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Items: 1 to 50 of 66

1.

Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease.

Kuzumaki N, Suda Y, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H, Narita M.

Brain. 2019 Jun 1;142(6):1675-1689. doi: 10.1093/brain/awz084.

PMID:
31135049
2.

Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity.

Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, Rammonhan M, Wong YC, Xie Z, Akamatsu W, Mazzulli JR, Surmeier DJ, Hattori N, Krainc D.

J Neurosci. 2019 Jul 17;39(29):5760-5772. doi: 10.1523/JNEUROSCI.3085-18.2019. Epub 2019 May 16.

PMID:
31097622
3.

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression.

Nishihara K, Shiga T, Nakamura E, Akiyama T, Sasaki T, Suzuki S, Ko MSH, Tada N, Okano H, Akamatsu W.

Stem Cell Reports. 2019 Feb 12;12(2):305-318. doi: 10.1016/j.stemcr.2018.12.018. Epub 2019 Jan 31.

4.

Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease.

Ueno SI, Saiki S, Fujimaki M, Takeshige-Amano H, Hatano T, Oyama G, Ishikawa KI, Yamaguchi A, Nojiri S, Akamatsu W, Hattori N.

Cells. 2018 Dec 29;8(1). pii: E14. doi: 10.3390/cells8010014.

5.

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.

Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5815-E5823. doi: 10.1073/pnas.1802179115. Epub 2018 May 7.

6.

Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling.

Imaizumi K, Fujimori K, Ishii S, Otomo A, Hosoi Y, Miyajima H, Warita H, Aoki M, Hadano S, Akamatsu W, Okano H.

eNeuro. 2018 Apr 26;5(2). pii: ENEURO.0368-17.2018. doi: 10.1523/ENEURO.0368-17.2018. eCollection 2018 Mar-Apr.

7.

Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction.

Suda Y, Kuzumaki N, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H, Narita M.

Mol Brain. 2018 Feb 20;11(1):6. doi: 10.1186/s13041-018-0349-8.

8.

Chemical decontamination of iPS cell-derived neural cell mixtures.

Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M.

Chem Commun (Camb). 2018 Feb 1;54(11):1355-1358. doi: 10.1039/c7cc08686e.

PMID:
29350722
9.

[Neural differentiation from induced pluripotent stem cells for disease modelling and drug discovery].

Akamatsu W.

Nihon Yakurigaku Zasshi. 2017;150(6):282-285. doi: 10.1254/fpj.150.282. Japanese. No abstract available.

PMID:
29225290
10.

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations.

Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.

Elife. 2017 Nov 28;6. pii: e21114. doi: 10.7554/eLife.21114.

11.

Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells.

Fujimori K, Matsumoto T, Kisa F, Hattori N, Okano H, Akamatsu W.

Stem Cell Reports. 2017 Nov 14;9(5):1675-1691. doi: 10.1016/j.stemcr.2017.09.024. Epub 2017 Oct 26.

12.

Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease.

Shiba-Fukushima K, Ishikawa KI, Inoshita T, Izawa N, Takanashi M, Sato S, Onodera O, Akamatsu W, Okano H, Imai Y, Hattori N.

Hum Mol Genet. 2017 Aug 15;26(16):3172-3185. doi: 10.1093/hmg/ddx201.

PMID:
28541509
13.

Assessment of Mitophagy in iPS Cell-Derived Neurons.

Ishikawa KI, Yamaguchi A, Okano H, Akamatsu W.

Methods Mol Biol. 2018;1759:59-67. doi: 10.1007/7651_2017_10.

PMID:
28324490
14.

Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine.

Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.

Schizophr Res. 2017 Mar;181:75-82. doi: 10.1016/j.schres.2016.10.012. Epub 2016 Oct 27.

15.

Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors.

Takayama Y, Wakabayashi T, Kushige H, Saito Y, Shibuya Y, Shibata S, Akamatsu W, Okano H, Kida YS.

FEBS Lett. 2017 Feb;591(4):590-602. doi: 10.1002/1873-3468.12572. Epub 2017 Feb 9.

16.

Differential X Chromosome Inactivation Patterns during the Propagation of Human Induced Pluripotent Stem Cells.

Andoh-Noda T, Akamatsu W, Miyake K, Kobayashi T, Ohyama M, Kurosawa H, Kubota T, Okano H.

Keio J Med. 2017 Mar 25;66(1):1-8. doi: 10.2302/kjm.2016-0015-OA. Epub 2017 Jan 20.

