15;121:78-87. doi: 10.1016/j.lfs.2014.11.028. Epub 2014 Dec 9.


Influence of aerobic training on the reduced vasoconstriction to angiotensin II in rats exposed to intrauterine growth restriction: possible role of oxidative stress and AT2 receptor of angiotensin II.

Oliveira V, Akamine EH, Carvalho MH, Michelini LC, Fortes ZB, Cunha TS, do Carmo Franco M.

PLoS One. 2014 Nov 18;9(11):e113035. doi: 10.1371/journal.pone.0113035. eCollection 2014.


An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies.

Ceravolo GS, Montezano AC, Jordão MT, Akamine EH, Costa TJ, Takano AP, Fernandes DC, Barreto-Chaves ML, Laurindo FR, Tostes RC, Fortes ZB, Chopard RP, Touyz RM, Carvalho MH.

PLoS One. 2014 Nov 4;9(11):e111117. doi: 10.1371/journal.pone.0111117. eCollection 2014.


Upregulation of ERK1/2-eNOS via AT2 receptors decreases the contractile response to angiotensin II in resistance mesenteric arteries from obese rats.

Hagihara GN, Lobato NS, Filgueira FP, Akamine EH, Aragão DS, Casarini DE, Carvalho MH, Fortes ZB.

PLoS One. 2014 Aug 29;9(8):e106029. doi: 10.1371/journal.pone.0106029. eCollection 2014.


Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets.

Marçal AC, Camporez JP, Lima-Salgado TM, Cintra DE, Akamine EH, Ribeiro LM, Almeida FN, Zanuto RP, Curi R, Boldrini SC, Liberti EA, Fiamoncini J, Hirabara SM, Deschamps FC, Carpinelli AR, Carvalho CR.

Br J Nutr. 2013 Jun 28;109(12):2154-65. doi: 10.1017/S0007114512004576. Epub 2012 Nov 27.


Role of nitric oxide and endothelin in endothelial maintenance of vasoconstrictor responses in aortas of diabetic female rats.

Sartoretto SM, Santos-Eichler R, de Cássia A Tostes R, Carvalho MH, Akamine EH, Fortes ZB.

J Diabetes. 2013 Jun;5(2):197-206. doi: 10.1111/1753-0407.12011.


Endogenous testosterone increases leukocyte-endothelial cell interaction in spontaneously hypertensive rats.

Filgueira FP, Lobato NS, DosSantos RA, Oliveira MA, Akamine EH, Tostes RC, Fortes ZB, Carvalho MH.

Life Sci. 2012 May 15;90(17-18):689-94. doi: 10.1016/j.lfs.2012.03.009. Epub 2012 Apr 1.


Mechanisms of endothelial dysfunction in obesity-associated hypertension.

Lobato NS, Filgueira FP, Akamine EH, Tostes RC, Carvalho MH, Fortes ZB.

Braz J Med Biol Res. 2012 May;45(5):392-400. Epub 2012 Apr 12.


Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats.

Bomfim GF, Dos Santos RA, Oliveira MA, Giachini FR, Akamine EH, Tostes RC, Fortes ZB, Webb RC, Carvalho MH.

Clin Sci (Lond). 2012 Jun;122(11):535-43. doi: 10.1042/CS20110523.


Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.

Lobato NS, Filgueira FP, Hagihara GN, Akamine EH, Pariz JR, Tostes RC, Carvalho MH, Fortes ZB.

Life Sci. 2012 Jan 30;90(5-6):228-35. doi: 10.1016/j.lfs.2011.11.005. Epub 2011 Nov 29.


Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update.

Davel AP, Wenceslau CF, Akamine EH, Xavier FE, Couto GK, Oliveira HT, Rossoni LV.

Braz J Med Biol Res. 2011 Sep;44(9):920-32. Epub 2011 Aug 19. Review.


Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats.

Camporez JP, Akamine EH, Davel AP, Franci CR, Rossoni LV, Carvalho CR.

J Physiol. 2011 May 15;589(Pt 10):2585-96. doi: 10.1113/jphysiol.2011.206078. Epub 2011 Mar 14.


Metformin reduces the stimulatory effect of obesity on in vivo Walker-256 tumor development and increases the area of tumor necrosis.

Fonseca EA, de Oliveira MA, Lobato Nde S, Akamine EH, Colquhoun A, de Carvalho MH, Zyngier SB, Fortes ZB.

Life Sci. 2011 May 9;88(19-20):846-52. doi: 10.1016/j.lfs.2011.03.005. Epub 2011 Mar 31.


Alterations of NADPH oxidase activity in rat pancreatic islets induced by a high-fat diet.

Valle MM, Graciano MF, Lopes de Oliveira ER, Camporez JP, Akamine EH, Carvalho CR, Curi R, Carpinelli AR.