17.

Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons.

Suzuki S, Akamatsu W, Kisa F, Sone T, Ishikawa KI, Kuzumaki N, Katayama H, Miyawaki A, Hattori N, Okano H.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):88-93. doi: 10.1016/j.bbrc.2016.12.188. Epub 2017 Jan 3.

PMID:
28057485
18.

Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss.

Hosoya M, Fujioka M, Sone T, Okamoto S, Akamatsu W, Ukai H, Ueda HR, Ogawa K, Matsunaga T, Okano H.

Cell Rep. 2017 Jan 3;18(1):68-81. doi: 10.1016/j.celrep.2016.12.020.

19.

Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome.

Okuno H, Nakabayashi K, Abe K, Ando T, Sanosaka T, Kohyama J, Akamatsu W, Ohyama M, Takahashi T, Kosaki K, Okano H.

Congenit Anom (Kyoto). 2017 Jul;57(4):96-103. doi: 10.1111/cga.12206. Epub 2017 Mar 22.

PMID:
28004416
20.

Generation of neural cells using iPSCs from sleep bruxism patients with 5-HT2A polymorphism.

Hoashi Y, Okamoto S, Abe Y, Matsumoto T, Tanaka J, Yoshida Y, Imaizumi K, Mishima K, Akamatsu W, Okano H, Baba K.

J Prosthodont Res. 2017 Jul;61(3):242-250. doi: 10.1016/j.jpor.2016.11.003.

PMID:
27916472
21.

Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.

Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, Iwayama Y, Toyota T, Matsumoto T, Itasaka N, Sugiyama S, Tanaka M, Yano M, Dean B, Okano H, Yoshikawa T.

Transl Psychiatry. 2016 Nov 1;6(11):e934. doi: 10.1038/tp.2016.206.

22.

Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines.

Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Hattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W, Okano H.

Mol Brain. 2016 Oct 3;9(1):88.

23.

In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.

Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H.

Mol Brain. 2016 Jul 19;9(1):70. doi: 10.1186/s13041-016-0246-y.

24.

LNGFR+THY-1+ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells.

Ouchi T, Morikawa S, Shibata S, Fukuda K, Okuno H, Fujimura T, Kuroda T, Ohyama M, Akamatsu W, Nakagawa T, Okano H.

Differentiation. 2016 Dec;92(5):270-280. doi: 10.1016/j.diff.2016.04.003. Epub 2016 May 10.

PMID:
27178356
25.

Modeling Rett Syndrome Using Human Induced Pluripotent Stem Cells.

Andoh-Noda T, Inouye MO, Miyake K, Kubota T, Okano H, Akamatsu W.

CNS Neurol Disord Drug Targets. 2016;15(5):544-50. Review.

PMID:
27071793
26.

Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.

Ichiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H.

Stem Cell Reports. 2016 Apr 12;6(4):496-510. doi: 10.1016/j.stemcr.2016.02.011. Epub 2016 Mar 17.

27.

Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling.

Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.

Stem Cell Reports. 2016 Mar 8;6(3):422-35. doi: 10.1016/j.stemcr.2016.01.010. Epub 2016 Feb 18.

28.

Erratum: Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.

Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T.

Sci Rep. 2016 Jan 29;6:20268. doi: 10.1038/srep20268. No abstract available.

29.

Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.

Imaizumi K, Sone T, Ibata K, Fujimori K, Yuzaki M, Akamatsu W, Okano H.

Stem Cell Reports. 2015 Dec 8;5(6):1010-1022. doi: 10.1016/j.stemcr.2015.10.005. Epub 2015 Nov 5.

30.

Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.

Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T.

Sci Rep. 2015 Nov 9;5:16239. doi: 10.1038/srep16239. Erratum in: Sci Rep. 2016;6:20268.

31.

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.

Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H.

Hum Mol Genet. 2015 Sep 1;24(17):4879-900. doi: 10.1093/hmg/ddv212. Epub 2015 Jun 8.

PMID:
26056228
32.

Pathophysiological analysis of Parkinson's disease using iPS cells.

Ishikawa KI, Hattori N, Akamatsu W.

Nihon Rinsho. 2015 Jun;73 Suppl 5:391-5. Japanese. No abstract available.

PMID:
30458086
33.

Pathophysiological analysis of Parkinson's disease using iPS cells.

Ishikawa KI, Hattori N, Akamatsu W.

Nihon Rinsho. 2015 Jun;73 Suppl 5:391-5. Japanese. No abstract available.

PMID:
30458085
34.

Direct reprogramming of somatic cells into neural cell lineages.

Akamatsu W.

Nihon Rinsho. 2015 Jun;73 Suppl 5:121-4. Japanese. No abstract available.

PMID:
30457750
35.

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.

Andoh-Noda T, Akamatsu W, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H.

Mol Brain. 2015 May 27;8:31. doi: 10.1186/s13041-015-0121-2.

36.

Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses.

Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T.

Biol Psychiatry. 2015 Jul 15;78(2):116-25. doi: 10.1016/j.biopsych.2014.07.025. Epub 2014 Sep 11.

37.

Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.

Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H.

Stem Cell Reports. 2014 Apr 24;2(5):648-61. doi: 10.1016/j.stemcr.2014.03.007. eCollection 2014 May 6. Erratum in: Stem Cell Reports. 2015 Jan 13;4(1):170.

38.

The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.

Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H.

Mol Brain. 2014 Jun 16;7:45. doi: 10.1186/1756-6606-7-45.

39.

Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors.

Zhou Z, Kohda K, Ibata K, Kohyama J, Akamatsu W, Yuzaki M, Okano HJ, Sasaki E, Okano H.

Mol Brain. 2014 Apr 3;7:24. doi: 10.1186/1756-6606-7-24.

40.

Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior.

DeBoer EM, Azevedo R, Vega TA, Brodkin J, Akamatsu W, Okano H, Wagner GC, Rasin MR.

J Neurosci. 2014 Mar 5;34(10):3674-86. doi: 10.1523/JNEUROSCI.3703-13.2014.

41.

Increased l1 retrotransposition in the neuronal genome in schizophrenia.

Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T, Iwamoto K.

Neuron. 2014 Jan 22;81(2):306-13. doi: 10.1016/j.neuron.2013.10.053. Epub 2014 Jan 2.

42.

The RNA-binding protein HuD regulates autophagosome formation in pancreatic β cells by promoting autophagy-related gene 5 expression.

Kim C, Kim W, Lee H, Ji E, Choe YJ, Martindale JL, Akamatsu W, Okano H, Kim HS, Nam SW, Gorospe M, Lee EK.

J Biol Chem. 2014 Jan 3;289(1):112-21. doi: 10.1074/jbc.M113.474700. Epub 2013 Nov 25.

43.

A human Dravet syndrome model from patient induced pluripotent stem cells.

Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S.

Mol Brain. 2013 May 2;6:19. doi: 10.1186/1756-6606-6-19.

44.

Generation of human melanocytes from induced pluripotent stem cells.

Ohta S, Imaizumi Y, Akamatsu W, Okano H, Kawakami Y.

Methods Mol Biol. 2013;989:193-215. doi: 10.1007/978-1-62703-330-5_16.

PMID:
23483397
45.

Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem Cells.

Shofuda T, Kanematsu D, Fukusumi H, Yamamoto A, Bamba Y, Yoshitatsu S, Suemizu H, Nakamura M, Sugimoto Y, Furue MK, Kohara A, Akamatsu W, Okada Y, Okano H, Yamasaki M, Kanemura Y.

Cell Med. 2012 Nov 1;4(3):125-47. doi: 10.3727/215517912X658918. eCollection 2013 Mar.

46.

Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy.

Nihei Y, Ito D, Okada Y, Akamatsu W, Yagi T, Yoshizaki T, Okano H, Suzuki N.

J Biol Chem. 2013 Mar 22;288(12):8043-52. doi: 10.1074/jbc.M112.408211. Epub 2013 Jan 30.

47.

Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo.

Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H, Ohyama M.

J Invest Dermatol. 2013 Jun;133(6):1479-88. doi: 10.1038/jid.2013.7. Epub 2013 Jan 15.

48.

[Modeling familial Alzheimer's disease with induced pluripotent stem cells].

Yagi T, Ito D, Okada Y, Akamatsu W, Nihei Y, Okano H, Suzuki N.

Rinsho Shinkeigaku. 2012;52(11):1134-6. Japanese.

PMID:
23196540
49.

[Exploring the neural diseases using stem cell technology].

Akamatsu W.

Rinsho Shinkeigaku. 2012;52(11):937-8. Japanese.

PMID:
23196475
50.

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.

Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H.

Mol Brain. 2012 Oct 6;5:35. doi: 10.1186/1756-6606-5-35.

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