Pancreas. 2011 Apr;40(3):390-5. doi: 10.1097/MPA.0b013e31820569d0.


Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice.

Kobayasi R, Akamine EH, Davel AP, Rodrigues MA, Carvalho CR, Rossoni LV.

J Hypertens. 2010 Oct;28(10):2111-9. doi: 10.1097/HJH.0b013e32833ca68c.


Obesity induced by neonatal treatment with monosodium glutamate impairs microvascular reactivity in adult rats: role of NO and prostanoids.

Lobato NS, Filgueira FP, Akamine EH, Davel AP, Rossoni LV, Tostes RC, Carvalho MH, Fortes ZB.

Nutr Metab Cardiovasc Dis. 2011 Oct;21(10):808-16. doi: 10.1016/j.numecd.2010.02.006. Epub 2010 May 31.


Obesity induced by high-fat diet promotes insulin resistance in the ovary.

Akamine EH, Marçal AC, Camporez JP, Hoshida MS, Caperuto LC, Bevilacqua E, Carvalho CR.

J Endocrinol. 2010 Jul;206(1):65-74. doi: 10.1677/JOE-09-0461. Epub 2010 May 7.


Modulation of bone morphogenetic protein-9 expression and processing by insulin, glucose, and glucocorticoids: possible candidate for hepatic insulin-sensitizing substance.

Caperuto LC, Anhê GF, Cambiaghi TD, Akamine EH, do Carmo Buonfiglio D, Cipolla-Neto J, Curi R, Bordin S.

Endocrinology. 2008 Dec;149(12):6326-35. doi: 10.1210/en.2008-0655. Epub 2008 Aug 14.


Long-term effects of intrauterine malnutrition on vascular function in female offspring: implications of oxidative stress.

Franco MC, Akamine EH, Rebouças N, Carvalho MH, Tostes RC, Nigro D, Fortes ZB.

Life Sci. 2007 Jan 30;80(8):709-15. Epub 2006 Nov 11.


Decreased endothelium-dependent vasodilation in diabetic female rats: role of prostanoids.

Akamine EH, Urakawa TA, de Oliveira MA, Nigro D, de Carvalho MH, de Cássia A Tostes R, Fortes ZB.

J Vasc Res. 2006;43(5):401-10. Epub 2006 Jul 27.


Correction of endothelial dysfunction in diabetic female rats by tetrahydrobiopterin and chronic insulin.

Akamine EH, Kawamoto EM, Scavone C, Nigro D, Carvalho MH, de Cássia A Tostes R, Britto LR, Fortes ZB.

J Vasc Res. 2006;43(4):309-20. Epub 2006 May 8.


Influence of insulin on the microvascular response to inflammatory mediators in neonatal streptozotocin diabetic rats.

Rastelli VM, Akamine EH, Oliveira MA, Nigro D, Passaglia Rde C, Carvalho MH, Fortes ZB.

Inflamm Res. 2005 Apr;54(4):173-9.


A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats.

Silva-Antonialli MM, Tostes RC, Fernandes L, Fior-Chadi DR, Akamine EH, Carvalho MH, Fortes ZB, Nigro D.

Cardiovasc Res. 2004 Jun 1;62(3):587-93.


Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.

Franco Mdo C, Fortes ZB, Akamine EH, Kawamoto EM, Scavone C, de Britto LR, Muscara MN, Teixeira SA, Tostes RC, Carvalho MH, Nigro D.

J Physiol. 2004 Jul 1;558(Pt 1):239-48. Epub 2004 May 7.


NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system.

Franco Mdo C, Akamine EH, Di Marco GS, Casarini DE, Fortes ZB, Tostes RC, Carvalho MH, Nigro D.

Cardiovasc Res. 2003 Sep 1;59(3):767-75.


Vitamins C and E improve endothelial dysfunction in intrauterine-undernourished rats by decreasing vascular superoxide anion concentration.

Franco Mdo C, Akamine EH, Aparecida de Oliveira M, Fortes ZB, Tostes RC, Carvalho MH, Nigro D.

J Cardiovasc Pharmacol. 2003 Aug;42(2):211-7.


Minalrestat and leukocyte migration in diabetes mellitus.

Cruz JW, Soto-Suazo MW, Hohman TC, Akamine EH, Zorn TT, Fortes ZB.

Diabetes Metab Res Rev. 2003 May-Jun;19(3):223-31.


Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes.

Akamine EH, Hohman TC, Nigro D, Carvalho MH, de Cássia Tostes R, Fortes ZB.

J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42.


Enhanced oxidative stress as a potential mechanism underlying the programming of hypertension in utero.

Franco Mdo C, Dantas AP, Akamine EH, Kawamoto EM, Fortes ZB, Scavone C, Tostes RC, Carvalho MH, Nigro D.

J Cardiovasc Pharmacol. 2002 Oct;40(4):501-9.


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